Article
Chemistry, Medicinal
Farhad Eisvand, Mohsen Imenshahidi, Mahboobeh Ghasemzadeh Rahbardar, Seyed Abbas Tabatabaei Yazdi, Maryam Rameshrad, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: Doxorubicin can lead to cardiotoxicity, while alpha-mangostin exerts protective effects against doxorubicin-induced cardiotoxicity through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms, improving heart function and ameliorating heart tissue damage.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Sara A. A. Al-Kenany, Nada N. N. Al-Shawi
Summary: This study found that cafestol can alleviate the cardiotoxic effects induced by doxorubicin through the activation of the Nrf2 pathway. Cafestol improved doxorubicin-induced cardiac injury, reduced levels of cardiac enzymes in the blood, increased antioxidant levels, suppressed inflammation, inhibited cardiac apoptosis, and regulated the expression of related genes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaojiao Yi, Fugen Wang, Yan Feng, Junfeng Zhu, Yongjiang Wu
Summary: The present study aimed to evaluate the potential protective effect of Danhong injection (DHI) on doxorubicin (DOX)-induced cardiotoxicity and investigate the underlying mechanisms. Results showed that DHI treatment attenuated the cardiotoxicity induced by DOX, possibly through regulating the apoptosis pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ekaterina Yu Podyacheva, Ekaterina A. Kushnareva, Andrei A. Karpov, Yana G. Toropova
Summary: Currently, there is an expansion in the pharmacological possibilities of treating cancer, leading to an increase in life expectancy with chemotherapy and supportive treatment. However, complications such as anthracycline-induced cardiomyopathy are a significant concern, requiring further research to understand its development mechanisms through new models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Apiwan Arinno, Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Sasiwan Kerdphoo, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Studies have shown that melatonin and metformin can reduce oxidative stress, inflammation, autophagy, apoptosis, and improve mitochondrial function to protect against Doxorubicin-induced cardiotoxicity.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Tavga Ahmed Aziz
Summary: The study evaluated the cardioprotective effects of quercetin and sitagliptin combination in doxorubicin-induced cardiotoxicity. Results demonstrated that the combination treatment was more effective in restoring several markers compared to individual treatments. The combination showed potential for clinical testing due to its additive effects in antioxidant, anti-inflammatory, lipid lowering, and anti-atherogenic activities.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Azar Hosseini, Mohammad-Kazem Safari, Arezoo Rajabian, Samaneh Boroumand-Noughabi, Ali H. Eid, Yusra Al Dhaheri, Eric Gumpricht, Amirhossein Sahebkar
Summary: The study demonstrated that Rheum turkestanicum extract alleviated doxorubicin-induced cardiac toxicity by modulating oxidative stress-related pathways. Liquid chromatography-mass spectrometry analysis of R. turkestanicum indicated several components with potent pharmacological properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chontida Yarana, Panjaree Siwaponanan, Chayodom Maneechote, Thawatchai Khuanjing, Benjamin Ongnok, Nanthip Prathumsap, Siriporn C. Chattipakorn, Nipon Chattipakorn, Kovit Pattanapanyasat
Summary: The study indicates that EVs released from DOXO-treated rats have protective effects on cardiomyocytes, reducing ROS production and cell death. However, they have detrimental effects on macrophages, leading to activation of immune responses and suppression. These results highlight the pleiotropic roles of EVs in DIC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Heba H. Awad, Marwa O. El-Derany, Eman M. Mantawy, Haidy E. Michel, Mona M. El-Naa, Rania A. Salah El-Din, Amany El-Brairy, Ebtehal El-Demerdash
Summary: The study investigated the cardioprotective effects of NAM and 1 alpha(OH)D3 against DOX-induced cardiotoxicity. Both NAM and 1 alpha(OH)D3 successfully reversed the DOX-induced abnormalities in cardiac tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Mingxiang Zhu, Yibing Chen, Liting Cheng, Xin Li, Yanying Shen, Ge Guo, Xiang Xu, Hanlu Li, Hao Yang, Chunlei Liu, Kunlun He
Summary: Our findings demonstrated that CLSTN1 promotes the pathogenesis of doxorubicin-induced DCM. CLSTN1 could be a therapeutic target to prevent the development of doxorubicin-induced DCM.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Chanisa Thonusin, Wichwara Nawara, Apiwan Arinno, Thawatchai Khuanjing, Nanthip Prathumsup, Benjamin Ongnok, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Using mass spectrometry-based targeted metabolomics, this study aimed to investigate the patterns of cardiac metabolic reprogramming and energetics in doxorubicin-induced heart failure, as well as the potential effects of melatonin on these processes. The results showed that co-treatment with melatonin could restore cardiac function, glucose and ketone body utilization, and adenosine triphosphate production, while also increasing cardiac fatty acid oxidation, branched-chain amino acid catabolism, and anaplerosis. These findings highlight the potential efficacy of melatonin in cardiac metabolic reprogramming and energetics, suggesting it as an adjunctive treatment for doxorubicin-induced heart failure.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Zeynab Sharifiaghdam, Seyed Mohammad Amini, Fereshteh Dalouchi, Amir Barzegar Behrooz, Yaser Azizi
Summary: This study investigated the cardioprotective effects of apigenin synthesized gold nanoparticles (Api-AuNPs) in doxorubicin-induced cardiotoxicity (DIC). The results showed that Api-AuNPs treatment significantly reduced body and heart weight loss caused by DOX, and decreased the levels of injury markers. Moreover, Api-AuNPs ameliorated tissue damage by regulating the expression of Bax, caspase3, and Bcl-2, thus exerting anti-apoptotic effects on cardiomyocytes.
