Article
Medicine, General & Internal
Peng Gu, Shengjin Han, Zhengwu Zhou, Jianzhong Ma
Summary: The objective of this study was to investigate the changes to the myocardial enzyme profile and its clinical value in patients with different degrees of spleen injury. The results showed that the increase in myocardial enzyme spectrum was positively correlated with the severity of spleen injury, suggesting that patients may have myocardial damage in the early stage of traumatic spleen injury and should be treated as soon as possible.
Review
Biochemistry & Molecular Biology
Yue Jiaming, Mohammad Hossein Rahimi
Summary: This meta-analysis indicates that creatine can significantly reduce creatine kinase concentration and have a positive impact on recovery after exercise-induced muscle damage. However, the effects on lactate dehydrogenase concentration were not significant overall. Creatine supplementation is recommended for reducing muscle damage and enhancing muscle function following exercise. Exercise-induced muscle damage (EIMD) causes increased soreness, impaired function of muscles, and reductions in muscle force.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Sport Sciences
Jorge M. Gonzalez-Hernandez, Pedro Jimenez-Reyes, Jose J. Ceron, Asta Tvarijonaviciute, Francisco J. Llorente-Canterano, Luis M. Martinez-Aranda, Amador Garcia-Ramos
Summary: This study aimed to examine the agreement between serum and saliva measurements of muscle damage markers in response to an accentuated eccentric training protocol. The results showed lower values of muscle damage markers in serum compared to saliva, with a significant increase in CK in men's saliva 96 hours after training. The correlation between serum and saliva measurements was small.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Biology
Iulia Cristina Bagiu, Ileana Luminita Scurtu, Delia Ioana Horhat, Ion Cristian Mot, Razvan Mihai Horhat, Radu Vasile Bagiu, Ionut Dragos Capraru, Mircea Mihai Diaconu, Ovidiu Adam, Bogdan Ciornei, Dan Dumitru Vulcanescu, Iulius Juganaru, Andrei-Cristian Bondar, Florin George Horhat
Summary: This study identified that CRP, LDH, and vitamin D levels are important biomarkers for COVID-19-positive pediatric patients, while CK levels were mostly within normal ranges. Clinical severity was associated with CRP, LDH, and vitamin D levels.
Article
Sport Sciences
Danilo Cialoni, Andrea Brizzolari, Nicola Sponsiello, Valentina Lancellotti, Cesare Lori, Gerardo Bosco, Alessandro Marroni, Alessandra Barassi
Summary: This study found that during a BH-diving training session, there were significant increases in serum cardiac and skeletal muscle markers, indicating stress-related responses in muscles to physical effort. Further research is needed to better understand if these biomarker changes are linked to physical exercise or acute hypoxia.
SPORTS MEDICINE-OPEN
(2021)
Article
Biochemistry & Molecular Biology
Francesca Arfuso, Maria Rizzo, Claudia Giannetto, Elisabetta Giudice, Roberta Cirincione, Giovanni Cassata, Luca Cicero, Giuseppe Piccione
Summary: This study aimed to evaluate the changes in serum oxidant and antioxidant parameters, as well as the levels of homocysteine and muscle enzymes, in regularly trained athletic horses during official races of different distances. The results showed that exercise had an effect on oxidative stress markers, homocysteine, and muscle enzymes, while the race distance did not have a significant impact on these parameters.
Article
Biochemistry & Molecular Biology
Qiuyun Tian, Junjie Li, Bin Wu, Jiaojiao Wang, Qian Xiao, Na Tian, Lilin Yi, Man Luo, Zhaolun Li, Yayan Pang, Xiuyu Shi, Zhifang Dong
Summary: This study investigates the role of VGLL4 in Alzheimer's disease (AD) and shows that overexpression of VGLL4 reduces amyloidogenic processing and synaptic damage in AD. Furthermore, VGLL4 upregulates LDHA expression, promoting lactate production and exerting a neuroprotective effect in AD.
Review
Nutrition & Dietetics
Sepide Talebi, Hamed Mohammadi, Sheida Zeraattalab-Motlagh, Arman Arab, Mohammad Keshavarz Mohammadian, Seyed Mojtaba Ghoreishy, Maryam Abbaspour Tehrani Fard, Reza Amiri Khosroshahi, Kurosh Djafarian
Summary: This umbrella review evaluated the effect of nutritional interventions on exercise-induced muscle damage (EIMD). The study found significant effects of supplements such as hydroxymethylbutyrate (HMB), l-carnitine, and branched-chain amino acids on reducing postexercise creatine kinase and lactate dehydrogenase levels, as well as reducing delayed onset of muscle soreness.
Article
Veterinary Sciences
Nikola Cobanovic, Silvana Stajkovic, Jasna Kureljusic, Jadranka Zutic, Branislav Kureljusic, Sanja D. J. Stankovic, Nedjeljko Karabasil
Summary: This study found a significant association between lung lesions and growth performance, biochemical indicators, and carcass and meat quality in slaughtered pigs, with pigs without lung lesions having better meat quality. Pigs with severe lung lesions may be simultaneously infected with multiple respiratory pathogens.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alhussain H. Aodah, Sushma Devi, Faisal K. Alkholifi, Hasan S. Yusufoglu, Ahmed I. Foudah, Aftab Alam
Summary: Myocardial infarction (MI) remains a significant issue in healthcare systems worldwide, leading to high rates of morbidity and mortality. Despite ongoing efforts, addressing the challenges posed by MI remains difficult. However, recent research has investigated the potential cardioprotective effects of taraxerol in an ISO-induced cardiotoxicity model in rats.
Article
Chemistry, Multidisciplinary
Kursat Yusuf Aytac, Ahmet Ozkaya, Aykut Oztekin, Vedat Cinar, Taner Akbulut, Ramazan Demirdag, Veysel Comakli, Kenan Bozbay
Summary: The study investigated the effects of pomegranate-black carrot juice mixture on serum and erythrocytes of sedentary individuals who had exhaustion test. The results showed that the mixture reduced the oxidative stress levels in subjects exposed to the exhaustion test.
JOURNAL OF CHEMISTRY
(2023)
Article
Oncology
Teng Zhu, Qinqin Han, Xiaoxiao Zhang, Qiuzhong Hou
Summary: The combination of Xinnaoning and trimetazidine significantly improves cardiac function and serum cardiac enzyme levels, lowers lipid levels, and enhances the quality of life in patients with myocardial ischemia.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Florina Marinela Doandes, Aniko-Maria Manea, Nicoleta Lungu, Daniela Cioboata, Timea Brandibur, Oana Costescu, Anca Hudisteanu, Eugen Radu Boia, Marioara Boia
Summary: Early evaluation of the severity of HIE, combined with blood tests and EEG monitoring, can predict short-term and even long-term neurological and multiorgan dysfunction outcomes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Leonie K. Stabenow, Darya Zibrova, Claudia Ender, Dario L. Helbing, Katrin Spengler, Christian Marx, Zhao-Qi Wang, Regine Heller
Summary: Vascular aging is associated with endothelial dysfunction, which is influenced by the accumulation of senescent cells in aged tissues and their environment. Senescence is closely linked to changes in cell metabolism, with senescent cells showing enhanced glycolytic and oxidative glucose metabolism.
Article
Nutrition & Dietetics
Yi-Ju Chen, Rathinasamy Baskaran, Marthandam Asokan Shibu, Wan-Teng Lin
Summary: This study investigated the efficacy of GT extract, a native perennial plant in Taiwan, in ameliorating physical fatigue during exercise and increasing exercise performance. The results showed that GT extract supplementation significantly improved forelimb grip strength and endurance swimming time in a dose-dependent manner. Additionally, GT extract increased serum glucose, creatine kinase, and lactate levels, while liver marker serum glutamic-oxaloacetic transaminase (GOT) was increased and renal markers were not affected. Muscle and hepatic glycogen levels were also significantly increased, indicating an improved energy source during exercise. No histological aberrations were observed in vital organs. These findings suggest that GT extract supplementation could benefit exercise performance and anti-fatigue function without toxicity at higher doses.
