LpxC inhibitors: a patent review (2010-2016)

Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design

(2016) Dmitrii V. Kalinin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficientAcinetobacter baumannii

(2016) Joseph M. Boll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug design from the cryptic inhibitor envelope

(2016) Chul-Jin Lee et al.   Nature Communications

Confronting the challenges of discovery of novel antibacterial agents

(2014) Sheo B. Singh   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

LpxC Inhibitors as New Antibacterial Agents and Tools for Studying Regulation of Lipid A Biosynthesis in Gram-Negative Pathogens

(2014) A. P. Tomaras et al.   mBio

Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer

(2013) Gina M. Clayton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutants Resistant to LpxC Inhibitors by Rebalancing Cellular Homeostasis

(2013) Daina Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors

(2013) Xiaofei Liang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug-resistant tuberculosis: time for visionary political leadership

(2013) Ibrahim Abubakar et al.   LANCET INFECTIOUS DISEASES

Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC

(2012) Joseph S. Warmus et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents

(2012) Laura A. McAllister et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods

(2012) Stefania Stefani et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections

(2012) Justin I. Montgomery et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

The rise of the Enterococcus: beyond vancomycin resistance

(2012) Cesar A. Arias et al.   NATURE REVIEWS MICROBIOLOGY

Initial Emergency Department Diagnosis and Management of Adult Patients with Severe Sepsis and Septic Shock

(2012) Sarah M Perman et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Inhibition of LpxC Protects Mice from Resistant Acinetobacter baumannii by Modulating Inflammation and Enhancing Phagocytosis

(2012) L. Lin et al.   mBio

Mechanisms DecreasingIn VitroSusceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa

(2011) Ruth E. Caughlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment

(2011) O. Zarkotou et al.   CLINICAL MICROBIOLOGY AND INFECTION

Will new antimicrobials overcome resistance among Gram-negatives?

(2011) Matteo Bassetti et al.   Expert Review of Anti-Infective Therapy

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

(2011) Matthew F. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

(2010) J. H. Moffatt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

(2010) Xiaofei Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of potent Gram-negative specific LpxC inhibitors

(2010) U. Faruk Mansoor et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design

(2010) Chul-Jin Lee et al.   CHEMISTRY & BIOLOGY

Hospital-Acquired Infections Due to Gram-Negative Bacteria

(2010) Anton Y. Peleg et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges

(2009) Peter Atadja   CANCER LETTERS

A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466

(2009) Gregory D Cuny   EXPERT OPINION ON THERAPEUTIC PATENTS

Outer membrane permeability and antibiotic resistance

(2008) Anne H. Delcour   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Metabolism Distribution and Excretion of a Matrix Metalloproteinase-13 Inhibitor, 4-[4-(4-Fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic Acid Hydroxyamide (CP-544439), in Rats and Dogs: Assessment of the Metabolic Profile of CP-544439 in Plasma and Urine of Humans

(2008) D. Dalvie et al.   DRUG METABOLISM AND DISPOSITION