Article
Obstetrics & Gynecology
Kyoko Kumagai, Jun Murotsuki, Satoshi Dohi, Naomi Nishikawa, Naomi Kimura, Makoto Nomiyama, Satoshi Osaga, Hiroya Hashimoto, Akihito Nakai, Mayumi Sugiura-Ogasawara, Yasuhiko Ozaki
Summary: The cervical pessary effectively reduces cervical shortening during pregnancy, but does not reduce the rate of preterm birth.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kaline Gomes Ferrari Marquart, Thais Valeria Silva, Ben W. Mol, Jose Guilherme Cecatti, Renato Passini Jr, Cynara M. Pereira, Thaisa B. Guedes, Tatiana F. Fanton, Rodolfo C. Pacagnella
Summary: This study aimed to construct a populational curve of cervical length in pregnant women during the second trimester and evaluate the variables related to cervical length <= 25 mm. The findings showed a relatively low percentage of cervical length <= 25 mm. Risk factors for short cervix included low BMI, higher education, personal history, preterm birth, previous low birth weight, and cervical surgery.
Article
Acoustics
Yingmin Huang, Xiaowen Liang, Jianyi Liao, Yingtao Li, Zhiyi Chen
Summary: This study aims to determine the relationship between amniotic fluid sludge (AFS) and/or short cervical length (<= 25 mm) with the rate of preterm birth in women after cervical cerclage. The study found that AFS and short cervical length were independent risk factors for preterm birth after cervical cerclage. Additionally, mid-trimester AFS can be used as a supplementary ultrasound index for detecting preterm birth in pregnant women with a short cervix.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Acoustics
C. Buskmiller, E. P. Bergh, C. Brock, J. Miller, A. Baschat, H. Galan, N. Behrendt, M. Habli, J. L. Peiro, S. Snowise, J. Fisher, C. Macpherson, E. Thom, C. Pedroza, A. Johnson, S. Blackwell, R. Papanna
Summary: This study aimed to compare secondary methods for the prevention of preterm birth in twin pregnancies with TTTS undergoing FLP, in the setting of a short cervix. The results showed that no treatment significantly improved outcome, and cervical cerclage should not be offered as a secondary prevention for preterm birth in these pregnancies.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
Vasilios Pergialiotis, Alexandros Psarris, Panagiotis Antsaklis, Marianna Theodora, Aggeliki Papapanagiotou, Alexandros Rodolakis, Georgios Daskalakis
Summary: The study aimed to compare the efficacy of cervical cerclage and cervical pessary in reducing preterm birth rates among women with a short (< 25 mm) or ultra-short (< 15 and < 10 mm) cervix during the second-trimester assessment. Retrospective analysis was conducted on hospital records of 294 singleton pregnancies diagnosed with cervical insufficiency. The results showed similar preterm birth rates < 37 weeks in both groups, but a higher prevalence of NICU admission and need for CPAP in the cerclage group.
ULTRASCHALL IN DER MEDIZIN
(2023)
Article
Medicine, General & Internal
Matthew K. Hoffman, Rebecca G. Clifton, Joseph R. Biggio, George R. Saade, Lynda G. Ugwu, Monica Longo, Sabine Z. Bousleiman, Kelly Clark, William A. Grobman, Heather A. Frey, Suneet P. Chauhan, Lorraine Dugoff, Tracy A. Manuck, Edward K. Chien, Dwight J. Rouse, Hyagriv N. Simhan, M. Sean Esplin, George A. Macones
Summary: A short cervix is a known risk factor for preterm birth, but the use of cervical pessary to prevent preterm delivery in singleton pregnancies with a short cervix has conflicting results. This study aimed to determine if cervical pessary placement reduces the risk of preterm birth in individuals with a short cervix. The findings showed that the use of cervical pessary did not decrease the risk of preterm birth in singleton pregnancies with a short cervix and was associated with a higher rate of fetal or neonatal/infant mortality.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Obstetrics & Gynecology
Viola Seravalli, Isabella Abati, Noemi Strambi, Lorenzo Tofani, Claudia Tucci, Enrico Tartarotti, Mariarosaria Di Tommaso
Summary: The predictive value of cervical length after 24(+0) weeks of gestation is low in asymptomatic women with singleton pregnancy at low risk for spontaneous preterm birth, suggesting that cervical length screening should be discouraged in these women.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Medicine, General & Internal
Lee Reicher, Yuval Fouks, Yariv Yogev
Summary: Preterm birth is considered a major cause of neonatal death and short- and long-term disabilities globally. Various pathophysiological processes leading to cervical modifications are the key factors in preterm birth. Cervical assessment is commonly used for prediction and risk stratification in women at high risk for preterm birth.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jane E. Norman, John Norrie, Graeme MacLennan, David Cooper, Sonia Whyte, Sue Chowdhry, Sarah Cunningham-Burley, Xue W. Mei, Joel B. E. Smith, Andrew Shennan, Stephen C. Robson, Steven Thornton, Mark D. Kilby, Neil Marlow, Sarah J. Stock, Phillip R. Bennett, Jane Denton
Summary: This study aimed to test the effectiveness of Arabin pessary in reducing preterm birth associated with preterm labour in women with twin pregnancies and a short cervix. The results showed that the Arabin pessary did not achieve the expected 40% reduction in risk, leaving the possibility of smaller treatment effects.
Article
Environmental Sciences
Yun Ji Jung, Hayan Kwon, Jeongeun Shin, Yejin Park, Seok-Jae Heo, Hyun Soo Park, Soo-young Oh, Ji-Hee Sung, Hyun-Joo Seol, Hyun Mi Kim, Won Joon Seong, Han Sung Hwang, Inkyung Jung, Ja-Young Kwon
Summary: This study demonstrated that cervical elastography before and after progesterone treatment in singleton pregnancies could be useful in predicting the risk of spontaneous preterm delivery at <32 weeks of gestation. Changes in cervical elastography parameters before and after progesterone treatment were significantly associated with the risk of preterm delivery.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Yongkang Sun, Feng Lian, Yuanyuan Deng, Sha Liao, Ying Wang
Summary: This study developed a reliable nomogram for predicting spontaneous preterm birth (sPTB) in singleton pregnancies by integrating patient characteristics and cervical elastography data. The nomogram showed significant predictive value for singleton pregnancies with a short cervix length, no history of preterm birth, and undergoing vaginal progesterone therapy.
Article
Obstetrics & Gynecology
Rachael K. Ross, Stephen R. Cole, Daniel Westreich, Jessie K. Edwards, Patrick Musonda, Bellington Vwalika, Margaret P. Kasaro, Joan T. Price, Jeffrey S. A. Stringer
Summary: This study aims to illustrate the difference between exposure effects and population attributable effects. The findings show that while short cervix significantly increases the risk of preterm birth, an intervention to counteract its impact would have minimal effect on the overall population risk.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Acoustics
C. J. J. Cuijpers, J. van't Hooft, C. Schneeberger, J. H. Van der Lee, N. E. Simons, M. A. Van Os, J. Van der Ven, C. J. M. De Groot, B. W. J. Mol, A. G. Van Wassenaer-Leemhuis
Summary: This study found no significant differences in neurodevelopmental, behavioral, health, and physical outcomes between children born to low-risk women with a short cervix who were exposed to vaginal progesterone and those exposed to a placebo.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
George Daskalakis, Dimitrios Zacharakis, Vasilios Pergialiotis, Konstantinos Kalmantis, Mariana Theodora, Charalambos Siristatidis, Panagiotis Antsaklis, Aris Antsaklis, Dimitrios Loutradis
Summary: The combined treatment of cervical pessary and vaginal progesterone has a similar impact on preterm delivery rate before 34 weeks in both low and high-risk women with a mid-trimester short cervix. However, high-risk women have a significantly higher rate of preterm birth before 37 weeks compared to low-risk women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Computer Science, Information Systems
Syed Muhammad Anwar, Ismail Irmakci, Drew A. Torigian, Sachin Jambawalikar, Georgios Z. Papadakis, Can Akgun, Jutta Ellermann, Mehmet Akcakaya, Ulas Bagci
Summary: In this study, a semi-supervised segmentation algorithm based on deep learning was designed to accurately differentiate thigh tissues including muscle, fat, IMAT, bone, and bone marrow. The proposed system showed high efficacy in clinical research studies where volumetric and distributional tissue quantification is crucial.
JOURNAL OF SIGNAL PROCESSING SYSTEMS FOR SIGNAL IMAGE AND VIDEO TECHNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tony T. Wong, Patrick Quarterman, Thomas S. Lynch, Michael J. Rasiej, Diego Jaramillo, Sachin R. Jambawalikar
Summary: The study demonstrated the feasibility of UTE T2* cartilage mapping in the hip, with significantly higher values in the anterosuperior region compared to the posterosuperior region.
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael Z. Liu, Cara Swintelski, Shawn Sun, Maham Siddique, Elise Desperito, Sachin Jambawalikar, Richard Ha
Summary: This study evaluates a weakly supervised deep learning approach for breast MRI assessment without pixel level segmentation, aiming to improve the specificity of lesion classification. The results show that the model achieved high accuracy, sensitivity, and specificity in distinguishing benign from malignant images.
ACADEMIC RADIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mariano Colon-Caraballo, Nicole Lee, Shanmugasundaram Nallasamy, Kristin Myers, David Hudson, Renato Iozzo, Mala Mahendroo
Summary: This study evaluated the relationship between collagen and elastic fiber structure and function in the cervix of mice. The results show that small-leucine rich proteoglycans (SLRPs) play a crucial role in regulating extracellular matrix (ECM) remodeling in the cervix. Loss of SLRPs leads to structural defects in collagen and elastic fibers and affects the function of the cervix.
