Review
Endocrinology & Metabolism
Jan-Inge Bjune, Pouda Panahandeh Stromland, Regine Asen Jersin, Gunnar Mellgren, Simon Nitter Dankel
Summary: Sex hormones play an important role in the differences between males and females in terms of body fat distribution and associated disease risk. Estrogen, in particular, is associated with more fat storage on hips and thighs rather than in visceral depots. It exerts its effects on adipocytes through estrogen receptors, protecting against adipose inflammation and fibrosis. The exact mechanisms of estrogen-dependent body fat distribution are not fully understood but involve signaling pathways, autophagy suppression, and epigenetic regulation. More research is needed to understand the specific effects of estrogen on different adipocyte subtypes and its role in sexual dimorphisms and obesity-related disease risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Zeltzin Ceja-Galicia, Diana Calderon-DuPont, Alberto Daniel, Luz Maria Chiu, Andrea Diaz-Villasenor
Summary: This study evaluated the expression of leptin and adiponectin in mature 3T3-L1 adipocytes exposed to palmitate, arsenite, or both. The results showed that the secretion of leptin and adiponectin was decreased, which could result in reduced satiety and decreased insulin sensitivity.
Article
Neurosciences
Cheng-Chun Liu, Qing-Hua Wang, Jia-Yan Xin, Yu-Hao Liu, Fan Zeng, Dong-Wan Chen, Hui-Yun Li, Xu Yi, Gui-Hua Zeng, Yan-Jiang Wang, Yang Xiang, Yang Chen
Summary: This study investigated the associations between adiponectin, leptin, and resistin levels and Alzheimer's Disease (AD). The results showed that plasma adiponectin and leptin levels were associated with the presence, symptomatic severity, and diagnostic power of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Oncology
Xi Pu, Deyu Chen
Summary: Obesity is a global epidemic and closely related to the occurrence and development of various tumors, adipokines secreted by adipocytes and insulin/IGF play important roles in tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Annamaria Schaffer, Eszter Ducza, Nikolett Bodi, Maria Bagyanszki, Zita Szalai, Mohsen Mirdamadi, Tamara Barna, Kalman F. Szucs, Robert Gaspar
Summary: Leptin and adiponectin play a role in the relaxation of the pregnant uterus, but their efficacy decreases towards the end of gestation. The endometrial receptors have a fine-tuning role in uterine contractions, indicating the importance of these adipokines under altered adipokine level conditions.
Review
Nutrition & Dietetics
Vali Musazadeh, Shaghayegh Abbasi, Zeynab Kavyani, Amir Hossein Moridpour, Diba Safarzadeh, Zahra Moradi, Fatemeh Bahadori, Amir Hossein Faghfouri
Summary: This study found that curcumin supplementation can increase serum adiponectin and decrease leptin levels.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Oncology
Wenting Tie, Tao Ma, Zhigang Yi, Jia Liu, Yanhong Li, Jun Bai, Lijuan Li, Liansheng Zhang
Summary: Multiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Obesity increases the risk of MM and worsens outcomes for MM patients, and adipokines play a crucial role in the close association between MM and metabolic derangements. Epidemiologic studies have shown that the risk of MM is increased in obese individuals, and clinical evidence suggests a correlation between adipokines and MM. Adipokines are linked to various aspects of MM, including the behavior of MM cells, bone loss, disease progression, and drug resistance.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Gamze Serarslan, Oguzhan Ozcan, Ebru Okyay, Bahar Unlu, Mehmet Karadag
Summary: This study found that adiponectin and leptin may play a role in the pathogenesis of AA with scalp hair involvement. The results showed significantly higher serum levels of adiponectin and leptin in AA patients.
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Endocrinology & Metabolism
Zongquan Zhao, Yihong Wu, Hao Zhang, Xiaohong Wang, Xiangfan Tian, Yijing Wang, Zhenjuan Qiu, Lingyan Zou, Zhenyuan Tang, Min Huang
Summary: In summary, women with endometriosis have higher levels of leptin and leptin/BMI ratio compared to controls, while they have lower levels of adiponectin. Additionally, patients with advanced-stage endometriosis exhibit significantly lower leptin levels, while adiponectin levels do not significantly differ between advanced and early-stage endometriosis patients.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Huiling Chen, Jiangbin Li, Yanchao Zhang, Wei Zhang, Xing Li, Huanwen Tang, Yungang Liu, Tianlan Li, Haoqi He, Bohai Du, Li Li, Ming Shi
Summary: This study aimed to explore the effects of BPF on glucose metabolism and insulin sensitivity. The results showed that BPF treatment altered the expression of adipokines, impaired the insulin signaling pathway, and reduced insulin-stimulated glucose metabolism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Karel M. Lopez-Vilaret, Jose L. Cantero, Marina Fernandez-Alvarez, Miguel Calero, Olga Calero, Monica Lindin, Montserrat Zurron, Fernando Diaz, Mercedes Atienza
Summary: The study suggests that in cognitively normal older adults, insulin resistance, circulating triglyceride, and glucose levels have an impact on the neuroprotective effect of adipocytokines, indicating that the neuroprotective role of adipocytokines is influenced by multiple factors.
Article
Dermatology
Ke Xue, Shuai Shao, Hui Fang, Lirong Ma, Caixia Li, Zifan Lu, Gang Wang
Summary: This study reveals the link between low CTRP3 levels, adipocyte dysfunction, and the development of psoriasis and metabolic syndrome, suggesting a vicious cycle mechanism between psoriasis and metabolic disorders.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Oncology
Ewa Wolinska, Maciej Skrzypczak
Summary: Hepatocellular carcinoma (HCC) is a life-threatening disease with unsatisfactory treatment outcomes. Epigenetic studies have revealed modified methylation patterns in HCC, dysfunction of enzymes engaged in DNA methylation process, aberrant function of non-coding RNAs, and histone modifications affecting gene expression.
Review
Oncology
Pin Zhao, Samiullah Malik, Shaojun Xing
Summary: Hepatocellular carcinoma (HCC) is predominantly caused by hepatitis C virus (HCV) infection, with chronic infection leading to a higher risk of HCC development. The mechanisms behind HCC in chronic HCV infection involve intricate epigenetic regulation and cellular signaling pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Bradley E. Aouizerat, Eeeseung Byun, Clive R. Pullinger, Caryl Gay, Anners Lerdal, Kathryn A. Lee
Summary: The study found associations between selected genes and plasma markers related to energy homeostasis and sleep disruption in adults with HIV/AIDS. Many of these associations were influenced by HIV disease markers. Higher levels of adiponectin were associated with less wake after sleep onset, while higher levels of ghrelin and glucose were associated with shorter total sleep time, and higher levels of leptin were associated with longer total sleep time.
Article
Biochemical Research Methods
Dan Huang, Xiansong Wang, Yingzhi Liu, Ziheng Huang, Xiaoxu Hu, Wei Hu, Qing Li, Hung Chan, Yidan Zou, Idy H. T. Ho, Yan Wang, Alfred S. L. Cheng, Wei Kang, Ka F. To, Maggie H. T. Wang, Sunny H. Wong, Jun Yu, Tony Gin, Qingpeng Zhang, Zheng Li, Jianxiong Shen, Lin Zhang, Matthew T. Chan, Xiaodong Liu, William K. K. Wu
Summary: Tumor suppressor genes exhibit unique promoter features that optimize cancer resistance by achieving high expression in normal tissues and resisting downregulation during tumorigenesis. The CpG dinucleotide frequencies in TSG promoters are higher and positively correlated with gene expression, suggesting an evolutionary pressure on young TSGs. Higher CpG frequencies and chromatin accessibility are associated with the ability of TSGs to resist downregulation during tumorigenesis.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Cell Biology
Hung Chan, Qing Li, Xiansong Wang, Wing Yingzhi Liu, Wei Hu, Judeng Zeng, Chuan Xie, Thomas Ngai Yeung Kwong, Idy Hiu Ting Ho, Xiaodong Liu, Huarong Chen, Jun Yu, Ho Ko, Raphael Chiu Yeung Chan, Margaret Ip, Tony Gin, Alfred Sze Lok Cheng, Lin Zhang, Matthew Tak Vai Chan, Sunny Hei Wong, William Ka Kei Wu
Summary: Clostridioides difficile infection (CDI) is a common cause of nosocomial diarrhea. TcdB impairs lysosomal function in macrophages, leading to inflammation. Vitamin D-3 and carbamazepine protect against CDI by restoring lysosomal function and the expression of the transcription factor MITF in macrophages.
Article
Oncology
Feng Wu, Liangliang Xu, Yalin Tu, Otto K. W. Cheung, Lemuel L. M. Szeto, Myth T. S. Mok, Weiqin Yang, Wei Kang, Qin Cao, Paul B. S. Lai, Stephen L. Chan, Patrick Tan, Joseph J. Y. Sung, Kevin Y. Yip, Alfred S. L. Cheng, Ka F. To
Summary: This study identified an average of about 500 somatically-acquired super-enhancers per patient in non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinomas (HCCs), which were functionally enriched for aberrant metabolism and cancer phenotypes. Particularly, SIRT7 played a crucial role in HCC, affecting chromatin regulatory network and potentially serving as a druggable vulnerability.
Article
Chemistry, Multidisciplinary
Philip Chiu-Tsun Tang, Jeff Yat-Fai Chung, Vivian Wei-wen Xue, Jun Xiao, Xiao-Ming Meng, Xiao-Ru Huang, Shuang Zhou, Alex Siu-Wing Chan, Anna Chi-Man Tsang, Alfred Sze-Lok Cheng, Tin-Lap Lee, Kam-Tong Leung, Eric W-F Lam, Ka-Fai To, Patrick Ming-Kuen Tang, Hui-Yao Lan
Summary: This study identified a novel role of macrophage-myofibroblast transition (MMT) in cancer, showing that MMT cells can de novo generate cancer-promoting cancer-associated fibroblasts (CAFs). Through fate-mapping, RNA velocity, and pseudotime analysis, a subset of CAFs derived from macrophages was confirmed in the tumor microenvironment. Targeting Smad3, a key regulator in the MMT process, effectively blocked CAF formation and cancer progression in vivo, suggesting MMT as a potential therapeutic target for cancer immunotherapy.
