Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonio Bianchi, Antonella Giampietro, Alfredo Pontecorvi, Gerald Raverot, Laura De Marinis
Summary: This review provides an overview of the second-line therapies for acromegaly, summarizing the evidence on clinical, molecular, and morphological aspects that can predict the response to these treatments and advocating for a patient-tailored therapeutic approach in clinical practice.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Thierry Brue, Philippe Chanson, Patrice Rodien, Brigitte Delemer, Delphine Drui, Lucile Marie, Laurene Juban, Lara Salvi, Robin Henocque, Gerald Raverot
Summary: The study aimed to estimate the cost-utility of second-line pharmacological treatments in acromegaly patients.
The incremental cost-utility ratios for pasireotide, pegvisomant, and pegvisomant + FGSA were estimated, showing pasireotide to be the least cost-efficient treatment option.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Melin M. Uygur, Stefano Frara
Summary: A personalized approach to acromegaly treatment, utilizing novel clinical and molecular biomarkers, has shown promising results in predicting responsiveness to second-line medical treatments. Integrating these findings into existing guidelines may significantly improve the management of difficult acromegaly patients.
Review
Medicine, General & Internal
Alexandru Dan Popescu, Mara Carsote, Ana Valea, Andreea Gabriela Nicola, Ionela Teodora Dascalu, Tiberiu Tirca, Jaqueline Abdul-Razzak, Mihaela Jana Tuculina
Summary: Acromegaly-related sub/infertility is associated with suboptimal disease control, hyperprolactinemia, hypogonadotropic hypogonadism, and glucose profile anomalies. This review explores the impact of acromegaly on pregnancy outcomes and discusses management strategies. The level of disease control, family history of diabetes, and body mass index are important predictors of maternal complications. Pharmacotherapy has been shown to be safe and effective in improving pregnancy outcomes.
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
YuanPu Meng, Bo Zhou, Zhe Pei, Ye Chen, Dongmin Chang
Summary: This study investigated the biological properties and mechanisms of growth hormone receptor (GHR) in gastric cancer cells. It was found that GHR can translocate into the nuclei of gastric cancer cells and is closely related to cell proliferation. The GHR inhibitor, pegvisomant, was shown to inhibit both cell proliferation and nuclear localization of GHR, suggesting its potential as a dual-effect antagonist. These findings highlight GHR as a potential target for gastric cancer treatment.
BIOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Fleseriu, Beverly M. K. Biller, Pamela U. Freda, Monica R. Gadelha, Andrea Giustina, Laurence Katznelson, Mark E. Molitch, Susan L. Samson, Christian J. Strasburger, A. J. van der Lely, Shlomo Melmed
Summary: This article focuses on recent advances in the management of acromegaly, emphasizing how key developments affect treatment decisions and outcomes. It also explores the potential role of recently FDA-approved therapies and combination therapies in the treatment arsenal.
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Denise Costa, Rosa Lauretta, Valeria Mercuri, Emilia Sbardella, Irene Samperi, Marialuisa Appetecchia, Antonio Bianchi, Antonella Giampietro, Patrizia Gargiulo, Andrea M. Isidori, Maurizio Poggi, Alfredo Pontecorvi, Laura De Marinis
Summary: This study investigated the treatment choices and outcomes for acromegaly patients resistant to first generation somatostatin analogues. The results showed that c-Peg-V and Pasi-Lar were chosen for the treatment of invasive tumors, and partial response to first gen-SSA seemed to be the main determinant for the choice of Pasi-Lar and positively predicted the treatment outcome.
Article
Oncology
Ahmed O. Kaseb, Abedul Haque, Deeksha Vishwamitra, Manal M. Hassan, Lianchun Xiao, Bhawana George, Vishal Sahu, Yehia I. Mohamed, Roberto Carmagnani Pestana, Jamie Lynne Lombardo, Rony Avritscher, James C. Yao, Robert A. Wolff, Asif Rashid, Jeffrey S. Morris, Hesham M. Amin
Summary: Hepatocellular carcinoma is an aggressive neoplasm with limited systemic therapy options. This study suggests that growth hormone receptor (GHR) signaling could be a potential therapeutic target for HCC, and pegvisomant may be an effective systemic therapy for this aggressive cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Amit Akirov, Hiba Masri-Iraqi, Idit Dotan, Ilan Shimon
Summary: The diagnosis, management, and treatment of acromegaly heavily rely on the levels of serum IGF-1, basal GH, and nadir GH following OGTT. However, these hormone concentrations can be influenced by various factors, leading to discordant levels that may require additional monitoring and data. New standards for GH and IGF-1 provide more accurate tools, but limitations should be considered along with clinical history and imaging studies when evaluating patients with acromegaly.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Betina Biagetti, Pedro Iglesias, Rocio Villar-Taibo, Maria-Dolores Moure, Miguel Paja, Marta Araujo-Castro, Jessica Ares, Cristina Alvarez-Escola, Almudena Vicente, Elia Alvarez Guivernau, Iria Novoa-Testa, Fernando Guerrero Perez, Rosa Camara, Beatriz Lecumberri, Carlos Garcia Gomez, Ignacio Bernabeu, Laura Manjon, Sonia Gaztambide, Fernando Cordido, Susan M. Webb, Edelmiro Luis Menendez-Torre, Juan J. Diez, Rafael Simo, Manel Puig-Domingo
Summary: The study found that the most common phenotype in elderly patients newly diagnosed with acromegaly includes small adenomas and moderately high IGF-1 levels. GH <= 6 ng/ml at diagnosis and female gender, rather than age per se, were associated with a greater chance of response to SRL.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Pamela U. Freda
Summary: Acromegaly is a hormonal disorder characterized by excess hormone production, leading to a specific lipodystrophy and insulin resistance. Understanding the pathophysiology of this condition and its effects on adipose tissue metabolism and insulin resistance is important for optimizing treatment and long-term outcomes for patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
M. Detomas, B. Altieri, J. Flitsch, W. Saeger, M. Korbonits, T. Deutschbein
Summary: This study reports a novel AIP mutation in a German family with acromegaly. It highlights the distinct clinical and histological features of AIP mutated pituitary neuroendocrine tumors and the poor responsiveness to dopamine agonists. Additionally, it emphasizes the increased mortality risk of comorbidities associated with acromegaly.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Li Li, Liheng Meng, Yuping Liu, Rashi Tamrakar, Xi Yang, Xinghuang Liang, Jia Zhou, Jing Xian, Zhenxing Huang, Yingfen Qin
Summary: Mixed pituitary TSH/GH adenomas are rare adenomas that produce both GH and TSH simultaneously, often associated with acromegaly and thyrotoxicosis. Treatment typically involves somatostatin analogs to regulate hormone levels before surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Adriana G. Ioachimescu
Summary: Patients with acromegaly often experience a significant delay between the onset of symptoms and diagnosis, with women and younger patients experiencing longer delays. Comorbidities usually improve after treatment except for irreversible osteoarticular structural changes. Early diagnosis and personalized care are crucial for better management of the condition.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2021)
Article
Endocrinology & Metabolism
Berta Soldevila, Manel Puig-Domingo, Monica Marazuela
Summary: The article discusses the mechanism of viral interaction with endocrine organs, emphasizing the importance of specific endocrine molecules in explaining the evolution and outcomes of COVID-19 disease.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Joan Gil, Montserrat Marques-Pamies, Elena Valassi, Araceli Garcia-Martinez, Guillermo Serra, Cristina Hostalot, Carmen Fajardo-Montanana, Cristina Carrato, Ignacio Bernabeu, Monica Marazuela, Helena Rodriguez-Lloveras, Rosa Camara, Isabel Salinas, Cristina Lamas, Betina Biagetti, Andreu Simo-Servat, Susan M. Webb, Antonio Pico, Mireia Jorda, Manel Puig-Domingo
Summary: Acromegaly is a condition caused by excessive growth hormone production due to a pituitary tumor. This study examines the relationship between epithelial-mesenchymal transition (EMT) and resistance to somatostatin receptor ligands (SRLs) in GH-producing tumors. The findings suggest that EMT-related gene expression patterns are heterogeneous, which may explain the varying responses to SRLs.
