Signalling and targeted therapy of inflammatory cells in epidermolysis bullosa acquisita

Mechanisms of Disease: Pemphigus and Bullous Pemphigoid

(2016) Christoph M. Hammers et al.   Annual Review of Pathology-Mechanisms of Disease

Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease

(2016) Liza Shrestha et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration

(2016) Upasana Kulkarni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dimethylfumarate Impairs Neutrophil Functions

(2016) Susen Müller et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita

(2016) Hiroshi Koga et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epidermolysis Bullosa Acquisita: From Pathophysiology to Novel Therapeutic Options

(2016) Michael Kasperkiewicz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autoantibody Profile Differentiates between Inflammatory and Noninflammatory Bullous Pemphigoid

(2016) Kentaro Izumi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Prevalence and Age Distribution of Pemphigus and Pemphigoid Diseases in Germany

(2016) Franziska Hübner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PI3K inhibitors as new cancer therapeutics: implications for clinical trial design

(2016) Cristian Massacesi et al.   OncoTargets and Therapy

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

(2016) Tamás Németh et al.   Nature Communications

A Retrospective Consecutive Case-series Study on The Effect of Systemic Treatment, Length of Admission Time, and Co-morbidities in 98 Bullous Pemphigoid Patients Admitted to a Tertiary Centre

(2015) L Kibsgaard et al.   ACTA DERMATO-VENEREOLOGICA

PI3K signalling in inflammation

(2015) P.T. Hawkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Conditional depletion of mast cells has no impact on the severity of experimental epidermolysis bullosa acquisita

(2015) Anika Kasprick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Heat shock protein 90 is required forex vivoneutrophil-driven autoantibody-induced tissue damage in experimental epidermolysis bullosa acquisita

(2015) Stefan Tukaj et al.   EXPERIMENTAL DERMATOLOGY

Caspase-1–Independent IL-1 Release Mediates Blister Formation in Autoantibody-Induced Tissue Injury through Modulation of Endothelial Adhesion Molecules

(2015) Hengameh Sadeghi et al.   JOURNAL OF IMMUNOLOGY

Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita

(2015) Hiroaki Iwata et al.   JOURNAL OF IMMUNOLOGY

Recombinant Soluble CD32 Suppresses Disease Progression in Experimental Epidermolysis Bullosa Acquisita

(2015) Hiroaki Iwata et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Malignancies in Pemphigus and Pemphigoid Diseases

(2015) Franziska Schulze et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effects of Intravenous Immunoglobulins on Mice with Experimental Epidermolysis Bullosa Acquisita

(2015) Misa Hirose et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita

(2015) Hengameh Sadeghi et al.   JOURNAL OF PATHOLOGY

Immunomodulatory effects of heat shock protein 90 inhibition on humoral immune responses

(2014) Stefan Tukaj et al.   EXPERIMENTAL DERMATOLOGY

p38 MAPK inhibitors: a patent review (2012 – 2013)

(2014) Stefanie Bühler et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

(2014) Miklós Kovács et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mortality of bullous pemphigoid in Singapore: risk factors and causes of death in 359 patients seen at the National Skin Centre

(2013) S.C.S. Cai et al.   BRITISH JOURNAL OF DERMATOLOGY

Jakpot! New small molecules in autoimmune and inflammatory diseases

(2013) Kamran Ghoreschi et al.   EXPERIMENTAL DERMATOLOGY

GM-CSF Modulates Autoantibody Production and Skin Blistering in Experimental Epidermolysis Bullosa Acquisita

(2013) U. K. S. R. L. Samavedam et al.   JOURNAL OF IMMUNOLOGY

Methylprednisolone Blocks Autoantibody-Induced Tissue Damage in Experimental Models of Bullous Pemphigoid and Epidermolysis Bullosa Acquisita through Inhibition of Neutrophil Activation

(2013) Lars Hellberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Aberrant Expression and Secretion of Heat Shock Protein 90 in Patients with Bullous Pemphigoid

(2013) Stefan Tukaj et al.   PLoS One

Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation

(2013) Susanne Roth et al.   TRENDS IN IMMUNOLOGY

Emerging treatments for pemphigoid diseases

(2013) Ralf J. Ludwig et al.   TRENDS IN MOLECULAR MEDICINE

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

(2013) Mélissa Beaudoin et al.   PLoS Genetics

Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen

(2012) Misa Hirose et al.   JOURNAL OF AUTOIMMUNITY

Melanoma: New Insights and New Therapies

(2012) Vasiliki A. Nikolaou et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trial

(2012) Kim Papp et al.   LANCET

Pemphigoid diseases

(2012) Enno Schmidt et al.   LANCET

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Epidermolysis Bullosa Acquisita: A Retrospective Clinical Analysis of 30 Cases

(2011) SC Kim et al.   ACTA DERMATO-VENEREOLOGICA

Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets

(2011) M. Kasperkiewicz et al.   BLOOD

Epidermolysis bullosa acquisita

(2011) Rishu Gupta et al.   CLINICS IN DERMATOLOGY

The C5a Receptor on Mast Cells Is Critical for the Autoimmune Skin-blistering Disease Bullous Pemphigoid

(2011) Lisa Heimbach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

PI3K  Plays a Critical Role in Neutrophil Activation by Immune Complexes

(2011) S. Kulkarni et al.   Science Signaling

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease in Mice

(2010) Jung Min Han et al.   PLoS One

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

(2008) John W. Rice et al.   ARTHRITIS AND RHEUMATISM

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Induction of p38MAPK and HSP27 Phosphorylation in Pemphigus Patient Skin

(2007) Paula Berkowitz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY