New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination

Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination

(2016) Shengfeng Huang et al.   CELL

Collaboration of RAG2 with RAG1-like proteins during the evolution of V(D)J recombination

(2016) Lina Marcela Carmona et al.   GENES & DEVELOPMENT

Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon

(2015) Vladimir V Kapitonov et al.   Biology Direct

RAG Represents a Widespread Threat to the Lymphocyte Genome

(2015) Grace Teng et al.   CELL

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures

(2015) Heng Ru et al.   CELL

Crystal structure of the V(D)J recombinase RAG1–RAG2

(2015) Min-Sung Kim et al.   NATURE

Re-evaluation of the Immunological Big Bang

(2014) Martin F. Flajnik   CURRENT BIOLOGY

Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes

(2014) Shengfeng Huang et al.   Nature Communications

Evolutionary implications of a third lymphocyte lineage in lampreys

(2013) Masayuki Hirano et al.   NATURE

An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1

(2013) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dual Interaction between the DNA Damage Response Protein MDC1 and the RAG1 Subunit of the V(D)J Recombinase

(2012) Gideon Coster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional characterization of an active Rag-like transposase

(2012) Cary G Hencken et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

V(D)J Recombination: Mechanisms of Initiation

(2011) David G. Schatz et al.   Annual Review of Genetics

VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity

(2011) Michele D Kassmeier et al.   EMBO JOURNAL

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci

(2010) Yanhong Ji et al.   CELL

Endogenous TCR Recombination in TCR Tg Single RAG-Deficient Mice Uncovered by Robust In Vivo T Cell Activation and Selection

(2010) Caroline Montaudouin et al.   PLoS One

Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination

(2010) G. J. Grundy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The roles of the RAG1 and RAG2 “non-core” regions in V(D)J recombination and lymphocyte development

(2009) Jessica M. Jones et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

A Zinc Site in the C-Terminal Domain of RAG1 Is Essential for DNA Cleavage Activity

(2009) Lori M. Gwyn et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis

(2009) Fang Fang Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Paleo-Immunology: Evidence Consistent with Insertion of a Primordial Herpes Virus-Like Element in the Origins of Acquired Immunity

(2009) David H. Dreyfus   PLoS One

The origins of the Rag genes—From transposition to V(D)J recombination

(2009) Sebastian D. Fugmann   SEMINARS IN IMMUNOLOGY

Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes

(2008) Yuri Panchin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tails

(2008) David R. Wilson et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Evidence for Ku70/Ku80 association with full-length RAG1

(2008) Prafulla Raval et al.   NUCLEIC ACIDS RESEARCH