Mechanisms of proton relay and product release by Class A β-lactamase at ultrahigh resolution

Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic

(2015) Eric M. Lewandowski et al.   CHEMICAL COMMUNICATIONS

Exploring the Mechanism of β-Lactam Ring Protonation in the Class A β-lactamase Acylation Mechanism Using Neutron and X-ray Crystallography

(2015) Venu Gopal Vandavasi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography

(2015) Derek A. Nichols et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3

(2013) Sander S. van Berkel et al.   ACS Chemical Biology

Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in β-Lactam Resistance

(2013) Jeffrey D. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Kinetic Characterization of Hydrolysis of Nitrocefin, Cefoxitin, and Meropenem by β-Lactamase from Mycobacterium tuberculosis

(2013) Carmen Chow et al.   BIOCHEMISTRY

Resistance to antibiotics targeted to the bacterial cell wall

(2013) I. Nikolaidis et al.   PROTEIN SCIENCE

Protonation states of active-site lysines of penicillin-binding protein 6 fromEscherichia coliand the mechanistic implications

(2013) Malika Kumarasiri et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Perspective of Peptidoglycan Biosynthesis and Assembly

(2012) Andrew L. Lovering et al.   Annual Review of Biochemistry

Neutron and X-ray Crystal Structures of a Perdeuterated Enzyme Inhibitor Complex Reveal the Catalytic Proton Network of the Toho-1 β-Lactamase for the Acylation Reaction

(2012) Stephen J. Tomanicek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Basis for Carbapenem Hydrolysis by Class A β-Lactamases: A Combined Investigation using Crystallography and Simulations

(2012) Fátima Fonseca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Noncovalent Complexes of an Inactive Mutant of CTX-M-9 with the Substrate Piperacillin and the Corresponding Product

(2011) David Leyssene et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epidemiological Expansion, Structural Studies, and Clinical Challenges of New β-Lactamases from Gram-Negative Bacteria

(2010) Karen Bush et al.   Annual Review of Microbiology

Structures of the Michaelis Complex (1.2 Å) and the Covalent Acyl Intermediate (2.0 Å) of Cefamandole Bound in the Active Sites of theMycobacterium tuberculosisβ-Lactamase K73A and E166A Mutants,

(2010) Lee W. Tremblay et al.   BIOCHEMISTRY

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Structural Insights into Substrate Recognition and Product Expulsion in CTX-M Enzymes

(2010) Julien Delmas et al.   JOURNAL OF MOLECULAR BIOLOGY

Three Decades of the Class A β-Lactamase Acyl-Enzyme

(2009) Jed Fisher et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Neutron Diffraction Studies of a Class A β-Lactamase Toho-1 E166A/R274N/R276N Triple Mutant

(2009) Stephen J. Tomanicek et al.   JOURNAL OF MOLECULAR BIOLOGY

Investigation of the Mechanism of the Cell Walldd-Carboxypeptidase Reaction of Penicillin-Binding Protein 5 ofEscherichia coliby Quantum Mechanics/Molecular Mechanics Calculations

(2008) Qicun Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Bacteria Fight Back

(2008) G. Taubes   SCIENCE