Review
Obstetrics & Gynecology
Ane Bayona, Victoria Martinez-Vaello, Javier Zamora, Lia Nattero-Chavez, Manuel Luque-Ramirez, Hector F. Escobar-Morreale
Summary: This systematic review and meta-analysis explored the prevalence of polycystic ovary syndrome (PCOS) and related hyperandrogenic traits in premenopausal women with type 1 diabetes (T1D). The study found that approximately one in four women with T1D had PCOS, and there was heterogeneity in the prevalence rates among different phenotypes. The findings highlight the need for larger studies to confirm the association between PCOS and T1D and to identify the factors influencing the occurrence of PCOS in this population.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Endocrinology & Metabolism
Lia Nattero-Chavez, Manuel Luque-Ramirez, Jhonatan Quinones-Silva, Laura Montanez, Elena Fernandez-Duran, Beatriz Dorado-Avendano, Hector F. Escobar-Morreale
Summary: This study aimed to evaluate the diagnostic performance of POCD for screening CAN in patients with type 1 diabetes mellitus. The results showed that AMP(POCD) had high accuracy in identifying CAN, and combining it with the duration of type 1 diabetes and A(1c) could predict CAN effectively.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Medicine, General & Internal
Manuel Luque-Ramirez, Andres E. Ortiz-Flores, Maria Angeles Martinez-Garcia, Maria Insenser, Alejandra Quintero-Tobar, Sara De Lope Quinones, Elena Fernandez-Duran, Maria Lia Nattero-Chavez, Francisco Alvarez-Blasco, Hector Francisco Escobar-Morreale
Summary: Women with functional hyperandrogenism may experience impaired redox status after taking combined oral contraceptives (COC), and scheduled bloodletting to reduce iron stores does not override this impairment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lia Nattero-Chavez, Maria Insenser, Alejandra Quintero Tobar, Elena Fernandez-Duran, Beatriz Dorado Avendano, Tom Fiers, Jean-Marc Kaufman, Manuel Luque-Ramirez, Hector F. Escobar-Morreale
Summary: This study aimed to investigate the relationship between sex and cardiovascular autonomic neuropathy in patients with type 1 diabetes. The results showed that women over 50 years old had twice the probability of developing cardiovascular autonomic neuropathy compared to younger women, and women had more severe cardiovascular autonomic neuropathy than men. Additionally, menopause was associated with an increased risk of cardiovascular autonomic neuropathy in women.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Lia Nattero-Chavez, Ane Bayona Cebada, Elena Fernandez-Duran, Alejandra Quintero Tobar, Beatriz Dorado Avendano, Hector Escobar-Morreale, Manuel Luque-Ramirez
Summary: This study evaluated the effect of arterial stiffness on the circadian rhythm of blood pressure in patients with type 1 diabetes and cardiovascular autonomic neuropathy (CAN). It was found that the presence of arterial stiffness did not cause abnormalities in the circadian rhythm of blood pressure. A1c levels were identified as an important predictor of nighttime decrease in mean blood pressure.
DIABETES & VASCULAR DISEASE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lia Nattero-Chavez, Edurne Lecumberri Pascual, Esther De La Calle, Ane Bayona Cebada, Teresa Ruiz, Alejandra Quintero Tobar, Mar Lorenzo, Cristina Sanchez, Ana Izquierdo, Manuel Luque-Ramirez, Hector F. Escobar-Morreale
Summary: The efficacy of an advance closed-loop (AHCL) system in restoring awareness of hypoglycemia in patients with type 1 diabetes (T1D) was evaluated. The results showed that the AHCL system had significant effectiveness in improving hypoglycemic awareness and metabolic control.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Obstetrics & Gynecology
M. Insenser, A. Quintero, S. de Lope, F. Alvarez-Blasco, M. A. Martinez-Garcia, M. Luque-Ramirez, H. F. Escobar-Morreale
Summary: This research found that the expression of miR-142-3p and miR-598-3p, which are associated with polycystic ovary syndrome (PCOS), differs significantly between women with PCOS and those without. These circulating miRNAs, when combined with easily available measurements such as waist-to-hip ratio (WHR) and circulating LH-to-FSH (LH/FSH) ratios, can effectively distinguish between women with and without PCOS.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Mercedes Millan-de-Meer, Manuel Luque-Ramirez, Lia Nattero-Chavez, Hector F. Escobar-Morreale
Summary: This study is a systematic review and meta-analysis on the consequences of PCOS during the late reproductive years and after menopause. The study found that women with PCOS in peri- and postmenopause presented increased levels of testosterone and androgens, as well as decreased levels of sex hormone-binding globulin. They also had higher measures of obesity, insulin resistance, and risk for diabetes and hypertension. Furthermore, they had lower levels of HDL cholesterol and higher levels of triglycerides. Although myocardial infarction and stroke were more prevalent in women with PCOS, the prevalence of cardiovascular disease, coronary artery disease, breast cancer, and age at menopause were similar between patients and controls. The study highlights the persistence of hyperandrogenism and the importance of addressing the comorbidity of weight excess in women with PCOS.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Endocrinology & Metabolism
Betina Biagetti, Pedro Iglesias, Rocio Villar-Taibo, Maria-Dolores Moure, Miguel Paja, Marta Araujo-Castro, Jessica Ares, Cristina Alvarez-Escola, Almudena Vicente, Elia Alvarez Guivernau, Iria Novoa-Testa, Fernando Guerrero Perez, Rosa Camara, Beatriz Lecumberri, Carlos Garcia Gomez, Ignacio Bernabeu, Laura Manjon, Sonia Gaztambide, Fernando Cordido, Susan M. Webb, Edelmiro Luis Menendez-Torre, Juan J. Diez, Rafael Simo, Manel Puig-Domingo
Summary: This study compared the clinical characteristics, comorbidities, treatment approaches, and mortality rate of patients diagnosed with acromegaly before or after 2010 and compared the overall mortality rate with the general Spanish population. The results showed no significant difference in mortality rate among acromegaly patients diagnosed at age 65 or older, and no significant difference compared to the general population in Spain.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hector F. Escobar-Morreale, M. Angeles Martinez-Garcia, Maria Insenser, Nicolau Canellas, Xavier Correig, Manuel Luque-Ramirez
Summary: Using proton nuclear magnetic resonance spectroscopy metabolomics profiling, we found that androgen excess in women with PCOS induces masculinization of intermediate metabolism, which is also modulated by obesity.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Neurosciences
Marta Araujo-Castroa, Victor Rodriguez-Berrocalb, Elena Diosc, Ramon Serramitod, Betina e Bernabeuf, e Ignacio Bernabeuf
Summary: Pituitary tumors, accounting for 15% of intracranial tumors, require surgical treatment for hormone hypersecretion and neurological symptoms. Multidisciplinary care is crucial and should be delivered in a center of excellence with a well-defined care protocol.
Article
Endocrinology & Metabolism
Eva Fernandez Rodriguez, Roclo Villar Taibo, Ignacio Bernabeu
Summary: Traumatic brain injury (TBI) is associated with hypopituitarism which can lead to various clinical manifestations. It is important to determine which patients require hormonal evaluation and replacement therapy, as well as the appropriate timing and methods for diagnosis.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2023)
Article
Endocrinology & Metabolism
Monica Marazuela, Concepcion Blanco, Ignacio Bernabeu, Edelmiro Menendez, Rocio Villar, Miguel Paja, Miguel Sampedro-Nunez, M. Luz Samaniego, Marcos Diaz-Munoz, Laura Sanchez-Cenizo
Summary: The study evaluated disease activity in Spanish acromegaly patients using ACRODAT(R) and found a moderate correlation with physicians' clinical evaluation. Discrepancies in symptom perception between physicians and patients were also identified through the study.