Article
Polymer Science
Khursheed Ahmad Shiekh, Mooksupang Liangpanth, Siriporn Luesuwan, Rinlanee Kraisitthisirintr, Kittaporn Ngiwngam, Saroat Rawdkuen, Pornchai Rachtanapun, Thomas Karbowiak, Wirongrong Tongdeesoontorn
Summary: Chitosan films loaded with cashew leaf extract showed potential as bioactive and eco-friendly packaging materials, with the ethanol-extracted mature cashew leaf extract displaying higher free radical scavenging activity. The film containing 5% mature cashew leaf extract exhibited superior mechanical properties compared to other samples.
Article
Food Science & Technology
Dinh-Chuong Pham, Dieu-Hien Truong, Quang Huy Tran, Quang Tien Ho, Thieu Anh Duy Nguyen, Thi Ngoc Huyen Nguyen, Thanh Vinh Nguyen, Thi Thao Vy Nguyen, Tan Sang Cao, Colin J. Barrow, Hoang Chinh Nguyen
Summary: This study investigated the chemical constituents and bioactivities of cashew leaves grown in Vietnam. The ethyl acetate fraction showed the highest total phenolic and flavonoid contents and exhibited promising antibacterial, enzyme inhibition, and anticancer activities.
FOOD SCIENCE & NUTRITION
(2023)
Article
Chemistry, Applied
Nurul Shafiqah Hashim, Mei Lan Tan, Kheng Leong Ooi, Shaida Fariza Sulaiman
Summary: This study found that flavonol compounds from cashew leaf extract possess antimicrobial and antioxidant activities. The hydrolyzed extract showed higher activities, with myricetin being the main active compound.
NATURAL PRODUCT RESEARCH
(2023)
Article
Food Science & Technology
P. Sruthi, C. Roopavathi, M. Madhava Naidu
Summary: This study investigated the phenolic compounds in cashew nut testa and evaluated their antioxidant and antimicrobial properties. The results showed that cashew nut testa is a rich source of phenolic compounds with strong antioxidant and antimicrobial activities against foodborne pathogens.
Article
Pharmacology & Pharmacy
Blessing O. Omolaso, Francis S. Oluwole, Olugbenga A. Odukanmi, Julius K. Adesanwo, Ahmed A. Ishola, Kayode E. Adewole
Summary: This study investigated the antidiarrheal activity of Anacardium occidentale stem bark extract, revealing that the inhibition of the muscarinic pathway plays a key role in its antimotility effect. Docking studies indicated that octadecanoic acid 2-(2-hydroxylethoxy) ethyl ester exhibited the highest binding affinity to the muscarinic acetylcholine receptor M3.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Pharmacology & Pharmacy
Ahmad Alshehri, Afza Ahmad, Rohit Kumar Tiwari, Irfan Ahmad, Ali G. Alkhathami, Mohammad Y. Alshahrani, Mohammed A. Asiri, Tahani M. Almeleebia, Mohd Saeed, Dharmendra Kumar Yadav, Irfan Ahmad Ansari
Summary: The study revealed the antioxidant, anticancer, and anti-inflammatory activities of Adenium obesum, commonly known as desert rose, suggesting its potential as a herbal-based medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Mathematics, Interdisciplinary Applications
Glenda Quaresma Ramos, Robert Saraiva Matos, Abhijeet Das, Sanjeev Kumar, Stefan Talu, Henrique Duarte da Fonseca Filho
Summary: This study analyzed the surface microtexture of Amazon Anacardium occidentale L. leaves using multifractal theory. The results showed that the adaxial and abaxial sides of the leaf had different surface structures, with the abaxial side being rougher and the adaxial side exhibiting stronger multifractality and increased vertical complexity.
