HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML

The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage

(2012) Madhavsai Gajjar et al.   CANCER CELL

Steroid Receptor RNA Activator – A nuclear receptor coregulator with multiple partners: Insights and challenges

(2011) Shane M. Colley et al.   BIOCHIMIE

Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice

(2011) A. M. Ramirez-Herrick et al.   BLOOD

Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1

(2010) Shin-Ae Kang et al.   BIOCHEMICAL PHARMACOLOGY

When one is better than two: RNA with dual functions

(2010) Damien Ulveling et al.   BIOCHIMIE

Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia

(2008) G. Garcia-Manero et al.   BLOOD

Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77-based mechanism

(2008) J. Chen et al.   BLOOD

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

(2008) K. Kojima et al.   BLOOD

Caspase-8 Cleaves Histone Deacetylase 7 and Abolishes Its Transcription Repressor Function

(2008) Fiona L. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei

(2008) Toshiko Sibayama-Imazu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

(2008) Jennifer Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of Adipocyte Differentiation by Nur77, Nurr1, and Nor1

(2008) Lily C. Chao et al.   MOLECULAR ENDOCRINOLOGY

The Induction of Orphan Nuclear Receptor Nur77 Expression by n-Butylenephthalide as Pharmaceuticals on Hepatocellular Carcinoma Cell Therapy

(2008) Y.-L. Chen et al.   MOLECULAR PHARMACOLOGY

p53 mRNA controls p53 activity by managing Mdm2 functions

(2008) Marco M. Candeias et al.   NATURE CELL BIOLOGY