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Title
Investigational therapies for hypercholesterolemia
Authors
Keywords
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Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 26, Issue 5, Pages 603-617
Publisher
Informa UK Limited
Online
2017-04-04
DOI
10.1080/13543784.2017.1315407
References
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- 2016 European Guidelines on cardiovascular disease prevention in clinical practice
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