Advanced monitoring and control of pharmaceutical production processes with Pichia pastoris by using Raman spectroscopy and multivariate calibration methods

Towards Process Spectroscopy in Complex Fermentation Samples and Mixtures

(2016) Andrea Paul et al.   CHEMIE INGENIEUR TECHNIK

Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors

(2015) Hamidreza Mehdizadeh et al.   BIOTECHNOLOGY PROGRESS

Comparison of the variable importance in projection (VIP) and of the selectivity ratio (SR) methods for variable selection and interpretation

(2015) Mireia Farrés et al.   JOURNAL OF CHEMOMETRICS

Quantitative monitoring of yeast fermentation using Raman spectroscopy

(2014) Jens A. Iversen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

(2014) Brandon Berry et al.   BIOTECHNOLOGY PROGRESS

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Multivariate PAT solutions for biopharmaceutical cultivation: current progress and limitations

(2014) Sarah M. Mercier et al.   TRENDS IN BIOTECHNOLOGY

Process analytical technology (PAT) tools for the cultivation step in biopharmaceutical production

(2013) Mathieu Streefland et al.   ENGINEERING IN LIFE SCIENCES

Diversity Covering AMA1-MSP119Fusion Proteins as Malaria Vaccines

(2013) Bart W. Faber et al.   INFECTION AND IMMUNITY

Bioreactor monitoring with spectroscopy and chemometrics: a review

(2012) N. D. Lourenço et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

(2012) Jessica Whelan et al.   BIOTECHNOLOGY PROGRESS

An integrated scale-down plant for optimal recombinant enzyme production by Pichia pastoris

(2011) Kai Loegering et al.   Biotechnology Journal

Fully automated production of potential Malaria vaccines with Pichia pastoris in integrated processing

(2011) Sanja Martens et al.   ENGINEERING IN LIFE SCIENCES

Development of Robust Calibration Models Using Support Vector Machines for Spectroscopic Monitoring of Blood Glucose

(2010) Ishan Barman et al.   ANALYTICAL CHEMISTRY

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes

(2010) T. De Beer et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Support vector machines (SVM) in near infrared (NIR) spectroscopy: Focus on parameters optimization and model interpretation

(2008) Olivier Devos et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS