Hyperglycemia- and hyperinsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle

Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome

(2016) Scott D. Zawieja et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats

(2016) Ivan Merdzo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Macrophage alterations within the mesenteric lymphatic tissue are associated with impairment of lymphatic pump in metabolic syndrome

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MicroRNA signature of inflamed lymphatic endothelium and role of miR-9 in lymphangiogenesis and inflammation

(2015) Sanjukta Chakraborty et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory PhenotypeSignificance

(2015) Sarah E. Gardner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARγ/Akt/NO signaling pathway

(2015) Rongchun Chen et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

VEGF‐C is required for intestinal lymphatic vessel maintenance and lipid absorption

(2015) Harri Nurmi et al.   EMBO Molecular Medicine

Nox2 Mediates Skeletal Muscle Insulin Resistance Induced by a High Fat Diet

(2015) Alvaro Souto Padron de Figueiredo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging trends in the pathophysiology of lymphatic contractile function

(2015) Sanjukta Chakraborty et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model

(2015) Sabyasachi Sen et al.   Stem Cell Research & Therapy

Obesity increases inflammation and impairs lymphatic function in a mouse model of lymphedema

(2014) Ira L. Savetsky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Lymphatic Vessel Insufficiency in Hypercholesterolemic Mice Alters Lipoprotein Levels and Promotes Atherogenesis

(2014) Taina Vuorio et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis

(2014) Sergio Martínez-Hervás et al.   CARDIOVASCULAR RESEARCH

Oxidative Stress and Obesity: The Chicken or the Egg?

(2014) A. R. Aroor et al.   DIABETES

Perivascular adipose tissue-derived leptin promotes vascular smooth muscle cell phenotypic switching via p38 mitogen-activated protein kinase in metabolic syndrome rats

(2014) Hao Li et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Insulin Regulates Nitric Oxide Production in the Kidney Collecting Duct Cells

(2014) Gaurav Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An abnormal lymphatic phenotype is associated with subcutaneous adipose tissue deposits in Dercum's disease

(2014) John C. Rasmussen et al.   Obesity

Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans

(2014) David Patsouris et al.   PLoS One

Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase

(2013) Yuhong Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle

(2013) Seung-Lark Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardamonin Ameliorates Insulin Resistance Induced by High Insulin and High Glucose through the mTOR and Signal Pathway

(2013) Peiguang Niu et al.   PLANTA MEDICA

Obesity Impairs Lymphatic Fluid Transport and Dendritic Cell Migration to Lymph Nodes

(2013) Evan S. Weitman et al.   PLoS One

Mitochondrial NDUFS3 regulates the ROS-mediated onset of metabolic switch in transformed cells

(2013) S. Suhane et al.   Biology Open

Impaired insulin-stimulated myosin phosphatase Rho-interacting protein signaling in diabetic Goto-Kakizaki vascular smooth muscle cells

(2012) Jin Hee Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species

(2012) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation?

(2012) N Arngrim et al.   INTERNATIONAL JOURNAL OF OBESITY

Activating transcription factor 6 protects insulin receptor from ER stress-stimulated desensitization via p42/44 ERK pathway

(2011) Xuan Tang et al.   ACTA PHARMACOLOGICA SINICA

Biological Basis of Therapeutic Lymphangiogenesis

(2011) Camilla Norrmén et al.   CIRCULATION

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models?

(2011) JennaLynn Styskal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential effects of myosin light chain kinase inhibition on contractility, force development and myosin light chain 20 phosphorylation of rat cervical and thoracic duct lymphatics

(2011) Zhanna V. Nepiyushchikh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lymphatic/Blood Endothelial Cell Connections at the Capillary Level in Adult Rat Mesentery

(2010) Jennifer L. Robichaux et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Lymphatic system: a vital link between metabolic syndrome and inflammation

(2010) Sanjukta Chakraborty et al.   Annals of the New York Academy of Sciences

Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor

(2010) Jessica Perez et al.   BIOCHEMICAL JOURNAL

Substance P Activates Both Contractile and Inflammatory Pathways in Lymphatics Through the Neurokinin Receptors NK1R and NK3R

(2010) SANJUKTA CHAKRABORTY et al.   MICROCIRCULATION

Inhibition of myosin light chain phosphorylation decreases rat mesenteric lymphatic contractile activity

(2009) Wei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

Mechanisms of Vascular Insulin Resistance

(2009) David J.R. Fulton   CIRCULATION RESEARCH

A comprehensive definition for metabolic syndrome

(2009) P. L. Huang   Disease Models & Mechanisms

Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats

(2009) Yanbin Zheng et al.   JOURNAL OF ENDOCRINOLOGY

Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation

(2008) Jin Hee Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Molecular Regulation of Lymphatic Contractility

(2008) Mariappan Muthuchamy et al.   Annals of the New York Academy of Sciences

Oxidative stress and vascular disease in diabetes: Is the dichotomization of insulin signaling still valid?

(2008) Angelo Avogaro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine

(2007) Jacek Zielonka et al.   Nature Protocols