Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer
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Title
Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer
Authors
Keywords
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Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 21, Issue 8, Pages 767-779
Publisher
Informa UK Limited
Online
2017-07-03
DOI
10.1080/14728222.2017.1349754
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Note: Only part of the references are listed.- hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents
- (2016) Elisa Barile et al. ACS Chemical Biology
- Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination
- (2016) Ting Song et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1
- (2016) J.-N. Gong et al. BLOOD
- Dual inhibition of Mcl-1 by the combination of carfilzomib and TG02 in multiple myeloma
- (2016) Katelyn G. Ponder et al. CANCER BIOLOGY & THERAPY
- Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling
- (2016) Victor Peperzak et al. CELL DEATH AND DIFFERENTIATION
- Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses
- (2016) B. Lamothe et al. CLINICAL CANCER RESEARCH
- Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage
- (2016) Weihua Zhou et al. CLINICAL CANCER RESEARCH
- Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia
- (2016) Peter H. Wiernik EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA
- (2016) E. Slinger et al. HAEMATOLOGICA
- Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment
- (2016) Arnold Bolomsky et al. Journal of Hematology & Oncology
- BCL2 Inhibitors as Anticancer Drugs: A Plethora of Misleading BH3 Mimetics
- (2016) R. S. Soderquist et al. MOLECULAR CANCER THERAPEUTICS
- The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
- (2016) András Kotschy et al. NATURE
- Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain
- (2016) Gizem Akçay et al. Nature Chemical Biology
- Targeting the cancer epigenome for therapy
- (2016) Peter A. Jones et al. NATURE REVIEWS GENETICS
- Allosteric inhibition of antiapoptotic MCL-1
- (2016) Susan Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
- (2016) Andrew W. Roberts et al. NEW ENGLAND JOURNAL OF MEDICINE
- Allosteric inhibition of antiapoptotic MCL-1
- (2016) Susan Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA
- (2016) E. Slinger et al. HAEMATOLOGICA
- BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32
- (2015) Kinya Otsu et al. Autophagy
- Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells
- (2015) Yanchun Wang et al. CANCER BIOLOGY & THERAPY
- Autophagy in malignant transformation and cancer progression
- (2015) L. Galluzzi et al. EMBO JOURNAL
- BH3-only proteins: a 20-year stock-take
- (2015) Marcel Doerflinger et al. FEBS Journal
- Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors
- (2015) R. Thijssen et al. HAEMATOLOGICA
- Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity
- (2015) Milan Bruncko et al. JOURNAL OF MEDICINAL CHEMISTRY
- EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival
- (2015) Nai Yang Fu et al. NATURE CELL BIOLOGY
- Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
- (2015) J D Leverson et al. Cell Death & Disease
- The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest
- (2015) Manuel D. Haschka et al. Nature Communications
- Lower expression of activating transcription factors 3 and 4 correlates with shorter progression-free survival in multiple myeloma patients receiving bortezomib plus dexamethasone therapy
- (2015) T Narita et al. Blood Cancer Journal
- Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors
- (2015) R. Thijssen et al. HAEMATOLOGICA
- Mcl-1 Ubiquitination and Destruction
- (2015) Hiroyuki Inuzuka et al. Oncotarget
- Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity
- (2014) R. W. Rooswinkel et al. BLOOD
- PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance
- (2014) B. Tessoulin et al. BLOOD
- Emerging Potential of Therapeutic Targeting of Ubiquitin-Specific Proteases in the Treatment of Cancer
- (2014) A. Pal et al. CANCER RESEARCH
- The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF- B Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
- (2014) J. C. Godbersen et al. CLINICAL CANCER RESEARCH
- Genome‐wide siRNA screen reveals coupling between mitotic apoptosis and adaptation
- (2014) Laura A Díaz‐Martínez et al. EMBO JOURNAL
- Gossypol Increases Expression of the Pro-apoptotic BH3-only Protein NOXA through a Novel Mechanism Involving Phospholipase A2, Cytoplasmic Calcium, and Endoplasmic Reticulum Stress
- (2014) Ryan S. Soderquist et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Quinone Methide Aurin Is a Heat Shock Response Inducer That Causes Proteotoxic Stress and Noxa-dependent Apoptosis in Malignant Melanoma Cells
- (2014) Angela L. Davis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BTK inhibitors in chronic lymphocytic leukemia: a glimpse to the future
- (2014) M Spaargaren et al. ONCOGENE
- Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells
- (2014) J Yan et al. Cell Death & Disease
- Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity
- (2014) Zhi-Fu Tao et al. ACS Medicinal Chemistry Letters
- Molecular Pathways: Targeting the Microenvironment in Chronic Lymphocytic Leukemia—Focus on the B-Cell Receptor
- (2013) Elisa ten Hacken et al. CLINICAL CANCER RESEARCH
- Structure-guided design of a selective BCL-XL inhibitor
- (2013) Guillaume Lessene et al. Nature Chemical Biology
- Mcl-1 is essential for the survival of plasma cells
- (2013) Victor Peperzak et al. NATURE IMMUNOLOGY
- Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells
- (2013) Wim Pierson et al. NATURE IMMUNOLOGY
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
- (2013) Peter E. Czabotar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- BID-induced structural changes in BAK promote apoptosis
- (2013) Tudor Moldoveanu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
- (2013) John C. Byrd et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA
- (2013) Kerstin Brinkmann et al. Cell Reports
- Apoptotic Machinery Diversity in Multiple Myeloma Molecular Subtypes
- (2013) Patricia Gomez-Bougie et al. Frontiers in Immunology
- The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
- (2012) M. F. M. de Rooij et al. BLOOD
- BH3 profiling – Measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions
- (2012) Victoria Del Gaizo Moore et al. CANCER LETTERS
- NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1
- (2012) A Craxton et al. CELL DEATH AND DIFFERENTIATION
- Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons
- (2012) M M Magiera et al. CELL DEATH AND DIFFERENTIATION
- Transcription Factors Sp1 and p73 Control the Expression of the Proapoptotic Protein NOXA in the Response of Testicular Embryonal Carcinoma Cells to Cisplatin
- (2012) Lara Grande et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML
- (2012) L Zhou et al. LEUKEMIA
- Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1
- (2011) Felix M. Wensveen et al. APOPTOSIS
- Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction
- (2011) Patricia Gomez-Bougie et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
- (2011) F. M. Wensveen et al. BLOOD
- KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells
- (2011) S. Mannava et al. BLOOD
- Radiosensitization of Human Pancreatic Cancer Cells by MLN4924, an Investigational NEDD8-Activating Enzyme Inhibitor
- (2011) D. Wei et al. CANCER RESEARCH
- Can the analysis of BH3-only protein knockout mice clarify the issue of ‘direct versus indirect’ activation of Bax and Bak?
