Article
Chemistry, Analytical
Wei Liu, Shengyan Yin, Yingcai Hu, Ting Deng, Jishan Li
Summary: A pH-responsive T2-T1 switchable MRI nanoprobe was constructed by combining the microemulsion method with the biomineralization principle, which can achieve T1-weighted imaging in tumor environments.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jin Wang, Yinhang Jia, Qiyue Wang, Zeyu Liang, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai, Daishun Ling
Summary: The article introduces a T-1-T-2 dual-mode contrast agent designed for ultrahigh-field MRI, which not only improves resolution and signal-to-noise ratio, but also effectively displays microvasculature structures with high sensitivity and accuracy in detecting tumor vascular permeability.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang
Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.
ADVANCED MATERIALS
(2021)
Article
Multidisciplinary Sciences
Qinrui Lin, Yuhong Yang, Zhengzhong Shao
Summary: This study reports MRI-active conjugated polymer nanoparticles based on polypyrrole (PPy) for in vivo imaging, extending the applications of conjugated polymers from optical imaging to MRI.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Shifaa M. Siribbal, Shaista Ilyas, Alexander M. Renner, Sumiya Iqbal, Sergio Munoz Vazquez, Abubakar Moawia, Martin Valldor, Muhammad S. Hussain, Klaus Schomaecker, Sanjay Mathur
Summary: This study developed functionalized nanocarriers for site-specific delivery in imaging applications. The nanocarriers improved the imaging capabilities of conventional contrast agents and increased targeting accuracy. Through a multi-layer formation approach and covalent binding, the nanocarriers showed excellent biocompatibility and the ability to serve as target-specific imaging probes.
Article
Biotechnology & Applied Microbiology
Heyu Yang, Hui Wang, Chenghao Wen, Shun Bai, Pengfei Wei, Bo Xu, Yunjun Xu, Chaozhao Liang, Yunjiao Zhang, Guilong Zhang, Huiqin Wen, Li Zhang
Summary: This study aimed to evaluate the effects of iron oxide nanoparticles (IONPs) on the male reproductive system of mice. The results showed that IONPs did not affect the major organs, but caused damage to Sertoli cells in the blood-testis barrier (BTB) at a relatively high concentration. This led to a temporary reduction in sperm quantity and quality, which was attributed to increased oxidative stress and apoptotic activity in the epididymis. However, these effects were reversible and returned to normal within 14 days after injection of IONPs.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Physical
Huan Zhang, Xiao Li Liu, Hai Ming Fan
Summary: Magnetic resonance imaging (MRI) has revolutionized medical imaging diagnostics. However, the clinical use of Gd-based contrast agents (CAs) still has limitations, making the development of magnetic nanoparticle-based CAs a promising avenue for research.
Article
Chemistry, Physical
Haiyang Jia, Fen Zhang, Chen Zhu, Jiawei Sun, Xiao Xie
Summary: This study synthesized amino-grafted ferromagnetic nanoparticles with highly stable dispersion using deep-eutectic-solvent electrolysis, and successfully applied them in magnetic resonance imaging. These nanoparticles exhibited high biocompatibility and had high longitudinal and transverse relaxation efficiencies, enabling prominent weighted imaging of T1 and T2 of the liver, as well as significant distinction between normal tissue and liver tumors.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Multidisciplinary Sciences
Hossein Danafar, Yasamin Baghdadchi, Murat Barsbay, Mohammadreza Ghaffarlou, Navid Mousazadeh, Ali Mohammadi
Summary: Insufficient contrast is a limitation of MRI, which can be overcome by using contrast agents. Nano-sized contrast materials, such as Fe3O4-Au hybrid NPs, have unique advantages but suffer from aggregation and accumulation. Surface modifications, like coating with BSA, are necessary to improve their stability and biocompatibility. The synthesized Fe3O4-Au-BSA NPs showed a significant reduction in signal intensity on MR images, confirming their contrast ability.
Article
Materials Science, Biomaterials
Li Yang, Shengxiang Fu, Zhongyuan Cai, Li Liu, Chunchao Xia, Qiyong Gong, Bin Song, Hua Ai
Summary: The T-1-T-2 dual-mode MRI probes can acquire comprehensive information of different tissues simultaneously, showing good stability and non-cytotoxicity. They are suitable for imaging blood vessels and liver tissue.
REGENERATIVE BIOMATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Simona Baroni, Rachele Stefania, Lionel M. Broche, Nicholas Senn, David J. Lurie, P. James Ross, Silvio Aime, Simonetta Geninatti Crich
Summary: This study introduces a novel class of MRI contrast agents with remarkable relaxation effects without the need for paramagnetic metal ions. Image acquisition at variable magnetic field strength is required for their detection using fast field cycling imaging scanners.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Medicine, Research & Experimental
Beatriz Brito, Thomas W. Price, Juan Gallo, Manuel Banobre-Lopez, Graeme J. Stasiuk
Summary: This review introduces smart theranostics that integrate multiple functions, especially responsive agents for MRI, aiming to improve cancer therapy efficiency and diagnostic accuracy. The challenges and obstacles in the design and application are also discussed.
