MECHANISMS IN ENDOCRINOLOGY: Clinical and pharmacogenetic aspects of the growth hormone receptor polymorphism

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

(2017) Danny Ben-Avraham et al.   Science Advances

Comorbidities, treatment patterns and cost-of-illness of acromegaly in Sweden: a register-linkage population-based study

(2016) Eva Lesén et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The growth hormone receptor

(2016) Michael J. Waters   GROWTH HORMONE & IGF RESEARCH

The Effect of the Exon-3-Deleted Growth Hormone Receptor on Pegvisomant-Treated Acromegaly: A Systematic Review and Meta-Analysis

(2016) Sanne E. Franck et al.   NEUROENDOCRINOLOGY

Growth hormone receptor exon 3 isoforms may have no importance in the clinical setting of multiethnic Brazilian acromegaly patients

(2016) Evelyn de Oliveira Machado et al.   Pituitary

Challenges in the diagnosis and management of acromegaly: a focus on comorbidities

(2016) Alin Abreu et al.   Pituitary

GH deficiency status combined with GH receptor polymorphism affects response to GH in children

(2015) Armand Valsesia et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Pegvisomant in combination with long-acting somatostatin analogues in acromegaly: the role of the GH receptor deletion of exon 3

(2015) S E Franck et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The growth hormone receptor exon 3-deleted/full-length polymorphism and response to growth hormone therapy in prepubertal idiopathic short children

(2015) G. Hellgren et al.   GROWTH HORMONE & IGF RESEARCH

Influence of growth hormone receptor (GHR) exon 3 and -202A/C IGFBP-3 genetic polymorphisms on clinical and biochemical features and therapeutic outcome of patients with acromegaly

(2015) Raquel S. Jallad et al.   Pituitary

GH receptor isoforms and skeletal fragility in acromegaly

(2014) Marilda Mormando et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The growth hormone receptor exon 3 polymorphism is not associated with height or metabolic traits in healthy young adults

(2014) Clarissa S. Martins et al.   GROWTH HORMONE & IGF RESEARCH

The clinical and cardiometabolic effects of d3-growth hormone receptor polymorphism in acromegaly

(2014) Nese Cinar et al.   Pituitary

Influence of the exon 3 deletion of GH receptor and IGF-I level at diagnosis on the efficacy and safety of treatment with somatotropin in adults with GH deficiency

(2014) P. Andujar-Plata et al.   Pituitary

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

(2014) A. J. Brooks et al.   SCIENCE

Growth hormone receptor (GHR) gene polymorphism and prader-willi syndrome

(2013) Merlin G. Butler et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women

(2013) K M J A Claessen et al.   ANNALS OF THE RHEUMATIC DISEASES

SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD adults

(2013) Camilla A M Glad et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Monitoring for potential residual disease activity by serum insulin-like growth factor 1 and soluble Klotho in patients with acromegaly after pituitary surgery: Is there an impact of the genomic deletion of exon 3 in the growth hormone receptor (d3-GHR) gene on “safe” GH cut-off values?

(2013) S. Kohler et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Personalized Approach to Growth Hormone Treatment: Clinical Use of Growth Prediction Models

(2013) J.M. Wit et al.   Hormone Research in Paediatrics

Growth Hormone Receptor Polymorphism and Growth Hormone Therapy Response in Children: A Bayesian Meta-Analysis

(2012) Andrew G. Renehan et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The Exon 3-Deleted/Full-Length Growth Hormone Receptor Polymorphism and Response to Growth Hormone Therapy in Growth Hormone Deficiency and Turner Syndrome: A Multicenter Study

(2012) Firdevs Baş et al.   Hormone Research in Paediatrics

Growth Hormone Receptor (GHR) Exon 3 Polymorphism Status Detection by Dual-Enzyme-Linked Immunosorbent Assay (ELISA)

(2012) JunXiang Wan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A polymorphism in the growth hormone receptor is associated with height in children with Prader-Willi syndrome

(2011) Sung Won Park et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Different relationships between the first 2 years on growth hormone treatment and the d3-growth hormone receptor polymorphism in short small-for-gestational-age (SGA) children

(2011) Helmuth G. Dörr et al.   CLINICAL ENDOCRINOLOGY

The growth hormone receptor gene deleted for exon three (GHRd3) polymorphism is associated with birth and placental weight

(2011) Raja Padidela et al.   CLINICAL ENDOCRINOLOGY

Evaluation of the association between GHR exon 3 polymorphism and polycystic ovary syndrome among Han Chinese women