Article
Pharmacology & Pharmacy
Rehab M. Elgharabawy, Maha A. Aldubayan, Mariah A. Alshaifani, Amira S. Ahmed
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Mohamed L. Salem, Enas A. Abdul Baki, Abdel-Aziz A. Zidan, Rehab M. Elgharabawy
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2020)
Article
Environmental Sciences
Enas R. Abdel Hamid, Nevin E. Sharaf, Hanaa H. Ahmed, Amira Ahmed, Abdel-Tawab H. Mossa
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Cell Biology
Maha A. Aldubayan, Amira S. Ahmed, Ashraf M. Emara, Ahmed A. Ahmed, Rehab M. Elgharabawy
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Medicine, Research & Experimental
Ehab Tousson, Ezar Hafez, Somia Zaki, Amani Gad, Rehab M. Elgharabawy
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Environmental Sciences
Amira S. Ahmed, Maha A. Aldubayan, Hatem A. Ahmed, Ahmed M. Refaat, Albatool S. Alsalloumi, Rawan A. Almasuood, Rehab M. Elgharabawy
Summary: Smoking cigarettes, shisha, or a mix of both is associated with heavy metal contamination in hair samples, DNA fragmentation, and hair loss. Factors such as age, incidence of hair loss, and duration of smoking affect the accumulation of metals and DNA fragmentation. There is a significant correlation between heavy metal contamination and DNA fragmentation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Amira S. Ahmed, Amal H. Al-Najjar, Hadeel Alshalahi, Waleed Mohammad Altowayan, Rehab M. Elgharabawy
Summary: The study revealed a potential role of H. pylori in the pathogenesis of psoriasis, showing that treatment of H. pylori can alleviate psoriasis severity. Haptoglobin may serve as a psoriatic biomarker with 1.95 g/L as the cutoff value, and in infected patients with H. pylori, C-13-UBT is the most reliable predictor for psoriasis.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2021)
Article
Medicine, Research & Experimental
Rehab M. Elgharabawy, Ahmad H. Alhowail, Ashraf M. Emara, Maha A. Aldubayan, Amira S. Ahmed
Summary: This study aimed to investigate the therapeutic effects of chicory extract on rat cardiac functions and oxidative stress, revealing that lead oxide nanoparticles can cause heart damage, which can be attenuated by chicory through scavenging of free radicals.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Rehab M. Elgharabawy, Ibrahim El Tantawy El Sayed, Nada Abd-Allah Rezk, Ehab Tousson
Summary: The study found that costus root had protective effects against EST-induced cardiac toxicity, improving cardiac toxicity, lipid profiles, electrolytes, and apoptosis, and providing protection against EST. This suggests the potential benefits of costus as an adjuvant in the prevention and treatment of cardiac toxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Amira S. Ahmed, Wejdan S. Alotaibi, Maha A. Aldubayan, Ahmad H. Alhowail, Amal H. Al-Najjar, Sridevi Chigurupati, Rehab M. Elgharabawy
Summary: The study found that comorbidities and vitamin D deficiency are risk factors for COVID-19 in patients with T1DM. Patients who do not take hydroxychloroquine and have higher blood sugar levels are more vulnerable to COVID-19. Vitamin D may be useful in preventing COVID-19 in T1DM patients.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Toxicology
Ashraf Mahmoud Emara, Khaled Ali Alrasheedi, Salha Dihim Alrashidi, Rehab Mohamed Elgharabawy
Summary: The research aimed to evaluate the effects of long-term exposure to waste anesthetic gases on the immune system of medical theater personnel. The results showed significant changes in immune parameters among the exposed groups, suggesting variations in immunomodulatory responses to WAG exposure among hospital personnel.
JOURNAL OF IMMUNOTOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
A. Alhowail, S. Chigurupati, R. Elgharabawy, M. Aldubayan
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2020)