☆ 4.6 Editorial Material

ADP-ribosylation of DNA moving into focus

FEBS JOURNAL (2017)

Journal

FEBS JOURNAL

Volume 284, Issue 23, Pages 3999-4001

Publisher

WILEY

DOI: 10.1111/febs.14326

Keywords

-

Categories

Biochemistry & Molecular Biology

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Biochemistry & Molecular Biology

Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA

Andrea Hlousek-Kasun, Petra Mikolcevic, Johannes Gregor Matthias Rack, Callum Tromans-Coia, Marion Schuller, Gytis Jankevicius, Marija Matkovic, Branimir Bertosa, Ivan Ahel, Andreja Mikoc

Summary: ADP-ribosylation is an important covalent modification that plays critical roles in various biological processes. The toxin/antitoxin pair DarT/DarG has been discovered, where DarT modifies DNA and DarG reverses this modification. The homologue SCO6735 is highly conserved and associated with antibiotic production in bacteria, and it can also reverse the ADP-ribosylation catalyzed by DarT.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

Add to Collection

Review Biochemistry & Molecular Biology

ADP-Ribosylation Post-Translational Modification: An Overview with a Focus on RNA Biology and New Pharmacological Perspectives

Giuseppe Manco, Giuseppina Lacerra, Elena Porzio, Giuliana Catara

Summary: Cellular functions are regulated through the gene expression program, including transcription of mRNA, alternative RNA splicing, and protein synthesis. Post-translational modifications of proteins, such as ADP-ribosylation, add another layer of complexity to the regulatory network. ADP-ribosylation plays a crucial role in various cellular processes, including DNA damage repair, transcriptional regulation, and cell survival. ADP-ribosyltransferases (ARTs), as enzymes involved in ADP-ribosylation, are emerging as potential drug targets. This review provides an overview of human ARTs and their biological functions, with a focus on the regulation of RNA functions by ADP-ribosyltransferase Diphtheria toxin-like enzymes (ARTD).

BIOMOLECULES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Control of cell signaling by Arf GTPases and their regulators: Focus on links to cancer and other GTPase families

Pei-Wen Chen, Anjelika Gasilina, Mukesh P. Yadav, Paul A. Randazzo

Summary: ADP-ribosylation factors (Arfs) are a family of regulatory GTP binding proteins that primarily regulate membrane trafficking and cytoskeleton remodeling. In addition, Arfs have been found to play a role in signaling and integrating multiple signaling pathways to influence specific cell behaviors.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2022)

Add to Collection

Article Multidisciplinary Sciences

Serine-linked PARP1 auto-modification controls PARP inhibitor response

Evgeniia Prokhorova, Florian Zobel, Rebecca Smith, Siham Zentout, Ian Gibbs-Seymour, Kira Schutzenhofer, Alessandra Peters, Josephine Groslambert, Valentina Zorzini, Thomas Agnew, John Brognard, Michael L. Nielsen, Dragana Ahel, Sebastien Huet, Marcin J. Suskiewicz, Ivan Ahel

Summary: Recent findings suggest that serine ADP-ribosylation plays a vital role in cellular responses to PARP1/PARP2 inhibitors. The efficient modification of three serine residues within PARP1 by HPF1 counters PARP1 trapping and contributes to inhibitor tolerance, implicating these residues as potential biomarkers for PARP inhibitor therapy.

NATURE COMMUNICATIONS (2021)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

TopBP1 comes into focus

William G. Dunphy

Summary: Frattini et al. (2021) demonstrate that TopBP1 forms phase-separated nuclear condensates to promote activation of ATR in cells experiencing genomic stress.

MOLECULAR CELL (2021)

Add to Collection

Article Biochemical Research Methods

Establishment of a Mass-Spectrometry-Based Method for the Identification of the In Vivo Whole Blood and Plasma ADP-Ribosylomes

Stephanie C. Luthi, Anna Howald, Kathrin Nowak, Robert Graage, Giody Bartolomei, Christine Neupert, Xaver Sidler, Deena Leslie Pedrioli, Michael O. Hottiger

Summary: Plasma phosphodiesterases and/or ADP-ribosylhydrolases were found to rapidly remove post-translational modifications in vitro ADP-ribosylated proteins. Mass spectrometry identified a total of 60 ADP-ribosylated proteins, with 17 of them being ADP-ribosylated plasma proteins. This new protocol marks an important advancement in the field of ADP-ribosylation and provides insights into ADP-ribosylomes in blood and plasma under different conditions.