Article
Materials Science, Biomaterials
Chengbin Wang, Chenglin Yan, Lu An, Huifeng Zhao, Shaoli Song, Shiping Yang
Summary: The study introduces ultra-small Fe3O4 nanoclusters as an endogenous GSH-responsive MRI contrast agent for improved tumor diagnosis by utilizing the overexpression of GSH in tumors to achieve T-2/T-1 signal switching.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Nanoscience & Nanotechnology
Can Chen, Jianxian Ge, Yun Gao, Lei Chen, Jiabin Cui, Jianfeng Zeng, Mingyuan Gao
Summary: USPIO nanoparticles, with their excellent MRI performance and remarkable biosafety profile, have shown considerable applications in developing T-1 contrast agents and T-2/T-1 switchable contrast agents, and have been widely used in the diagnosis of vascular pathological changes, inflammations, and malignant tumors.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Bo Song, Xinyue Zhang, Xinyi Wen, Qi Liu, Hua Ma, Weihua Guo, Mingqian Tan, Lei Jia, Jingli Yuan
Summary: The study developed a novel bioconjugate, Tf-Eu-Gd, with intense long-lived luminescence, high MR relaxivity, and good biocompatibility. As a probe, Tf-Eu-Gd can specifically accumulate in cancer cells overexpressing Tf receptors for TGL and MR imaging of tumors.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Casey M. Platnich, Jachym S. Slaby, David O'Connell, Simon Trudel
Summary: This work presents a solvothermal method for synthesizing hematite thin films on fluorine-doped tin oxide substrates, utilizing a precursor solution of iron(III) 2,4-pentanedionate dissolved in ethanol with a small amount of water. By incorporating water into the solution, nanocrystalline films of hematite with different morphologies, nanocrystal size distributions, and surface areas can be generated, giving control over the films' physical and electrochemical characteristics. Doping of hematite thin films is also achievable using this method, as demonstrated by doping with tin in the precursor solution for building prototype photoelectrochemical cells with the synthesized hematite as the photoanode.
CANADIAN JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Elizabeth L. Castle, Carolyn-Ann Robinson, Pauline Douglas, Kristina D. Rinker, Jennifer A. Corcoran
Summary: The viral protein KapB from Kaposi's sarcoma-associated herpesvirus induces PB disassembly by promoting actin rearrangements, RhoA effectors, and the mechanoresponsive transcription activator YAP. Ectopic expression of active YAP or exposure of ECs to mechanical forces can also cause PB disassembly in the absence of KapB. This study suggests that KapB activates a mechanoresponsive signaling axis to enhance inflammatory molecule expression through changes in cell shape and cytoskeletal structures.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Felix J. Rizzuto, Casey M. Platnich, Xin Luo, Yao Shen, Michael D. Dore, Christophe Lachance-Brais, Alba Guarne, Gonzalo Cosa, Hanadi F. Sleiman
Summary: The study demonstrates that slow proton dissipation can select for otherwise inaccessible morphologies of fibers built from DNA and cyanuric acid, influence the growth mechanism of supramolecular polymerization, and convert branched, interwoven networks into nanocable superstructures.
Article
Cell & Tissue Engineering
Kenneth F. Fuh, Jessica Withell, Robert D. Shepherd, Kristina D. Rinker
Summary: This study found that exposing HMECs to fluid flow upregulates S100 genes, particularly S100A7 and S100P, which are clinically identified as overexpressed during breast cancer development. These results are the first to show that S100 genes are responsive to flow stimulation and may be involved in a fundamental adaptation pathway in normal tissue and breast cancer.
CELLULAR AND MOLECULAR BIOENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Piotr Pawlik, Barbara Blasiak, Joanna Depciuch, Marcin Pruba, Diana Kitala, Svetlana Vorobyova, Malgorzata Stec, Maxim Bushinsky, Artem Konakov, Jaroslaw Baran, Julia Fedotova, Oleg Ivashkevich, Magdalena Parlinska-Wojtan, Alexey Maximenko
Summary: The novel iron-oxide nanoparticles stabilized with triethanolammonium oleate were found to have potential applications in MRI-guided hyperthermia and regenerative medicine.
JOURNAL OF MATERIALS SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Andrea Doricchi, Casey M. Platnich, Andreas Gimpel, Friederikee Horn, Max Earle, German Lanzavecchia, Aitziber L. Cortajarena, Luis M. Liz-Marzan, Na Liu, Reinhard Heckel, Robert N. Grass, Roman Krahne, Ulrich F. Keyser, Denis Garoli
Summary: This article discusses the latest advances in DNA-based data storage, highlighting its advantages over traditional storage methods, while also addressing current challenges and future directions for development.
Article
Chemistry, Physical
M. Taheri, S. Maaref, A. Kantzas, S. Bryant, S. Trudel
Summary: This study investigated the effect of different surfactants on the stability of PEGylated BaTiO3 nanoparticles in water and ethylene glycol. The results showed that the anionic surfactant acted as the best stabilizer, while the cationic surfactant was the least favorable stabilizer.
Article
Chemistry, Physical
Katelynn M. Daly, Santiago Jimenez-Villegas, Benjamin Godwin, Martin A. W. Schoen, Oliver Calderon, Ning Chen, Simon Trudel
Summary: The storage of renewable energy is a challenge in transitioning to a power grid based on intermittent energy supplies. The electrocatalytic conversion of water to hydrogen fuel is an attractive option, but requires better catalysts for better performance. This study evaluated different RuOx catalysts and found that nanocrystalline RuOx catalysts outperform their amorphous counterparts and are more stable under alkaline conditions, which is a significant step towards using RuOx for alkaline water electrolysis.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Renaud Miclette Lamarche, Akpeko Gasonoo, Anderson Hoff, Roman Chernikov, Gregory C. Welch, Simon Trudel
Summary: This study demonstrates the formation of vanadium oxide films using a room-temperature, ambient photochemical deposition route. The films consist of V2O5 with a significant amount of V4+. The films become nanocrystalline after annealing and show no improvement in device performance when used as hole-transport layers in organic photovoltaic cells and organic light-emitting diodes.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Piotr Pawlik, Barbara Blasiak, Marcin Pruba, Arkadiusz Miaskowski, Oskar Moraczynski, Justyna Miszczyk, Boguslaw Tomanek, Joanna Depciuch
Summary: This work presents a new aerosol-based technique for synthesizing magnetite nanoparticles (Fe3O4 NPs) and explores their potential medical applications. The refinement of processing conditions resulted in monodispersed NPs with narrow size distribution. The NPs were coated with TEA-oleate for stability in water dispersion. The study also discovered diverse mechanisms of interaction between cancer and normal cell lines and Fe3O4 NPs, suggesting potential applications in magnetic hyperthermia and magnetic resonance imaging (MRI).
Review
Chemistry, Physical
Abhinandan Banerjee, Barbara Blasiak, Armita Dash, Boguslaw Tomanek, Frank C. J. M. van Veggel, Simon Trudel
Summary: There is a need for non-invasive diagnostic tools, which has led to the use of magnetic resonance imaging (MRI). High-field MRI offers advantages in terms of signal-to-noise ratio and spectral resolution. This review discusses the development of new contrast agents for high-field MRI.
CHEMICAL PHYSICS REVIEWS
(2022)
Article
Oncology
Kenneth F. Fuh, Robert D. Shepherd, Jessica S. Withell, Brayden K. Kooistra, Kristina D. Rinker
Summary: The mechanical interactions between tumor cells and microenvironments during breast cancer progression are not well understood in how they affect EMT. This study found that fluid flow stimulation promotes EMT and adhesion of breast cancer cells to an endothelial monolayer, and identified distinct biomarkers expressed in patient populations.
BREAST CANCER RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
M. Taheri, B. Zanca, M. Dolgos, S. Bryant, S. Trudel
Summary: This research presents the development of highly dispersed nano-sized ferroelectric barium titanate powders using a simple, one-step low temperature solution method. The surface of these nanoparticles was modified with poly(ethylene glycol) as a stabilizer and dispersant. It was demonstrated that changing the reaction conditions allows for tuning the nanoparticle size.
MATERIALS ADVANCES
(2021)
Article
Chemistry, Physical
Martin A. W. Schoen, Oliver Calderon, Nicholas M. Randell, Santiago Jimenez-Villegas, Katelynn M. Daly, Roman Chernikov, Simon Trudel
Summary: Amorphous nickel-iron mixed metal oxides are efficient oxygen evolution reaction catalysts that offer an economical alternative to traditional platinum- or iridium-based catalysts. The synergistic effect between Fe and Ni plays a crucial role in their superior OER performance, with potential- and rate-determining steps occurring at Ni and Fe sites, respectively. However, at higher annealing temperatures, this synergistic effect is suppressed, possibly due to phase separation into NiOx and FeOx phases.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Nanoscience & Nanotechnology
Armita Dash, Barbara Blasiak, Boguslaw Tomanek, Abhinandan Banerjee, Simon Trudel, Peter Latta, Frank C. J. M. van Veggel
Summary: The article demonstrates the synthesis of stable Fe NPs for MRI applications. Different sizes of Fe NPs show high stability against oxidation when dispersed in chloroform and deionized water, exhibiting strong contrast enhancement in MRI. Fe NPs are promising contrast agents for medical imaging.
ACS APPLIED NANO MATERIALS
(2021)
