Article
Cardiac & Cardiovascular Systems
Halit Yaakobovich, Or Koren, Sharon Chapas, Sapir Gohari, Uri Zaretsky, Oren M. Rotman, Dar Weiss
Summary: The novel design of a very short peripheral catheter showed promising results in reducing mechanical irritation to the vein wall in a pig model. Experimental and computational models demonstrated that the novel catheter design had faster drug release kinetics, favorable spatial distribution within the vein, and substantially lower wall shear stress compared to a standard commercial catheter. It is suggested that the novel design could potentially reduce chemical irritation to the vein wall and minimize the risk for thrombophlebitis.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Nursing
Nicole Marsh, Emily N. Larsen, Mari Takashima, Tricia Kleidon, Samantha Keogh, Amanda J. Ullman, Gabor Mihala, Vineet Chopra, Claire M. Rickard
Summary: Peripheral intravenous catheters are essential medical devices that are prone to complications and failure. Factors associated with failure and complications include patient gender and age, provider use of intravenous antibiotics, and specific device characteristics. Targeted updates to guidelines and models of care are necessary to improve patient outcomes.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Article
Engineering, Civil
M. Basterrechea-Arevalo, J. M. Cabrero, B. Iraola, R. Goni
Summary: Accurate structural modelling techniques are necessary for the promotion of timber as a renewable alternative in construction, with a focus on describing the performance of structural connections. This paper develops a finite element model to simulate the behavior of moment transmitting beam-to-column connections with dowel-type fasteners under quasi-static loading, highlighting the significant influence of friction on rotational response.
ENGINEERING STRUCTURES
(2021)
Article
Engineering, Manufacturing
Xie Li, Sonya A. Brown, Mathew W. Joosten, Garth M. Pearce
Summary: This study conducted short beam shear tests to validate the capability of tow-wise modelling (TWM) in predicting the failure mechanisms of AP-Ply laminates, achieving excellent correlation between numerical and experimental results.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2022)
Article
Engineering, Mechanical
Konstantinos G. Lyras, Jack Lee
Summary: The study evaluated the performance of various CFD solvers for modeling arterial flow in stenosed arteries. The accuracy of solver predictions varied depending on the complexity of artery geometries, with disagreements growing in more complex scenarios. The choice of CFD solver may impact clinical recommendations for diseased arteries, highlighting the importance of considering application-specific factors.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2021)
Article
Engineering, Civil
Satheeskumar Navaratnam, Julian Thamboo, Keerthan Poologanathan, Krishanu Roy, Perampalam Gatheeshgar
Summary: The research investigates the structural behavior and design guidelines for timber infilled steel tubular columns (TIST), revealing that TIST columns can be on par with concrete infilled steel tubular (CIST) columns with potential maximum strength and ductility enhancement of 60% and 65% respectively. The study also verifies suitable design formulations for TIST columns based on parametric analyses results, which can be extended from CIST columns.
Article
Engineering, Mechanical
Jianjun Li, Tianyu Chen, Tingting Chen, Zhong Yun, Xiaodong Xia
Summary: A finite element model was established to investigate the deformation of bimodal structured copper during scratch test, showing that bimodal nanostructures can achieve a lower coefficient of friction by adjusting the grain size and volume fraction of the hard and soft domains.
The study found that the heterogeneity of bimodal nanostructures can effectively restrain strain localization, leading to reduced coefficient of friction and a better balance of high strength and low COF.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Article
Engineering, Civil
A. P. C. Duarte, N. Silvestre, J. de Brito, E. Julio
Summary: This paper numerically studies the mechanical behavior of short rubberized concrete-filled steel tubular (RuCFST) columns with square cross-section under combined cyclic bending and (monotonic) compression. The study shows that RuC leads to a moderate reduction (of up to 2%) of the strength of the columns and generally reduces the energy dissipation capacity by approximately 2.5% per each 5% of rubber aggregates replacement, compared to natural aggregate concrete (NAC).
ENGINEERING STRUCTURES
(2021)
Article
Instruments & Instrumentation
Qiaozhen Zhang, Xiangyong Zhao, Feifei Wang, Yang Luo, Hongwei Mao, Tao Han
Summary: This paper introduces a bio-inspired cantilever-type SAW pressure sensor based on Scandium-doped AlN (ScAlN)/3CSiC/Si layer structure. By optimizing the design of the microcantilever, a significant pressure coefficient of frequency is achieved, particularly for the Rayleigh mode. The results show that this novel sensor design has great potential for developing highly sensitive and reproducible pressure sensors.
