Article
Medicine, Research & Experimental
Stefan Lennard Krautschneider, Fabian M. Troschel, Eduardo Vadillo, Hans Theodor Eich, Martin Goette, Nancy Adriana Espinoza-Sanchez, Burkhard Greve
Summary: This study aimed to investigate the interplay between heparan sulfate (HS) degradation and radiation response in triple-negative breast cancer (TNBC) cells. The results showed significantly increased radioresistance and cell migration after HS degradation. Furthermore, the expression and activation of certain signaling pathway molecules were altered after HS degradation, impacting the radiation resistance of TNBC cells.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Oncology
Catarina Marques, Celso A. Reis, Romain R. Vives, Ana Magalhaes
Summary: Heparan Sulfate Proteoglycans (HSPGs) play important roles in orchestrating cellular events in physiology and pathology by modulating cell signaling networks and cell interactions. The structural features of HS chains are crucial for the functions of HSPGs, influencing protein interactions and signaling. The tightly controlled biosynthetic pathway of HS leads to structural diversity, which is differently regulated in various tissues, developmental stages, and pathologies such as cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Maxine Umeh-Garcia, Henriette O'Geen, Catalina Simion, Melanie Hayden Gephart, David J. Segal, Colleen A. Sweeney
Summary: This study reveals the association between DNA methylation and the silencing of the LRIG1 gene in basal/triple-negative breast cancer. The global demethylating agent 5-aza-2'-deoxycytidine decreases methylation and increases LRIG1 expression. Targeted demethylation and transcriptional activation using CRISPR/deadCas9 technology significantly enhances LRIG1 expression and reduces cancer cell viability.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Josh W. DiGiacomo, Ines Godet, Michael Trautmann-Rodriguez, Daniele M. Gilkes
Summary: Studies have shown that the ECM can play a crucial role in driving ER signaling and resistance to endocrine therapy in breast cancer. By inhibiting FGF2-FGFR1 binding, the sensitivity to ER-targeted therapy can be restored.
MOLECULAR CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Sherif Attalla, Tarek Taifour, Tung Bui, William Muller
Summary: Understanding breast cancer progression, metastasis, and therapeutic discovery is crucial. The MMTV-PyMT mouse model is a valuable tool that helps researchers better understand the molecular basis of breast cancer.
Article
Multidisciplinary Sciences
Alicia Traughber, Gauravi M. Deshpande, Kalash Neupane, Nilam Bhandari, Mariam R. Khan, Megan R. McMullen, Shadi Swaidani, Emmanuel Opoku, Santoshi Muppala, Jonathan D. Smith, Laura E. Nagy, Kailash Gulshan
Summary: The roles of NLRP3, AIM2 inflammasomes, and Gasdermin D (GsdmD) in lung cancer progression are unclear. Using a metastatic LLC cell model, this study found that GsdmD knockout mice exhibited significantly fewer lung cancer foci, decreased metastasis, and increased median survival rate. GsdmD and IL-1 beta were detected in lung tumor tissue, indicating inflammasome activity. Conditioned media from wild-type macrophages enhanced migration and growth of LLC cells, while GsdmD(-/-) macrophages did not. Bone marrow transplantations confirmed the myeloid-specific role of GsdmD in lung cancer metastasis.
Article
Cell Biology
Yi-Hsiang Wang, Chia-Yi Shen, Sheng-Chieh Lin, Wen-Hung Kuo, Yuan-Ting Kuo, Yu-Ling Hsu, Wen-Ching Wang, Kai-Ti Lin, Lu-Hai Wang
Summary: This study identified an important immune cytokine, CXCL7, secreted by tumor infiltrating monocytes, to stimulate cancer cell migration, invasion, and metastasis, contributing to the promotion of breast cancer progression.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Sohyun Moon, Ying-Tao Zhao
Summary: The study systematically analyzed the spatial, temporal, and cell-type-specific expression of genes encoding HS biosynthesis enzymes and HSPG core proteins, providing a valuable resource for the research community in the field of heparan sulfate.
Review
Cell Biology
Jessica Oyie Sousa Onyeisi, Carla Cristina Lopes, Martin Goette
Summary: Aberrant expression of syndecan-4 is associated with worse prognosis in breast cancer. It is regulated by various mechanisms, including transcriptional and posttranscriptional mechanisms. Syndecan-4 plays a crucial role in breast cancer progression by interacting with different ligands and regulating cellular processes such as adhesion, migration, and invasion. Additionally, syndecan-4 expression is modulated by drugs used in breast cancer treatment.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Oncology
Emanuela Fina
Summary: This review summarizes the current state of research on gene expression analysis of circulating tumor cells (CTCs) in breast cancer, addresses technical and clinical issues related to the application of CTC-derived signatures, and discusses potential research directions.
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Syazalina Zahari, Saiful Effendi Syafruddin, M. Aiman Mohtar
Summary: Breast cancer is a complex and challenging disease. The secretome, which includes proteins, lipids, and nucleic acids secreted by breast cancer cells, plays a crucial role in the development, progression, and drug resistance of breast cancer. Understanding the role of the secretome is essential for developing innovative therapies. This review explores the impact of the secretome on breast cancer progression and its interactions with the tumor microenvironment, and identifies potential therapeutic opportunities.
Review
Oncology
Weihua Wang, Hongdan Chen, Supeng Yin, Zeyu Yang, Fan Zhang
Summary: Adipocytes play a crucial role in breast cancer by regulating progression, therapeutic efficacy, and prognosis. They communicate with tumor infiltrating immune cells through secreted factors, shaping the tumor supporting environment. Understanding the crosstalk between adipocytes and the tumor immune microenvironment can aid in identifying novel targets for precision targeted therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nikos K. Karamanos, Zoi Piperigkou, Alberto Passi, Martin Gotte, Patricia Rousselle, Israel Vlodavsky
Summary: Tumor extracellular matrix collaborates with cancer and stroma cells to facilitate the multistep process of metastasis, highlighting the importance of ECM networks in cancer therapeutics and diagnostics.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ana Luisa Correia, Joao C. Guimaraes, Priska Auf Der Maur, Duvini De Silva, Marcel P. Trefny, Ryoko Okamoto, Sandro Bruno, Alexander Schmidt, Kirsten Mertz, Katrin Volkmann, Luigi Terracciano, Alfred Zippelius, Marcus Vetter, Christian Kurzeder, Walter Paul Weber, Mohamed Bentires-Alj
Summary: The study investigates how different tissue-specific microenvironments can either inhibit or support the progression of breast cancer in the liver. It identifies the interplay between natural killer (NK) cells and activated hepatic stellate cells (aHSCs) as a master switch of cancer dormancy, suggesting that therapies aimed at normalizing the NK cell pool may be successful in preventing metastatic outgrowth.
