Chinese Herbal Medicine Meets Biological Networks of Complex Diseases: A Computational Perspective

A network analysis of the Chinese medicine Lianhua-Qingwen formula to identify its main effective components

(2016) Chun-Hua Wang et al.   Molecular BioSystems

Herb-target interaction network analysis helps to disclose molecular mechanism of traditional Chinese medicine

(2016) Hao Liang et al.   Scientific Reports

Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution

(2015) Hu Meng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations

(2015) Yiran Wu et al.   Molecular BioSystems

Mechanism of Action of Thalassospiramides, A New Class of Calpain Inhibitors

(2015) Liang Lu et al.   Scientific Reports

Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening

(2014) Liyan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Network pharmacology study on the mechanism of traditional Chinese medicine for upper respiratory tract infection

(2014) Xinzhuang Zhang et al.   Molecular BioSystems

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

(2014) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Quantitatively Characterizing the Ligand Binding Mechanisms of Choline Binding Protein Using Markov State Model Analysis

(2014) Shuo Gu et al.   PLoS Computational Biology

Exploring the Ligand-Protein Networks in Traditional Chinese Medicine: Current Databases, Methods, and Applications

(2013) Mingzhu Zhao et al.   Evidence-based Complementary and Alternative Medicine

Platelet Aggregation Pathway Network-Based Approach for Evaluating Compounds Efficacy

(2013) Jiangyong Gu et al.   Evidence-based Complementary and Alternative Medicine

Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network

(2013) Mengzhu Xue et al.   Evidence-based Complementary and Alternative Medicine

A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets

(2013) Jianling Liu et al.   Evidence-based Complementary and Alternative Medicine

Understanding traditional Chinese medicine anti-inflammatory herbal formulae by simulating their regulatory functions in the human arachidonic acid metabolic network

(2013) Shuo Gu et al.   Molecular BioSystems

Understanding molecular mechanisms of traditional Chinese medicine for the treatment of influenza viruses infection by computational approaches

(2013) Shuo Gu et al.   Molecular BioSystems

Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds, non-drug-like compounds, and natural compounds from traditional Chinese medicines

(2013) Sheng Tian et al.   Journal of Cheminformatics

A co-module approach for elucidating drug–disease associations and revealing their molecular basis

(2012) Shiwen Zhao et al.   BIOINFORMATICS

Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery

(2012) Jian Li et al.   Evidence-based Complementary and Alternative Medicine

Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease

(2012) Weiyang Tao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors

(2012) Yiran Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug-likeness Analysis of Traditional Chinese Medicines: Prediction of Drug-likeness Using Machine Learning Approaches

(2012) Sheng Tian et al.   MOLECULAR PHARMACEUTICS

TCMID: traditional Chinese medicine integrative database for herb molecular mechanism analysis

(2012) Ruichao Xue et al.   NUCLEIC ACIDS RESEARCH

Boolean modeling in systems biology: an overview of methodology and applications

(2012) Rui-Sheng Wang et al.   PHYSICAL BIOLOGY

Drug-likeness analysis of traditional Chinese medicines: 1. property distributions of drug-like compounds, non-drug-like compounds and natural compounds from traditional Chinese medicines

(2012) Mingyun Shen et al.   Journal of Cheminformatics

Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae

(2011) Shao Li et al.   BMC BIOINFORMATICS

Molecular dynamics simulations and drug discovery

(2011) Jacob D Durrant et al.   BMC BIOLOGY

Network target for screening synergistic drug combinations with application to traditional Chinese medicine

(2011) Shao Li et al.   BMC Systems Biology

A network-based analysis of traditional Chinese medicine cold and hot patterns in rheumatoid arthritis

(2011) Gao Chen et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Future perspectives of personalized medicine in traditional Chinese medicine: A systems biology approach

(2011) Aihua Zhang et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Drug–target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus

(2011) Jiangyong Gu et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Discovery of Dual Target Inhibitors against Cyclooxygenases and Leukotriene A4Hydrolyase

(2011) Zheng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug design for hemagglutinin: Screening and molecular dynamics from traditional Chinese medicine database

(2011) Tung-Ti Chang et al.   Journal of the Taiwan Institute of Chemical Engineers

High performance screening, structural and molecular dynamics analysis to identify H1 inhibitors from TCM Database@Taiwan

(2011) Su-Sen Chang et al.   Molecular BioSystems

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

(2011) Calvin Yu-Chian Chen   PLoS One

A Network-Based Multi-Target Computational Estimation Scheme for Anticoagulant Activities of Compounds

(2011) Qian Li et al.   PLoS One

Fast and effective identification of the bioactive compounds and their targets from medicinal plants via computational chemical biology approach

(2011) Shoude Zhang et al.   MedChemComm

The fundamental theory of traditional Chinese medicine and the consideration in its research strategy

(2011) Zhenji Li et al.   Frontiers of Medicine

HIT: linking herbal active ingredients to targets

(2010) H. Ye et al.   NUCLEIC ACIDS RESEARCH

Network-Based Relating Pharmacological and Genomic Spaces for Drug Target Identification

(2010) Shiwen Zhao et al.   PLoS One

Molecular networks for the study of TCM Pharmacology

(2009) J. Zhao et al.   BRIEFINGS IN BIOINFORMATICS

Network Systems Underlying Traditional Chinese Medicine Syndrome and Herb Formula

(2009) Shao Li   Current Bioinformatics

Discovery of Multitarget Inhibitors by Combining Molecular Docking with Common Pharmacophore Matching

(2008) Dengguo Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Finding multiple target optimal intervention in disease-related molecular network

(2008) Kun Yang et al.   Molecular Systems Biology

Network-based global inference of human disease genes

(2008) Xuebing Wu et al.   Molecular Systems Biology

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Chinese Medicine and Its Modernization Demands

(2007) Wei-Feng Li et al.   ARCHIVES OF MEDICAL RESEARCH