Article
Cell Biology
Candela Velazquez, Yamila Herrero, Maria Silvia Bianchi, Debora Juana Cohen, Patricia Cuasnicu, Katherine Prost, Rocio Marinoni, Natalia Pascuali, Fernanda Parborell, Dalhia Abramovich
Summary: Female fertility is affected by energy balance, and a high-fat diet can lead to infertility and ovulatory disorders. This study investigates the effects of metformin on the ovarian function of female mice fed with a high-fat diet. The study suggests that altered ovarian blood vessel formation is one of the mechanisms responsible for subfertility caused by high-fat diet intake. Metformin is found to improve ovarian angiogenesis, steroidogenesis, fibrosis, and ovulation, thus potentially offering new treatment strategies for women with metabolic disturbances.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Chiara Di Berardino, Alessia Peserico, Giulia Capacchietti, Alex Zappacosta, Nicola Bernabo, Valentina Russo, Annunziata Mauro, Mohammad El Khatib, Francesca Gonnella, Fani Konstantinidou, Liborio Stuppia, Valentina Gatta, Barbara Barboni
Summary: This review systematically investigates the adverse effects of obesity and high-fat diets on female reproductive processes, highlighting the fragmented nature of the current information. Obesity may negatively impact reproductive processes through direct and indirect mechanisms. Given the high incidence and prevalence of obesity in Western countries, further research is needed to increase awareness of the reproductive risks associated with diet and to develop preventive and therapeutic interventions.
Review
Nutrition & Dietetics
Kinga Skoracka, Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Infertility is a growing issue, with diet playing a significant role in female fertility. The Mediterranean dietary pattern has positive effects on fertility, while folic acid supplementation is important for women of childbearing age.
ADVANCES IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Carlos Larque, Haydee Lugo-Martinez, Xiadany Mendoza, Monserrat Nochebuena, Luis Novo, Ricardo Vilchis, Guadalupe Sanchez-Bringas, Laura Ubaldo, Myrian Velasco, Rene Escalona
Summary: This study investigates the effects of paternal obesity on the metabolic and reproductive health of offspring. The results show that a high-fat diet led to weight gain, increased visceral fat, impaired glucose control, and reduced insulin sensitivity in the obese fathers. Additionally, the offspring of these obese fathers exhibited increased body weight, reduced sperm viability in males, and a decrease in the number of primordial follicles in females. These findings suggest that metabolic and reproductive issues can be inherited through the paternal line.
Article
Endocrinology & Metabolism
Brian Akhaphong, Brigid Gregg, Doga Kumusoglu, Seokwon Jo, Kanakadurga Singer, Joshua Scheys, Jennifer DelProposto, Carey Lumeng, Ernesto Bernal-Mizrachi, Emilyn U. Alejandro
Summary: Maternal high-fat diet before and during pregnancy may predispose female offspring to insulin resistance in adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiangyu Qi, Meijie Zhang, Mingqi Sun, Dandan Luo, Qingbo Guan, Chunxiao Yu
Summary: The study demonstrated that high-fat diet-induced obesity impairs male fertility during puberty and in adulthood. The loss of acrosome integrity, increased oxidative stress, increased cell apoptosis, and down-regulation of StAR and WT-1 may be the underlying mechanisms. Switching from high-fat diets during puberty to normal diets in adulthood can improve male fertility.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lu Lu, Jingming Ren, Tong Yuan, Xinran Lu, Yinping Dong, Wenxuan Li, Xinyue Wang, Qidong Huo, Junling Zhang, Deguan Li, Saijun Fan
Summary: A high-fat diet increases the risk of malignant tumors, while ionizing radiation is used as a treatment in oncology. This study examined the effects of an 8-week high-fat diet on radiation tolerance and the influence of melatonin. The results showed that the high-fat diet altered radiation tolerance in female mice, but not in males. However, pre-treatment with melatonin attenuated radiation-induced damage and affected the composition of gut microbiota and metabolites in both males and females.
Article
Agriculture, Dairy & Animal Science
Jiahao Shao, Jie Wang, Yanhong Li, Mauricio A. Elzo, Tao Tang, Tianfu Lai, Yuan Ma, Mingchuan Gan, Li Wang, Xianbo Jia, Songjia Lai
Summary: The study showed that high-fat diet led to increased weight, fat accumulation, and behavioral changes in young female rabbits, along with physiological abnormalities such as hyperlipidemia and hyperthyroidism.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Juliane Weiner, Sebastian Dommel, Claudia Gebhardt, Martha Hanschkow, Yulia Popkova, Kerstin Krause, Nora Kloeting, Matthias Blueher, Juergen Schiller, John T. Heiker
Summary: The study compared the effects of a high-sucrose diet and a high-fat diet on metabolic health in mice. The results showed that the high-fat diet led to more severe obesity, glucose intolerance, and insulin resistance, while the high-sucrose diet resulted in more pronounced hepatic steatosis and inflammation.
FRONTIERS IN NUTRITION
(2023)
Correction
Multidisciplinary Sciences
Kalpana D. Acharya, Xing Gao, Elizabeth P. Bless, Jun Chen, Marc J. Tetel
Summary: An updated version of this paper has been published and is accessible through a link at the top of the paper.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Vinicius S. Barco, Franciane Q. Gallego, Veronyca G. Paula, Yuri K. Sinzato, Larissa L. Cruz, Maysa R. Souza, Isabela L. Iessi, Barshana Karki, Jose E. Corrente, Gustavo T. Volpato, Debora C. Damasceno
Summary: The aim of this study was to evaluate the morphological changes in the pancreatic islet cells of adult female pups born to diabetic rats and fed a high-fat diet. The results showed that both a high-fat diet and maternal diabetes can affect the pancreatic islets of offspring, especially when they act together.
Article
Medicine, Research & Experimental
Toluwalope E. Adeyemi, Mahendra L. Channa, Anand Nadar
Summary: The study suggests that maternal high-fat diet may impact the reproductive functions of male offspring, with limited ameliorative effect of Quercetin-3-O-rutinoside. Specifically, there was a significant decrease in GnRH levels in the male offspring of the HFD group at PND 21 and PND 28, which was significantly reduced by QR treatment.
Article
Nutrition & Dietetics
Natacha Fourny, Carole Lan, Monique Bernard, Martine Desrois
Summary: In this study, it was found that female rats on a high-fat high-sucrose diet were more likely to develop glucose intolerance, while male rats exhibited a more significant increase in heart weight. Both female and male rats on the HFS diet showed a similar decrease in tolerance to ischemia-reperfusion injury.
Article
Biochemistry & Molecular Biology
Junting Xie, Xiaoning Hou, Wanshi He, Jie Xiao, Yong Cao, Xiaojuan Liu
Summary: Although the specific action site and signal pathway of astaxanthin in weight loss remain unclear, this study used Caenorhabditis elegans to shed light on its efficacy and specific action sites. The supplementation of 60 μM astaxanthin significantly reduced fat deposition and triglyceride levels and prevented obesity caused by excessive energy accumulation. These effects were induced by sbp-1/mdt-15 and insulin/insulin-like growth factor pathways, and co-regulated the down-regulation of specific sites fat-6 and fat-7.
Article
Multidisciplinary Sciences
Jesse Bertinato, Philip Griffin
Summary: Trivalent chromium may potentiate insulin action, but its effects on metabolic parameters are unclear. This study examined the effects of different dietary chromium levels on body weight, composition, energy intake, food efficiency, and lipid and glucose metabolism in rats. The results showed that low chromium intake affected metabolic parameters common in chronic diseases, highlighting the need for clinical trials to further investigate the nutritional and pharmacological effects of chromium.
Article
Reproductive Biology
Malgorzata E. Skaznik-Wikiel, Delaney C. Swindle, Amanda A. Allshouse, Alex J. Polotsky, James L. McManaman
BIOLOGY OF REPRODUCTION
(2016)
Article
Cell Biology
Natalie M. Hohos, Kirstin J. Cho, Delaney C. Swindle, Malgorzata E. Skaznik-Wikiel
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Article
Pathology
Malgorzata E. Skaznik-Wikiel, Stefanie M. Ueda, Heidi E. Frasure, Peter G. Rose, Aimee Fleury, Francis C. Grumbine, Amanda Nickles Fader
Article
Pathology
Malgorzata E. Skaznik-Wikiel, Paniti Sukumvanich, R. Marshall Austin, Kristin K. Zorn, Thomas C. Krivak, Robert P. Edwards, Alexander B. Olawaiye
Article
Obstetrics & Gynecology
Malgorzata E. Skaznik-Wikiel, Rakesh K. Sharma, Kaisa Selesniemi, Ho-Joon Lee, Jonathan L. Tilly, Tommaso Falcone
FERTILITY AND STERILITY
(2011)
Article
Obstetrics & Gynecology
Malgorzata E. Skaznik-Wikiel, Megan M. McGuire, Meena Sukhwani, Julia Donohue, Tianjiao Chu, Thomas C. Krivak, Aleksandar Rajkovic, Kyle E. Orwig
FERTILITY AND STERILITY
(2013)
Article
Oncology
Malgorzata E. Skaznik-Wikiel, Paniti Sukumvanich, Sushil Beriwal, Kristin K. Zorn, Joseph L. Kelley, Scott D. Richard, Thomas C. Krivak
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2011)
Article
Oncology
Malgorzata E. Skaznik-Wikiel, Jamie L. Lesnock, William C. Mcbee, Sushil Beriwal, Kristin K. Zorn, Scott D. Richard, Thomas C. Krivak, Robert P. Edwards
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2012)
Review
Geriatrics & Gerontology
Malgorzata E. Skaznik-Wikiel, Alex J. Polotsky
Article
Obstetrics & Gynecology
Malgorzata. E. Skaznik-Wikiel, J. Eric Jelovsek, Brenda Andrews, Linda D. Bradley
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2010)
Article
Obstetrics & Gynecology
Sara Babcock Gilbert, Amanda Allshouse, Malgorzata E. Skaznik-Wikiel
FERTILITY AND STERILITY
(2019)
Article
Immunology
Elizabeth A. Caine, Suzanne M. Scheaffer, Darcy E. Broughton, Vanessa Salazar, Jennifer Govero, Subhajit Poddar, Augustine Osula, Jacques Halabi, Malgorzata E. Skaznik-Wikiel, Michael S. Diamond, Kelle H. Moley
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Cell Biology
Natalie M. Hohos, Emily M. Elliott, Kirstin J. Cho, Ivy S. Lin, Michael C. Rudolph, Malgorzata E. Skaznik-Wikiel
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Natalie M. Hohos, Kirstin J. Cho, Delaney C. Swindle, Amanda A. Allshouse, Michael C. Rudolph, Malgorzata E. Skaznik-Wikiel