A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017)

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

(2017) Carlotta Granchi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Contrasting effects of selective MAGL and FAAH inhibition on dopamine depletion and GDNF expression in a chronic MPTP mouse model of Parkinson's disease

(2017) Noemi Pasquarelli et al.   NEUROCHEMISTRY INTERNATIONAL

The cannabinoid system and pain

(2017) Stephen G. Woodhams et al.   NEUROPHARMACOLOGY

Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS

(2017) Noemi Pasquarelli et al.   NEUROPHARMACOLOGY

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

(2016) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Monoacylglycerol Lipase Prevents Chronic Traumatic Encephalopathy-like Neuropathology in a Mouse Model of Repetitive Mild Closed Head Injury

(2015) Jian Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

(2015) Carlotta Granchi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity

(2015) John D. Douglass et al.   JOURNAL OF LIPID RESEARCH

Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells

(2015) Rea Pihlaja et al.   Journal of Neuroinflammation

Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice

(2015) E.L. von Rüden et al.   NEUROBIOLOGY OF DISEASE

A Reversible and Selective Inhibitor of Monoacylglycerol Lipase Ameliorates Multiple Sclerosis

(2014) Gloria Hernández-Torres et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and characterization of a new reversible MAGL inhibitor

(2014) Tiziano Tuccinardi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

(2014) Harry R. Chobanian et al.   ACS Medicinal Chemistry Letters

Evaluation of NHS Carbamates as a Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors

(2013) Micah J. Niphakis et al.   ACS Chemical Neuroscience

Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism

(2013) Caleb C. Lord et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy

(2013) Mireille Alhouayek et al.   DRUG DISCOVERY TODAY

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

(2012) Dina Navia-Paldanius et al.   JOURNAL OF LIPID RESEARCH

Therapeutic potential of monoacylglycerol lipase inhibitors

(2012) Melinda M. Mulvihill et al.   LIFE SCIENCES

Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity

(2012) Su-Hyoun Chon et al.   PLoS One

Discovery of potent, non-carbonyl inhibitors of fatty acid amide hydrolase (FAAH)

(2012) Sumithra Gowlugari et al.   MedChemComm

A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease

(2012) Justin R. Piro et al.   Cell Reports

Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease

(2012) Rongqing Chen et al.   Cell Reports

Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer

(2011) Lin Ye et al.   CANCER LETTERS

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

(2011) Daniel K. Nomura et al.   CHEMISTRY & BIOLOGY

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation

(2011) Mireille Alhouayek et al.   FASEB JOURNAL

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

(2011) Céline Schalk-Hihi et al.   PROTEIN SCIENCE

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain

(2010) Josée Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Glycerophospho Metabolome and Its Influence on Amino Acid Homeostasis Revealed by Brain Metabolomics of GDE1(−/−) Mice

(2010) Florian Kopp et al.   CHEMISTRY & BIOLOGY

A Review on the Monoacylglycerol Lipase: At the Interface Between Fat and Endocannabinoid Signalling

(2010) G. Labar et al.   CURRENT MEDICINAL CHEMISTRY

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

(2010) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors

(2009) AR King et al.   BRITISH JOURNAL OF PHARMACOLOGY

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Synthesis and in Vitro Evaluation of N-Substituted Maleimide Derivatives as Selective Monoglyceride Lipase Inhibitors

(2009) Nicolas Matuszak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology