T3SS effector ExoY reduces inflammasome-related responses by suppressing bacterial motility and delaying activation of NF-κB and caspase-1

Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins

(2016) Alexander Belyy et al.   Nature Communications

Prostaglandin E2Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages

(2015) Milena Sokolowska et al.   JOURNAL OF IMMUNOLOGY

A novel regulator PA5022 (aefA) is involved in swimming motility, biofilm formation and elastase activity of Pseudomonas aeruginosa

(2015) Yingli Li et al.   MICROBIOLOGICAL RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The Pseudomonas aeruginosa exoenzyme Y impairs endothelial cell proliferation and vascular repair following lung injury

(2014) Trevor C. Stevens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation

(2014) Urike Beckert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pseudomonas aeruginosa injects NDK into host cells through a type III secretion system

(2014) Dennis Neeld et al.   MICROBIOLOGY-SGM

Sequential inactivation of Rho GTPases and Lim kinase by Pseudomonas aeruginosa toxins ExoS and ExoT leads to endothelial monolayer breakdown

(2013) P. Huber et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Caspase-1: The inflammasome and beyond

(2013) Gabriel Sollberger et al.   Innate Immunity

Repression of Inflammasome by Francisella tularensis during Early Stages of Infection

(2013) Rachel J. Dotson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pseudomonas aeruginosa Exotoxin Y-Mediated Tau Hyperphosphorylation Impairs Microtubule Assembly in Pulmonary Microvascular Endothelial Cells

(2013) Ron Balczon et al.   PLoS One

Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

(2013) Cierra N. Casson et al.   PLoS Pathogens

Vibrio parahaemolyticus Effector Proteins Suppress Inflammasome Activation by Interfering with Host Autophagy Signaling

(2013) Naomi Higa et al.   PLoS Pathogens

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses

(2013) Shaan L. Gellatly et al.   Pathogens and Disease

Analysis of Human Bronchial Epithelial Cell Proinflammatory Response toBurkholderia cenocepaciaInfection

(2012) Devyn D. Gillette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pseudomonas aeruginosaExotoxin Y Is a Promiscuous Cyclase That Increases Endothelial Tau Phosphorylation and Permeability

(2012) Cristhiaan D. Ochoa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-1 Protein Induces Apoptosis-associated Speck-like Protein Containing a Caspase Recruitment Domain (ASC)-mediated Necrosis Independently of Its Catalytic Activity

(2011) Kou Motani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence

(2011) Victoria Hritonenko et al.   MICROBIAL PATHOGENESIS

Bacterial Delivery of Nuclear Proteins into Pluripotent and Differentiated Cells

(2011) Candace Bichsel et al.   PLoS One

A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System

(2010) Igor E. Brodsky et al.   Cell Host & Microbe

In Vivo Discrimination of Type 3 Secretion System-Positive and -Negative Pseudomonas aeruginosa via a Caspase-1-Dependent Pathway

(2010) T. Wangdi et al.   INFECTION AND IMMUNITY

The Pseudomonas aeruginosa Vfr Regulator Controls Global Virulence Factor Expression through Cyclic AMP-Dependent and -Independent Mechanisms

(2010) E. L. Fuchs et al.   JOURNAL OF BACTERIOLOGY

The type III secretion system of Pseudomonas aeruginosa: infection by injection

(2009) Alan R. Hauser   NATURE REVIEWS MICROBIOLOGY

Role of Small GTPases and αvβ5 Integrin inPseudomonas aeruginosa–Induced Increase in Lung Endothelial Permeability

(2008) Michael T. Ganter et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

ThePseudomonas aeruginosa TypeIII secretion system plays a dual role in the regulation of caspase-1 mediated IL-1β maturation

(2008) M. Galle et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE