Chromogranin A as circulating marker for diagnosis and management of neuroendocrine neoplasms: more flaws than fame

Reply to V. Amoroso et al

(2017) James C. Yao et al.   JOURNAL OF CLINICAL ONCOLOGY

Baseline plasma chromogranin A levels in patients with well-differentiated neuroendocrine tumors of the pancreas: A potential predictor of postoperative recurrence

(2017) Yoshihide Nanno et al.   PANCREATOLOGY

Diagnostic value of chromogranin A in pancreatic neuroendocrine tumors depends on tumor size: A prospective observational study from a single institute

(2017) Eunsung Jun et al.   SURGERY

Neuroendocrine Tumors

(2017) Matthew H. Kulke et al.   Journal of the National Comprehensive Cancer Network

Establishing the Quantitative Relationship Between Lanreotide Autogel®, Chromogranin A, and Progression-Free Survival in Patients with Nonfunctioning Gastroenteropancreatic Neuroendocrine Tumors

(2016) Núria Buil-Bruna et al.   AAPS Journal

Chromogranin A – unspecific neuroendocrine marker. Clinical utility and potential diagnostic pitfalls

(2016) Paweł Gut et al.   Archives of Medical Science

Reference intervals for the Kryptor second-generation chromogranin A assay

(2016) Simona Ferraro et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Utility of chromogranin A, pancreatic polypeptide, glucagon and gastrin in the diagnosis and follow-up of pancreatic neuroendocrine tumours in multiple endocrine neoplasia type 1 patients

(2016) Wei Qiu et al.   CLINICAL ENDOCRINOLOGY

NET Blood Transcript Analysis Defines the Crossing of the Clinical Rubicon: When Stable Disease Becomes Progressive

(2016) Marianne Pavel et al.   NEUROENDOCRINOLOGY

ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors

(2016) M. Falconi et al.   NEUROENDOCRINOLOGY

ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum

(2016) B. Niederle et al.   NEUROENDOCRINOLOGY

Serum Chromogranin A as a Complementary Marker for the Prediction of Prostate Cancer-Specific Survival

(2016) Christian Niedworok et al.   PATHOLOGY & ONCOLOGY RESEARCH

Label-Free Detection of Human Glycoprotein (CgA) Using an Extended-Gated Organic Transistor-Based Immunosensor

(2016) Tsukuru Minamiki et al.   SENSORS

Blood measurement of neuroendocrine gene transcripts defines the effectiveness of operative resection and ablation strategies

(2016) Irvin M. Modlin et al.   SURGERY

Chromogranin A

(2016) Mark Kidd et al.   Current Opinion in Endocrinology Diabetes and Obesity

Comparison of the Automated KRYPTOR Chromogranin A Assay with the DAKO ELISA

(2016) Magnus Wolf et al.   Clinical Laboratory

The Clinical Utility of a Novel Blood-Based Multi-Transcriptome Assay for the Diagnosis of Neuroendocrine Tumors of the Gastrointestinal Tract

(2015) I M Modlin et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids

(2015) M. E. Caplin et al.   ANNALS OF ONCOLOGY

Porównanie stężeń chromograniny A (CgA) w surowicy i w osoczu (EDTA2K) oraz odnośnych zakresów referencyjnych u zdrowych mężczyzn

(2015) Piotr Glinicki et al.   Endokrynologia Polska

Measurement of circulating transcripts and gene cluster analysis predicts and defines therapeutic efficacy of peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors

(2015) L. Bodei et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Circulating Transcript Analysis (NETest) in GEP-NETs Treated With Somatostatin Analogs Defines Therapy

(2015) Jarosław B. Ćwikła et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Neuroendocrine Tumors, Version 1.2015

(2015) Matthew H. Kulke et al.   Journal of the National Comprehensive Cancer Network

Consensus on biomarkers for neuroendocrine tumour disease

(2015) Kjell Oberg et al.   LANCET ONCOLOGY

Standard Pre- and Postoperative Determination of Chromogranin A in Resectable Non-Functioning Pancreatic Neuroendocrine Tumors - Diagnostic Accuracy: NF-pNET and Low Tumor Burden

(2015) Anneke P.J. Jilesen et al.   DIGESTIVE SURGERY

Chromogranin A: a paradoxical player in angiogenesis and vascular biology

(2014) Karen B. Helle et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Impact of long-acting octreotide in patients with early-stage MEN1-related duodeno-pancreatic neuroendocrine tumours

(2014) V. Ramundo et al.   CLINICAL ENDOCRINOLOGY

A multianalyte PCR blood test outperforms single analyte ELISAs (chromogranin A, pancreastatin, neurokinin A) for neuroendocrine tumor detection

(2014) Irvin M Modlin et al.   ENDOCRINE-RELATED CANCER

The biological characterization of neuroendocrine tumors: The role of neuroendocrine markers

(2014) P. Ferolla et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Hepatic arterial embolization in patients with neuroendocrine tumors

(2014) Michela Del Prete et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Neuroendocrine Tumor Biomarkers: Current Status and Perspectives

(2014) Irvin M. Modlin et al.   NEUROENDOCRINOLOGY

A PCR blood test outperforms chromogranin A in carcinoid detection and is unaffected by proton pump inhibitors

(2014) Irvin M Modlin et al.   Endocrine Connections

Intervention in gastro-enteropancreatic neuroendocrine tumours

(2013) Eric Baudin et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Analytical and preanalytical validation of a new mass spectrometric serum 5-hydroxyindoleacetic acid assay as neuroendocrine tumor marker

(2013) Niina Tohmola et al.   CLINICA CHIMICA ACTA

Automated two-site immunofluorescent assay for the measurement of serum chromogranin A

(2013) Théodora Popovici et al.   CLINICAL BIOCHEMISTRY

Targeted therapy with kinase inhibitors in aggressive endocrine tumors

(2013) Vincenzo Marotta et al.   EXPERT OPINION ON PHARMACOTHERAPY

Low Accuracy of Tumor Markers for Diagnosing Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1 Patients

(2013) Joanne M. de Laat et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clinical Usefulness of Plasma Chromogranin A in Pancreatic Neuroendocrine Neoplasm

(2013) Woo Hyun Paik et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Consensus Guidelines for the Management and Treatment of Neuroendocrine Tumors

(2013) Pamela L. Kunz et al.   PANCREAS

The Identification of Gut Neuroendocrine Tumor Disease by Multiple Synchronous Transcript Analysis in Blood

(2013) Irvin M. Modlin et al.   PLoS One

Cystic Pancreatic Neuroendocrine Tumors

(2012) Aatur D. Singhi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Neuroendocrine bronchial and thymic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2012) K. Oberg et al.   ANNALS OF ONCOLOGY

Limitations of Chromogranin A in clinical practice

(2012) Vincenzo Marotta et al.   BIOMARKERS

Neuroendocrine tumors of the digestive tract

(2012) Kjell Öberg   CURRENT OPINION IN ONCOLOGY

Neuroendocrine tumor disease: an evolving landscape

(2012) Andrea Frilling et al.   ENDOCRINE-RELATED CANCER

Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1)

(2012) Rajesh V. Thakker et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes

(2012) Robert T. Jensen et al.   NEUROENDOCRINOLOGY

ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, Midgut, Hindgut, and Unknown Primary

(2012) Marianne Pavel et al.   NEUROENDOCRINOLOGY

Systems Approaches to Biology and Disease Enable Translational Systems Medicine

(2012) Leroy Hood et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Circulating biomarkers in gastroenteropancreatic neuroendocrine tumours

(2011) Kjell Oberg   ENDOCRINE-RELATED CANCER

6564 POSTER Correlation of PFS With Early Response of Chromogranin A and 5-hydroxyindoleacetic Acid Levels in Pts With Advanced Neuroendocrine Tumours: Phase III RADIANT-2 Study Results

(2011) E. Baudin et al.   EUROPEAN JOURNAL OF CANCER

Choice of tumour markers in patients with neuroendocrine tumours is dependent on the histological grade. A marker study of Chromogranin A, Neuron specific enolase, Progastrin-releasing peptide and cytokeratin fragments

(2011) Catharina M. Korse et al.   EUROPEAN JOURNAL OF CANCER

Is the combination of chromogranin A and pancreatic polypeptide serum determinations of interest in the diagnosis and follow-up of gastro-entero-pancreatic neuroendocrine tumours?

(2011) Thomas Walter et al.   EUROPEAN JOURNAL OF CANCER

Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)

(2011) John K Ramage et al.   GUT

Biomarkers and Molecular Imaging in Gastroenteropancreatic Neuroendocrine Tumors

(2011) D. Lindholm et al.   HORMONE AND METABOLIC RESEARCH

Clinical and Prognostic Implications of the Genetic Diagnosis of Hereditary NET Syndromes in Asymptomatic Patients

(2011) V. Ramundo et al.   HORMONE AND METABOLIC RESEARCH

Chromogranin A and Neuron-Specific Enolase as Prognostic Markers in Patients with Advanced pNET Treated with Everolimus

(2011) James C. Yao et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study

(2011) Marianne E Pavel et al.   LANCET

Everolimus for Advanced Pancreatic Neuroendocrine Tumors

(2011) James C. Yao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuroendocrine gastroenteropancreatic tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2010) K. Oberg et al.   ANNALS OF ONCOLOGY

Chromogranin A—Biological Function and Clinical Utility in Neuro Endocrine Tumor Disease

(2010) Irvin M. Modlin et al.   ANNALS OF SURGICAL ONCOLOGY

Inositol 1,4,5-Trisphosphate Receptor in Chromaffin Secretory Granules and Its Relation to Chromogranins

(2010) Seung Hyun Yoo et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Circulating Biomarkers in Neuroendocrine Tumors of the Enteropancreatic Tract: Application to Diagnosis, Monitoring Disease, and as Prognostic Indicators

(2010) Joy E.S. Ardill et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Chromogranins as regulators of exocytosis

(2010) Ricardo Borges et al.   JOURNAL OF NEUROCHEMISTRY

Metabolic effects and mechanism of action of the chromogranin A-derived peptide pancreastatin

(2010) Víctor Sánchez-Margalet et al.   REGULATORY PEPTIDES

Catestatin: A multifunctional peptide from chromogranin A

(2010) Sushil K. Mahata et al.   REGULATORY PEPTIDES

Evaluation of chromogranin A determined by three different procedures in patients with benign diseases, neuroendocrine tumors and other malignancies

(2010) Rafael Molina et al.   TUMOR BIOLOGY

High blood levels of chromogranin A in giant cell arteritis identify patients refractory to corticosteroid treatment

(2009) G Di Comite et al.   ANNALS OF THE RHEUMATIC DISEASES

Midgut neuroendocrine tumours with liver metastases: results of the UKINETS study

(2009) A Ahmed et al.   ENDOCRINE-RELATED CANCER

Secretory granules in inositol 1,4,5-trisphosphate-dependent Ca2+ signaling in the cytoplasm of neuroendocrine cells

(2009) Seung Hyun Yoo   FASEB JOURNAL

Serum Chromogranin A Concentration in Hyperthyroidism before and after Medical Treatment

(2009) Kamal A. S. Al-Shoumer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Daily Oral Everolimus Activity in Patients With Metastatic Pancreatic Neuroendocrine Tumors After Failure of Cytotoxic Chemotherapy: A Phase II Trial

(2009) James C. Yao et al.   JOURNAL OF CLINICAL ONCOLOGY

Elevated Plasma Chromogranin A Is the First Indication of Recurrence in Radically Operated Midgut Carcinoid Tumors

(2009) Staffan Welin et al.   NEUROENDOCRINOLOGY

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biochemical Markers

(2009) Dermot O’Toole et al.   NEUROENDOCRINOLOGY

Two Chromogranin A-Derived Peptides Induce Calcium Entry in Human Neutrophils by Calmodulin-Regulated Calcium Independent Phospholipase A2

(2009) Dan Zhang et al.   PLoS One

Chromogranin A: A new proposal for trafficking, processing and induction of granule biogenesis

(2009) Hisatsugu Koshimizu et al.   REGULATORY PEPTIDES

Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients

(2009) Pierre Goudet et al.   WORLD JOURNAL OF SURGERY

Elevated chromogranin A (CgA) serum levels in the patients with advanced pancreatic cancer

(2008) Michele Malaguarnera et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Prognostic Factors and Survival in 324 Patients with Pancreatic Endocrine Tumor Treated at a Single Institution

(2008) S. Ekeblad et al.   CLINICAL CANCER RESEARCH

Multiple endocrine neoplasia type 1 (MEN1): its manifestations and effect of genetic screening on clinical outcome

(2008) C. R. C. Pieterman et al.   CLINICAL ENDOCRINOLOGY

Plasma Chromogranin A as Marker for Survival in Patients With Metastatic Endocrine Gastroenteropancreatic Tumors

(2008) R ARNOLD et al.   Clinical Gastroenterology and Hepatology

Prognostic value of circulating chromogranin A levels in acute coronary syndromes

(2008) A. M. Jansson et al.   EUROPEAN HEART JOURNAL

Plasma chromogranin a in patients with inflammatory bowel disease

(2008) Valentina Sciola et al.   INFLAMMATORY BOWEL DISEASES

Psychological Stress Evaluation of Patients with Bronchial Asthma Based on the Chromogranin A Level in Saliva

(2008) Ken Hoshino et al.   JOURNAL OF ASTHMA

Efficacy of RAD001 (Everolimus) and Octreotide LAR in Advanced Low- to Intermediate-Grade Neuroendocrine Tumors: Results of a Phase II Study

(2008) James C. Yao et al.   JOURNAL OF CLINICAL ONCOLOGY

One Hundred Years After “Carcinoid”: Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United States

(2008) James C. Yao et al.   JOURNAL OF CLINICAL ONCOLOGY

Circulating chromogranin A reveals extra-articular involvement in patients with rheumatoid arthritis and curbs TNF- -elicited endothelial activation

(2008) G. Di Comite et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gastroenteropancreatic neuroendocrine tumours

(2008) Irvin M Modlin et al.   LANCET ONCOLOGY

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Towards a Standardized Approach to the Diagnosis of Gastroenteropancreatic Neuroendocrine Tumors and Their Prognostic Stratification

(2008) Günter Klöppel et al.   NEUROENDOCRINOLOGY

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological Examinations

(2008) Anders Sundin et al.   NEUROENDOCRINOLOGY

Chromogranin A Levels in Diagnosis, Treatment and Follow-Up of 42 Patients with Non-Functioning Pancreatic Endocrine Tumours

(2008) G.C. Nikou et al.   PANCREATOLOGY

Serum gastrin and chromogranin A levels in patients with fundic gland polyps caused by long-term proton-pump inhibition

(2007) Reidar Fossmark et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY