Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo

Projected estimates of cancer in Canada in 2020

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A25 PTPRH Mutations in NSCLC Regulate EGFR Phosphorylation

(2020) M.R. Swiatnicki et al.   Journal of Thoracic Oncology

Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer

(2020) Rushendhiran Kesavan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

(2020) Bin Xiao et al.   Cell Reports

The genomic landscape of metastasis in treatment-naïve breast cancer models

(2020) Christina Ross et al.   PLoS Genetics

Point-activated ESR1Y541S has a dramatic effect on the development of sexually dimorphic organs

(2020) Alexandra M. Simond et al.   GENES & DEVELOPMENT

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review

(2019) Jiang-Jiang Qin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Integrins, CAFs and Mechanical Forces in the Progression of Cancer

(2019) Imjoo Jang et al.   Cancers

Integrated analyses of murine breast cancer models reveal critical parallels with human disease

(2019) Jonathan P. Rennhack et al.   Nature Communications

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy

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Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

(2018) Arthur Winer et al.   MOLECULAR CANCER THERAPEUTICS

Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program

(2018) Alison Hirukawa et al.   Nature Communications

Epigenetic alterations to Polycomb targets precede malignant transition in a mouse model of breast cancer

(2018) Ying Cai et al.   Scientific Reports

Inhibition of RON kinase potentiates anti-CTLA-4 immunotherapy to shrink breast tumors and prevent metastatic outgrowth

(2018) Huseyin Atakan Ekiz et al.   OncoImmunology

Progressive polarity loss and luminal collapse disrupt tissue organization in carcinoma

(2017) Ruba Halaoui et al.   GENES & DEVELOPMENT

Mouse Models of Breast Cancer Share Amplification and Deletion Events with Human Breast Cancer

(2017) Jonathan Rennhack et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation

(2017) Elizabeth Allen et al.   Science Translational Medicine

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

(2017) Ryuhjin Ahn et al.   Nature Communications

Immunosurveillance and immunoediting in MMTV-PyMT-induced mammary oncogenesis

(2017) Emilie T. E. Gross et al.   OncoImmunology

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells

(2016) Saïda Dadi et al.   CELL

Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer

(2016) Ting Ni et al.   NATURE CELL BIOLOGY

Overexpression of HIF1α and CAXI predicts poor outcome in early-stage triple negative breast cancer

(2016) Min-Sun Jin et al.   VIRCHOWS ARCHIV

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

(2016) Uri Ben-David et al.   Nature Communications

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis

(2015) Laura M. Jones et al.   CANCER RESEARCH

Differentiation of mammary tumors and reduction in metastasis uponMalat1lncRNA loss

(2015) Gayatri Arun et al.   GENES & DEVELOPMENT

The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages

(2015) Sarah T. Boyle et al.   Molecular Cancer

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

T H 2-Polarized CD4 + T Cells and Macrophages Limit Efficacy of Radiotherapy

(2015) Stephen L. Shiao et al.   Cancer Immunology Research

Monitoring mammary tumor progression and effect of tamoxifen treatment in MMTV-PymT using MRI and magnetic resonance spectroscopy with hyperpolarized [1-13C]pyruvate

(2014) Sadia Asghar Butt et al.   MAGNETIC RESONANCE IN MEDICINE

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of Ron Kinase Blocks Conversion of Micrometastases to Overt Metastases by Boosting Antitumor Immunity

(2013) H. Eyob et al.   Cancer Discovery

Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

(2013) Adam D Pfefferle et al.   GENOME BIOLOGY

Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance

(2012) Elizabeth S. Nakasone et al.   CANCER CELL

Nanobody-Based Targeting of the Macrophage Mannose Receptor for EffectiveIn VivoImaging of Tumor-Associated Macrophages

(2012) Kiavash Movahedi et al.   CANCER RESEARCH

Characterization of mammary cancer stem cells in the MMTV-PyMT mouse model

(2012) Jun Ma et al.   TUMOR BIOLOGY

ErbB3 Ablation Impairs PI3K/Akt-Dependent Mammary Tumorigenesis

(2011) R. S. Cook et al.   CANCER RESEARCH

TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

(2011) Abigail F. Welford et al.   JOURNAL OF CLINICAL INVESTIGATION

PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target

(2011) Jiarong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14

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Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis

(2011) R. Marcotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Family History, Mammographic Density, and Risk of Breast Cancer

(2010) L. J. Martin et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors

(2009) Laureen S. Ojalvo et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia

(2009) Xin Li et al.   AMERICAN JOURNAL OF PATHOLOGY

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

The Origins of Breast Cancer Prognostic Gene Expression Profiles

(2008) L. Lukes et al.   CANCER RESEARCH

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

(2008) Josie Ursini-Siegel et al.   EMBO JOURNAL

The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression

(2008) L. Qin et al.   MOLECULAR AND CELLULAR BIOLOGY

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

(2008) Christian Stockmann et al.   NATURE