Review
Chemistry, Multidisciplinary
Wanxiao Sun, Yaxin Deng, Meihui Zhao, Ying Jiang, Jingxin Gou, Yanjiao Wang, Tian Yin, Yu Zhang, Haibing He, Xing Tang
Summary: Nanotechnology has provided new treatment opportunities for prostate cancer patients in recent years, with specific nanoparticles targeting tumors more effectively. Combined administration and synergistic effects of different drugs have also shown promising therapeutic progress.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Zongyi Wei, Yuxin Zhou, Rongjie Wang, Jin Wang, Zhenhua Chen
Summary: Undesirable side effects and multidrug tolerance are major challenges in conventional chemotherapy for cancer treatment. Targeted drug delivery using aptamers as smart ligands can enhance drug accumulation at the target site and minimize toxicity to normal tissues and cells. Aptamers have high target affinity and specificity, making them attractive ligands for targeted drug delivery. This article reviews the application of aptamers in cancer therapy, focusing on their use as smart ligands, conjugation with nanocarriers, targeting strategies for the tumor microenvironment, and specific aptamers for crucial cancer biomarkers.
Review
Oncology
Mobarakeh Ajam-Hosseini, Fatemeh Akhoondi, Mohammad Doroudian
Summary: Oncolytic viruses show promise as a dual attack therapy for cancer, but their effectiveness is hindered by elimination in the body. Nanoparticles have the potential for targeted drug delivery, but face challenges in non-specificity. By encapsulating oncolytic viruses with nanoparticles, the efficacy of both treatments can be improved and successful clinical results have been achieved. In this review, we will discuss the mechanisms and benefits of each treatment method.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Cell Biology
Mengping Liu, Lin Wang, Young Lo, Simon Chi-Chin Shiu, Andrew B. Kinghorn, Julian A. Tanner
Summary: The interdisciplinary field of nanomaterials and aptamer science has significant potential for biomedical applications in drug delivery, imaging, and therapy. However, there are challenges to be addressed for their future development.
Article
Immunology
Mohsen Keshavarz, Seyed Mohammad Miri, Emad Behboudi, Yaser Arjeini, Hassan Dianat-Moghadam, Amir Ghaemi
Summary: This paper summarizes the latest advancements in the use of chemical and biological compounds for safe and efficient delivery of oncolytic viruses to target tissues or tumor deposits.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Daniel Barak, Shira Engelberg, Yehuda G. Assaraf, Yoav D. Livney
Summary: The binding and internalization of S15-APT-decorated nanoparticles by different NSCLC cell lines were studied, revealing variations among different cell lines, suggesting variable expression of the putative S15 target receptor. Cytotoxicity assays with APT-NPs also demonstrated that A549 cells had the lowest IC50 value.
Article
Biotechnology & Applied Microbiology
Wenzhi Tan, Mai Thi-Quynh Duong, Chaohui Zuo, Yeshan Qin, Ying Zhang, Yanxia Guo, Yeongjin Hong, Jin Hai Zheng, Jung-Joon Min
Summary: Pancreatic cancer is resistant to conventional therapies due to abundant stromal cells and poor immune cell infiltration. This study used engineered Salmonella typhimurium expressing ClyA to target cancer stromal cells and cancer cells, effectively treating pancreatic cancer in mice. The bacteria accumulated in tumor tissues and secreted ClyA into the tumor microenvironment, leading to inhibition of cancer growth and increased immune cell infiltration. This approach provides a novel strategy for treating pancreatic cancer by combining anticancer and antistromal therapy.
