Loss of PINK1 leads to metabolic deficits in adult neural stem cells and impedes differentiation of newborn neurons in the mouse hippocampus

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

(2017) Ruth Beckervordersandforth et al.   NEURON

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Cellular Allometry of Mitochondrial Functionality Establishes the Optimal Cell Size

(2016) Teemu P. Miettinen et al.   DEVELOPMENTAL CELL

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease

(2016) Zacharias Kohl et al.   NEUROBIOLOGY OF DISEASE

Subtle alterations of excitatory transmission are linked to presynaptic changes in the hippocampus of PINK1-deficient mice

(2016) Marco Feligioni et al.   SYNAPSE

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

The current state of the neurogenic theory of depression and anxiety

(2015) Bradley R Miller et al.   CURRENT OPINION IN NEUROBIOLOGY

Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival

(2015) Amabel M. Orogo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-βProduction in Alzheimer’s Disease

(2015) Li Zuo et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adult neurogenesis: a substrate for experience-dependent change

(2015) Maya Opendak et al.   TRENDS IN COGNITIVE SCIENCES

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

(2015) Maria Maryanovich et al.   Nature Communications

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling

(2015) Riikka H. Hämäläinen et al.   Cell Reports

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression

(2014) Jaclyn Nicole Le Grand et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis

(2014) Julia Marschallinger et al.   EXPERIMENTAL GERONTOLOGY

Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis

(2014) Heather M. Wilkins et al.   HUMAN MOLECULAR GENETICS

Ca2+-mediated Mitochondrial Reactive Oxygen Species Metabolism Augments Wnt/β-Catenin Pathway Activation to Facilitate Cell Differentiation

(2014) Tareck Rharass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria Modify Exercise-Induced Development of Stem Cell-Derived Neurons in the Adult Brain

(2014) K. Steib et al.   JOURNAL OF NEUROSCIENCE

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

Bioenergetic Shifts during Transitions between Stem Cell States (2013 Grover Conference Series)

(2014) Lianghui Zhang et al.   Pulmonary Circulation

Mitochondrial fission-fusion as an emerging key regulator of cell proliferation and differentiation

(2013) Kasturi Mitra   BIOESSAYS

Mitochondrial Regulation in Pluripotent Stem Cells

(2013) Xiuling Xu et al.   Cell Metabolism

Mitochondrial Diseases of the Brain

(2013) Rajnish K. Chaturvedi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired basal and running-induced hippocampal neurogenesis coincides with reduced Akt signaling in adult R6/1 HD mice

(2013) Mark I. Ransome et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Metabolism in physiological cell proliferation and differentiation

(2013) Michalis Agathocleous et al.   TRENDS IN CELL BIOLOGY

Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice

(2012) Marie Paus et al.   BRAIN RESEARCH

Adult neurogenesis in Parkinson’s disease

(2012) Franz Marxreiter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Age-dependent effects of hippocampal neurogenesis suppression on spatial learning

(2012) Alonso Martinez-Canabal et al.   HIPPOCAMPUS

Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy

(2012) Aleksandar Rakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells

(2012) Zhiyin Xun et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Shared and Cell Type-Specific Mitochondrial Defects and Metabolic Adaptations in Primary Cells from PINK1-Deficient Mice

(2012) Ravi S. Akundi et al.   Neurodegenerative Diseases

Adult Neurogenesis Transiently Generates Oxidative Stress

(2012) Noah M. Walton et al.   PLoS One

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

(2011) Clifford D.L. Folmes et al.   Cell Metabolism

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

(2011) P. Seibler et al.   JOURNAL OF NEUROSCIENCE

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

(2011) Ravi S. Akundi et al.   PLoS One

Mutant α-synuclein and aging reduce neurogenesis in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson’s disease

(2010) Jun Peng et al.   AGING CELL

Neurogenesis in mouse models of Alzheimer's disease

(2010) Tsu Tshen Chuang   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system

(2010) Chenbo Zeng et al.   BRAIN RESEARCH

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease

(2010) Jessica M. Simpson et al.   NEUROBIOLOGY OF DISEASE

The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

(2010) Alessandro Prigione et al.   STEM CELLS

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Caspase-2 activation in neural stem cells undergoing oxidative stress-induced apoptosis

(2008) Christoffer Tamm et al.   APOPTOSIS

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

 -Synuclein Alters Notch-1 Expression and Neurogenesis in Mouse Embryonic Stem Cells and in the Hippocampus of Transgenic Mice

(2008) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease

(2008) José J. Rodríguez et al.   PLoS One

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A chemical method for fast and sensitive detection of DNA synthesis in vivo

(2008) A. Salic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant α-synuclein exacerbates age-related decrease of neurogenesis

(2007) Beate Winner et al.   NEUROBIOLOGY OF AGING