Review
Biochemistry & Molecular Biology
Liejing Lu, Qinyuan Zhang, Zhe Wang, Liqian Gao, Jun Shen
Summary: Nanoparticles modified with peptides show great potential in tumor targeting therapy and molecular imaging, as peptides are small, easy to synthesize, and typically non-immunogenic. The active targeting mechanisms of nanoparticles modified with ligands against overexpressed moieties on tumor tissues have attracted increasing attention.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Xiaohan Liu, Limeng Pan, Kaiye Wang, Wei Pan, Na Li, Bo Tang
Summary: This review summarizes and discusses the importance of real-time monitoring of the immune response to evaluate immune status and guide immunotherapy. It also explores various imaging methods, immune-related imaging probes, and current challenges and opportunities.
Article
Chemistry, Multidisciplinary
Luntao Liu, Qingqing Li, Lanlan Chen, Lihong Song, Xueqiang Zhang, Hongqi Huo, Zhixin You, Ying Wu, Zongsheng Wu, Jiamin Ye, Qinrui Fu, Lichao Su, Xuan Zhang, Huanghao Yang, Jibin Song
Summary: In this study, multifunctional photocatalysis-powered nanomotors were developed for synergistically enhanced cancer radiotherapy. The nanomotors showed superior motility and efficient accumulation in tumor due to the catalytic generation of hydrogen. The nanomotors also exhibited a high radiation dose deposition, leading to enhanced therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Ying Zhao, Yang Liu, Yinghui Wang, Bo Xu, Songtao Zhang, Jianhua Liu, Tianqi Zhang, Longhai Jin, Songyan Song, Hongjie Zhang
Summary: This study successfully prepared MnCo2O4@PAA nanodots with dual-mode MRI imaging and photothermal therapy functions, providing precise diagnostic information for cancer and demonstrating good anticancer effects in vivo, with great potential for clinical applications.
Review
Engineering, Biomedical
Miffy Hok Yan Cheng, Yulin Mo, Gang Zheng
Summary: Optical sensors provide a valuable tool for noninvasively imaging hypoxia and personalized treatment planning. Small optical molecular probes and optical nanoprobes have unique advantages in hypoxia detection, enabling analyte triggered response and unique intrinsic optical properties.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Analytical
Alexandre Verdin, Cedric Malherbe, Gauthier Eppe
Summary: The highly selective SERS nanoprobes, based on Au@Ag nanoparticles protected by a PEG coating and functionalized with monoclonal antibodies against HER2, allow for specific targeting and quantification of HER2 in breast cancerous tissues. The proportional relationship between SERS signal and HER2 antigen quantity enables localized quantitative measurements, showing significant differences in HER2 expression levels within the same tissue slide. SERS has the potential to be a valuable tool for characterizing molecular heterogeneity in tumors at the microscopic scale due to its high multiplexing capabilities.
Review
Biochemical Research Methods
Lisen Lu, Yajie Sun, Chao Wan, Yan Hu, Pui-Chi Lo, Jonathan F. Lovell, Kunyu Yang, Honglin Jin
Summary: Although nanomedicines show promising anti-tumor effects, their limited clinical success is hindered by the diverse toxicities and therapeutic effects of their multiple components. Intravital imaging provides high resolution for evaluating nanomedicine's interactions with immune cells and tumor cells, offering direct evidence to better understand mechanisms and accelerate clinical translation.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Vanessa Jing Xin Phua, Chang-Tong Yang, Bin Xia, Sean Xuexian Yan, Jiang Liu, Swee Eng Aw, Tao He, David Chee Eng Ng
Summary: Nuclear imaging is a rapidly developing non-invasive imaging technique that uses radiolabeled nanomaterials as probes. By modifying the surface of nanomaterials, multifunctional radio-labeled nanomaterials can be obtained, enabling high sensitivity, resolution, and specificity in multimodal molecular imaging.
Article
Biochemistry & Molecular Biology
Alexey A. Lipengolts, Yulia A. Finogenova, Vsevolod A. Skribitsky, Kristina E. Shpakova, Adi Anaki, Menachem Motiei, Alevtina S. Semkina, Maxim A. Abakumov, Anna V. Smirnova, Elena Y. Grigorieva, Rachela Popovtzer
Summary: In this study, core/shell Fe3O4@Au theranostic nanoparticles were developed with the aim of providing bimodal CT and MRI enhancement. These nanoparticles showed significant enhancement of tumors and tumor blood vessels and accumulated in the liver and spleen. They were found to be non-toxic and effective contrast agents for CT and MRI diagnostics, with potential applications in cancer diagnostics and beyond.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Melanie A. Kimm, Christopher Klenk, Marianna Alunni-Fabbroni, Sophia Kaestle, Matthias Stechele, Jens Ricke, Michel Eisenblaetter, Moritz Wildgruber
Summary: This review provides an overview of the origin of tumor-associated macrophages, their polarization into different subtypes, and how characteristic markers of the subtypes can be used as targets for molecular imaging and theranostic approaches.
Article
Optics
Q. Fan, G. W. Zhang, B. Peng
Summary: This study successfully prepared a biocompatible near-infrared fluorescent tumor targeting nanoparticle, which can target HeLa cells through covalent binding with folic acid. In vivo experiments showed that this nanoparticle could accurately accumulate in HeLa tumor tissue and generate significant fluorescence signals.
JOURNAL OF LUMINESCENCE
(2021)
Article
Medicine, Research & Experimental
M. A. Sanzhakov, V. A. Kudinov, K. K. Baskaev, G. E. Morozevich, D. S. Stepanova, T. I. Torkhovskaya, Yu. A. Tereshkina, E. I. Korotkevich, E. G. Tikhonova
Summary: The study focused on constructing composite phospholipid-gold nanoparticles using soy phosphatidylcholine and a targeted ligand to enhance specific delivery into tumor cells and visualization of malignant neoplasms. In vitro and in vivo experiments demonstrated a significant increase in accumulation of the nanoparticles with a targeted fragment, showing promising potential for early diagnosis and treatment of various types of tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Xiaoqing Wei, Dan Mu, Yingping Li, Jingya Zhao, Shaobing Zhou
Summary: Researchers have developed a magnetic exosome that responds to bacteria associated with tumors, enabling sensitive tumor imaging. The magnetic exosome can rapidly respond in the tumor microenvironment and release iron oxide nanoparticles for dynamic MRI of tumors. After MRI, the iron oxide nanoparticles can be eliminated through renal clearance to avoid potential toxicity.
Article
Nanoscience & Nanotechnology
Thomas Abraham, Christopher O. McGovern, Samuel S. Linton, Zachary Wilczynski, James H. Adair, Gail L. Matters
Summary: Aptamer-targeted nanoparticles loaded with imaging agents showed enhanced detection of pancreatic and prostate tumors in vivo and ex vivo. The specific interaction with CCK-B receptors allows for well-distributed distribution of the tumor-targeted nanoparticles in the tumor matrix, improving early cancer detection.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Tianye Yang, Hui Ren, Wei Zhang, Li Rong, Duo Zhang
Summary: This article focuses on photothermal therapy (PTT) of tumors using gold nanomaterials. It proposes a method of surface coating gold nanomaterials with natural polyphenols with antitumor activity to address the issues faced in related research. The results showed that this method effectively induced apoptosis of tumor cells and achieved synergistic therapy through the photothermal conversion effect of the gold nanomaterials under near-infrared (NIR) laser.
Review
Radiology, Nuclear Medicine & Medical Imaging
Linda Osei Poku, Yongna Cheng, Kai Wang, Xilin Sun
Summary: The regulation of sodium ion influx and efflux in cells plays a crucial role in cell function and cancer metastasis. Changes in sodium ion concentration could serve as a potential biomarker for cancer diagnosis and prognosis. Na-23-MRI technology shows promise in noninvasive in vivo assessment of cancer therapy and monitoring of cancer immunotherapy.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Nanoscience & Nanotechnology
Lina Wu, Hongyan Zou, Hongbin Wang, Sihang Zhang, Shuang Liu, Ying Jiang, Jing Chen, Yingbo Li, Mengping Shao, Ruixin Zhang, Xiaona Li, Jing Dong, Lili Yang, Kai Wang, Xinyuan Zhu, Xilin Sun
Summary: Molecular imaging has gained global attention, with Chinese scientists contributing to impactful research through national programs and international collaborations, providing innovative solutions to unmet medical needs in the field.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yang Li, Ran Jia, Huiming Lin, Xilin Sun, Fengyu Qu
Summary: The MoSe2/CoSe2@PEG nanosheets can generate H2O2 in tumors, elevate the intracellular H2O2 level, and have great potential in anticancer applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Zhaoguo Han, Mingxing Ke, Xiang Liu, Jing Wang, Zhengqi Guan, Lina Qiao, Zhexi Wu, Yingying Sun, Xilin Sun
Summary: Precision medicine plays a crucial role in cancer therapy by providing individualized treatment plans to improve efficacy and minimize side effects. Molecular imaging, as a noninvasive tool, can detect tumor biology features and provide valuable information for guiding cancer precision medicine, such as treatment targets and response evaluation.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yingbo Li, Jie Yang, Guangying Gu, Xu Guo, Chunbo He, Jiemei Sun, Hongyan Zou, Hongbin Wang, Shuang Liu, Xiaona Li, Shujun Zhang, Kai Wang, Lili Yang, Ying Jiang, Lina Wu, Xilin Sun
Summary: Smart nanoclusters can enhance therapy efficacy of lung cancer by increasing drug penetration and providing superior antitumor effects. pH-sensitive superparamagnetic iron oxide nanoclusters disintegrate into smaller particles and release more iron ions in an acidic microenvironment, which enhance tumor ferroptosis and apoptosis with radiotherapy and chemodynamic therapy.
Article
Chemistry, Physical
Lixin Cheng, Dongmiao Sang, Fangyu Zhao, Lili Yang, Zhilin Guo, Xinfeng Zhang, Qiaoqiao Yang, Wenju Qiao, Xiaohong Sun, Xiaohong Guan, Haoyu Wang, Jiannan Wang, Hongyan Zou, Xiu'e Li, Fang Fang, Yang Li, Shujun Zhang, Lina Wu, Huiming Lin, Xilin Sun, Kai Wang
Summary: This study developed Gd-surface functionalized copper sulfide nanoparticles modified with folic acid for efficient synergistic photothermal/photodynamic therapy. The nanoparticles showed high longitudinal relaxivity, strong photothermal conversion efficiency, and enhanced reactive oxygen species production. The targeted Cu1.96S-Gd@FA nanoparticles exhibited higher signal enhancement for magnetic resonance and could be visualized in infrared imaging. Additionally, the nanoparticles showed biodegradation behavior and good drug elimination performance.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Jie Yang, Yingbo Li, Jiemei Sun, Hongyan Zou, Yige Sun, Jing Luo, Qian Xie, A. Rong, Hongbin Wang, Xiaona Li, Kai Wang, Lili Yang, Teng Ma, Lina Wu, Xilin Sun
Summary: Low accumulation of anticancer drugs in tumors and serious systemic toxicity are still major challenges in pharmaceuticals. Pulmonary delivery of nanoscale-based drug delivery systems offers a strategy to increase antitumor activity with minimal adverse exposure. In this study, we report an osimertinib-loaded nanoemulsion system that synergizes with F-19 MRI-guided LIFU for lung cancer therapy. The research validates the potential of this nanoemulsion system for lung cancer treatment, achieving quick distribution and drug release without severe side effects.
Article
Biochemistry & Molecular Biology
Yige Sun, Jie Yang, Yingbo Li, Jing Luo, Jiemei Sun, Daoshuang Li, Yuchen Wang, Kai Wang, Lili Yang, Lina Wu, Xilin Sun
Summary: The study developed a multirooted delivery system INC280-PFCE nanoparticles (NPs) for improving MET-targeted therapy in NSCLC patients with liver metastases. The NPs demonstrated excellent antitumor ability in vitro and real-time MRI visualization of sustained release and prolonged retention behaviors within tumors. These results suggest high efficacy and biocompatibility of NPs after a single low-dose administration.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuefeng Yan, Fabrice G. Simeon, Jeih-San Liow, Cheryl L. Morse, Jose A. Montero Santamaria, Madeline Jenkins, Lester S. Manly, Maia Van Buskirk, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis, Paolo Zanotti-Fregonara
Summary: This study assessed the ability of [F-18]SF51 to quantify TSPO in rhesus monkey brain. The results demonstrate that [F-18]SF51 is an excellent radioligand that can quantify TSPO with a good ratio of specific to nondisplaceable uptake and has minimal radiometabolite accumulation in brain. These findings suggest that [F-18]SF51 should be further evaluated in humans.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Chemistry, Multidisciplinary
Qingchen Bai, Miao Wang, Jingwei Liu, Xilin Sun, Piaoping Yang, Fengyu Qu, Huiming Lin
Summary: Given its physiological functions, nitric oxide (NO) has potential as a cancer therapy. This study utilizes a transition metal nitride MoN@PEG as an efficient NO donor, which releases NO specifically to the tumor microenvironment. The MoN@PEG also serves as a peroxidase and sonosensitizer, enhancing the anticancer treatment. The improved MoN-Pt@PEG enhances the sonodynamic therapy effect for generating more reactive oxygen species and facilitating in situ peroxynitrite generation. This work not only brings efficient antitumor effects but also expands the application of NO therapy.
Review
Nanoscience & Nanotechnology
A. Rong, Zhaoguo Han, Tianyi Wang, Mengyuan Zhu, Meifang Zhou, Xilin Sun
Summary: Lung cancer is a disease with high incidence and mortality rate, mainly due to limited efficacy of therapeutic drugs and insufficient drug delivery to the lungs. Nanoparticles pulmonary delivery techniques offer a new approach for precise diagnosis and treatment of lung cancer.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuichi Wakabayashi, Per Stenkrona, Ryosuke Arakawa, Xuefeng Yan, Maia G. Van Buskirk, Madeline D. Jenkins, Jose A. Montero Santamaria, Kevin P. Maresca, Akihiro Takano, Jeih-San Liow, Thomas A. Chappie, Andrea Varrone, Sangram Nag, Lei Zhang, Zoe A. Hughes, Christopher J. Schmidt, Shawn D. Doran, Andrew Mannes, Paolo Zanotti-Fregonara, Maarten Ooms, Cheryl L. Morse, Sami S. Zoghbi, Christer Halldin, Victor W. Pike, Robert B. Innis
Summary: This study evaluated the properties of a newly developed selective PDE4B radioligand in the brains of rodents, monkeys, and humans. The results showed that the radioligand could quantify PDE4B in the human brain reasonably well, and it has the potential to be used in clinical studies.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Correction
Materials Science, Biomaterials
Lili Yang, Shanshan Liu, Jingjing Chu, Shuang Miao, Kai Wang, Qingwei Zhang, Yingyi Wang, Yadi Xiao, Lina Wu, Yang Liu, Longjian Yu, Caihong Yu, Xiang Liu, Mingxing Ke, Zhen Cheng, Xilin Sun
Summary: This article is a correction of the study on novel anilino quinazoline-based EGFR tyrosine kinase inhibitors for the treatment of non-small cell lung cancer. The authors have made a series of corrections to rectify the previously published errors.
BIOMATERIALS SCIENCE
(2022)
Article
Surgery
Ruifeng Wang, Zhen Quan, Tongsen Zheng, Kai Wang, Yang Liu, Zhaoguo Han, Xiance Wang, Shiling Ma, Lianxin Liu, Wan Yee Lau, Xilin Sun
Summary: This study used multiple imaging methods to assess the pathophysiological mechanisms of the future liver remnant (FLR) and tumors after the first stage of ALPPS. Changes in tumor volume, metabolism, and hemodynamics were observed. Molecular and functional imaging are promising non-invasive methods for investigating the pathophysiological mechanisms of ALPPS.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Materials Science, Biomaterials
Lili Yang, Shanshan Liu, Jingjing Chu, Shuang Miao, Kai Wang, Qingwei Zhang, Yingyi Wang, Yadi Xiao, Lina Wu, Yang Liu, Longjian Yu, Caihong Yu, Xiang Liu, Mingxing Ke, Zhen Cheng, Xilin Sun
Summary: EGFR-targeted F-MPG and OH-MPG exhibit promising anti-tumor activity in NSCLC treatment with limited liver damage, making them promising drug candidates for further investigation in combating the deadly NSCLC.
BIOMATERIALS SCIENCE
(2021)