Article
Biochemistry & Molecular Biology
Nonhlakanipho F. Sangweni, Kwazi Gabuza, Ruzayda van Aarde, Lawrence Mabasa, Derick van Vuuren, Barbara Huisamen, Reenen Barry, Rabia Johnson
Summary: In this study, the protective effects of 7-hydroxyflavanone (7H), a flavonoid with antioxidative properties, against doxorubicin-induced cardiotoxicity (DIC) were investigated in an in vitro model. The results showed that 7H co-treatment alleviated oxidative stress, improved mitochondrial function, and attenuated apoptosis and necrosis. These findings suggest that 7H could be a potential cardioprotective agent against DIC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pei-Ling Hsieh, Pei-Ming Chu, Hui-Ching Cheng, Yu-Ting Huang, Wan-Ching Chou, Kun-Ling Tsai, Shih-Hung Chan
Summary: This study demonstrated that dapagliflozin could mitigate doxorubicin-induced cardiotoxicity by reducing oxidative stress, improving mitochondrial dysfunction, decreasing fibrosis, hypertrophy, and inflammation through the PI3K/AKT/Nrf2 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Dongliang Cheng, Ping Liu, Zhiwei Wang
Summary: The study demonstrates that palmatine treatment can alleviate doxorubicin-induced cardiotoxicity, improve cardiac function, and exert protective effects by suppressing inflammatory response, oxidative damage, and cardiomyocyte apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Soudabeh Balarastaghi, Ramin Rezaee, A. Wallace Hayes, Fatemeh Yarmohammadi, Gholamreza Karimi
Summary: Arsenic is a toxic element that can cause cardiovascular diseases when exposed to humans. Oxidative damage induced by reactive oxygen species is a major cause of arsenic-induced toxicity. Arsenic exposure through drinking water can lead to vascular endothelial dysfunction and increase the risk of hypertension and atherosclerosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Clinical Neurology
Ali Rismanbaf, Khashayar Afshari, Mehdi Ghasemi, Abolfazl Badripour, Arvin Haj-Mirzaian, Ahmad Reza Dehpour, Hamed Shafaroodi
Summary: The study demonstrates that AZM treatment significantly improves locomotor function, reduces mechanical and thermal allodynia sensitivity, decreases TNF-α levels, and increases IL-10 levels in SCI rats. Additionally, AZM reduces M1 expression, increases M2 macrophages, and improves neuroinflammation after SCI.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2022)
Article
Surgery
Armin Aryannejad, Faezeh Eslami, Maryam Shayan, Nafise Noroozi, Keshvad Hedayatyanfard, Seyed Mohammad Tavangar, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: This study aimed to evaluate the efficacy of CBD on random-pattern skin flap survival in rats and explore the involvement of CB2 receptors. The results showed that pretreatment with CBD significantly improved flap survival in rats and exerted desirable anti-inflammatory effects, possibly mediated by CB2 receptors.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2023)
Article
Pharmacology & Pharmacy
Sanaz Mokhtari, Neda Sistani Karampour, Mohammad-Hossein Shams, Ahmad Reza Dehpour, Amin Hasanvand
Summary: Progesterone has anti-inflammatory and antioxidative effects and protects against diabetic neuropathy. Treatment with progesterone reduces neuropathic sensitivity, inflammation, and edema, while improving nerve conduction velocity and reducing oxidative stress and inflammatory factors.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Food Science & Technology
Ramin Goudarzi, Golnaz Zamanian, Zahra Seyyedian, Partow Mirzaee Saffari, Ahmad Reza Dehpour, Alireza Partoazar
Summary: This study evaluated the anti-inflammatory effect of arthrocen, avocado/soybean unsaponifiables (ASU), in improving poststroke complications like depression in a mice model. The results showed that arthrocen had significant antidepressant-like effects and reduced the production of proinflammatory cytokines in the ischemic brain hippocampus. Moreover, arthrocen increased the number of viable neurons in the stroke mice. These findings suggest that arthrocen has potential as a treatment for poststroke depression by reducing inflammation and protecting neural cells.
FOOD SCIENCE & NUTRITION
(2023)
Article
Behavioral Sciences
Mohammad Amin Sadeghi, Sara Hemmati, Hasan Yousefi-Manesh, Saba Fekrvand, Laleh Foroutani, Ehsan Nassireslami, Mojtaba Yousefi Zoshk, Yasaman Hosseini, Ahmad Reza Dehpour, Mohsen Chamanara
Summary: Combining subchronic fluoxetine with selective nNOS inhibitor 7-nitroindazole accelerated the efficacy of fluoxetine in treating post-traumatic stress disorder, and hippocampal activity showed biphasic correlation with anxiety-related behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sina Jourian, Mohammad Rahimi, Mohammad Amin Manavi, Mohammad-Taha Pahlevan-Fallahy, Razieh Mohammad Jafari, Ali Amini, Ahmad Reza Dehpour
Summary: This study found that ivermectin has an anticonvulsant effect on clonic seizure threshold. Furthermore, the anticonvulsant effect of ivermectin may be mediated through the interaction of the opioidergic system and the nitric oxide pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Maryam Shayan, Faezeh Eslami, Ayda Khosravi, Amir Rashidian, Razie Mohammad Jafari, Seyed Farzad Maroufi, Hasti Tashak Golroudbari, Ahmad Reza Dehpour
Summary: This study found that cyclosporine, ondansetron, and tropisetron have neuroprotective effects against optic nerve crush injury in rats, possibly through the suppression of apoptosis and modulation of calcineurin activity directly and via 5-HT3 receptors.
Article
Pharmacology & Pharmacy
Aysa Ostovaneh, Faezeh Eslami, Nastaran Rahimi, Pegah Dejban, Hamed Shafaroodi, Ata Abbasi, Shirin Shahsavarhaghighi, Ahmad Reza Dehpour
Summary: This study investigated the beneficial effect of sumatriptan in rats with gastric ulcer by stimulating 5HT(1B/1D) receptors and suppressing pro-inflammatory cytokines. Sumatriptan significantly improved gastric injury induced by different ulcer models, suggesting its gastroprotective effects through the involvement of 5HT(1B/1D) receptors.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hasan Yousefi-Manesh, Samira Shirooie, Tayebeh Noori, Mohammad Sheibani, Seyed Mohammad Tavangar, Sara Hemmati, Mohammad Amin Sadeghi, Hassan Akbarniakhaky, Zohreh Mohammadi, Laleh Foroutani, Ahmad Reza Dehpour
Summary: English summary: The study investigates the effects of spermidine on oxidative stress markers and pain threshold in a rat model of chronic constriction injury. The findings suggest that spermidine treatment can alleviate neuropathic pain by reducing oxidative stress and improving pathological changes.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Arya Afrooghe, Mohammadreza Babaei, Maryam Shayan, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad-Reza Dehpour
Summary: Itching is an unpleasant sensation on the skin that affects the quality of life. Bromhexine, derived from Adhatoda vasica, has been found to alleviate acute itch by inhibiting TMPRSS2 and reducing KP activation. Administering 1-Methyl Tryptophan, an IDO inhibitor, also reduces itching. The combined use of bromhexine and 1-MT results in synergistic antipruritic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Moein Ala, Mohammad Reza Fallahpour Khoshdel, Razieh Mohammad Jafari, Mehrdokht Sadrkhanloo, Sepideh Goudarzi, Meisam Asl Soleimani, Ahmad Reza Dehpour
Summary: In this study, it was found that sumatriptan has protective effects against mesenteric ischemia and the inhibition of the kynurenine pathway may be involved in this process. Therefore, sumatriptan has the potential to be repurposed as a treatment for acute mesenteric ischemia.
PHARMACOLOGICAL REPORTS
(2023)
Review
Surgery
Arya Afrooghe, Amirmasoud Rayati Damavandi, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: The incorporation of skin flaps in wound closure management has shown promise in achieving desirable cosmetic outcomes. However, skin flaps are prone to complications, such as ischemia-reperfusion injury (IRI), due to various factors. Numerous approaches have been attempted to enhance skin flap survival, including pre/post-conditioning with surgical and pharmacological methods. These approaches utilize cellular and molecular mechanisms to reduce inflammation, promote angiogenesis, induce apoptosis and autophagy. The emerging role of stem cells in improving skin flap viability has led to the development of more translational methods. This review aims to provide current evidence on these approaches.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Medicine, General & Internal
Arash Amanlou, Ehsan Nassireslami, Ahmad Reza Dehpour, Amir Rashidian, Mohsen Chamanara
Summary: Seizures and epilepsy have a severe impact on the quality of life for those affected. This review examines the effect of statins on the prevention and treatment of seizures and epilepsy using both animal models and human studies. It discusses the mechanisms of action, side effects, and comparison of different types of statins in relation to seizures. This review provides valuable insights for researchers to clarify the beneficial effects of statins on neurological disorders.
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Mahla Masoumi, Mohammad Amin Manavi, Razieh Mohammad Jafari, Alireza Mirzaei, Keshvad Hedayatyanfard, Mohammad Taghi Beigmohammadi, Ahmad Reza Dehpour
Summary: This study investigated the anticonvulsant effects of CBD on lithium-pilocarpine-induced SE in rats and found a possible involvement of CB1 receptors and anti-inflammatory effects. The results suggest that CBD may have therapeutic potential for SE, independent of CB2 and GABA(A) receptors.
CANNABIS AND CANNABINOID RESEARCH
(2023)