JOURNAL OF PROTEOME RESEARCH (2021)

Add to Collection

Article Multidisciplinary Sciences

Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs

Johannes Rudolph, Genevieve Roberts, Karolin Luger

Summary: PARP1 and PARP2 are key enzymes in the DNA damage response. HPF1 plays an essential role in modulating the PARylation of histones by forming a complex with both PARP1 and PARP2. Results show how HPF1 can affect the binding affinity of certain inhibitors to PARP1.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Hematology

Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells

Andrew M. Cobb, Syabira Yusoff, Robert Hayward, Sadia Ahmad, Mengxi Sun, Anja Verhulst, Patrick C. D'Haese, Catherine M. Shanahan

Summary: The study found that DNA damage stimulates Runx2 accumulation and enhances its activation of osteogenic target genes, leading to increased calcification. Runx2 also participates in DNA repair and its PARylation in response to genotoxic stress affects its localization at DNA lesions.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Progress and outlook in studying the substrate specificities of PARPs and related enzymes

Marcin J. Suskiewicz, Luca Palazzo, Rebecca Hughes, Ivan Ahel

Summary: Despite years of research on ADP-ribosyltransferases from the PARP family, their substrate specificity has remained unclear. Recent breakthroughs include identifying protein serine residues, cysteine, and tyrosine as potential targets of specific PARPs. These findings shed new light on PARP-mediated catalysis and caution to expect the unexpected with potential substrates.

FEBS JOURNAL (2021)

Add to Collection

Article Multidisciplinary Sciences

Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins

Tomoko Kubori, Junyup Lee, Hyunmin Kim, Kohei Yamazaki, Masanari Nishikawa, Tomoe Kitao, Byung-Ha Oh, Hiroki Nagai

Summary: The intracellular bacterial pathogen Legionella pneumophila utilizes a pair of effector proteins, Lpg0080 and Lpg0081, to coordinately manipulate mitochondrial activity in host cells by enzymatically modifying ADP/ATP translocases.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection

Review Cell Biology

Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology

Yujie Gan, Huanhuan Sha, Renrui Zou, Miao Xu, Yuan Zhang, Jifeng Feng, Jianzhong Wu

Summary: This review provides an update on methodological advances in the study of ADP-ribosylation and discusses the function and therapeutic potential of mono-ADP-ribosylation in cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal

Johannes Gregor Matthias Rack, Qiang Liu, Valentina Zorzini, Jim Voorneveld, Antonio Ariza, Kourosh Honarmand Ebrahimi, Julia M. Reber, Sarah C. Krassnig, Dragana Ahel, Gijsbert A. van der Marel, Aswin Mangerich, James S. O. McCullagh, Dmitri V. Filippov, Ivan Ahel

Summary: Poly(ADP-ribosyl)ation is a versatile posttranslational modification involved in regulating cellular processes. This study focuses on the mechanisms of PAR removal by PARG and ARH3, highlighting their differences in hydrolysis of linear and terminal ADP-ribose linkages.

NATURE COMMUNICATIONS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Nanobodies as probes to investigate purinergic signaling

Marie Eggers, Felix Ruehl, Friedrich Haag, Friedrich Koch-Nolte

Summary: Nanobodies, the single variable immunoglobulin domains of heavy chain antibodies naturally occurring in camelids, have a hydrophilic surface area which makes them highly soluble, robust in harsh environments, and exceptionally easy to format into bispecific reagents. The unique properties of nanobodies have been utilized in modulating purinergic signaling, with examples targeting P2X7, CD38, and ARTC2.2.

BIOCHEMICAL PHARMACOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-(3 signaling

Daniel J. Sanderson, Kelsie M. Rodriguez, Daniel S. Bejan, Ninni E. Olafsen, Inga D. Bohn, Ana Kojic, Sunil Sundalam, Ivan R. Siordia, Anna K. Duell, Nancy Deng, Carsten Schultz, Denis M. Grant, Jason Matthews, Michael S. Cohen

Summary: PARP7 is a key negative regulator of cytosolic NA-sensors of the innate immune system. Through rational design, a pan-PARP inhibitor was converted into a potent selective PARP7 inhibitor. Treatment with the inhibitor and NA-sensor ligands synergistically induced expression of type I interferon. The results also showed that the inhibitor increased PARP7 protein levels and highlighted the importance of structurally distinct chemical probes for the same target.

CELL CHEMICAL BIOLOGY (2023)

Add to Collection

Article Oncology

A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma

Louise Ramos, Sarah Truong, Beibei Zhai, Jay Joshi, Fariba Ghaidi, Michael M. Lizardo, Taras Shyp, Sonia H. Y. Kung, Alireza M. Rezakhanlou, Htoo Zarni Oo, Hans Adomat, Stephane Le Bihan, Colin Collins, Jeffrey Bacha, Dennis Brown, John Langlands, Wang Shen, Nada Lallous, Poul H. Sorensen, Mads Daugaard

Summary: This study reports a novel bifunctional PARP inhibitor (kt-3283) that has dual activity towards PARP1/2 and HDAC enzymes in Ewing sarcoma cells. Compared to commonly used PARP and HDAC inhibitors, kt-3283 exhibits enhanced cytotoxicity and inhibition effects.

CLINICAL CANCER RESEARCH (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Keeping the balance in NAD metabolism

Oyvind Stromland, Marc Niere, Andrey A. Nikiforov, Magali R. VanLinden, Ines Heiland, Mathias Ziegler

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Add to Collection

Review Cell Biology

Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing

Brian C. Gilmour, Ruben Gudmundsrud, Johannes Frank, Amund Hov, Sofie Lautrup, Yahyah Aman, Helge Rosjo, Charles Brenner, Mathias Ziegler, Ole-Bjorn Tysnes, Charalampos Tzoulis, Torbjorn Omland, Arne Soraas, Trygve Holmoy, Linda H. Bergersen, Jon Storm-Mathisen, Hilde Nilsen, Evandro F. Fang

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

Add to Collection

Article Medicine, Research & Experimental

Disease-specific phenotypes iniPSC-derived neural stem cells withPOLGmutations

Kristina Xiao Liang, Cecilie Katrin Kristiansen, Sepideh Mostafavi, Guro Helen Vatne, Gina Alien Zantingh, Atefeh Kianian, Charalampos Tzoulis, Lena Elise Hoyland, Mathias Ziegler, Roberto Megias Perez, Jessica Furriol, Zhuoyuan Zhang, Novin Balafkan, Yu Hong, Richard Siller, Gareth John Sullivan, Laurence A. Bindoff

EMBO MOLECULAR MEDICINE (2020)

Add to Collection

Article Multidisciplinary Sciences

SLC25A51 is a mammalian mitochondrial NAD+ transporter

Timothy S. Luongo, Jared M. Eller, Mu-Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne, Joseph A. Baur

NATURE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells

Andrey Kropotov, Veronika Kulikova, Kirill Nerinovski, Alexander Yakimov, Maria Svetlova, Ljudmila Solovjeva, Julia Sudnitsyna, Marie E. Migaud, Mikhail Khodorkovskiy, Mathias Ziegler, Andrey Nikiforov

Summary: Nicotinamide riboside can be imported into cells by equilibrative nucleoside transporters, while nicotinic acid riboside requires active utilization in the cytosol before being taken up by HEK293 cells. Concentrative nucleoside transporters do not mediate the uptake of nicotinamide riboside.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Multidisciplinary Sciences

Discovery of fungal surface NADases predominantly present in pathogenic species

Oyvind Stromland, Juha P. Kallio, Annica Pschibul, Renate H. Skoge, Hulda M. Hardardottir, Lars J. Sverkeli, Thorsten Heinekamp, Olaf Kniemeyer, Marie Migaud, Mikhail Makarov, Toni Gossmann, Axel A. Brakhage, Mathias Ziegler

Summary: Nicotinamide adenine dinucleotide (NAD) plays a crucial role in cellular bioenergetics and signalling. Fungal NADases on the surface of Aspergillus fumigatus and Neurospora crassa exhibit unique biochemical and structural properties, suggesting potential advantages during interactions with hosts or competing microorganisms.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Chemistry, Analytical

Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes.a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS

Alienke van Pijkeren, Jorn Dietze, Alejandro Sanchez Brotons, Anna-Sophia Egger, Tim Lijster, Andrei Barcaru, Madlen Hotze, Philipp Kobler, Frank J. Dekker, Peter Horvatovich, Barbro N. Melgert, Mathias Ziegler, Kathrin Thedieck, Ines Heiland, Rainer Bischoff, Marcel Kwiatkowski

Summary: The study introduces a new approach, combining metabolic and chemical labeling, to accurately observe site-specific lysine acetylation dynamics. This method allows for the determination of reaction rates for acetylation and deacetylation.