(2011) Yun Shen et al.   GROWTH HORMONE & IGF RESEARCH

Growth Hormone Receptor Variants and Response to Pegvisomant in Monotherapy or in Combination with Somatostatin Analogs in Acromegalic Patients: A Multicenter Study

(2011) M. Filopanti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The growth hormone receptor (GHR) exon 3 polymorphism and its correlation with metabolic profiles in obese Chinese children

(2011) Lingling Gao et al.   PEDIATRIC DIABETES

The growth hormone receptor polymorphism in patients with acromegaly: relationship to BMI and glucose metabolism

(2011) Sebahat Turgut et al.   Pituitary

d3-Growth hormone receptor polymorphism in acromegaly: effects on metabolic phenotype

(2010) Laura Montefusco et al.   CLINICAL ENDOCRINOLOGY

Influence of the d3GH receptor polymorphism on the metabolic and biochemical phenotype of GH-deficient adults at baseline and during short- and long-term recombinant human GH replacement therapy

(2010) Claudia Giavoli et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Rapid and high throughput genotyping of the growth hormone receptor exon 3 deleted/full-length polymorphism using a tagSNP

(2010) Camilla A.M. Glad et al.   GROWTH HORMONE & IGF RESEARCH

The Exon 3 Deleted Growth Hormone Receptor Gene Is Associated with Small Birth Size and Early Pubertal Onset in Healthy Boys

(2010) Kaspar Sørensen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

d3-GHR genotype does not explain heterogeneity in GH responsiveness in hypopituitary adults

(2009) V. J. Moyes et al.   CLINICAL ENDOCRINOLOGY

The common exon 3 polymorphism of the growth hormone receptor gene and the effect of growth hormone therapy on growth in Korean patients with Turner syndrome

(2009) Jung Min Ko et al.   CLINICAL ENDOCRINOLOGY

Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients

(2009) O.R. Adetunji et al.   CLINICAL ENDOCRINOLOGY

D3 GH receptor polymorphism is not associated with IGF1 levels in untreated acromegaly

(2009) Peter Kamenicky et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy

(2009) O R Adetunji et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Growth Hormone Receptor (GHR) Polymorphism in Growth-retarded Children with Cushing Disease: Lack of Association with Growth and Measures of the Somatotropic Axis

(2009) L. Drori-Herishanu et al.   HORMONE AND METABOLIC RESEARCH

Influence of Growth Hormone Receptor d3 and Full-Length Isoforms on Biochemical Treatment Outcomes in Acromegaly

(2009) Antonio Bianchi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Impact of the Exon 3-Deleted Growth Hormone (GH) Receptor Polymorphism on Baseline Height and the Growth Response to Recombinant Human GH Therapy in GH-Deficient (GHD) and Non-GHD Children with Short Stature: A Systematic Review and Meta-Analysis

(2009) M. J. E. Wassenaar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Impact of the Growth Hormone Receptor Exon 3 Deletion Gene Polymorphism on Glucose Metabolism, Lipids, and Insulin-Like Growth Factor-I Levels during Puberty

(2009) Kaspar Sørensen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Exon-3 Deleted Growth Hormone Receptor Polymorphism Predisposes to Long-Term Complications of Acromegaly

(2009) M. J. E. Wassenaar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Exon 3-Deleted Growth Hormone Receptor Is Associated with Better Response to Pegvisomant Therapy in Acromegaly

(2009) Ignacio Bernabeu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association of the exon 3 deleted/full-lengthGHRpolymorphism with recombinant growth hormone dose in growth hormone-deficient adults

(2009) Silke Meyer et al.   PHARMACOGENOMICS

Lack of an association between GHR exon 3 polymorphism and diabetic nephropathy in the Genetics of Kidneys in Diabetes (GoKinD) population

(2008) H. F. Gu et al.   DIABETOLOGIA

Influence of the d3-Growth Hormone (GH) Receptor Isoform on Short-Term and Long-Term Treatment Response to GH Replacement in GH-Deficient Adults

(2008) Agatha A. van der Klaauw et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clinical and Biochemical Impact of the d3 Growth Hormone Receptor Genotype in Acromegaly

(2008) Moisés Mercado et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Influence of the Exon 3-Deleted/Full-Length Growth Hormone (GH) Receptor Polymorphism on the Response to GH Replacement Therapy in Adults with Severe GH Deficiency

(2008) Edna J. L. Barbosa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Growth hormone receptor polymorphism and the effects of pegvisomant in acromegaly

(2008) Antonio Bianchi et al.   Pituitary