- (2011) A Villunger et al. CELL DEATH AND DIFFERENTIATION
- BCL2A1: the underdog in the BCL2 family
- (2011) M Vogler CELL DEATH AND DIFFERENTIATION
- Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia
- (2011) J. M. Tromp et al. CLINICAL CANCER RESEARCH
- Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
- (2011) Andreas Strasser et al. EMBO JOURNAL
- Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells
- (2011) Alba Pérez-Perarnau et al. Epigenetics
- Multiple BH3 Mimetics Antagonize Antiapoptotic MCL1 Protein by Inducing the Endoplasmic Reticulum Stress Response and Up-regulating BH3-only Protein NOXA
- (2011) Tina C. Albershardt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
- (2011) Haiming Dai et al. JOURNAL OF CELL BIOLOGY
- Bortezomib stabilizes NOXA and triggers ROS-associated apoptosis in medulloblastoma
- (2011) Sachiko Ohshima-Hosoyama et al. JOURNAL OF NEURO-ONCOLOGY
- Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
- (2011) Mohamed Elgendy et al. MOLECULAR CELL
- Reovirus therapy stimulates endoplasmic reticular stress, NOXA induction and augments bortezomib-mediated apoptosis in multiple myeloma
- (2011) K R Kelly et al. ONCOGENE
- The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia
- (2010) Y. Herishanu et al. BLOOD
- AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells
- (2010) A. F. Santidrian et al. BLOOD
- Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
- (2010) K. J. Campbell et al. BLOOD
- BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma
- (2010) L Bodet et al. BRITISH JOURNAL OF CANCER
- Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells
- (2010) M. Baou et al. HAEMATOLOGICA
- BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak
- (2010) Han Du et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PRDM1 Is Required for Mantle Cell Lymphoma Response to Bortezomib
- (2010) S. Desai et al. MOLECULAR CANCER RESEARCH
- The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose
- (2010) Xazmin H. Lowman et al. MOLECULAR CELL
- Noxa: A Sweet Twist to Survival and More
- (2010) Alfredo Gimenez-Cassina et al. MOLECULAR CELL
- Eaten alive: a history of macroautophagy
- (2010) Zhifen Yang et al. NATURE CELL BIOLOGY
- Mitochondria and cell death: outer membrane permeabilization and beyond
- (2010) Stephen W. G. Tait et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Dichotomy in NF-κB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering
- (2010) J M Tromp et al. ONCOGENE
- ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia
- (2010) S H Tonino et al. ONCOGENE
- An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs
- (2010) C Sheridan et al. ONCOGENE
- BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program
- (2010) D. Ren et al. SCIENCE
- Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory
- (2010) I. Vikstrom et al. SCIENCE
- Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
- (2009) F. Parlati et al. BLOOD
- Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells
- (2009) Damià Tormo et al. CANCER CELL
- Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70
- (2009) A R Stankiewicz et al. CELL DEATH AND DIFFERENTIATION
- Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells
- (2009) Jane L. Armstrong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members
- (2009) Tristan Gallenne et al. JOURNAL OF CELL BIOLOGY
- Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
- (2009) Martin Schwickart et al. NATURE
- Noxa: at the tip of the balance between life and death
- (2009) C Ploner et al. ONCOGENE
- ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
- (2009) Q. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Why is CLL refractory to bortezomib?
- (2008) R. G. Wickremasinghe BLOOD
- Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib
- (2008) F.-T. Liu et al. BLOOD
- Unique Biology of Mcl-1: Therapeutic Opportunities in Cancer
- (2008) Gordon Shore et al. CURRENT MOLECULAR MEDICINE
- Bmi1 regulates memory CD4 T cell survival via repression of theNoxagene
- (2008) Masakatsu Yamashita et al. JOURNAL OF EXPERIMENTAL MEDICINE
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