Article
Biochemistry & Molecular Biology
Lilli Arndt, Andreas Lindhorst, Julia Neugebauer, Anne Hoffmann, Constance Hobusch, Vasileia-Ismini Alexaki, Adhideb Ghosh, Matthias Blueher, Christian Wolfrum, Markus Glass, Martin Gericke
Summary: White adipose tissue fibrosis is strongly associated with inflammation and dysfunction due to obesity. IL-13 and IL-4 have been identified as critical mediators in fibrotic diseases, but their role in WAT fibrosis is still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuhan Yang, Yanfei Zhang, Xueliang Zhou, Dandan Chen, Gaoliang Ouyang, Yingfu Liu, Dan Cui
Summary: The study showed that POSTN expression is increased in adipose tissue after LPS or HFD treatment, while deficiency of POSTN can reduce adipose tissue fibrosis and improve insulin resistance.
Article
Medical Laboratory Technology
Qipan Zhang, Lun Guo, Xuxiang Song, Chengna Lv, Pan Tang, Yan Li, Qunli Ding, Mingcai Li
Summary: The study revealed significantly higher levels of IL-36 alpha and IL-36 gamma in CTD-ILD and IPF patients compared to healthy controls, while IL-36Ra levels did not differ significantly. Increased IL-36 levels were associated with disease severity in IPF patients, with high diagnostic value demonstrated by ROC curve analysis for IL-36 alpha in both IPF and CTD-ILD patients.
CLINICA CHIMICA ACTA
(2022)
Article
Endocrinology & Metabolism
Andrew D. Hildreth, Eddie T. Padilla, Meha Gupta, Yung Yu Wong, Ryan Sun, Akshara R. Legala, Timothy E. O'Sullivan
Summary: This study reveals that conventional type 1 dendritic cells (cDC1s) in white adipose tissue (WAT) take up DNA-containing apoptotic bodies from adipocytes, which triggers STING-dependent interleukin-12 production from cDC1s, contributing to WAT inflammation in mice.
Article
Medicine, Research & Experimental
Jonathan R. Baker, Peter S. Fenwick, Carolin K. Koss, Harriet B. Owles, Sarah L. Elkin, Jay Fine, Matthew Thomas, Karim C. El Kasmi, Peter J. Barnes, Louise E. Donnelly
Summary: Current treatments for chronic obstructive pulmonary disease (COPD) are unable to modify the underlying pathophysiology and disease progression, necessitating the search for alternative therapies. This study reveals that COPD patients have increased levels of IL-36α and decreased levels of IL-36 receptor antagonist (IL-36Ra) in bronchoalveolar and nasal fluid. IL-36α stimulates the release of CXCL1, which can be inhibited by exogenous IL-36Ra, suggesting that blocking IL-36R could attenuate COPD-induced inflammation.
Review
Medicine, Research & Experimental
Michael Elias, Shuai Zhao, Hongnga T. Le, Jie Wang, Markus F. Neurath, Clemens Neufert, Claudio Fiocchi, Florian Rieder
Summary: IL-36, a member of the IL-1 superfamily, consists of three agonists and one receptor antagonist. It plays a crucial role in inflammation and fibrosis, and is linked to various diseases such as psoriasis, arthritis, inflammatory bowel diseases, and allergic rhinitis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Valentina Frezza, Zaneta Najda, Pavel Davidovich, Graeme P. Sullivan, Seamus J. Martin
Summary: Inflammation driven by environmental allergens, such as asthma and eczema, is a major cause of morbidity. Recent studies have shown that proteases associated with common allergens can activate IL-36 family cytokines and enhance IL-1α activity. This suggests that IL-1 family cytokines may function as sentinels for protease activity and link it to the pro-inflammatory activity of these cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Gema Fruehbeck, Javier Gomez-Ambrosi, Beatriz Ramirez, Amaia Mentxaka, Amaia Rodriguez, Sara Becerril, Gabriel Reina, Victor Valenti, Rafael Moncada, Camilo Silva, Victoria Catalan
Summary: This study found that circulating levels of IL-36 gamma were increased in patients with obesity, and decreased after weight and fat loss. The gene expression levels of IL36G were upregulated in visceral adipose tissue and peripheral blood mononuclear cells from patients with obesity. IL-36 gamma plays a role in regulating chronic inflammation in adipose tissue, and serves as a link between adipose tissue biology and obesity-associated comorbidities.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jessica E. Miller, Harshavardhan Lingegowda, Lindsey K. Symons, Olga Bougie, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Summary: The study found that IL-33 contributes to the expansion of ILC2s in both humans and murine models, regulating the microenvironment of endometriosis lesions, and driving severe endometriosis symptoms such as inflammation, lesion proliferation, and fibrosis. IL-33 neutralization shows promise as a potential novel therapeutic avenue for treating the debilitating symptoms of endometriosis.
Article
Cell Biology
Tian Wei, Kangxin Wang, Shuting Liu, Yunxuan Fang, Zixi Hong, Yingfu Liu, Huimin Zhang, Chaoyong Yang, Gaoliang Ouyang, Tiantian Wu
Summary: Periostin, a multifunctional extracellular protein, plays a crucial role in the immune microenvironment of colorectal cancer (CRC) by promoting the infiltration of PD-1+ tumor-associated macrophages (TAMs) and enhancing the expression of PD-1 on TAMs. This, in turn, leads to the production of IL-6 and IFN-g by PD-1+ TAMs, which induce the expression of PD-L1 on colorectal tumor cells. Combined inhibition of periostin and PD-1 shows significant efficacy in suppressing CRC progression.
Article
Cell Biology
Guanxi Xiao, Rosie Kumar, Yutaro Komuro, Jasmine Burguet, Visesha Kakarla, Ida Azizkhanian, Sunil A. Sheth, Christopher K. Williams, Xinhai R. Zhang, Michal Macknicki, Andrew Brumm, Riki Kawaguchi, Phu Mai, Naoki Kaneko, Harry V. Vinters, S. Thomas Carmichael, Leif A. Havton, Charles DeCarli, Jason D. Hinman
Summary: Cardiovascular risk factors including obesity worsen cerebral small vessel disease and brain white matter injury. Chronic cerebrovascular risk factors activate molecular pathways in cerebral endothelial cells that alter cell-cell signaling, blocking endogenous and post-ischemic white matter repair. Using cell-specific translating ribosome affinity purification (RiboTag), a coordinated interleukin-chemokine signaling cascade is identified within the oligovascular niche of subcortical white matter triggered by diet-induced obesity (DIO). DIO induces interleukin-17B (IL-17B) signaling, which acts on cerebral endothelial cells through IL-17Rb, increasing both circulating and local endothelial expression of CXCL5. In white matter endothelia, CXCL5 promotes the association of oligodendrocyte progenitor cells (OPCs) with the vasculature and triggers OPC gene expression programs regulating cell migration through chemokine signaling. Targeted blockade of IL-17B reduces vessel-associated OPCs by reducing endothelial CXCL5 expression. CXCL5 blood levels serve as diagnostic and prognostic biomarkers of vascular cognitive impairment in multiple human cohorts.
Article
Cell Biology
Emily L. Goldberg, Irina Shchukina, Yun-Hee Youm, Seungjin Ryu, Takeshi Tsusaka, Kyrlia C. Young, Christina D. Camell, Tamara Dlugos, Maxim N. Artyomov, Vishwa Deep Dixit
Summary: The study highlighted the decrease in type 2 innate lymphoid cells (ILC2) in aged adipose tissue, leading to changes in the immune system and thermogenic failure. Supplementation of IL-33 and transplantation of adult ILC2 cells can protect old mice from the effects of cold stress to some extent.
Review
Endocrinology & Metabolism
Andres A. Herrada, Alexandra Olate-Briones, Armando Rojas, Chaohong Liu, Noelia Escobedo, Matthias Piesche
Summary: Obesity presents a higher risk for various diseases, and adipose tissue-infiltrating macrophages (ATMs) play a significant role in obesity and its associated complications.
