Article
Pharmacology & Pharmacy
Hui Wang, Jian-Ying Dai, Yu-Zhen He, Zhe-Wei Xia, Xiao-Fei Chen, Zhan-Ying Hong, Yi-Feng Chai
Summary: This study examined the therapeutic effect and mechanism of Anemarrhenae Rhizoma (AR) on AD model rats using serum metabolomics. The results showed that AR significantly affected the levels of multiple metabolites involved in various metabolic pathways in the serum of AD model rats. These findings were consistent with the results of behavior study, histopathological observations, and biochemical analyses, providing a scientific basis for the application of AR in the prevention and treatment of AD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Yiyang Li, Nyuk Ling Ma, Huiling Chen, Jiateng Zhong, Dangquan Zhang, Wanxi Peng, Su Shiung Lam, Yafeng Yang, Xiaochen Yue, Lijun Yan, Ting Wang, Bjarne Styrishave, Tomasz Maciej Ciesielski, Christian Sonne
Summary: According to the World Health Organization, breast cancer is a common and serious health issue for women. This study focuses on searching for bioactive compounds from plants for breast cancer treatment. By screening plant extracts from Chinese ancient forests, the researchers identified potent extracts from Amur honeysuckle and Nigaki plants. Further experiments showed that these extracts significantly reduced tumor growth and killed breast cancer cells. The study also found that the extracts target and interact with known breast cancer genes, providing new insights for future cancer treatments.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Food Science & Technology
Srikanth Ponneganti, Upadhyayula Suryanarayana Murty, Chandrakant Bagul, Roshan M. Borkar, P. Radhakrishnananda
Summary: In this study, the chemical profile of Phlogacanthus thyrsiformis leaf extracts was analyzed, and their antioxidant and enzyme inhibitory potential were evaluated. The results showed that the chloroform extract had the highest total phenolic content and antioxidant activity, while the ethyl acetate extract exhibited the highest enzyme inhibition potential.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Tassia Henrique Nievierowski, Flavio Fonseca Veras, Rafaela Diogo Silveira, Barbara Giocastro, Ivan Aloisi, Peter Q. Tranchida, Paola Dugo, Adriano Brandelli, Claudia Alcaraz Zini, Juliane Elisa Welke
Summary: Bacillus-based biocontrol agents are a promising alternative to synthetic fungicides that are harmful to health and the environment. In vineyards, the control of Aspergillus carbonarius, a fungus known for producing ochratoxins, is a major concern. This study evaluated the impact of a biocontrol strategy using Bacillus velezensis P1 on the volatile profile and occurrence of ochratoxins in winemaking.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Environmental Sciences
Klaudia Godlewska, Piotr Stepnowski, Monika Paszkiewicz
Summary: Passive sampling is a cost-effective strategy for quantifying micropollutants in water environments. In this study, carbon nanotubes were used as sorbents in POCIS-like samplers, and their effectiveness in field sampling was proven. The use of CNTs-PSDs allowed for the determination of various chemicals in surface waters.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Parasitology
Turkmen T. Ciftci, Samiye Yabanoglu-Ciftci, Emre Unal, Devrim Akinci, Ipek Baysal, Gokhan Yuce, Ahmet Bulent Dogrul, Serra Orsten, Okan Akhan, Emirhan Nemutlu
Summary: Cystic Echinococcosis is a life-threatening parasitic zoonosis with varying treatment options depending on the nature of the cyst. Metabolite concentrations play a crucial role in discriminating between active and inactive cysts.
Article
Engineering, Environmental
Liliana Cahuas, Derek J. Muensterman, Mitchell L. Kim-Fu, Patrick N. Reardon, Ivan A. Titaley, Jennifer A. Field
Summary: This study analyzed the presence of per- and polyfluoroalkyl substances (PFAS) in indoor paints and found that 6:2 fluorotelomer alcohol and 6:2 fluorotelomer phosphate ester were the main components. The evaluation of paints indicated a potential risk of human exposure during the painting process.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Derek J. Muensterman, Liliana Cahuas, Ivan A. Titaley, Christopher Schmokel, Florentino B. De la Cruz, Morton A. Barlaz, Courtney C. Carignan, Graham F. Peaslee, Jennifer A. Field
Summary: Facemasks are important in preventing disease spread, but prolonged use of PFAS-treated masks can pose potential health risks, especially for children. Inhalation is the primary exposure route.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yilei Fan, Jianhong Gao, Xianxin Chen, Hao Wu, Xing Ke, Yu Xu
Summary: This study systematically investigates ketamine analogues and summarizes their mass spectrometry fragmentation pathways and fragments. This contributes to the rapid screening of ketamine analogues in suspicious powder by identifying their chemical structure.
Article
Chemistry, Analytical
Kiwao Kadokami, Takashi Miyawaki, Sokichi Takagi, Katsumi Iwabuchi, Hironori Towatari, Tomohiro Yoshino, Masahiro Yagi, Yuji Aita, Tomoko Ito, Shusuke Takemine, Daisuke Nakajima, Xuehua Li
Summary: This study has developed an automated identification and quantification system for toxic chemicals, which is highly efficient, low-cost, labor-saving, and environmentally friendly. It uses a novel acquisition method to obtain accurate mass spectrometry data with minimal interference from co-eluted peaks. Collaborative tests demonstrate the accuracy and reliability of the system, meeting the standards for analytical method validity.
ANALYTICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Nguyen Hai Doan, Hanh Thi Duong, Ha Thu Trinh, Yoshinari Tanaka, Kiwao Kadokami
Summary: Air pollution is a serious issue in Vietnam's big cities, with limited data on organic micro-pollutants in atmospheric particulate matters, especially in regards to pesticides. A study surveyed 107 insecticides in APMs and detected 19 insecticides, with many being reported for the first time.
Article
Food Science & Technology
Rui Min Vivian Goh, Aileen Pua, Kim Huey Ee, Yunle Huang, Shao Quan Liu, Benjamin Lassabliere, Bin Yu
Summary: The study analyzed changes in non-traditional maturity indices, such as flavonoids and volatile compounds, in Navel oranges during maturation. Most flavonoids and limonoids showed decreasing abundances during maturation, while alcohols peaked in middle maturation stages and aldehydes peaked at full maturity. These findings could aid in selecting Navel oranges for extraction of valuable bioactive or flavorful compounds for fragrance, flavor, and nutraceutical industries.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Applied
Diletta Piatti, Simone Angeloni, Filippo Maggi, Giovanni Caprioli, Massimo Ricciutelli, Lolita Arnoldi, Stefania Bosisio, Giacomo Mombelli, Ettore Drenaggi, Gianni Sagratini
Summary: The polar extracts and essential oils of sea fennel cultivated in central Italy were analyzed. The extracts contained 21 bioactive compounds, with 5-O-caffeoylquinic acid being the most abundant. Melatonin, a hormone that regulates sleep/wake cycle, was identified for the first time in sea fennel extract. The essential oil was mainly composed of monoterpene hydrocarbons and oxygenated monoterpenes. This study highlights the potential use of sea fennel as an edible plant and a source of nutraceutical compounds.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Chemistry, Applied
Maria Constantinou, Despo Louca-Christodoulou, Agapios Agapiou
Summary: A validated multi-residue method using LC-MS/MS and GC-MS/MS for analyzing various pesticides in raisins was conducted according to DG SANTE guidelines. Results showed the presence of multiple pesticides in conventional samples, while no analyzed pesticides were detected in samples from organic farming. The study highlights the need for official controls on pesticide residues in processed samples, particularly on high consumption dried fruits like raisins.
Article
Biochemistry & Molecular Biology
Mehdi Rahimmalek, Antoni Szumny, Shima Gharibi, Natalia Pachura, Mehran Miroliaei, Jacek Lyczko
Summary: Kelussia odoratissima Mozaff. is an endemic species of Apiaceae in Iran. This study determined the polyphenolic compounds and flavonoids of its leaves for the first time using LC-MS and SPME techniques. The results revealed the main phenolic compounds to be p-coumaric acid, ferulic acid, caffeic acid, chlorogenic acid, acetyl phloroglucinol, vanillic acid, m-coumaric acid, and 4-methylsiringol, while the main flavonoids included 3-hydroxyflavone, flavone, quercetin, rutin, neohesperidin, polydatin, and diosmin. Additionally, several new compounds were identified, and the fragmentation of phthalides was discussed.
Article
Environmental Sciences
Dimitri Panagopoulos Abrahamsson, Jon R. Sobus, Elin M. Ulrich, Kristin Isaacs, Christoph Moschet, Thomas M. Young, Deborah H. Bennett, Nicolle S. Tulve
Summary: The study aimed to develop a workflow to identify and rank organic chemicals as tracers for calculating children's dust ingestion rates. Despite proposing criteria and conducting related research, no individual compound was found to fully meet all criteria as a suitable tracer for dust ingestion rates. Future studies should consider larger datasets and refinements to selection criteria for identifying robust and defensible tracer compounds.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Construction & Building Technology
Kyunghoon Kim, Hyeong-Moo Shin, Luann Wong, Thomas M. Young, Deborah H. Bennett
Summary: The study examined the temporal variability of indoor dust concentrations of semivolatile organic compounds (SVOCs) and found that most SVOCs have small within-home temporal variability, but some may vary over time due to seasonal changes.
Article
Engineering, Environmental
Thomas M. Young, Gabrielle P. Black, Luann Wong, Clayton S. Bloszies, Oliver Fiehn, Guochun He, Michael S. Denison, Christoph F. A. Vogel, Blythe Durbin-Johnson
Summary: The study found that urban wildfires can produce unknown toxic chemicals, which were identified through analysis of ash samples with high bioactivity. Despite differences in chemical compositions, the bioactivity of ash samples from residential areas did not significantly differ from the undeveloped reference site samples. Overall, the combination of nontarget analysis, in vitro bioassays, and statistical analysis proved effective in identifying bioactive compounds in complex mixtures.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Yin Li, Jian Xue, Joshua Peppers, Norman Y. Kado, Christoph F. A. Vogel, Christopher P. Alaimo, Peter G. Green, Ruihong Zhang, Bryan M. Jenkins, Minji Kim, Thomas M. Young, Michael J. Kleeman
Summary: The study found that the toxicity of renewable natural gas (RNG) exhaust is comparable or lower than fossil compressed natural gas (CNG) exhaust, with lower concentrations of potentially toxic chemical constituents in the exhaust. This suggests that adopting RNG may be an effective strategy to reduce the carbon intensity of transportation fuels.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Food Science & Technology
Kanarat Pinkanjananavee, Swee J. Teh, Tomofumi Kurobe, Chelsea H. Lam, Franklin Tran, Thomas M. Young
Summary: The study found that recycling cyanotoxin-laden dewatered sludge supernatant in water treatment process may lead to an increase in microcystin-LR and cyanobacteria cell counts, but the effluent still met the relevant standards.
Article
Environmental Sciences
Kyunghoon Kim, Hyeong-Moo Shin, Luann Wong, Thomas M. Young, Deborah H. Bennett
Summary: Couch PUF can absorb many SVOCs and may be an important reservoir for some SVOCs, but it may not be an effective passive sampling medium for those with relatively high Koa values. Direct dermal contact with couch seats may be an important exposure route for non-users of skin-applied compounds.
Article
Engineering, Environmental
Gabrielle P. Black, Guochun He, Michael S. Denison, Thomas M. Young
Summary: This study utilized high-tech techniques to identify 12 estrogen-active contaminants in California sewage sludge, highlighting the importance of evaluating both agonistic and antagonistic responses when assessing the bioactivity of complex samples.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Reza Aalizadeh, Nikiforos A. Alygizakis, Emma L. Schymanski, Martin Krauss, Tobias Schulze, Maria Ibanez, Andrew D. McEachran, Alex Chao, Antony J. Williams, Pablo Gago-Ferrero, Adrian Covaci, Christoph Moschet, Thomas M. Young, Juliane Hollender, Jaroslav Slobodnik, Nikolaos S. Thomaidis
Summary: This study proposed a unified retention time index (RTI) approach for liquid chromatography, aiming to achieve comparable retention times among different laboratories. By calibrating the elution pattern with two sets of calibration compounds, the RTI range was set between 1 and 1000, which was considered the most appropriate RTI system after rigorous evaluation.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Dimitri Abrahamsson, Adi Siddharth, Thomas M. Young, Marina Sirota, June-Soo Park, Jonathan W. Martin, Tracey J. Woodruff
Summary: This study aims to develop a computational pipeline that integrates HRMS data and physicochemical properties to propose molecular structures for detected chemical features. The use of physicochemical fingerprints can assist in compound identification and increase the number of identified compounds.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Biochemical Research Methods
Madison E. Hattaway, Gabrielle P. Black, Thomas M. Young
Summary: Nontarget chemical analysis using high-resolution mass spectrometry has been increasingly employed to study anthropogenic chemical abundance in natural and engineered systems. In this study, the impact of batch effects on the analysis and interpretation of nontarget data was assessed by examining 56 samples collected from a municipal wastewater system over 7 months. The results showed that using multiple small batches with batch correction steps significantly reduced the influence of batch effects compared to analyzing samples in a single batch.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Robert Budd, Jennifer Teerlink, Christopher Alaimo, Luann Wong, Thomas M. Young
Summary: The study reveals pesticide concentrations in sub-sewershed sites within a single sewer catchment, providing valuable information for prioritizing future monitoring efforts, calibrating down-the-drain models, and identifying potential mitigation strategies at pesticide use locations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Florian Mauduit, Amelie Segarra, Julia R. Sherman, Michelle L. Hladik, Luann Wong, Thomas M. Young, Levi S. Lewis, Tien-Chieh Hung, Nann A. Fangue, Richard E. Connon
Summary: The development and behavior of threatened Longfin Smelt were affected by environmentally relevant concentrations of bifenthrin, indicating it could contribute to the observed decline in population.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Prabhash Ragbir, Ajith Kaduwela, David Passovoy, Preet Amin, Shuchen Ye, Christopher Wallis, Christopher Alaimo, Thomas Young, Zhaodan Kong
Summary: Smoke plumes from wildfires in wildland-urban interface released toxic chemical substances, mainly due to synthetic components burning. Using UAVs with air quality sensors and VOC samplers can provide high-resolution data for analyzing these air toxics. The prototype developed by CAL FIRE has been successfully tested in prescribed fires.
Article
Engineering, Environmental
Robert Budd, Jennifer Teerlink, Christopher Alaimo, Luann Wong, Thomas M. Young
Summary: Pesticides were found in treated wastewater effluent at concentrations exceeding aquatic toxicity thresholds, suggesting that current treatment methods may not adequately address their impact on aquatic life. This study provides the first report of pesticide concentrations in sub-sewershed sites within a single sewer catchment, offering insights into the contribution from various urban sources. Significant removal of pyrethroids was observed within the treatment facility, while imidacloprid and fiproles were the only pesticides detected above reporting limits in effluent, highlighting the need for source identification and control. Single source monitoring identified pet groomers as a major contributor of certain pesticides, emphasizing the importance of implementing mitigation strategies at pesticide use sites to prevent their introduction into sewersheds.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Olivia M. Wrightwood, Madison E. Hattaway, Thomas M. Young, Heather N. Bischel
Summary: A bench-scale woodchip bioreactor was utilized to evaluate the removal of pesticides and nitrates under field-like conditions. While the continuous-flow reactor achieved high removal rates for diuron and imidacloprid, the sequencing-batch reactor showed better nitrate removal performance. Sorption was identified as the main removal mechanism for pesticides under denitrifying conditions, highlighting the need to improve microbial degradation in woodchip bioreactors for enhanced pesticide removal.