Article
Multidisciplinary Sciences
Majid S. Jabir, Ahmed M. Al-Shammari, Zainab O. Ali, Salim Albukhaty, Ghassan M. Sulaiman, Sabrean F. Jawad, Sawsan S. Hamzah, Asad Syed, Abdallah M. Elgorban, Rajalakshmanan Eswaramoorthy, Nouf S. S. Zaghloul, Ali G. Al-Dulimi, Mazin A. A. Najm
Summary: Combining viruses and nanoparticles can effectively treat breast cancer by inducing apoptosis in cancer cells.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Yujian Zou, Yufei Wang, Xiaohong Wen, Chihao Li, Lei Lei, Qiuping Guo, Guoming Sun, Li Yu, Hemin Nie
Summary: This study reports for the first time that FN is the target protein of aptamer ZY-1 and explores the mechanism of ZY-1 binding to cFN. The specific binding of ZY-1 to cFN and its sensitivity in detecting tumors are validated through in vitro assay and noninvasive in vivo fluorescence imaging. A proof-of-concept study further proves the ZY-1-mediated targeted cancer therapy using a ZY-1-based complex loaded with Dox. This study would facilitate more comprehensive studies of anti-FN aptamers in the imaging and treatment of tumors and other FN-associated diseases.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Zhenmeng Wang, Jinrui Lv, Hong Huang, Huo Xu, Jingjing Zhang, Chang Xue, Songbai Zhang, Zai-Sheng Wu
Summary: Structural DNA nanotechnology has great potential in applications such as bioimaging, drug delivery, and cancer therapy. This study demonstrates an intelligent aptamer-incorporated DNA nanonetwork for cancer cell imaging and targeted drug delivery. The nanonetwork can transform into nanosheet intermediates and specifically enter target cells through cancer cell-surface receptors, showing increased binding affinity and maintaining structural integrity.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Fei Gao, Jianhui Yin, Yan Chen, Changyong Guo, Honggang Hu, Jiacan Su
Summary: Aptamer-embedded drug delivery systems have shown great potential in cancer therapy, as they can specifically bind to a variety of target molecules. They offer numerous advantages, including high biostability, versatile chemical modification, low immunogenicity, and strong tissue penetration. Therefore, they have attracted extensive interest in the field of precision medicine and hold significant importance for cancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lijuan Zhu, Jiapei Yang, Yuan Ma, Xinyuan Zhu, Chuan Zhang
Summary: Aptamer-drug conjugates (ApDCs) are a promising drug delivery system for targeted cancer therapy. However, the conventional ApDC has limited drug loading capacity. To address this challenge, researchers have developed drugtamers, whole drug-constituted DNA-like oligomers, which have 100% drug loading ratio, active targeting capability, and enzyme-mediated release of active therapeutics.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Pharmacology & Pharmacy
Nabab Khan, Ruchika, Rakesh Kumar Dhritlahre, Ankit Saneja
Summary: Dual-ligand targeted nanocarriers can enhance the accuracy and efficacy of cancer therapy by improving cancer cell recognition, and they have a more efficient targeting effect compared to single-ligand targeted nanocarriers.
DRUG DISCOVERY TODAY
(2022)
Article
Biotechnology & Applied Microbiology
Jeong Heo, Ja-Der Liang, Chang Won Kim, Hyun Young Woo, I-Lun Shih, Tung-Hung Su, Zhong-Zhe Lin, So Young Yoo, Stanley Chang, Yasuo Urata, Pei-Jer Chen
Summary: OBP-301 is a modified oncolytic adenovirus that can replicate within cancer cells and cause their lysis. This phase I trial aimed to determine the safety and optimal dosage of OBP-301 in patients with advanced hepatocellular carcinoma. The study found that OBP-301 was well tolerated, with a maximum tolerated dose of 6 x 1012 viral particles. Injection of OBP-301 resulted in increased levels of CD8+ T cells and showed potential antitumor efficacy.
Review
Oncology
Masmudur M. Rahman, Grant McFadden
Summary: Oncolytic viruses (OVs) are a novel cancer treatment modality that selectively target and kill cancer cells while sparing normal ones. Engineered OVs show great potential in clinical trials, but combination therapies with other treatments may further improve their efficacy.
Article
Chemistry, Multidisciplinary
Gaofeng Chen, Olga A. Syzgantseva, Maria A. Syzgantseva, Shuliang Yang, Guihua Yan, Li Peng, Changyan Cao, Wenxing Chen, Zhiwei Wang, Fengjuan Qin, Tingzhou Lei, Xianhai Zeng, Lu Lin, Weiguo Song, Buxing Han
Summary: By anchoring Co and Cu sites onto a hierarchical porous N-doped carbon matrix, we designed a diatomic catalyst (Co/Cu-N-C) that exhibits outstanding performance in higher alcohol synthesis. With a CO conversion of 81.7%, it achieves a C(2+)OH selectivity of 58.5% and a remarkable C2+OH STY of 851.8 mg/g center dot h. The N-4-Co-1 and Cu-1-N-4 sites demonstrate excellent synergistic effects, with CO adsorbing on the Co site and surrounding nitrogen sites acting as a hydrogen reservoir for CO reduction reactions to form CHxCo. Simultaneously, the Cu sites stabilize a CHOCu species to interact with CHxCo, promoting barrier-free formation of C-2 species and enhancing the selectivity of higher alcohols.
Article
Energy & Fuels
Jiahong Chen, Wenlong Jia, Xin Yu, Yong Sun, Jiaren Zhang, Shuliang Yang, Xing Tang, Lincai Peng, Xianhai Zeng, Lu Lin
Summary: In this study, a highly stable chromium-free catalyst Co3AlOx was prepared for the synthesis of furfuryl alcohol. The catalyst exhibited excellent catalytic activity and stability, enabling efficient hydrogenation of furfural to furfuryl alcohol.
Review
Pharmacology & Pharmacy
Kei Xian Tan, Michael K. Danquah, Jaison Jeevanandam, Ahmed Barhoum
Summary: Janus particles have emerged as a novel and smart material for improving pharmaceutical formulation, drug delivery, and therapeutics. They have two distinct compartments that can accommodate opposing pharmaceutical agents and allow for controlled drug release. This article discusses the development of Janus particles and their potential applications in diabetes treatment and antimicrobial therapy. It highlights the advances in synthesizing Janus particles from different materials using various approaches and evaluates their potential for improving conventional drug delivery systems.
Article
Agricultural Engineering
Liangqing Zhang, Jiarong Qiu, Jiahui Deng, Shunming Song, Zelong Hong, Wenlong Jia, Suchang Huang, Xianhai Zeng
Summary: This study synthesized a series of non-precious catalysts through co-precipitation and impregnation methods for the conversion of hemicellulosic biomass into sugar alcohols. The Ni8.98Fe1 @ 1.54SiO(2) catalyst prepared by the impregnation method showed excellent catalytic performance for converting xylose to sugar alcohols in a neutral aqueous solution, and it could also be applied to the direct conversion of hemicellulose. The catalyst with mesoporous properties and proper acidic sites played a vital role in the hydrolysis of hemicellulose into pentose sugars.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Thermodynamics
Nihong Zhuang, Jiacheng Wang, Sen Ma, Qiang Liu, Wenlong Jia, Xin Yu, Zheng Li, Shuliang Yang, Yong Sun, Xing Tang, Xianhai Zeng, Lu Lin
Summary: In this study, the solubility of FDCA in different ethers and binary solvent systems with water was measured. It was found that the solubility of FDCA was improved in binary solvent systems compared to pure solvents, and it initially increased and then gradually decreased with the increasing mole fraction of water. Various models and equations were used to analyze the solubility data and thermodynamic characteristics of FDCA in different solvent systems.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2023)
Article
Chemistry, Multidisciplinary
Chengfeng Li, Qishen Lyu, Zheng Li, Shuliang Yang, Yong Sun, Xing Tang, Xianhai Zeng, Lu Lin
Summary: The hydrogenation of biomass-based furan compounds is a crucial step in catalytic utilization of biobased chemicals. Ru-based catalysts supported on various supports were evaluated for the hydrogenation of dimethyl 2,5-furandicarboxylate (FDMC), and Ru/HY exhibited the highest yield of tetrahydrofuran-2,5-dicarboxylic acid dimethyl ester (THFDMC) under certain conditions. The superior performance of Ru/HY was attributed to the presence of more surface Ru-0 species and carbon radical intermediates, favoring the activation of hydrogen and the subsequent hydrogenation of FDMC.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Qiang Liu, Yong Sun, Xianhai Zeng, Lu Lin, Xing Tang
Summary: Efficient production of furancarboxylic acid (FA) through furfural oxidation at room temperature is of great significance. A CuO-MnCO3 bimetallic catalyst was used in a sodium hypochlorite solution as an efficient and sustainable heterogeneous catalyst system for the selective oxidation of furfural to FA. Cu-6-Mn-4 showed excellent catalytic performance with 100% furfural conversion and 96.9% selectivity to FA. The introduction of MnCO3 into the Cu-Mn catalyst increased the reactivity of lattice oxygen, and Cu-6-Mn-4 also exhibited excellent stability in reusability test. This study provides a simple and rapid catalytic strategy and scientific basis for the development of an efficient and mild aerobic oxidation of furfural.
Article
Chemistry, Physical
Ye Tian, Yunchao Femg, Zheng Li, Yi Fan, Jonathan Sperry, Young Sun, Shuliang Yang, Xiang Tang, Lu Lin, Xianhai Zeng
Summary: In this study, a CoOx/Nb2O5 nanostructure catalyst was synthesized for the selective hydrogenation of furfural (FF) to furfuryl alcohol (FA). The optimized conditions resulted in a 95.7% yield of FA with a TOF of 155.7 h-1. The catalyst characterization revealed the interaction between Nb2O5 and CoO, which prevented the further reduction of CoO to metal Co. DFT calculations confirmed that CoO was the main adsorption site for FF in CoOx/Nb2O5-ctr.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Physical
Sishi Long, Yunchao Feng, Binglin Chen, Lihui Gan, Xianhai Zeng, Minnan Long, Jian Liu
Summary: Zr-carbon aerogel (Zr-DCCA) was prepared using renewable deep eutectic solvents (DESs) and cellulose nanofiber as templates. Zr-DCCA exhibited high conversion, selectivity, and stability for transfer hydrogenation of various biomass aldehydes. Comparative studies with Zr-based carbon aerogels (Zr-CCA) prepared without DESs showed lower catalytic performance. Characterizations revealed that Zr-DCCA had higher dispersion and smaller size of ZrO2 nanoparticles, resulting in stronger acid/base properties. Furthermore, the absence of traditional stirring and centrifugation in the reaction simplified equipment and operations, making the process more practical.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Physical
Gaofeng Chen, Olga A. Syzgantseva, Maria A. Syzgantseva, Li Peng, Dragos Stoian, Mo Li, Isil Akpinar, Guihua Yan, Tianwei Xue, Qishen Lyu, Zhiwei Wang, Tingzhou Lei, Xianhai Zeng, Lu Lin, Shuliang Yang
Summary: In this study, a hydrophobic CuCoSNTs-c catalyst with a hollow tubular structure and mesoporous wall was successfully synthesized for higher alcohol synthesis (HAS). The synthesized catalyst exhibited excellent stability for 360 h without obvious activity loss and suppressed the selectivity of CO2 to less than 1.2%, while achieving a C2+OH selectivity of up to 66.6% at a CO conversion of 80.4%. Furthermore, the elaborately designed hydrophobic and aerophilic properties of the CuCoSNTs-c catalyst played a crucial role in enhancing CO conversion and C2+OH selectivity.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Thermodynamics
Zhizhou Tan, Xianhai Zeng, Boqiang Lin
Summary: This study investigates the economic viability of retrofitting current coal-fired power plants with biomass co-firing and carbon capture and storage technology as a feasible option for decarbonization. Using the real options approach, the study evaluates the potential project value under different uncertainties and policy scenarios. The study suggests that raising carbon prices and implementing a composite policy scheme including electricity price subsidy and carbon tax credit can promote retrofit projects and effectively advance decarbonization efforts worldwide.
Article
Chemistry, Physical
Binglin Chen, Zhendong Yu, Renjie Huang, Ye Tian, Zheng Li, Jonathan Sperry, Shuliang Yang, Xing Tang, Yong Sun, Lu Lin, Xianhai Zeng
Summary: This study reports the synthesis of 2,5-hexanedione (HD) from 5-(chloromethyl)furfural (CMF) using polymethylhydrosiloxane (PMHS) as the hydrogen donor for the first time. It was found that the yield of HD reached 78% at 160°C for 30 minutes. The presence of acidic protons significantly promoted the coupling reaction (hydrodechlorination, hydrogenolysis, and hydrolysis) from a kinetic and thermodynamic perspective. Modifying Pd nanoparticles (NPs) with in situ generated Cl species improved the adsorption of substrate molecules on step sites compared to corner sites. This work provides insights into the role of acidic protons and the migration mechanism of Cl species, and offers a basis for the development of future catalytic systems and the synthesis of biomass-derived chemicals.
Article
Chemistry, Physical
Xin Yu, Xiaoyi Huang, Wenlong Jia, Jiahong Chen, Shibo Yang, Lincai Peng, Yong Sun, Xing Tang, Xianhai Zeng, Shuliang Yang, Zheng Li, Feng Xu, Lu Lin
Summary: In this study, a CoNi bimetallic nitrogen-doped carbon nanotubes (CNTs) catalyst was successfully prepared and demonstrated excellent catalytic performance for furfural oxidative esterification under base-free conditions (methyl furoate yield >99%) and great recyclability (5th recycle). Notably, an impressive methyl furoate formation rate of around 1980 mu mol(methyl furoate)center dot g(cat)(-1)center dot h(-1) was achieved, which is one of the highest rates reported. The results indicate that the doping of Ni into the CoxNiy-CNTs catalyst provides more active sites, and the introduction of Ni enhances basicity, promoting beta-hydride elimination and overall activity for furfural oxidative esterification.
MOLECULAR CATALYSIS
(2023)
Review
Chemistry, Physical
Weiping Deng, Yunchao Feng, Jie Fu, Haiwei Guo, Yong Guo, Buxing Han, Zhicheng Jiang, Lingzhao Kong, Changzhi Li, Haichao Liu, Phuc T. T. Nguyen, Puning Ren, Feng Wang, Shuai Wang, Yanqin Wang, Ye Wang, Sie Shing Wong, Kai Yan, Ning Yan, Xiaofei Yang, Yuanbao Zhang, Zhanrong Zhang, Xianhai Zeng, Hui Zhou
Summary: This review article focuses on the state-of-the-art catalytic transformation of lignocellulosic biomass into value-added chemicals and fuels, including the conversion of cellulose, hemicellulose, and lignin, as well as the gasification and pyrolysis of whole biomass. The opportunities, challenges, and prospects of woody biomass valorization are highlighted.
GREEN ENERGY & ENVIRONMENT
(2023)
Article
Chemistry, Physical
Xin Yu, Tingke Jin, Huiqiang Wang, Guoqing Zhang, Wenlong Jia, Lincai Peng, Yong Sun, Xing Tang, Xianhai Zeng, Shuliang Yang, Zheng Li, Feng Xu, Lu Lin
Summary: A cost-effective and sustainable catalyst system based on Mn-Cu bimetallic oxides was found to be highly efficient for the selective oxidation of furfural to furancarboxylic acid. The incorporation of CuO into the Mn-Cu oxides weakened the Mn-O bonds, resulting in improved catalytic activity. The study provides insights into the relationship between the morphology, surface chemistry, and catalytic activity of Mn-Cu bimetallic oxides.
GREEN ENERGY & ENVIRONMENT
(2023)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)