Article
Materials Science, Biomaterials
Nini Xin, Xiaoyin Liu, Suping Chen, Yusheng Zhang, Dan Wei, Jing Sun, Liangxue Zhou, Chengheng Wu, Hongsong Fan
Summary: This study proposes a biomaterial-based strategy for spinal cord injury (SCI) repair by constructing hydrogel microfibers that combine neuroprotection and neuroinduction. These implanted microfibers protect endogenous neural cells, promote neuronal differentiation, axonal regrowth, and remyelination, and improve locomotor function.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biochemistry & Molecular Biology
C. Moermans, K. Damas, J. Guiot, M. S. Njock, J. L. Corhay, M. Henket, F. Schleich, R. Louis
Summary: This study aimed to investigate the expression and production of cytokines in induced sputum from patients with chronic airway obstructive diseases, finding that patients with eosinophilic airway inflammation had reduced IL-36 levels which may increase susceptibility to infections, while IL-36 and IL-23 were implicated in airway neutrophilic inflammation in chronic airway obstructive diseases.
Letter
Dermatology
F. M. Ghazawi, N. Iga, R. Tanaka, Y. Fujisawa, K. Yoshino, C. Yamashita, Y. Yamamoto, T. Fujimura, T. Yanagi, H. Hata, S. Matsushita, M. Le, S. F. Roy, F. Lagace, Y. Ishida, K. Kabashima, A. Otsuka
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
Ryo Amagai, Taku Fujimura, Yusuke Muto, Yumi Kambayashi, Sadanori Furudate, Kentaro Ohuchi, Takami Okuma, Akira Hashimoto, Setsuya Aiba
Summary: In patients treated with dabrafenib plus trametinib combination therapy, pyrexia is the most common adverse event, potentially correlated with interferon-inducible chemokines. The elevation of sCD163 along with increased levels of CXCL9, CXCL10, and CXCL11 in serum may be associated with the onset of adverse events.
DERMATOLOGIC THERAPY
(2021)
Letter
Dermatology
Yusuke Muto, Taku Fujimura, Yumi Kambayashi, Kentaro Ohuchi, Ryo Amagai, Takami Okuma, Sadanori Furudate, Akira Hashimoto, Setsuya Aiba
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Kentaro Ohuchi, Taku Fujimura, Chunbing Lyu, Ryo Amagai, Yusuke Muto, Setsuya Aiba
Summary: The study indicates that CXCL13/CXCR5-mediated migration of Tfh cells plays a role in the development of BP, with CXCL13 levels positively correlated with antibody titers in BP patients. LL37 promotes the secretion of chemokines by M2 macrophages, with CXCL10 acting as a negative regulator in BP development.
JOURNAL OF DERMATOLOGY
(2021)
Letter
Dermatology
Mayuko Amagai, Maki Ozawa, Ryo Amagai, Kentaro Ohuchi, Yusuke Muto, Yumi Kambayashi, Setsuya Aiba, Taku Fujimura
DERMATOLOGIC THERAPY
(2022)
Letter
Dermatology
Kentaro Ohuchi, Ryo Amagai, Erika Tamabuchi, Yumi Kambayashi, Taku Fujimura
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Toshihisa Hamada, Akimichi Morita, Hiraku Suga, Hikari Boki, Taku Fujimura, Yoji Hirai, Takatoshi Shimauchi, Chiharu Tateishi, Eiji Kiyohara, Ikko Muto, Hideki Nakajima, Riichiro Abe, Kazuyasu Fujii, Chikako Nishigori, Eiji Nakano, Kentaro Yonekura, Takeru Funakoshi, Masahiro Amano, Tomomitsu Miyagaki, Noriko Makita, Katsunori Manaka, Yoshihito Shimoyama, Makoto Sugaya
Summary: The study suggests that starting bexarotene at 300 mg/m(2) and combining it with photo(chemo)therapy show promising efficacy in treating patients with mycosis fungoides. Further evaluation of low-dose bexarotene plus photo(chemo)therapy efficacy is recommended for future studies.
JOURNAL OF DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Taku Fujimura
Summary: Tumor-infiltrating leukocytes (TILs) play a crucial role in immunotherapy using ICIs, highlighting the significance of evaluating the characteristics of tumor-associated cells in predicting the efficacy of immune checkpoint inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Rui Sasaki, Yoshihide Asano, Taku Fujimura
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Ryo Amagai, Yumi Kambayashi, Kentaro Ohuchi, Sadanori Furudate, Akira Hashimoto, Yoshihide Asano, Taku Fujimura
Summary: The anti-tumor effects of mogamulizumab and post mogamulizumab therapy were evaluated in 11 cases of CTCL. The best response rate was 45.5% for the total cohort, 50.0% for MF, and 33.3% for PCPTCL-NOS. The objective response rate at 1 month was 45.5% and 27.3% at 4 months. The efficacy rate of etoposide-based therapy was 71.4%.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Kentaro Ohuchi, Ryo Amagai, Tetsuya Ikawa, Yusuke Muto, Yuna Roh, Junko Endo, Takeo Maekawa, Yumi Kambayashi, Yoshihide Asano, Taku Fujimura
Summary: PAI-1 expression is associated with vascular tumor progression and angiogenesis in Cutaneous Angiosarcoma (CAS), promoting the expression of angiogenic factors and facilitating the formation of tumor-derived tube networks.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Taku Fujimura, Takeo Maekawa, Hiroshi Kato, Takamichi Ito, Shigeto Matsushita, Koji Yoshino, Yasuhiro Fujisawa, Shoichiro Ishizuki, Kojiro Segawa, Jun Yamamoto, Akira Hashimoto, Yumi Kambayashi, Yoshihide Asano
Summary: This study retrospectively evaluated the efficacy and safety profiles of taxane-switch, eribulin methylate, and pazopanib regimens in second-line chemotherapy for taxane-resistant cutaneous angiosarcoma (CAS) patients. Although there was no significant difference in progression-free survival among the regimens, the incidence of all adverse events, as well as severe G3 or more adverse events, was significantly higher in the eribulin methylate group and pazopanib group compared to the taxane-switch group. Therefore, switching to another taxane should be considered for the treatment of taxane-resistant CAS in second-line therapy based on the safety profiles.
JOURNAL OF DERMATOLOGY
(2023)
Article
Allergy
Yusuke Muto, Taku Fujimura, Yumi Kambayashi, Kentaro Ohuchi, Chunbing Lyu, Hitoshi Terui, Masato Mizuashi, Setsuya Aiba, Yoshihide Asano
Summary: The main objective of this study was to determine the main source of IFN-inducible chemokines in the lesional skin of GVHD. Through immunohistochemical staining, it was found that CD163+ macrophages may be the main source of IFN-inducible chemokines, and the chemokine expression patterns on CD163+ macrophages matched the phosphorylation pattern of STATs in epidermal keratinocytes. Therefore, CD163+ macrophages may be a therapeutic target in GVHD.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2023)
Article
Dermatology
Ryo Amagai, Taku Fujimura, Emi Yamazaki, Manami Takahashi, Erika Tamabuchi, Yumi Kambayashi, Akira Hashimoto, Kazuki Hashimoto, Yoshihide Asano
Summary: The combination of BRAF kinase inhibitors and MEK kinase inhibitors may lead to severe VKH disease-like uveitis in melanoma patients with the HLA-DRB1*04 haplotype.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Taku Fujimura, Koji Yoshino, Motoki Nakamura, Hiroshi Kato, Takamichi Ito, Takeo Maekawa, Yasuhiro Fujisawa, Shigeto Matsushita, Ryo Amagai, Emi Yamazaki, Manami Takahashi, Erika Tamabuchi, Akira Hashimoto, Yumi Kambayashi, Naoya Yamazaki, Toshio Miyata, Yoshihide Asano
Summary: This study aims to evaluate the efficacy and safety of PTX in combination with TM5614 (PAI-1 inhibitor) in patients with PTX-resistant CAS. The primary endpoint is the overall response rate at 28 weeks after starting treatment, and the study also includes secondary endpoints and data quality control measures. The study will contribute to the development of novel combination therapy for PTX-resistant CAS patients.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)