SMART MATERIALS AND STRUCTURES
(2021)
Article
Materials Science, Composites
Jagan Selvaraj, Luiz F. Kawashita, Mehdi Yasaee, Gordon Kalwak, Stephen R. Hallett
Summary: A novel cohesive element formulation is proposed for modelling composite delamination, offering increased stability and requiring fewer elements. This new formulation combines nodal rotations and multiple integration points to improve the accuracy of delamination propagation simulation.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Physiology
Lin Qi, Wenbo Zhu, Wei Qian, Lisheng Xu, Ying He, Feihu Zhao
Summary: The study evaluated the performance of a catheter with a spherical-tip design in post-dilation, showing that the spherical-tip catheter is easier and safer to pass through a stent in a curved vessel. The finite element analysis and experimental validation demonstrated the consistency of the design, making it a useful tool for future optimization and evaluation of catheters.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Mechanical
Huaidong Yang, Itzhak Green
Summary: This study develops a comprehensive adhesion model using finite element analysis for a deformable hemisphere under fretting conditions. The model combines normal adhesion based on JKR model and tangential resistance based on shear strength and surface free energy, implemented through interfacial bilinear springs. The research shows that while spring breakage may be gradual or avalanching, the tangential resistance effect is robust and not affected by meshing or spring settings, with significant plastic deformation and energy losses observed.
TRIBOLOGY INTERNATIONAL
(2021)
Article
Engineering, Manufacturing
Antonio Piccininni, Gianfranco Palumbo
Summary: Local modification of material properties, especially in Aluminium alloys, is proposed to improve formability at room temperature. This study presents a numerical methodology to predict the effect of laser heating on AA5754-H32 Aluminium blanks. The methodology involves calibration of a sigmoid function describing the annealing level based on hardness measurements, followed by thermal transient simulation to predict the final distribution of properties. The methodology is validated by comparing predicted and measured results on AA5754-H32 samples subjected to different laser heating strategies.
CIRP JOURNAL OF MANUFACTURING SCIENCE AND TECHNOLOGY
(2023)
Article
Biophysics
Gurpreet Singh, Shubham Gupta, Arnab Chanda
Summary: Extensive biomechanical modeling of diabetic foot ulcers was conducted, focusing on the physiological changes post ulceration, providing important information for potential further developments in diabetic foot ulcers.
JOURNAL OF BIOMECHANICS
(2021)
Article
Engineering, Mechanical
Tongming Qu, Shaoheng Guan, Y. T. Feng, Gang Ma, Wei Zhou, Jidong Zhao
Summary: This study aims to develop a deep active learning strategy to improve the data-driven constitutive modelling of granular materials. The results confirm the importance of active learning in this field and suggest its potential application in other data-centric applications in various science and engineering fields.
INTERNATIONAL JOURNAL OF PLASTICITY
(2023)
Review
Dermatology
Amit Gefen
Summary: This article evaluates the performance of materials used for pressure ulcer prevention, focusing on the alleviation of tissue loads and microclimate management. It provides quantitative performance criteria and grades commonly used material types, guiding clinicians and industry in selecting dressings for pressure ulcer prevention.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Dermatology
Aleksei Orlov, Adi Lustig, Angela Grigatti, Amit Gefen
Summary: This study develops a robotic phantom system to evaluate the fluid absorbency, retention performance, and mechanical durability of silver-containing gelling fiber primary dressings when used with a secondary dressing. The results demonstrate that the primary dressing has better fluid absorbency, retention, and mechanical strength compared to other dressings.
ADVANCES IN SKIN & WOUND CARE
(2022)
Review
Dermatology
Mai Dabas, Dafna Schwartz, Dimitri Beeckman, Amit Gefen
Summary: This study provides an in-depth overview of the methodologies of artificial intelligence (AI) and their potential implementation in wound care and management. The findings highlight the positive impact and prospects of AI in improving healthcare quality and efficiency, as well as the emergence of AI-based remote consultation systems.