Article
Biology
Shawn Sun, Simukayi Mutasa, John Nemer, Mary Sun, Maham Siddique, Elise Desperito, Sachin Jambawalikar, Richard S. Ha
Summary: It is feasible to predict axillary lymph node metastasis from breast cancer ultrasound images using a convolutional neural network, which can potentially aid nodal staging in patients with breast cancer.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olga M. Dona Lemus, Yi-Fang Wang, Fiona Li, Sachin Jambawalikar, David P. Horowitz, Yuanguang Xu, Cheng-Shie Wuu
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Biophysics
Yun Shang, Sebastian Theilenberg, Maxim Terekhov, Wolfram Mattar, Boyu Peng, Sachin R. Jambawalikar, Laura M. Schreiber, Christoph Juchem
Summary: This study used clinical CT images to simulate the B-0 conditions in the human heart at high spatial resolution, enabling the development of subject- and population-specific B-0 shim strategies.
NMR IN BIOMEDICINE
(2022)
Article
Obstetrics & Gynecology
Carrie E. Barnum, Snehal S. Shetye, Hossein Fazelinia, Benjamin A. Garcia, Shuyang Fang, Maria Alzamora, Hongyu Li, Lewis M. Brown, Chuanning Tang, Kristin Myers, Ronald Wapner, Louis J. Soslowsky, Joy Y. Vink
Summary: Appropriate timing of cervical remodeling is important for normal term parturition. Recent studies have shown regional differences in human cervical tissue structure and the distribution of extracellular matrix (ECM) and cervical smooth muscle (CSM) cells. This study used a systematic proteomic approach to identify the soluble ECM and cellular proteins in different regions of the human cervix and compare the proteomic profiles between non-pregnant and pregnant states. The findings suggest that the abundance of proteins involved in elastic fiber formation and ECM organization/degradation increases, while proteins involved in RNA polymerase I/promoter opening, DNA methylation, senescence, immune system, and complement activation decrease in the pregnant cervix compared to the non-pregnant cervix.
REPRODUCTIVE SCIENCES
(2022)
Article
Biology
Elise Desperito, Lawrence Schwartz, Kathleen M. Capaccione, Brian T. Collins, Sachin Jamabawalikar, Boyu Peng, Rebecca Patrizio, Mary M. Salvatore
Summary: The study retrospectively analyzed the ability of standard chest CT scans to correctly diagnose breast cancer. The results showed that chest CT had high sensitivity, specificity, and accuracy in detecting breast cancer compared to mammography. Breast masses were the most common finding on chest CT, and Hounsfield units were important for distinguishing benign from malignant masses. Chest CT alone, without prior exams or patient recall, accurately diagnosed cancer and had similar specificity and accuracy with or without contrast.
Article
Multidisciplinary Sciences
Alberto Pappalardo, David Alvarez Cespedes, Shuyang Fang, Abigail R. Herschman, Eun Young Jeon, Kristin M. Myers, Jeffrey W. Kysar, Hasan Erbil Abaci
Summary: Despite advancements in skin bioengineering, the current 3D skin constructs do not effectively cover complex body sites and cannot mimic the fully enclosed geometry of human skin. In this study, researchers engineered wearable edgeless skin constructs (WESCs) that can be shaped to fit different body parts and seamlessly transplanted as biological clothing. The WESCs showed improved dermal extracellular matrix (ECM) deposition and mechanical properties compared to traditional constructs, and successfully replaced skin in full-thickness wounds with minimal suturing and shorter surgery time. This technology has the potential to significantly improve wound care by recapitulating tissue macroanatomy and enhancing biological function.
Article
Engineering, Biomedical
Lei Shi, Kristin Myers
Summary: The cervix is a vital mechanical barrier to protect the growing fetus and its remodeling is necessary for safe parturition. This study investigates the time-dependent behavior of the cervix under compressive states using a porous-viscoelastic material model and inverse finite element analysis. The results show that the porous-viscoelastic model captures the force-relaxation response of the cervix well and has the potential to understand premature cervical remodeling and interpret force readings from in-vivo measurement tools.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Jounghyun H. Lee, Kevin L. Shores, Jason J. Breithaupt, Caleb S. Lee, Daniella M. Fodera, Jennifer B. Kwon, Adarsh R. Ettyreddy, Kristin M. Myers, Benny J. Evison, Alexandra K. Suchowerska, Charles A. Gersbach, Kam W. Leong, George A. Truskey
Summary: Atherosclerosis is influenced by PCSK9 activation or repression, and inhibiting PCSK9 can reduce vascular inflammation.
APL BIOENGINEERING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Maham Siddique, Michael Liu, Phuong Duong, Sachin Jambawalikar, Richard Ha
Summary: Breast cancer remains the leading cause of cancer-related deaths in women worldwide. Current screening and risk assessment methods use demographics and patient history, but artificial intelligence methods like deep learning and convolutional neural networks have shown promise in personalized risk models.
Meeting Abstract
Obstetrics & Gynecology
Nicole Lee, ShanmugaPriyaa Madhukaran, Mala Mahendroo, Kristin Myers
REPRODUCTIVE SCIENCES
(2022)
Meeting Abstract
Obstetrics & Gynecology
Shuyang Fang, Lei Shi, Ivan Rosado-Mendez, Helen Feltovich, Timothy Hall, Kristin Myers
REPRODUCTIVE SCIENCES
(2022)