Article
Oncology
Jace P. Landry, Brianne A. Voros, Robert A. Ramirez, J. Philip Boudreaux, Eugene A. Woltering, Ramcharan Thiagarajan
Summary: The study evaluated the metastatic potential of appendiceal neuroendocrine tumors (ANETs) < 2 cm diameter and found that smaller tumors had metastatic capability. Factors like patient age, tumor characteristics were associated with metastatic diseases. Appendectomy alone was deemed sufficient for most ANETs patients, regardless of tumor size.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Pathology
Alexandros D. Polydorides, Qingqing Liu
Summary: The study reviewed 162 patients with small bowel NETs and found that primary tumor size and lymphovascular invasion were associated with lymph node metastasis, while TDs and higher pT stage were associated with distant metastasis. A cutoff of >= 7 positive lymph nodes predicted distant metastasis, and the modified pN stage was a better predictor than the prototypical pN stage. Higher pNmod and pM were associated with disease progression, worse progression-free survival, and worse disease-specific survival.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Kenneth P. Seastedt, George A. Alyateem, Karthik Pittala, Seth M. Steinberg, David S. Schrump, Lynnette K. Nieman, Chuong D. Hoang
Summary: This study analyzed the outcomes of lung neuroendocrine tumors associated with Cushing syndrome and found that these tumors have higher nodal metastasis, higher recurrence rates, and shorter disease-free survival compared to quiescent bronchopulmonary carcinoid tumors. However, many patients still experienced favorable outcomes, indicating that a lung-sparing approach could be sufficient. These results suggest that the hormone physiology may play a more important role than the carcinoid biologic factors in determining prognosis.
Review
Oncology
Claire K. Mulvey
Summary: Precision medicine is a new approach to diagnosing and treating cancer that considers individual patient differences. The precision medicine treatment options for lung neuroendocrine tumors have been lagging behind other cancers, but recent advances in understanding the molecular basis of these tumors and increasing clinical trials offer potential for personalized treatment.
Article
Endocrinology & Metabolism
Elisa Lenotti, Andrea Alberti, Francesca Spada, Vito Amoroso, Patrick Maisonneuve, Salvatore Grisanti, Alice Baggi, Susanna Bianchi, Nicola Fazio, Alfredo Berruti
Summary: This study retrospectively evaluated the outcomes of patients with metastatic lung NET treated with first line SSAs in two Italian reference Institutions from 2014 to 2019. The results showed that the long PFS and OS obtained suggest that SSAs could be effective as a first line approach in managing patients with progressive, metastatic pulmonary NET.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Oncology
Thomas Yang Sun, Andrew Hendifar, Sukhmani K. Padda
Summary: This review highlights the role of molecular profiling in the prognosis and treatment of lung neuroendocrine tumors (NETs). Currently, there are no identified molecular prognostic factors for lung NETs, and no routinely used molecular markers to guide patient management. Lung NETs have low tumor mutation burden and low PD-L1 expression, distinguishing them from non-small cell lung cancer and small cell lung cancer. Everolimus, an mTOR inhibitor, is the only FDA approved therapy for unresectable lung NETs, but its predictive value for treatment response in the presence of molecular alterations is unknown.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Multidisciplinary Sciences
Kiyoun Yi, Gwang Ha Kim, Su Jin Kim, Cheol Woong Choi, Moon Won Lee, Bong Eun Lee, Geun Am Song
Summary: Endoscopic resection provides favorable long-term outcomes for d-NETs <= 10 mm in size, limited to the submucosal layer, and without lymph node or distant metastasis, when endoscopically complete resection is achieved.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Emma N. Rizen, Alexandria T. Phan
Summary: This review summarizes recent findings and updates in the management of neuroendocrine neoplasms (NENs), highlighting the improvement in NENs classification and the expansion of epidemiological understanding through global collaborations and tumor registries. The review also discusses the evolving utility of some NET biomarkers, the increasing knowledge of molecular drivers of tumorigenesis, and the multiple drug approvals for the treatment of advanced NENs. The authors emphasize the importance of further understanding molecular drivers and the role of immunotherapy in transforming care for all NENs patients.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Oncology
Daisuke Takayanagi, Hourin Cho, Erika Machida, Atsushi Kawamura, Atsuo Takashima, Satoshi Wada, Takuya Tsunoda, Takashi Kohno, Kouya Shiraishi
Summary: This review provides updates on the epidemiology, diagnosis, and management of gastroenteropancreatic neuroendocrine neoplasms. The incidence of these malignancies originating from the pancreatic and gastrointestinal neuroendocrine cell system has been increasing. Advances in molecular diagnosis, treatment strategies, and liquid biopsy have contributed to personalized management for patients.
Article
Oncology
Julie Hallet, Elie Isenberg-Grzeda, Calvin H. L. Law, Victoria Barabash, Jesse Zuckerman, Simron Singh, Sten D. Myrehaug, Angela Assal, Wing C. Chan, Natalie G. Coburn, Alyson L. Mahar
Summary: This study aimed to compare the occurrence of psychiatric illness in neuroendocrine tumor (NET) patients and colon cancer (CC) patients after diagnosis. The results showed no difference in the incidence of psychiatric illness between all NET patients and CC patients. However, the incidence of psychiatric illness was higher in the subgroup of small bowel and lung NETs, as well as serotonin-producing NETs, compared to CC.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Medicine, Research & Experimental
Cornel Savu, Alexandru Melinte, Camelia Diaconu, Ovidiu Stiru, Florentina Gherghiceanu, Stefan Dragos Octavian Tudorica, Oana Clementina Dumitrascu, Angelica Bratu, Irina Balescu, Nicolae Bacalbasa
Summary: Neuroendocrine tumors (NETs) are a group of heterogeneous malignancies that often appear in the thorax, especially in the tracheobronchial tree and thymus. The focus is on molecular diagnosis data and differentiating lung neuroendocrine tumors (LNETs). Understanding histological evaluation, genetic aberrations, prognosis, and therapeutic options is crucial for efficient management of these rare tumors.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Jonathan Ragheb, Shruti Mony, Jason Klapman, Tolga Erim, Angela Reagan, Robert Butler, Yanbin Dong, Michael Cruise, Barbara A. Centeno, Pablo Bejarano, Tyler Stevens, Umar Hayat, Amit Bhatt
Summary: The study suggests that the main predictor of recurrence in low-grade DNETs <1.0 cm is the presence of positive tumor margins at the initial endoscopic resection. Ninety-two percent of recurrences were detected within 3 years of resection, indicating the need for more frequent, earlier surveillance. No recurrences occurred in the cohort after 4 years of surveillance.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Cardiac & Cardiovascular Systems
Lara Girelli, Monica Casiraghi, Alberto Sandri, Francesco Petrella, Domenico Galetta, Roberto Gasparri, Patrick Maisonneuve, Nicola Fazio, Lorenzo Spaggiari
Summary: Surgical resection remains the treatment of choice for bronchial carcinoids with good prognosis, while aggressive forms like LCNEC with lymph nodal metastasis have a poor prognosis and require aggressive multidisciplinary treatment.
ANNALS OF THORACIC SURGERY
(2021)
Article
Gastroenterology & Hepatology
Ken Namikawa, Tomoari Kamada, Junko Fujisaki, Yuichi Sato, Takahisa Murao, Tsutomu Chiba, Yasuharu Kaizaki, Kenji Ishido, Yutaro Ihara, Koichi Kurahara, Tomoaki Suga, Haruhisa Suzuki, Masanori Ito, Katsuya Hirakawa, Yasuhiko Maruyama, Takuji Gotoda, Osamu Hosokawa, Tomohiro Koike, Katsuhiro Mabe, Takashi Yao, Kazuo Inui, Hiroyasu Iishi, Haruhiko Ogata, Takahisa Furuta, Ken Haruma
Summary: This study investigated the clinical characteristics and long-term prognosis of T1-GNETs and found that they exhibited indolent behavior and favorable long-term prognoses. Lymphovascular invasion (LVI) may be useful in indicating the need for additional treatments.
DIGESTIVE ENDOSCOPY
(2023)
Article
Oncology
Kimberly Perez, Matthew H. Kulke, Anu Chittenden, Chinedu Ukaegbu, Kristina Astone, Holly Alexander, Lauren Brais, Jinming Zhang, John Garcia, Edward D. Esplin, Shan Yang, Annacarolina Da Silva, Jonathan A. Nowak, Matthew B. Yurgelun, Judy Garber, Sapna Syngal, Jennifer Chan
Summary: The study found that 9%-11% of patients with small intestine NET have pathogenic germline variants associated with inherited susceptibility for malignancy, including genes such as ATM, RAD51C, MUTYH, and BLM. Further research is needed to understand the implications of these genetic variants on neuroendocrine carcinogenesis and risk.
JCO PRECISION ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Piero Ferolla, Alfredo Berruti, Francesca Spada, Maria Pia Brizzi, Toni Ibrahim, Riccardo Marconcini, Dario Giuffrida, Vito Amoroso, Anna La Salvia, Vanja Vaccaro, Antongiulio Faggiano, Annamaria Colao, Marco Volante, Simona Ghizzoni, Paola Mazzanti, Aude Houchard, Nicola Fazio
Summary: This study showed that the combination therapy of LAN/TMZ has promising efficacy in progressive T-NETs, and was well tolerated.
NEUROENDOCRINOLOGY
(2023)
Correction
Endocrinology & Metabolism
R. M. Ruggeri, E. Benevento, F. De Cicco, B. Fazzalari, E. Guadagno, I. Hasballa, M. G. Tarsitano, A. M. Isidori, A. Colao, A. Faggiano, I Aini, I Aini, M. Albertelli, Y. Alessi, B. Altieri, S. Antonini, L. Barrea, F. Birtolo, F. Campolo, G. Cannavale, C. Cantone, S. Carra, R. Centello, A. Cozzolino, S. Molfetta, V. Vito, G. Fanciulli, T. Feola, F. Ferrau, S. Gay, E. Giannetta, F. Grillo, E. Grossrubatscher, V Guarnotta, A. Salvia, A. Laffi, A. Lania, A. Liccardi, P. Malandrino, R. Mazzilli, E. Messina, N. Mikovic, R. Minotta, R. Modica, G. Muscogiuri, C. Pandozzi, G. Pugliese, G. Puliani, A. Ragni, M. Rubino, F. Russo, F. Sesti, L. Verde, A. Veresani, C. Vetrani, G. Vitale, V Zamponi, I Zanata
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
R. M. Ruggeri, E. Benevento, F. De Cicco, B. Fazzalari, E. Guadagno, I Hasballa, M. G. Tarsitano, A. M. Isidori, A. Colao, A. Faggiano
Summary: This review reevaluates the genetic basis and clinical features of gastroenteropancreatic and thoracic neuroendocrine tumors (NETs) in the context of inherited syndromes, with a special focus on molecularly targeted therapies. Significant advances have been made in understanding the genetic and epigenetic mechanisms of NET development, leading to the identification of targetable alterations and the development of novel targeted therapies.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Oncology
Ludovica Magi, Matteo Marasco, Maria Rinzivillo, Antongiulio Faggiano, Francesco Panzuto
Summary: Functional pancreatic neuroendocrine neoplasms (pNENs) are rare and heterogeneous diseases that secrete hormones or peptides, causing various symptoms. Surgery is the main treatment for local disease, while non-resectable cases have multiple therapeutic options. This review provides a summary of the clinical management and therapeutic approaches for functional pNENs.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Giuseppe Defeudis, Rossella Mazzilli, Cristiano Scandurra, Alfonso Maria Di Tommaso, Danilo Cimadomo, Rocky Strollo, Antongiulio Faggiano, Silvia Migliaccio, Nicola Napoli
Summary: The purpose of this study was to evaluate the relationships between health literacy, unrealistic optimism, and adherence to glycometabolic disease management related to erectile dysfunction (ED) in male patients with type 2 diabetes (T2D) or preDM. The results showed a close relationship between health literacy, unrealistic optimism, and treatment adherence.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Giuseppe Defeudis, Rossella Mazzilli, Domenico Benvenuto, Massimo Ciccozzi, Alfonso Maria Di Tommaso, Antongiulio Faggiano, Dario Tuccinardi, Mikiko Watanabe, Silvia Manfrini, Yeganeh Manon Khazrai
Summary: The study aimed to evaluate glucose control and insulin regimen modifications during pregnancy in women with T1D, comparing them to non-diabetic, normal-weight pregnant women. The findings showed that women with T1D need to modify their insulin regimen and dietary habits to control weight gain and promote optimal birth outcomes. However, due to the increase in insulin regimen, women with T1D gave birth to babies with higher birth weights than non-diabetic pregnant women.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Vitale, Silvia Carra, Ylenia Alessi, Federica Campolo, Carla Pandozzi, Isabella Zanata, Annamaria Colao, Antongiulio Faggiano
Summary: Carcinoid syndrome is a debilitating paraneoplastic disease occurring in 10-40% of patients with neuroendocrine tumors. Its main symptoms include flushing, diarrhea, hypotension, tachycardia, bronchoconstriction, venous telangiectasia, dyspnea, and fibrotic complications. Although there are drugs available, lack of therapeutic response and resistance remain challenges. Preclinical models serve as crucial tools for studying tumor progression and developing new therapies. This paper provides an overview of in vitro and in vivo models in NETs with carcinoid syndrome and discusses future developments and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Louis de Mestier, Matthieu Resche-Rigon, Clarisse Dromain, Angela Lamarca, Anna La Salvia, Lesley de Baker, Uli Fehrenbach, Sara Pusceddu, Annamaria Colao, Ivan Borbath, Robbert de Haas, Maria Rinzivillo, Alessandro Zerbi, Luigi Funicelli, Wouter W. de Herder, Andreas Selberherr, Anna Dorothea Wagner, Prakash Manoharan, Andrea De Cima, Willem Lybaert, Henning Jann, Natalie Prinzi, Antongiulio Faggiano, Laurence Annet, Annemiek Walenkamp, Francesco Panzuto, Vittorio Pedicini, Maria Giovanna Pitoni, Alexander Siebenhuener, Marius E. Mayerhoefer, Philippe Ruszniewski, Marie-Pierre Vullierme
Summary: In this study, alternative criteria for evaluating the efficacy of systemic treatments in patients with neuroendocrine tumors (NETs) and liver metastases (LMs) were explored. It was found that a reduction of ≥10% in the size of three LMs predicted prolonged treatment duration, which is more clinically relevant than the current threshold of 30% utilized by RECIST 1.1.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Antongiulio Faggiano, Beatrice Fazzalari, Nevena Mikovic, Flaminia Russo, Virginia Zamponi, Rossella Mazzilli, Vito Guarnieri, Maria Piane, Vincenzo Visco, Simona Petrucci
Summary: The aim of this study was to evaluate the predictive role of specific clinical factors for the diagnosis of MEN1 and MEN4 in patients with an initial diagnosis of gastrointestinal, bronchial, or thymic neuroendocrine tumor (NET). The preliminary data showed that a diagnosis of NET in patients with a negative family history may suggest MEN1 in the presence of >= three positive phenotypic criteria.
Review
Endocrinology & Metabolism
A. Faggiano
Summary: This review summarizes the relevant data on long-acting SSAs in NET patients, showing that long-acting SSAs are an effective and safe initial therapy for well differentiated NET, providing long-term tumor growth and symptom control in selected patients.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Gerardo Salerno, Marina Borro, Vincenzo Visco, Soraya Olana, Francesca Gargano, Salvatore Raffa, Virginia Zamponi, Camilla Mancini, Antongiulio Faggiano, Maurizio Simmaco, Rossella Mazzilli
Summary: This study aimed to evaluate the impact of medications on oxidative stress, inflammatory biomarkers, and semen characteristics in males with idiopathic infertility. The findings suggest a correlation between drug use and activation of the inflammatory response, which could help clarify the pathogenic mechanism of action for several pharmacological classes on male infertility.
MEDICINA-LITHUANIA
(2023)
Article
Endocrinology & Metabolism
Luigi Camera, Francesca Boccadifuoco, Roberta Modica, Luca Messerini, Antongiulio Faggiano, Valeria Romeo, Valeria Gaudieri, Annamaria Colao, Simone Maurea, Arturo Brunetti
Review
Oncology
Pasqualino Malandrino, Rossella Mazzilli, Giulia Puliani, Sergio Di Molfetta, Gabriella Pugliese, Soraya Olana, Anna Maria Colao, Antongiulio Faggiano
Summary: Patients with neuroendocrine neoplasm treated with peptide receptor radionuclide therapy (PRRT) experienced an improvement in health-related quality of life (HRQoL), but the impact on sexual function requires further investigation.
Article
Endocrinology & Metabolism
Rosaria M. Ruggeri, Irene Aini, Stefano Gay, Erika Maria Grossrubatscher, Camilla Mancini, Maria Grazia Tarsitano, Virginia Zamponi, Andrea M. Isidori, Annamaria Colao, Antongiulio Faggiano
Summary: With the increasing incidence of neuroendocrine tumors, interest in gender-driven management has grown. However, current studies have not shown substantial differences between males and females in the efficacy and toxicity of SSTR-targeted therapies.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Endocrinology & Metabolism
F. Sesti, G. Puliani, T. Feola, F. Campolo, F. Sciarra, V. Hasenmajer, A. Lenzi, A. Faggiano, A. M. Isidori, M. A. Venneri, E. Giannetta
Summary: The immune environment plays an important role in understanding the behavior of neuroendocrine neoplasms (NENs). This study found that NENs patients have an immunosuppressed environment, characterized by a decrease in cytotoxic natural killer cell count, an increase in anti-inflammatory non-classical monocytes count, and a decrease in T-helper lymphocyte count.