FRACTAL AND FRACTIONAL
(2022)
Article
Plant Sciences
Renato Dantas-Medeiros, Allanny Alves Furtado, Ana C. Zanatta, Manoela Torres-Rego, Estela Mariana Guimaraes Lourenco, Jovelina Samara Ferreira Alves, Eder Galinari, Hugo Alexandre de Oliveira Rocha, Gerlane Coelho Bernardo Guerra, Wagner Vilegas, Thiago Antonio de Sousa Araujo, Matheus de Freitas Fernandes-Pedrosa, Silvana Maria Zucolotto
Summary: The study aimed to characterize the phytochemical profile, anti-inflammatory and antioxidant potential of Commiphora leptophloeos leaf extract. The results showed that the extract exhibited significant anti-inflammatory effects by modulating cytokine levels, decreasing TNF-alpha levels, increasing IL-10 levels, and inhibiting nitric oxide production in RAW 264.7 cells activated by LPS.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Jose Guilherme de Souza Correa, Mirelli Bianchin, Ana Paula Lopes, Evandro Silva, Franciele Q. Ames, Armando M. Pomini, Solange T. Carpes, Jaqueline de Carvalho Rinaldi, Raquel Cabral Melo, Erika S. Kioshima, Ciomar A. Bersani-Amado, Eduardo J. Pilau, Joao Ernesto de Carvalho, Ana Lucia T. G. Ruiz, Jesui V. Visentainer, Silvana M. de Oliveira Santin
Summary: The fruit extract of Miconia albicans has high antioxidant properties, rich content of phenolic compounds, flavonoids, and fatty acids, as well as good topical anti-inflammatory activity with low toxicity on VERO cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mirco Vacca, Daniela Pinto, Alessandro Annunziato, Arianna Ressa, Maria Calasso, Erica Pontonio, Giuseppe Celano, Maria De Angelis
Summary: This study aimed to investigate the characteristics of a laboratory-made gluten-free bread supplemented with powdered extract from artichoke leaves. The results showed that the bread with artichoke extract had a lower glycemic index and higher antioxidant properties. Fecal fermentation experiments revealed that the bread with artichoke extract had higher levels of volatile organic compounds and could reduce the expression of inflammatory cytokines in cells. Overall, this preliminary study suggests that combining artichoke extract with sourdough technology could enhance the nutritional and healthy features of gluten-free bread.
Article
Biochemistry & Molecular Biology
Ahmed S. Abdelbaky, Taia A. Abd El-Mageed, Ahmad O. Babalghith, Samy Selim, Abir M. H. A. Mohamed
Summary: In this study, zinc oxide nanoparticles were synthesized using an aqueous leaf extract of Pelargonium odoratissimum as a reducing agent. The biosynthesized nanoparticles exhibited antioxidant, antibacterial, and anti-inflammatory activities, making them potential candidates for applications in the biomedical and pharmaceutical industries.
Article
Plant Sciences
Glenda Q. Ramos, Italo C. da Costa, Marcelo E. H. Maia da Costa, Erveton P. Pinto, Robert S. Matos, Henrique D. da Fonseca Filho
Summary: AFM, profilometry and SEM measurements on both sides of the Anacardium occidentale L. leaf reveal some singularities in ultrastructure due to their different morphologies and roughness. The study shows that adaxial and abaxial sides have similar microtextures but different spatial frequencies. This research provides insights into the surface morphology of leaves at different scales, with quantitative parameters confirming the spatial patterns displayed.
Article
Biochemistry & Molecular Biology
Samar Rezq, Mona F. Mahmoud, Assem M. El-Shazly, Mohamed A. El Raey, Mansour Sobeh
Summary: The study found that Potamogeton perfoliatus extract exhibited anti-inflammatory, antioxidant, analgesic, and antipyretic effects, supporting its traditional use and potential as a candidate for treating diseases associated with oxidative stress. It identified 15 secondary metabolites that likely contributed to these biological activities. The extract showed potent inhibition of enzymes and significant effects in in vivo models, indicating its promising medicinal properties.
Article
Food Science & Technology
Roger Dakuyo, Kiessoun Konate, Kabakde Kabore, Abdoudramane Sanou, Frederic Anderson Konkobo, David Bazie, Hemayoro Sama, Mamoudou Hama Dicko
Summary: This study aimed to evaluate the phytochemical characterization, antioxidant properties, and the influence of temperature on phytonutrient composition of cashew fruits. The antioxidant activities of cashew apples and nuts were determined using various methods. Results showed that cashew apples had the highest antioxidant activities for FRAP, SOD, and LPO, while cashew nuts had the highest antioxidant activity for free radical scavenging. Increasing temperatures significantly decreased the contents of tannins, phytates, and anthocyanins, and completely eliminated ascorbic acid in the fruit. The study also found that lycopene content increased with temperature, while beta-carotene content was not affected. These findings provide valuable information for cashew fruit processing in the food industry and highlight the nutraceutical potential of cashew fruit.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Review
Nutrition & Dietetics
Kabelo Mokgalaboni, Wendy Nokhwezi Phoswa
Summary: This article investigates the efficacy of the plant-based remedy Corchorus olitorius in combating obesity and type 2 diabetes. The study found that C. olitorius significantly reduces blood glucose, body weight, total cholesterol, triglycerides, and low-density lipoprotein, while increasing high-density lipoprotein-cholesterol. It also reduces oxidative stress and inflammation, making it highly effective in improving symptoms of obesity and diabetes.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemical Research Methods
Milena A. Cardoso, Luis E. A. Rizzardi, Leonardo W. Kume, Clarice Groeneveld, Sheyla Trefflich, Diego A. A. Morais, Rodrigo J. S. Dalmolin, Bruce A. J. Ponder, Kerstin B. Meyer, Mauro A. A. Castro
Summary: This study presents TreeAndLeaf, an R/Bioconductor package that implements a hybrid layout strategy for representing tree diagrams with a focus on the leaves. The package allows projection of multiple layers of information onto a graph-tree diagram.
Article
Microbiology
Monique Michels, Gabriel Fernandes Alves Jesus, Ana Paula Lorenzen Voytena, Marina Rossetto, Fernanda Ramlov, Emily Corneo, Paulo Feuser, Daniel Gelain, Felipe Dal-Pizzol
Summary: The discovery of the potential of paraprobiotics to exert different immunological benefits suggests the need for further studies to determine their potential and mechanisms of action in modulating the immune system. This study investigated the immune response of macrophage cell lines, stimulated with lipopolysaccharide, to several microbial-associated molecular patterns (MAMPS) at different doses. The results showed that MAMPS at different doses had varying effects on immune response, and paraprobiotics may contribute to improving intestinal homeostasis, immunomodulation, and host metabolism.
CURRENT MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Thomaz Luscher-Dias, Rodrigo Juliani Siqueira Dalmolin, Paulo de Paiva Amaral, Tiago Lubiana Alves, Viviane Schuch, Gloria Regina Franco, Helder I. Nakaya
Summary: This study used cognitive computing text-mining techniques to construct a knowledge network of genes and diseases and analyzed the changes in these networks over the past 30 years. The study revealed the molecular basis of diseases, shared mechanisms between different diseases, and the genes commonly associated with multiple disorders. By exploring this knowledge network, relevant biological information and insights about human diseases can be extracted.
Article
Genetics & Heredity
Diego A. A. Morais, Joao V. F. Cavalcante, Shenia S. Monteiro, Matheus A. B. Pasquali, Rodrigo J. S. Dalmolin
Summary: Metagenomic studies provide valuable insights into the taxonomic composition and functional characteristics of microbial communities. However, selecting and setting up the appropriate tools for comprehensive metagenomic analysis poses challenges. In this study, the researchers surveyed state-of-the-art tools, created simulated datasets, and performed benchmarks to develop an efficient and flexible metagenomic analysis pipeline called MEDUSA. Compared to existing tools, MEDUSA accurately identifies a greater number of species and is well-suited for functional analysis.
FRONTIERS IN GENETICS
(2022)
Review
Food Science & Technology
Shenia Santos Monteiro, Veronica Macario de Oliveira, Matheus Augusto de Bittencourt Pasquali
Summary: The relationship between food and human health drives the search for knowledge of food components that are related to these benefits. The scientific community shows a growing interest in the knowledge of the interactions between components of citrus fruits and probiotics to develop ways to improve the quality of the food produced. This bibliometric review examines scientific publications on the potential of probiotics in citrus fermentation and discusses the importance and future trends of plant-based products as an alternative to the dairy market in the functional food group.
Article
Food Science & Technology
Larissa Marina Pereira Silva, Maria Raquel Cavalcanti Inacio, Gualter Guenter Costa da Silva, Jucier Magson de Souza e Silva, Jefferson Romaryo Duarte da Luz, Maria das Gracas Almeida, Edgar Perin Moraes, Debora Esposito, Leandro De Santis Ferreira, Silvana Maria Zucolotto
Summary: Moringa oleifera leaves are rich in flavonoids, and the highest flavonoid content can be obtained through ultrasound-assisted extraction. The optimal cultivation condition is using mineral soil fertilizer in the drought season, with the optimized extraction conditions being 80% ethanol and 13.4 minutes extraction time. The extract is safe and significantly reduces inflammation, with major compounds derived from apigenin, quercetin, and kaempferol glycosides.
Article
Food Science & Technology
Wanessa Dayane Leite Lima, Shenia Santos Monteiro, Matheus Augusto de Bittencourt Pasquali
Summary: This study evaluated the growth characteristics of L. gasseri in passion fruit juice and passion fruit with the addition of green tea. The results showed that a pH of 7.5 and temperature of 44 degrees C had higher cell production, and the addition of 15% green tea induced the growth of L. gasseri in passion fruit juice.
Article
Food Science & Technology
Thais Jaciane Araujo Rodrigues, Aline Pacheco Albuquerque, Antonio Vinicius Silva de Azevedo, Layanne Rodrigues da Silva, Matheus Augusto de Bittencourt Pasquali, Gilmar Trindade de Araujo, Shenia Santos Monteiro, Wanessa Dayane Leite Lima, Ana Paula Trindade Rocha
Summary: This study investigated the fermentation of caja fruit pulp using Bifidobacterium animalis ssp. lactis B94 and found that caja pulp is a favorable medium for its growth. The stability test demonstrated that the probiotic pulp can preserve the probiotic attributes of the final product. These findings suggest that caja pulp can be used for the development of new food products using biotechnology.
Article
Biology
Daniel DiCorpo, Sheila M. Gaynor, Emily M. Russell, Kenneth E. Westerman, Laura M. Raffield, Timothy D. Majarian, Peitao Wu, Chloe Sarnowski, Heather M. Highland, Anne Jackson, Natalie R. Hasbani, Paul S. de Vries, Jennifer A. Brody, Bertha Hidalgo, Xiuqing Guo, James A. Perry, Jeffrey R. O'Connell, Samantha Lent, May E. Montasser, Brian E. Cade, Deepti Jain, Heming Wang, Ricardo D'Oliveira Albanus, Arushi Varshney, Lisa R. Yanek, Leslie Lange, Nicholette D. Palmer, Marcio Almeida, Juan M. Peralta, Stella Aslibekyan, Abigail S. Baldridge, Alain G. Bertoni, Lawrence F. Bielak, Chung-Shiuan Chen, Yii-Der Ida Chen, Won Jung Choi, Mark O. Goodarzi, James S. Floyd, Marguerite R. Irvin, Rita R. Kalyani, Tanika N. Kelly, Seonwook Lee, Ching-Ti Liu, Douglas Loesch, JoAnn E. Manson, Ryan L. Minster, Take Naseri, James S. Pankow, Laura J. Rasmussen-Torvik, Alexander P. Reiner, Muagututi'a Sefuiva Reupena, Elizabeth Selvin, Jennifer A. Smith, Daniel E. Weeks, Huichun Xu, Jie Yao, Wei Zhao, Stephen Parker, Alvaro Alonso, Donna K. Arnett, John Blangero, Eric Boerwinkle, Adolfo Correa, L. Adrienne Cupples, Joanne E. Curran, Ravindranath Duggirala, Jiang He, Susan R. Heckbert, Sharon L. R. Kardia, Ryan W. Kim, Charles Kooperberg, Simin Liu, Rasika A. Mathias, Stephen T. McGarvey, Braxton D. Mitchell, Alanna C. Morrison, Patricia A. Peyser, Bruce M. Psaty, Susan Redline, Alan R. Shuldiner, Kent D. Taylor, Ramachandran S. Vasan, Karine A. Viaud-Martinez, Jose C. Florez, James G. Wilson, Robert Sladek, Stephen S. Rich, Jerome Rotter, Xihong Lin, Josee Dupuis, James B. Meigs, Jennifer Wessel, Alisa K. Manning
Summary: This study utilized high-coverage whole genome sequencing on over 23,000 non-diabetic individuals from diverse populations, identifying multiple genetic loci associated with fasting glucose and insulin levels. The findings provide a foundation for future sequencing-based investigations of glycemic traits.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Maud Gratuze, Johannes C. M. Schlachetzki, Ricardo D'Oliveira Albanus, Nimansha Jain, Brenna Novotny, Logan Brase, Lea Rodriguez, Clayton Mansel, Michal Kipnis, Sydney O'Brien, Martina P. Pasillas, Choonghee Lee, Melissa Manis, Marco Colonna, Oscar Harari, Christopher K. Glass, Jason D. Ulrich, David M. Holtzman
Summary: In addition to tau and Ab pathologies, inflammation and variants in APOE and TREM2 play important roles in Alzheimer's disease (AD). This study explores the relationship between microgliosis and tau-mediated neurodegeneration in the presence of ApoE4. Surprisingly, the knockout of TREM2 exacerbates neurodegeneration and tau pathology, suggesting that tau pathology-dependent microgliosis facilitates neurodegeneration in the presence of ApoE4.
Article
Multidisciplinary Sciences
Logan Brase, Shih-Feng You, Ricardo D'Oliveira Albanus, Jorge L. Del-Aguila, Yaoyi Dai, Brenna C. Novotny, Carolina Soriano-Tarraga, Taitea Dykstra, Maria Victoria Fernandez, John P. Budde, Kristy Bergmann, John C. Morris, Randall J. Bateman, Richard J. Perrin, Eric McDade, Chengjie Xiong, Alison M. Goate, Martin Farlow, Greg T. Sutherland, Jonathan Kipnis, Celeste M. Karch, Bruno A. Benitez, Oscar Harari
Summary: By performing single-nucleus RNA-sequencing on AD genetic variant carriers, this study reveals the cell-specific effects of variants in genes related to the amyloid cascade, lipid metabolism, and neuroimmune modulation. The results show dysregulated pathways in specific cell types, such as autophagy-lysosomal pathway in TREM2 oligodendrocytes and complement cascade genes in MS4A microglia. Additionally, the study maps GWAS signals to effector cell types, including neurons in addition to microglia, providing insights into the transcriptional diversity resulting from AD genetic architecture and cellular heterogeneity.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Rafaella Sousa Ferraz, Joao Vitor Ferreira Cavalcante, Leandro Magalhaes, Andrea Ribeiro-dos-Santos, Rodrigo Juliani Siqueira Dalmolin
Summary: This study aimed to reconstruct the lncRNA-centered regulatory network of mCRPC and identify the lncRNAs acting as master regulators (MRs). It identified 31 lncRNAs involved in cellular proliferation, tumor metabolism, and invasion-metastasis cascade. SNHG18 and HELLPAR were highlighted as potential new diagnostic targets in mCRPC.
Article
Microbiology
Bianca C. F. Santiago, Iara D. de Souza, Joao Vitor F. Cavalcante, Diego A. A. Morais, Mikaelly B. da Silva, Matheus Augusto de B. Pasquali, Rodrigo J. S. Dalmolin
Summary: The emergence of open ocean global-scale studies has provided valuable insights into the genomics of oceanic microbial communities. Metagenomic analyses have revealed the structure and biodiversity of marine habitats. However, there is still much to learn about the taxonomic and functional features of microbial communities at different depths.