ADVANCES IN WOUND CARE
(2023)
Article
Dermatology
Aleksei Orlov, Amit Gefen
Summary: There are two design concepts for single-use negative pressure wound therapy systems: canister-based and canisterless. The canister-based technology provides stable delivery of negative pressure, while canisterless systems may result in loss of negative pressure. Research shows that continuous delivery of the intended pressure is necessary for an effective influence zone.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Aleksei Orlov, Amit Gefen
Summary: Prolonged use of positive airway pressure masks can lead to facial tissue breakdown, but this risk can be reduced with suitable cushioning materials. By comparing different dressings through experiments and computational modeling, it was found that foam-based dressings generally outperformed hydrocolloid dressings.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Aleksei Orlov, Amit Gefen
Summary: In this study, we developed a robotic system with two venous leg ulcers to test the fluid handling performance of three wound dressing types. The results indicated that foam-based dressing technology is not effective for managing exuding venous leg ulcers. Additionally, wound dressings containing superabsorbent polymers do not demonstrate equal performance in fluid handling for different wound scenarios.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Dermatology
Breda Cullen, Amit Gefen
Summary: Chronic wounds are a global issue that not only affects patients' health but also imposes a significant burden on society. This review explores the reasons for wound healing failure, the pathophysiology of chronic wounds, and the design and evaluation of dressings. It emphasizes the importance of understanding wound exudates and developing laboratory models for testing dressings. The findings have significant implications for improving dressing effectiveness, enhancing patient outcomes, and reducing the economic burden of chronic wounds.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Amit Gefen, Paulo Alves, Dimitri Beeckman, Jose Luis Lazaro-Martinez, Hadar Lev-Tov, Bijan Najafi, Terry Swanson, Kevin Woo
Summary: The mechanical performance of foam materials in foam-based wound dressings plays a crucial role in the clinical outcomes and cost of care. This article provides a comprehensive overview of the theoretical and practical considerations related to the mechanical performance of foams in wound dressings, based on published research and clinical experience. This information is important for clinicians, researchers, regulators, and buyers in the wound care field.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Neurosciences
Hadar Shaulian, Amit Gefen, Hen Biton, Alon Wolf
Summary: This study investigates a novel graded-stiffness offloading method for diabetic heel ulcers, which can effectively redistribute heel pressure and reduce focal stress concentration areas. The results show that the graded-stiffness offloading solution is more effective in reducing and redistributing peak pressure and pressure dose compared to existing solutions.
Article
Dermatology
Tomer Katz, Amit Gefen
Summary: Support surfaces play a crucial role in preventing pressure ulcers/injuries for at-risk patients. Hybrid support surfaces, combining reactive and active properties, provide pressure redistribution through the use of high-quality foam material inside inflatable air cells. This study uses computational modelling and simulations to investigate the effects of static and dynamic modes of a hybrid support surface on soft tissue loading at the buttocks. Results show that the dynamic mode effectively relieves deep tissue pressure under the sacral bone and generates a deep tissue offloading effect by shifting the loading towards the coccyx.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Charlotte Raepsaet, Paulo Alves, Breda Cullen, Amit Gefen, Jose Luis Lazaro-Martinez, Hadar Lev-Tov, Bijan Najafi, Nick Santamaria, Andrew Sharpe, Terry Swanson, Kevin Woo, Dimitri Beeckman
Summary: The aim of this project was to develop a core outcome set (COS) for clinical effectiveness studies of bordered foam dressings in the treatment of complex wounds. The project followed the COMET initiative and consisted of two phases. The outcomes were generated through a systematic review, qualitative study, Delphi consensus study, and consensus meeting.
JOURNAL OF TISSUE VIABILITY
(2023)
Article
Biology
Maayan Lustig, Yoram Epstein, Amit Gefen
Summary: This study developed a novel finite element modeling framework to evaluate and rate the biomechanical efficacy of ballistic protective plates (BPPs) in protecting the torso from non-penetrating impacts acquired on the battlefield.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Dermatology
Aleksei Orlov, Marino Ciliberti, Rosa Somma, Amit Gefen
Summary: In this study, we compared the fluid handling performance of different wound care products using advanced robotic technology. The single-use negative pressure wound therapy system emerged as the leading treatment option, while the foam dressing exhibited the poorest fluid handling performance.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Mai Dabas, Ida Kreychman, Tomer Katz, Amit Gefen
Summary: We investigated the reactions of healthy sacral skin to sustained mechanical loading by measuring inflammatory and thermal responses. Infrared thermography outperformed digital photography in detecting skin irritation trends. Polymeric membrane dressings were more effective in reducing inflammation and managing microclimate compared to polyurethane foam. Infrared thermography is a feasible method for monitoring skin health and risk for pressure ulcers.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Suzanne Kapp, Marie Gerdtz, Charne Miller, Amit Gefen, William Padula, Lauren Wilson, Michael Woodward, Nick Santamaria
Summary: Pressure injuries are common in aged care facilities and have a significant impact on healthcare systems. Remote expert wound nurse consultation shows potential in improving pressure injury outcomes, but more research is needed to determine its effectiveness and cost-effectiveness in residential aged care. This study describes a pilot randomized controlled trial investigating the intervention, with outcomes including wound healing rate, infection, quality of life, and cost of treatment. The results will inform future trials evaluating the clinical and economic benefits of remote expert wound nurse consultation in this setting.
INTERNATIONAL WOUND JOURNAL
(2023)