Article
Neurosciences
Hongxiao Yu, Luo Shi, Jinting Chen, Shirui Jun, Yinchao Hao, Shuang Wang, Congrui Fu, Xiang Zhang, Haiyan Lu, Sheng Wang, Fang Yuan
Summary: The study demonstrates that neurons expressing LepRb in the nucleus tractus solitarii (NTS) play a key role in respiratory control, with leptin potentiating breathing via an NTS-LPBN-preBotC circuit. Stimulation of NTSLepRb neurons notably activates breathing, while ablation of NTSLepRb neurons projecting to the LPBN eliminates the enhanced effect.
NEUROSCIENCE BULLETIN
(2022)
Article
Food Science & Technology
Ying Li, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia, Hong-Bao Li, Yu-Ming Kang
Summary: The study reveals that Vitamin C can reduce elevated blood pressure in hypertensive animals by improving the diversity and abundance of gut microbiota, as well as enhancing gut pathology and integrity while reducing inflammatory responses and oxidative stress in the hypothalamus paraventricular nucleus.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Chieh-Jen Wu, Pei-Wen Cheng, Ming-Hsiang Kung, Chiu-Yi Ho, Jun-Yen Pan, Ching-Jiunn Tseng, Hsin-Hung Chen
Summary: This study investigated the impact of NTS Glut5 knockdown on fructose-induced hypertension. The results showed that Glut5 KD reduced sympathetic nerve hyperactivity, improved central insulin signaling, lowered blood pressure, restored signaling dependent on adenosine 5'-monophosphate-activated protein kinase, and reduced fructose-induced oxidative stress within the NTS.
JOURNAL OF NUTRITION
(2022)
Article
Neurosciences
Yinchao Hao, Ziqian Wei, Shuang Wang, Pei An, Yifei Huang, Lingxiao Yu, Mengchu Zhu, Hongxiao Yu, Fang Yuan, Sheng Wang
Summary: The disrupted medullary leptin signaling contributes to obesity-related hypoventilation, and inhibiting the upregulated SOCS3 in the NTS and RTN can alleviate this condition.
Article
Neurosciences
Davi J. A. Moraes, Melina P. da Silva, Daniel P. de Souza, Viviane Felintro, Julian F. R. Paton
Summary: In hypertension, the carotid body chemoreceptors are hyperactive and contribute to bronchoconstriction. Denervation of the carotid body can reduce bronchoconstrictor tone, while stimulation of the carotid body enhances chemoreflex-induced bronchoconstriction. These findings suggest that the carotid body plays a significant role in modulating bronchoconstriction in hypertensive individuals.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
Elenia Cinelli, Ludovica Iovino, Fulvia Bongianni, Tito Pantaleo, Federico Lavorini, Claudia Mannini, Donatella Mutolo
Summary: It has been shown that muscarinic acetylcholine receptors (mAChRs) located within the caudal nucleus tractus solitarii (cNTS) mediate a cholinergic inhibitory control mechanism of the cough reflex. Identification of the involved mAChR subtypes could be of considerable interest for novel therapeutic strategies.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Neurosciences
Shirui Jun, Xianhong Ou, Luo Shi, Hongxiao Yu, Tianjiao Deng, Jinting Chen, Xiaojun Nie, Yinchao Hao, Yishuo Shi, Wei Liu, Yanming Tian, Sheng Wang, Fang Yuan
Summary: The NTS is involved in the autonomic regulation of cardiovascular activity. NTSPNMT neurons have different effects on blood pressure depending on their projections. Stimulation of NTSPNMT neurons projecting to different areas can cause either a decrease or increase in blood pressure and heart rate. Ablation of NTSPNMT neurons and their projections to specific areas impairs the arterial baroreflex.
NEUROSCIENCE BULLETIN
(2023)
Article
Psychology, Biological
Winfried L. Neuhuber, Hans -Rudolf Berthoud
Summary: Due to its important role in autonomic networks and interoception, the vagus nerve continues to attract interest from both basic scientists and therapists. In addition to the classical vagal brainstem nuclei, the spinal trigeminal and paratrigeminal nuclei also play a role in vagal innervation. Furthermore, the nucleus of the solitary tract integrates not only visceral but also somatic sensory inputs.
BIOLOGICAL PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhe Chen, Ming-Tong Lin, Chen Zhan, Nan-Shan Zhong, Di Mu, Ke-Fang Lai, Mingzhe J. Liu
Summary: This study reveals that GABAergic neurons in the l/vlPAG region suppress cough processing through a descending pathway. Activation of these neurons decreases coughing-like behaviors, while suppression of these neurons enhances cough sensitivity. These findings provide important insights into the neural mechanisms underlying chronic cough.
Article
Biology
Julia Chu-Ning Hsu, Shinichi Sekizawa, Ryota Tochinai, Masayoshi Kuwahara
Summary: The study suggests that injecting a metabotropic glutamate receptor antagonist into the brainstem can slightly increase systolic blood pressure in young spontaneously hypertensive rats. This effect is associated with an increase in blood catecholamine concentration and can last even after the treatment ends. However, this treatment has little effect on autonomic activity.
Article
Peripheral Vascular Disease
Theodore S. Kalbfleisch, Nahla A. Hussien A. AbouEl Ela, Kai Li, Wesley A. Brashear, Kelli J. Kochan, Andrew E. Hillhouse, Yaming Zhu, Isha S. Dhande, Eric J. Kline, Elizabeth A. Hudson, Terence D. Murphy, Francoise Thibaud-Nissen, Melissa L. Smith, Peter A. Doris
Summary: We report the creation and evaluation of a de novo assembly of the genome of the spontaneously hypertensive rat, which is a widely used model for studying human cardiovascular disease. The assembly was assembled from long read sequencing data and scaffolded with long-range structural information. The results show that the assembly is comparable in contiguity and completeness to the current rat reference assembly, and the use of HiFi sequencing improves the accuracy at the single base level. The generated transcript sequence reads were used to validate the coding assembly and annotate the assembly with RNA transcripts.
Article
Biochemistry & Molecular Biology
Gwo-Ching Sun, Jockey Tse, Yung-Ho Hsu, Chiu-Yi Ho, Ching-Jiunn Tseng, Pei-Wen Cheng
Summary: Opioids play a role in the development of hypertension by causing inflammation and affecting blood pressure control. The formation of AT1R and mu OR heterodimers may contribute to the progression of hypertension.
Article
Pharmacology & Pharmacy
Maurizio Forte, Simona Marchitti, Maria Cotugno, Flavio Di Nonno, Rosita Stanzione, Franca Bianchi, Leonardo Schirone, Sonia Schiavon, Daniele Vecchio, Gianmarco Sarto, Mariarosaria Scioli, Salvatore Raffa, Giuliano Tocci, Michela Relucenti, Maria Rosaria Torrisi, Valentina Valenti, Francesco Versaci, Carmine Vecchione, Massimo Volpe, Giacomo Frati, Speranza Rubattu, Sebastiano Sciarretta
Summary: The study demonstrated that trehalose (TRE) could reduce the occurrence of stroke and renal damage in stroke-prone spontaneously hypertensive rats (SHRSP) fed with high salt diet, as well as decrease systolic blood pressure. It also showed beneficial effects on the vascular function of high salt-fed SHRSP, restoring brain autophagy and reducing mitochondrial mass.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Grazyna Lietzau, Stelia Ntika, Hiranya Pintana, Linda Tracy, Thomas Klein, Thomas Nystrom, Vladimer Darsalia, Cesare Patrone, Camilla Krizhanovskii
Summary: GLP-1 is a peripheral incretin and centrally active peptide that regulates metabolism, improves cognition, and has neuroprotective effects. Obesity-induced type 2 diabetes may impair the function of GLP-1-producing neurons, but normalization of blood sugar levels may counteract this effect.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Anastassios Karagiannis, Sergiy Sylantyev, Anna Hadjihambi, Patrick S. Hosford, Sergey Kasparov, Alexander V. Gourine
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)
Review
Neurosciences
Nephtali Marina, Egor Turovsky, Isabel N. Christie, Patrick S. Hosford, Anna Hadjihambi, Alla Korsak, Richard Ang, Svetlana Mastitskaya, Shahriar Sheikhbahaei, Shefeeq M. Theparambil, Alexander V. Gourine
Article
Gastroenterology & Hepatology
Anna Hadjihambi, Francesco De Chiara, Patrick S. Hosford, Abeba Habtetion, Anastassios Karagiannis, Nathan Davies, Alexander V. Gourine, Rajiv Jalan
Article
Endocrinology & Metabolism
Patrick S. Hosford, Isabel N. Christie, Arun Niranjan, Qadeer Aziz, Naomi Anderson, Richard Ang, Mark F. Lythgoe, Jack A. Wells, Andrew Tinker, Alexander Gourine
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Article
Neurosciences
P. S. Hosford, V. Mosienko, K. Kishi, G. Jurisic, K. Seuwen, B. Kinzel, M. G. Ludwig, J. A. Wells, I. N. Christie, L. Koolen, A. P. Abdala, B. H. Liu, A. V. Gourine, A. G. Teschemacher, S. Kasparov
Article
Multidisciplinary Sciences
Shahriar Sheikhbahaei, Egor A. Turovsky, Patrick S. Hosford, Anna Hadjihambi, Shefeeq M. Theparambil, Beihui Liu, Nephtali Marina, Anja G. Teschemacher, Sergey Kasparov, Jeffrey C. Smith, Alexander V. Gourine
NATURE COMMUNICATIONS
(2018)
Article
Gastroenterology & Hepatology
Anna Hadjihambi, Ian F. Harrison, Marta Costas-Rodriguez, Frank Vanhaecke, Natalia Arias, Rocio Gallego-Duran, Svetlana Mastitskaya, Patrick S. Hosford, Steven W. M. Olde Damink, Nathan Davies, Abeba Habtesion, Mark F. Lythgoe, Alexander V. Gourine, Rajiv Jalan
JOURNAL OF HEPATOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Richard Ang, Svetlana Mastitskaya, Patrick S. Hosford, Marina Basalay, Mark Specterman, Qadeer Aziz, Yiwen Li, Michele Orini, Peter Taggart, Pier D. Lambiase, Andrey Gourine, Andrew Tinker, Alexander V. Gourine
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2018)
Review
Behavioral Sciences
Patrick S. Hosford, Alexander V. Gourine
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Editorial Material
Physiology
Robert T. R. Huckstepp, Patrick Hosford, Alexander V. Gourine
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2019)
Article
Neurosciences
Svetlana Mastitskaya, Egor Turovsky, Nephtali Marina, Shefeeq M. Theparambil, Anna Hadjihambi, Sergey Kasparov, Anja G. Teschemacher, Andrew G. Ramage, Alexander Gourine, Patrick S. Hosford
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Nephtali Marina, Isabel N. Christie, Alla Korsak, Maxim Doronin, Alexey Brazhe, Patrick S. Hosford, Jack A. Wells, Shahriar Sheikhbahaei, Ibrahim Humoud, Julian F. R. Paton, Mark F. Lythgoe, Alexey Semyanov, Sergey Kasparov, Alexander V. Gourine
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Patrick S. Hosford, Jack A. Wells, Shereen Nizari, Isabel N. Christie, Shefeeq M. Theparambil, Pablo A. Castro, Anna Hadjihambi, L. Felipe Barros, Ivan Ruminot, Mark F. Lythgoe, Alexander Gourine
Summary: The study indicates that CO2 plays a crucial role in regulating neurovascular coupling by mediating signaling between neurons and cerebral blood vessels to adjust local brain blood flow based on neuronal activity. The neurovascular coupling mechanism ensures an adequate energy supply for the brain to meet demands.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Renato W. Martins Sa, Shefeeq M. Theparambil, Karoline Martins dos Santos, Isabel N. Christie, Nephtali Marina, Barbara V. Cardoso, Patrick S. Hosford, Vagner R. Antunes
Summary: In this study, the authors aimed to determine the source of ATP that drives osmotically-induced increases in sympathetic outflow. They found that salt loading stimulated the release of ATP in the PVN, primarily from glial cells through a vesicle-mediated route. This finding provides insight into the neural control of circulation during osmotic challenges.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
