The Pro-inflammatory Effects of Glucocorticoids in the Brain

Phosphorylation of glucocorticoid receptor tau1c transactivation domain enhances binding to CREB binding protein (CBP) TAZ2

(2015) Carl W. Carruthers et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

(2015) M. D. Weber et al.   JOURNAL OF NEUROSCIENCE

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres

(2015) Simona Boncompagni et al.   JOURNAL OF PHYSIOLOGY-LONDON

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia

(2015) Ruth M. Barrientos et al.   NEUROBIOLOGY OF AGING

One Hormone, Two Actions: Anti- and Pro-Inflammatory Effects of Glucocorticoids

(2015) Diana Cruz-Topete et al.   NEUROIMMUNOMODULATION

Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds

(2015) Nora Sundahl et al.   PHARMACOLOGY & THERAPEUTICS

Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target

(2014) Enrica Golia et al.   Current Atherosclerosis Reports

Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease

(2014) Nathalie Esser et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Glucocorticoids Increase Excitotoxic Injury and Inflammation in the Hippocampus of Adult Male Rats

(2014) Shawn F. Sorrells et al.   NEUROENDOCRINOLOGY

Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

(2014) Jannie Pedersen et al.   TRENDS IN MOLECULAR MEDICINE

Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge

(2013) Michael D. Weber et al.   BRAIN BEHAVIOR AND IMMUNITY

Aldosterone Mediates Cardiac Fibrosis in the Setting of Hypertension

(2013) Feriel Azibani et al.   CURRENT HYPERTENSION REPORTS

The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease

(2013) Robert H. Oakley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Glucocorticoid Signaling in Myeloid Cells Worsens Acute CNS Injury and Inflammation

(2013) S. F. Sorrells et al.   JOURNAL OF NEUROSCIENCE

Severe asthma: from characteristics to phenotypes to endotypes

(2012) S. Wenzel   CLINICAL AND EXPERIMENTAL ALLERGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells

(2012) Boonrat Chantong et al.   Journal of Neuroinflammation

Mifepristone Inhibits GRβ Coupled Prostate Cancer Cell Proliferation

(2012) Martin Ligr et al.   JOURNAL OF UROLOGY

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

(2012) Dariusz Ratman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver

(2012) Debra C. DuBois et al.   STEROIDS

Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses

(2011) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Rapid signaling of steroid hormones in the vertebrate nervous system

(2011) Hirotaka Sakamoto   Frontiers in Bioscience-Landmark

Glucocorticoids Sensitize the Innate Immune System through Regulation of the NLRP3 Inflammasome

(2011) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Glucocorticoids in the Control of Neuroinflammation

(2011) N. Schweingruber et al.   JOURNAL OF NEUROENDOCRINOLOGY

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Eplerenone Survival Benefits in Heart Failure Patients Post-Myocardial Infarction Are Independent From its Diuretic and Potassium-Sparing Effects

(2011) Patrick Rossignol et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

(2011) Sam John et al.   NATURE GENETICS

Innate immunity and adjuvants

(2011) S. Akira   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs

(2011) Min-Dian Li et al.   PPAR Research

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of Glucocorticoids

(2010) Robert H. Oakley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo

(2010) Matthew G. Frank et al.   JOURNAL OF NEUROIMMUNOLOGY

Synaptic Correlates of Increased Cognitive Vulnerability with Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst Late-Phase Long-Term Potentiation in Hippocampal Area CA1

(2010) T. R. Chapman et al.   JOURNAL OF NEUROSCIENCE

Glucocorticoids Exacerbate Lipopolysaccharide-Induced Signaling in the Frontal Cortex and Hippocampus in a Dose-Dependent Manner

(2010) C. D. Munhoz et al.   JOURNAL OF NEUROSCIENCE

Dexamethasone Enhances ATP-Induced Inflammatory Responses in Endothelial Cells

(2010) Y. Ding et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Aldosterone: effects on the kidney and cardiovascular system

(2010) Marie Briet et al.   Nature Reviews Nephrology

Myeloid-Specific Deletion of the Mineralocorticoid Receptor Reduces Infarct Volume and Alters Inflammation During Cerebral Ischemia

(2010) Ryan A. Frieler et al.   STROKE

Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide

(2009) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Crosstalk in Inflammation: The Interplay of Glucocorticoid Receptor-Based Mechanisms and Kinases and Phosphatases

(2009) Ilse M. E. Beck et al.   ENDOCRINE REVIEWS

Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury

(2009) Seija Lehnardt   GLIA

The Stressed CNS: When Glucocorticoids Aggravate Inflammation

(2009) Shawn F. Sorrells et al.   NEURON

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

(2009) S. H. Meijsing et al.   SCIENCE

ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO

(2009) Marieke A.D. van Zoelen et al.   SHOCK

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE