Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis

Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis

(2013) M Takata et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proteins in Microglial Activation - Inputs and Outputs by Subsets

(2013) Uwe-Karsten Hanisch   CURRENT PROTEIN & PEPTIDE SCIENCE

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

(2012) Melissa Bowerman et al.   BMC Medicine

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

(2012) L. Tonges et al.   BRAIN

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype

(2012) Kate Roberts et al.   GLIA

Altered astrocytic response to activation in SOD1G93Amice and its implications on amyotrophic lateral sclerosis pathogenesis

(2012) Chen Benkler et al.   GLIA

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Abnormal Regenerative Responses and Impaired Axonal Outgrowth after Nerve Crush in TDP-43 Transgenic Mouse Models of Amyotrophic Lateral Sclerosis

(2012) V. Swarup et al.   JOURNAL OF NEUROSCIENCE

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor Fasudil reveals cytoskeletal and pro-survival responses

(2011) Chew L. Lau et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration

(2011) Lars Tönges   Frontiers in Molecular Neuroscience

CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS

(2010) Tommy Regen et al.   BRAIN BEHAVIOR AND IMMUNITY

Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model

(2010) Mélissa Bowerman et al.   HUMAN MOLECULAR GENETICS

The human G93A SOD1 phenotype closely resembles sporadic amyotrophic lateral sclerosis

(2010) M. Synofzik et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Astrogliosis in amyotrophic lateral sclerosis: Role and therapeutic potential of astrocytes

(2010) Marcelo R. Vargas et al.   Neurotherapeutics

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Microglia in ALS: The Good, The Bad, and The Resting

(2009) Jenny S. Henkel et al.   Journal of Neuroimmune Pharmacology

Spinal anterior horn has the capacity to self-regenerate in amyotrophic lateral sclerosis model mice

(2009) Kazunori Miyazaki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells

(2009) Christina Bermel et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos

(2009) Stefan Wiese et al.   Nature Protocols

Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice

(2009) Mei Li et al.   NEUROBIOLOGY OF DISEASE

BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity

(2008) Véronique Planchamp et al.   BRAIN

Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis

(2008) Claudia Pitzer et al.   BRAIN

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY