An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Adaptability of protein structures to enable functional interactions and evolutionary implications

(2015) Turkan Haliloglu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2)

(2015) Cathryn Weston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

(2015) Jason M. Booe et al.   MOLECULAR CELL

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Propagation of conformational changes during μ-opioid receptor activation

(2015) Rémy Sounier et al.   NATURE

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

A Unified View of “How Allostery Works”

(2014) Chung-Jung Tsai et al.   PLoS Computational Biology

Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation

(2013) Debbie L Hay et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of CGRP-Receptor Component Protein (RCP) in CLR/RAMP Function

(2013) Ian Dickerson   CURRENT PROTEIN & PEPTIDE SCIENCE

G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection

(2013) Patricia M Lenhart et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Insights into the structure of class B GPCRs

(2013) Kaspar Hollenstein et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT(a)function

(2012) T Qi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Receptor activity modifying proteins (RAMPs) interact with the VPAC2receptor and CRF1receptors and modulate their function

(2012) D Wootten et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development

(2011) Julia K. Archbold et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A key role for tryptophan 84 in receptor activity-modifying protein 1 in the amylin 1 receptor

(2010) Joseph J. Gingell et al.   PEPTIDES

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Molecular Basis of Association of Receptor Activity-Modifying Protein 3 with the Family B G Protein-Coupled Secretin Receptor

(2009) Kaleeckal G. Harikumar et al.   BIOCHEMISTRY

Structure−Function Analysis of RAMP1 by Alanine Mutagenesis†

(2009) John Simms et al.   BIOCHEMISTRY

Modulating receptor function through RAMPs: can they represent drug targets in themselves?

(2009) Patrick M. Sexton et al.   DRUG DISCOVERY TODAY

Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides

(2009) Augen A. Pioszak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

(2009) Christina Rye Underwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors

(2008) Maria Morfis et al.   ENDOCRINOLOGY

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

(2008) Steffen Runge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

(2008) Augen A. Pioszak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA