Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer

Exploring the UDP pocket of LpxC through amino acid analogs

(2013) Michael R. Hale et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections

(2012) Justin I. Montgomery et al.   JOURNAL OF MEDICINAL CHEMISTRY

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of the Metal-Dependent Deacetylase LpxC fromYersinia enterocoliticaComplexed with the Potent Inhibitor CHIR-090,

(2010) Kathryn E. Cole et al.   BIOCHEMISTRY

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

(2010) Xiaofei Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design

(2010) Chul-Jin Lee et al.   CHEMISTRY & BIOLOGY

Purification and Characterization of the Lipid A Disaccharide Synthase (LpxB) fromEscherichia coli, a Peripheral Membrane Protein

(2009) Louis E. Metzger et al.   BIOCHEMISTRY

Daptomycin: mechanisms of action and resistance, and biosynthetic engineering

(2009) Richard H Baltz   CURRENT OPINION IN CHEMICAL BIOLOGY

Lipopolysaccharide: Biosynthetic pathway and structure modification

(2009) Xiaoyuan Wang et al.   PROGRESS IN LIPID RESEARCH

Mechanism and Inhibition of LpxC: An Essential Zinc-Dependent Deacetylase of Bacterial Lipid A Synthesis

(2008) Pei Zhou et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor

(2008) Igor Mochalkin et al.   PROTEIN SCIENCE