ANALYTICAL CHEMISTRY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

ADP-ribosyltransferases, an update on function and nomenclature

Bernhard Luscher, Ivan Ahel, Matthias Altmeyer, Alan Ashworth, Peter Bai, Paul Chang, Michael Cohen, Daniela Corda, Francoise Dantzer, Matthew D. Daugherty, Ted M. Dawson, Valina L. Dawson, Sebastian Deindl, Anthony R. Fehr, Karla L. H. Feijs, Dmitri V. Filippov, Jean-Philippe Gagne, Giovanna Grimaldi, Sebastian Guettler, Nicolas C. Hoch, Michael O. Hottiger, Patricia Korn, W. Lee Kraus, Andreas Ladurner, Lari Lehtio, Anthony K. L. Leung, Christopher J. Lord, Aswin Mangerich, Ivan Matic, Jason Matthews, George-Lucian Moldovan, Joel Moss, Gioacchino Natoli, Michael L. Nielsen, Mario Niepel, Friedrich Nolte, John Pascal, Bryce M. Paschal, Krzysztof Pawlowski, Guy G. Poirier, Susan Smith, Gyula Timinszky, Zhao-Qi Wang, Jose Yelamos, Xiaochun Yu, Roko Zaja, Mathias Ziegler

Summary: ADP-ribosylation, a post-translational modification of proteins, nucleic acids, and metabolites, plays diverse roles in cellular processes such as stress responses, signaling, and transcriptional regulation. Recent advances in research have identified a wide range of cellular pathways regulated by ADP-ribosylation, highlighting the importance of understanding this mechanism in cell biology.

FEBS JOURNAL (2022)

Add to Collection

Article Cell Biology

The balance between NAD+ biosynthesis and consumption in ageing

Oyvind Stromland, Joseph Diab, Eugenio Ferrario, Lars J. Sverkeli, Mathias Ziegler

Summary: NAD(+) is an important coenzyme in redox reactions and cellular signaling, regulating essential processes like DNA repair, immune cell function, senescence, and chromatin remodeling. The decline of NAD(+) levels with age has been linked to various age-related diseases such as metabolic diseases and cognitive decline. Therapeutic augmentation of NAD(+) levels can halt or reverse the progression of age-related diseases.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Add to Collection

Article Biology

Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

Knut H. Lauritzen, Maria Belland Olsen, Mohammed Shakil Ahmed, Kuan Yang, Johanne Egge Rinholm, Linda H. Bergersen, Qin Ying Esbensen, Lars Jansen Sverkeli, Mathias Ziegler, Havard Attramadal, Bente Halvorsen, Pal Aukrust, Arne Yndestad

Summary: High levels of mtDNA damage lead to reduced NAD(+) levels, affecting the activity of SIRT3, while high dosages of nicotinamide riboside also inhibit sirtuin activity, resulting in irregular cardiac mitochondrial morphology. Therefore, caution should be exercised when using high doses of NR in cases where cardiomyopathic symptoms are caused by mitochondrial dysfunction and mtDNA instability.

ELIFE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25

Mathias Ziegler, Magnus Monne, Andrey Nikiforov, Gennaro Agrimi, Ines Heiland, Ferdinando Palmieri

Summary: Subcellular compartmentation is a fundamental property of eukaryotic cells, where the transport of solutes across membranes plays a crucial role in cellular communication and metabolic regulation. In mammals, the SLC family comprises carriers that selectively transport molecules across biological membranes, with the SLC25 family playing a particularly important role in supplying mitochondria with metabolic intermediates. The recent discovery of SLC25A51 as the major mitochondrial NAD(+) carrier in mammals has resolved a long-standing mystery in NAD(+) biology.

BIOMOLECULES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD

Lars Jansen Sverkeli, Faisal Hayat, Marie E. Migaud, Mathias Ziegler

Summary: Recent studies have shown that vacor can interfere with mammalian NAD metabolism and transform into the toxic molecule VAD. Efficient enzymatic and chemical procedures have been developed to produce vacor analogs. Phosphorylation of vacor riboside by nicotinamide riboside kinases offers a valuable alternative for generating the vacor analog of NMN.

BIOMOLECULES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria

Suraj Sharma, Yin-Chen Hsieh, Jorn Dietze, Mathias Bockwoldt, Oyvind Stromland, Mathias Ziegler, Ines Heiland

Summary: Bacteria use two alternative pathways to synthesize NAD, with the four-step route being energetically unfavourable but still prevalent in bacteria, yeast, and plants. The higher chemical stability of deamidated intermediates compensates for the additional energy expenditure at elevated temperatures.

METABOLITES (2022)

Add to Collection

Article Multidisciplinary Sciences

Kinetic and oligomeric study of Leishmania braziliensis nicotinate/nicotinamide mononucleotide adenylyltransferase

Luis Ernesto Contreras Rodriguez, Mathias Ziegler, Maria Helena Ramirez Hernandez

HELIYON (2020)

Add to Collection

Article Medicine, Research & Experimental

Sirtuin 2 enhances allergic asthmatic inflammation

Yong Gyu Lee, Brenda F. Reader, Derrick Herman, Adam Streicher, Joshua A. Englert, Mathias Ziegler, Sangwoon Chung, Manjula Karpurapu, Gye Young Park, John W. Christman, Megan N. Ballinger

JCI INSIGHT (2019)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.