Development of pneumococcal vaccines over the last 10 years

Impact of pneumococcal conjugate vaccines for children in high- and non–high-income countries

(2017) Robert Cohen et al.   Expert Review of Vaccines

Discovery of Novel Pneumococcal Serotype 35D, a Natural WciG-Deficient Variant of Serotype 35B

(2017) K. Aaron Geno et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Serotype distribution, antimicrobial resistance and prevalence of pilus islets in pneumococci following the use of conjugate vaccines

(2017) Mitsuyo Kawaguchiya et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Multidrug Resistance in Non-PCV13 Serotypes of Streptococcus pneumoniae in Northern Japan, 2014

(2017) Mitsuyo Kawaguchiya et al.   Microbial Drug Resistance

Serotypes not Included in 13-Valent Pneumococcal Vaccine as Causes of Acute Otitis Media with Spontaneous Tympanic Membrane Perforation in a Geographic Area with High Vaccination Coverage

(2017) Paola Marchisio et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine (PCV13) formulated with 2-phenoxyethanol in multidose vials given with routine vaccination in healthy infants: An open-label randomized controlled trial

(2017) Olubukola T. Idoko et al.   VACCINE

Surveillance of pneumococcal colonization and invasive pneumococcal disease reveals shift in prevalent carriage serotypes in Massachusetts’ children to relatively low invasiveness

(2017) I. Yildirim et al.   VACCINE

Trivalent pneumococcal protein vaccine protects against experimental acute otitis media caused by Streptococcus pneumoniae in an infant murine model

(2017) Qingfu Xu et al.   VACCINE

Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study

(2017) Aderonke Odutola et al.   VACCINE

Pneumococcal carriage among children after four years of routine 10-valent pneumococcal conjugate vaccine use in Brazil: The emergence of multidrug resistant serotype 6C

(2017) Felipe P.G. Neves et al.   VACCINE

Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity

(2017) Greiciely O. Andre et al.   Frontiers in Microbiology

Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and meta-analysis

(2017) Evelyn Balsells et al.   PLoS One

Intranasal vaccination with  -irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses

(2016) R. Babb et al.   CLINICAL SCIENCE

Safety and tolerability of pneumococcal vaccines in children

(2016) Susanna Esposito et al.   Expert Opinion On Drug Safety

The effects of differences in pspA alleles and capsular types on the resistance of Streptococcus pneumoniae to killing by apolactoferrin

(2016) Shaper Mirza et al.   MICROBIAL PATHOGENESIS

Emerging Streptococcus pneumoniae Strains Colonizing the Nasopharynx in Children After 13-valent Pneumococcal Conjugate Vaccination in Comparison to the 7-valent Era, 2006–2015

(2016) Ravinder Kaur et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Status of research and development of pediatric vaccines for Streptococcus pneumoniae

(2016) Mark R. Alderson   VACCINE

Safety and immunogenicity of a new 13-valent pneumococcal conjugate vaccine versus a licensed 7-valent pneumococcal conjugate vaccine: a study protocol of a randomised non-inferiority trial in China

(2016) Jing Jing Chen et al.   BMJ Open

Noninvasive Pneumococcal Clones Associated with Antimicrobial Nonsusceptibility Isolated from Children in the Era of Conjugate Vaccines

(2015) Martha McElligott et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Postexposure Prophylaxis Against Human Immunodeficiency Virus (HIV): New Guidelines From the WHO: A Perspective

(2015) Jonathan E. Kaplan et al.   CLINICAL INFECTIOUS DISEASES

Direct and indirect effects of the 13-valent pneumococcal conjugate vaccine administered to infants and young children

(2015) Susanna Esposito et al.   Future Microbiology

Characterization of MDR and XDRStreptococcus pneumoniaein Canada, 2007–13

(2015) Alyssa R. Golden et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults

(2015) Marc J.M. Bonten et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Tolerability and Immunogenicity of 15-valent Pneumococcal Conjugate Vaccine in Toddlers Previously Vaccinated With 7-valent Pneumococcal Conjugate Vaccine

(2015) Ajoke Sobanjo-ter Meulen et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Decline in Pneumococcal Nasopharyngeal Carriage of Vaccine Serotypes After the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Children in Atlanta, Georgia

(2015) Ankita P. Desai et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Safety and immunogenicity of a trivalent recombinant PcpA, PhtD, and PlyD1 pneumococcal protein vaccine in adults, toddlers, and infants: A phase I randomized controlled study

(2015) W. Abdullah Brooks et al.   VACCINE

Safety, tolerability, and immunogenicity of 15-valent pneumococcal conjugate vaccine in healthy adults

(2015) Richard McFetridge et al.   VACCINE

Surveillance of the impact of pneumococcal conjugate vaccines in developing countries

(2015) Gail L Rodgers et al.   Human Vaccines & Immunotherapeutics

Serological criteria and carriage measurement for evaluation of new pneumococcal vaccines

(2015) Nicola Principi et al.   Human Vaccines & Immunotherapeutics

Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?

(2015) Chiara Azzari et al.   Human Vaccines & Immunotherapeutics

Next generation protein basedStreptococcus pneumoniaevaccines

(2015) Michael E Pichichero et al.   Human Vaccines & Immunotherapeutics

Rationale and prospects for novel pneumococcal vaccines

(2015) Kristin Moffitt et al.   Human Vaccines & Immunotherapeutics

Reactogenicity, safety and immunogenicity of a protein-based pneumococcal vaccine in Gambian children aged 2–4 years: A phase II randomized study

(2015) A Odutola et al.   Human Vaccines & Immunotherapeutics

Changes in Pneumococcal Serotypes and Antimicrobial Resistance after Introduction of the 13-Valent Conjugate Vaccine in the United States

(2014) Sandra S. Richter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human Antibodies to PhtD, PcpA, and Ply Reduce Adherence to Human Lung Epithelial Cells and Murine Nasopharyngeal Colonization by Streptococcus pneumoniae

(2014) Ravinder Kaur et al.   INFECTION AND IMMUNITY

Toll-Like Receptor 2-Dependent Protection against Pneumococcal Carriage by Immunization with Lipidated Pneumococcal Proteins

(2014) Kristin Moffitt et al.   INFECTION AND IMMUNITY

Pneumococcal conjugate vaccination: correlates of protection

(2014) Angel Vila-Corcoles et al.   LANCET INFECTIOUS DISEASES

Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: A phase II randomized clinical trial

(2014) Roman Prymula et al.   VACCINE

Timing of bacterial carriage sampling in vaccine trials: A modelling study

(2014) Pippa Scott et al.   Epidemics

Vaccine effectiveness of the pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against clinically suspected invasive pneumococcal disease: a cluster-randomised trial

(2014) A A Palmu et al.   Lancet Respiratory Medicine

Estimating Strain-Specific and Overall Efficacy of Polyvalent Vaccines Against Recurrent Pathogens From a Cross-Sectional Study

(2013) Kari Auranen et al.   BIOMETRICS

The history of pneumococcal conjugate vaccine development: dose selection

(2013) Jan T Poolman et al.   Expert Review of Vaccines

Oropharyngeal and nasopharyngeal sampling for the detection of adolescent Streptococcus pneumoniae carriers

(2013) N. Principi et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Improvement of pneumococcal pneumonia diagnostics by the use of rt-PCR on plasma and respiratory samples

(2013) Vesna Cvitkovic Spik et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

A Phase I, dose-escalation trial in adults of three recombinant attenuated Salmonella Typhi vaccine vectors producing Streptococcus pneumoniae surface protein antigen PspA

(2013) Sharon E. Frey et al.   VACCINE

Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites

(2013) Daniel R. Feikin et al.   PLOS MEDICINE

Vaccine process technology

(2012) Jessica O. Josefsberg et al.   BIOTECHNOLOGY AND BIOENGINEERING

Impact of Pneumococcal Conjugate Vaccination on Otitis Media: A Systematic Review

(2012) S. Taylor et al.   CLINICAL INFECTIOUS DISEASES

Pharmacotherapy for pneumococcal infections: an update

(2012) Susanna Esposito et al.   EXPERT OPINION ON PHARMACOTHERAPY

Issues and challenges in the development of pneumococcal protein vaccines

(2012) Amy Sarah Ginsburg et al.   Expert Review of Vaccines

PcpA of Streptococcus pneumoniae mediates adherence to nasopharyngeal and lung epithelial cells and elicits functional antibodies in humans

(2012) M. Nadeem Khan et al.   MICROBES AND INFECTION

Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans

(2012) M. Nadeem Khan et al.   VACCINE

Safety and immunogenicity of pneumococcal protein vaccine candidates: Monovalent choline-binding protein A (PcpA) vaccine and bivalent PcpA–pneumococcal histidine triad protein D vaccine

(2012) Monica Bologa et al.   VACCINE

Safety and immunogenicity of the pneumococcal pneumolysin derivative PlyD1 in a single-antigen protein vaccine candidate in adults

(2012) Thierry Kamtchoua et al.   VACCINE

Distinct Effects on Diversifying Selection by Two Mechanisms of Immunity against Streptococcus pneumoniae

(2012) Yuan Li et al.   PLoS Pathogens

TH17-Based Vaccine Design for Prevention of Streptococcus pneumoniae Colonization

(2011) Kristin L. Moffitt et al.   Cell Host & Microbe

Serotype replacement in disease after pneumococcal vaccination

(2011) Daniel M Weinberger et al.   LANCET

Healthcare utilization and cost of pneumococcal disease in the United States

(2011) Susan S. Huang et al.   VACCINE

Th17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age

(2011) Petra Schmid et al.   VACCINE

Options for Inactivation, Adjuvant, and Route of Topical Administration of a Killed, Unencapsulated Pneumococcal Whole-Cell Vaccine

(2010) Y.-J. Lu et al.   Clinical and Vaccine Immunology

Preclinical Evaluation of the Pht Proteins as Potential Cross-Protective Pneumococcal Vaccine Antigens

(2010) Fabrice Godfroid et al.   INFECTION AND IMMUNITY

Concomitant administration of recombinant PsaA and PCV7 reduces Streptococcus pneumoniae serotype 19A colonization in a murine model

(2010) Melissa J. Whaley et al.   VACCINE

GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis

(2010) Ying-Jie Lu et al.   VACCINE

Serotype specific invasive capacity and persistent reduction in invasive pneumococcal disease

(2010) Inci Yildirim et al.   VACCINE

Systematic Evaluation of Serotypes Causing Invasive Pneumococcal Disease among Children Under Five: The Pneumococcal Global Serotype Project

(2010) Hope L. Johnson et al.   PLOS MEDICINE

Impact of pneumococcal conjugate vaccine on infections caused by antibiotic-resistant Streptococcus pneumoniae

(2009) R. Dagan   CLINICAL MICROBIOLOGY AND INFECTION

Comparison of Pneumococcal Conjugate Polysaccharide and Free Polysaccharide Vaccines in Elderly Adults: Conjugate Vaccine Elicits Improved Antibacterial Immune Responses and Immunological Memory

(2008) Andrés de Roux et al.   CLINICAL INFECTIOUS DISEASES

Streptococcus pneumoniae Surface Protein PcpA Elicits Protection against Lung Infection and Fatal Sepsis

(2008) D. T. Glover et al.   INFECTION AND IMMUNITY

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY