Regulation of NANOG in cancer cells

Syndecan-1 responsive microRNA-126 and 149 regulate cell proliferation in prostate cancer

(2015) Tomomi Fujii et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced expression of microRNA-134 correlates with malignancy and poor prognosis in human glioma

(2015) Jianfeng Zhong et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Bmi1 regulates self-renewal and epithelial to mesenchymal transition in breast cancer cells through Nanog

(2014) Anurag N Paranjape et al.   BMC CANCER

miRNA-128 Suppresses Prostate Cancer by Inhibiting BMI-1 to Inhibit Tumor-Initiating Cells

(2014) M. Jin et al.   CANCER RESEARCH

Hepatitis C virus core protein regulates NANOG expression via the stat3 pathway

(2014) Jia-Jia Zhou et al.   FEBS LETTERS

The pluripotency factor Nanog is directly upregulated by the Androgen Receptor in prostate cancer cells

(2014) Steven Kregel et al.   PROSTATE

ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal

(2014) Sung-Hyun Kim et al.   Stem Cell Research

NANOG Is Multiply Phosphorylated and Directly Modified by ERK2 and CDK1 In Vitro

(2014) Justin Brumbaugh et al.   Stem Cell Reports

Nanog expression is negatively regulated by protein kinase C activities in human cancer cell lines

(2013) Wing-Keung Chu et al.   CARCINOGENESIS

The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134

(2013) S. Bicker et al.   GENES & DEVELOPMENT

Nuclear β-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer

(2013) Xi-Qing Li et al.   Journal of Translational Medicine

Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis

(2013) X Xie et al.   ONCOGENE

Activated 5′flanking region of NANOGP8 in a self-renewal environment is associated with increased sphere formation and tumor growth of prostate cancer cells

(2013) Kai Zhang et al.   PROSTATE

Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma

(2012) Juanjuan Shan et al.   HEPATOLOGY

Prognostic Impact of the Cancer Stem Cell–Related Marker NANOG in Ovarian Serous Carcinoma

(2012) Maria Lee et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

MicroRNA MiR-214 Regulates Ovarian Cancer Cell Stemness by Targeting p53/Nanog

(2012) Cheng-Xiong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated

(2012) Baotran Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of colony stimulating factor-1 expression and ovarian cancer cell behavior in vitro by miR-128 and miR-152

(2012) Ho-Hyung Woo et al.   Molecular Cancer

NANOG modulates stemness in human colorectal cancer

(2012) J Zhang et al.   ONCOGENE

SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2

(2012) Yongyan Wu et al.   PLoS One

E-cadherin and, in Its Absence, N-cadherin Promotes Nanog Expression in Mouse Embryonic Stem Cells via STAT3 Phosphorylation

(2012) Kate Hawkins et al.   STEM CELLS

Prognostic significance of NANOG and KLF4 for breast cancer

(2012) Takuya Nagata et al.   Breast Cancer

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance

(2011) Ayesha B. Alvero et al.   CELL CYCLE

microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

(2011) Elisa Penna et al.   EMBO JOURNAL

Hypoxia-Dependent Inhibition of Tumor Cell Susceptibility to CTL-Mediated Lysis Involves NANOG Induction in Target Cells

(2011) Meriem Hasmim et al.   JOURNAL OF IMMUNOLOGY

Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma

(2011) Ting Lin et al.   MEDICAL ONCOLOGY

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation

(2011) C R Jeter et al.   ONCOGENE

MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation

(2011) Cheng-Chia Yu et al.   ORAL ONCOLOGY

Prostate Cancer Cell Lines under Hypoxia Exhibit Greater Stem-Like Properties

(2011) Yuanyuan Ma et al.   PLoS One

PEST Motif Sequence Regulating Human NANOG for Proteasomal Degradation

(2011) Suresh Ramakrishna et al.   STEM CELLS AND DEVELOPMENT

The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells

(2010) Selma Masri et al.   BREAST CANCER RESEARCH AND TREATMENT

Over-expression of Nanog predicts tumor progression and poor prognosis in colorectal cancer

(2010) Hui-Min Meng et al.   CANCER BIOLOGY & THERAPY

Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation

(2010) S.-H. Chiou et al.   CANCER RESEARCH

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

The role of mutant p53 in human cancer

(2010) Amanda M Goh et al.   JOURNAL OF PATHOLOGY

Oct4 and Nanog Expression Is Associated With Early Stages of Pancreatic Carcinogenesis

(2010) Jing Wen et al.   PANCREAS

MicroRNA 128a Increases Intracellular ROS Level by Targeting Bmi-1 and Inhibits Medulloblastoma Cancer Cell Growth by Promoting Senescence

(2010) Sujatha Venkataraman et al.   PLoS One

Phosphorylation stabilizes Nanog by promoting its interaction with Pin1

(2010) M. Moretto-Zita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Quantitative Proteomic Profiling of Prostate Cancer Reveals a Role for miR-128 in Prostate Cancer

(2009) Amjad P. Khan et al.   MOLECULAR & CELLULAR PROTEOMICS

Direct cell reprogramming is a stochastic process amenable to acceleration

(2009) Jacob Hanna et al.   NATURE

Functional Evidence that the Self-Renewal GeneNANOGRegulates Human Tumor Development

(2009) Collene R. Jeter et al.   STEM CELLS

Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells

(2008) Feng Ye et al.   BMC CANCER

Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors

(2008) S. Zhang et al.   CANCER RESEARCH

MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN

(2008) H. Yang et al.   CANCER RESEARCH

Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High-Grade Oral Squamous Cell Carcinoma

(2008) S.-H. Chiou et al.   CLINICAL CANCER RESEARCH

Identification of a tumor-initiating stem cell population in human renal carcinomas

(2008) Benedetta Bussolati et al.   FASEB JOURNAL

Regulation of Pluripotency and Reprogramming by Transcription Factors

(2008) Duanqing Pei   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells

(2008) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multilevel Regulation of Gene Expression by MicroRNAs

(2008) E. V. Makeyev et al.   SCIENCE

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1

(2007) Yvonne M.-S. Tay et al.   STEM CELLS