Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response

HUWE1 interacts with PCNA to alleviate replication stress

(2016) Katherine N Choe et al.   EMBO REPORTS

The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells

(2016) Bryan King et al.   NATURE IMMUNOLOGY

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein

(2016) Noelia Urbán et al.   SCIENCE

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

(2015) Yuko Atsumi et al.   Cell Reports

Ubiquitylation, neddylation and the DNA damage response

(2015) J. S. Brown et al.   Open Biology

Mouse Spermatogenic Stem Cells Continually Interconvert between Equipotent Singly Isolated and Syncytial States

(2014) Kenshiro Hara et al.   Cell Stem Cell

Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1

(2014) Joel W. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal

(2014) M. Kanatsu-Shinohara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OpenComet: An automated tool for comet assay image analysis

(2014) Benjamin M. Gyori et al.   Redox Biology

HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin–proteasome pathway

(2013) Xiaozhen Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

(2013) S. Inoue et al.   GENES & DEVELOPMENT

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia

(2012) Shannon J. Gallagher et al.   DEVELOPMENTAL BIOLOGY

The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis

(2012) Zhenyue Hao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

The Germline Stem Cell Niche Unit in Mammalian Testes

(2012) Jon M. Oatley et al.   PHYSIOLOGICAL REVIEWS

A Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation

(2012) Skye C. McIver et al.   PLoS One

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2

(2011) J. Zhang et al.   GENES & DEVELOPMENT

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis

(2011) Meredith J. Goertz et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of oxidative DNA damage repair by DNA polymerase   and MutYH by cross-talk of phosphorylation and ubiquitination

(2011) E. Markkanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vasa genes: Emerging roles in the germ line and in multipotent cells

(2010) Eric A. Gustafson et al.   BIOESSAYS

Protecting the heritable genome: DNA damage response mechanisms in spermatogonial stem cells

(2010) Claudia E. Rübe et al.   DNA REPAIR

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum

(2010) D. D'Arca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment

(2010) T. Nakagawa et al.   SCIENCE

Gonocytes, the forgotten cells of the germ cell lineage

(2009) Martine Culty   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain

(2009) Xudong Zhao et al.   DEVELOPMENTAL CELL

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

(2008) Steffi Herold et al.   EMBO JOURNAL

The PDGF signaling pathway controls multiple steroid-producing lineages

(2008) J. Schmahl et al.   GENES & DEVELOPMENT

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

(2008) Xudong Zhao et al.   NATURE CELL BIOLOGY