Article
Oncology
Xiansong Wang, Wei Hu, Xiangchun Li, Dan Huang, Qing Li, Hung Chan, Judeng Zeng, Chuan Xie, Huarong Chen, Xiaodong Liu, Tony Gin, Maggie Haitian Wang, Alfred Sze Lok Cheng, Wei Kang, Ka-Fai To, Dariusz Plewczynski, Qingpeng Zhang, Xiaoting Chen, Danny Cheuk Wing Chan, Ho Ko, Sunny Hei Wong, Jun Yu, Matthew Tak Vai Chan, Lin Zhang, William Ka Kei Wu
Summary: This study reveals that X-linked tumor suppressor genes (TSGs) are under negative selection and have experienced extensive relocation from the X chromosome to autosomes during evolution. X-linked TSGs in mammals are younger or larger in size, and exhibit more frequent nonsynonymous somatic mutations, potentially conferring a survival advantage by evading single-hit inactivation.
Article
Gastroenterology & Hepatology
Xuezhen Zeng, Guanrui Liao, Shumin Li, Haining Liu, Xiao Zhao, Shuang Li, Kai Lei, Shenghua Zhu, Zhihang Chen, Yi Zhao, Xuxin Ren, Tianhong Su, Alfred Sze-Lok Cheng, Sui Peng, Shuibin Lin, Ji Wang, Shuling Chen, Ming Kuang
Summary: METTL1 plays a role in shaping the immunosuppressive tumor microenvironment after insufficient RFA, influencing tumor recurrence and treatment efficacy.
Article
Oncology
Tian Liu, Yubing Wang, Yiwei Wang, Stanley Kwok-Kuen Cheung, Penelope Mei-Yu Or, Chi-Wai Wong, Jingyu Guan, Zhining Li, Weiqin Yang, Yalin Tu, Jing Wang, Wayne Lut-Heng Ho, Haiwei Gu, Alfred Sze-Lok Cheng, Stephen Kwok-Wing Tsui, Andrew M. Chan
Summary: Weighted gene co-expression network analysis (WGCNA) identified a cell-cycle module associated with poor prognosis and aggressiveness of glioma. Within this module, Regulator of chromatin condensation 2 (RCC2) serves as a core member and plays a vital role in the mitotic process. Abnormal RCC2 expression is involved in cancer development. Gene silencing experiments confirm the importance of RCC2 in glioma cell proliferation and migration. RNA-Sequencing analysis reveals that RCC2 has a dual role in the cell cycle and metabolism.
Article
Biotechnology & Applied Microbiology
Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-lok Cheng
Summary: The local microenvironment where tumors develop can affect cancer progression and treatment outcomes. In hepatocellular carcinoma (HCC), which often develops in a liver fibrotic environment, nanodelivery of a PD-L1 trap gene shows superior efficacy compared to conventional monoclonal antibodies in treating fibrosis-associated HCC.
Editorial Material
Gastroenterology & Hepatology
Alfred Sze-Lok Cheng
Article
Gastroenterology & Hepatology
Zhiwu Tan, Mei Sum Chiu, Xinxiang Yang, Ming Yue, Tan To Cheung, Dongyan Zhou, Yuewen Wang, Anthony Wing-Hung Chan, Chi Wing Yan, Ka Yi Kwan, Yik Chun Wong, Xin Li, Jingying Zhou, Ka Fai To, Jiye Zhu, Chung Mau Lo, Alfred Sze-Lok Cheng, Stephen Lam Chan, Li Liu, You-Qiang Song, Kwan Man, Zhiwei Chen
Summary: A PD-1 isoform called Delta 42PD-1 plays an important role in the development and resistance to nivolumab immune checkpoint blockade (ICB) in hepatocellular carcinoma (HCC). We investigated the role of Delta 42PD-1 in HCC patients and found that Delta 42PD-1(+) T cells accounted for up to 71% of cytotoxic T lymphocytes in untreated HCC patients and were associated with HCC severity. These Delta 42PD-1(+) T cells were more exhausted than PD-1(+) T cells. HCC patients treated with anti-PD-1 ICB showed increased frequencies of Delta 42PD-1(+) T cells over time, especially in patients with progressive disease. Delta 42PD-1(+) T cells sustained HCC through toll-like receptor 4 signaling. An anti-Delta 42PD-1 antibody inhibited tumor growth in murine HCC models.
Article
Chemistry, Medicinal
Ping Sun, Jing Wang, Khadija S. Khan, Weiqin Yang, Billy Wai-Lung Ng, Nikita Ilment, Matthes Zessin, Emre F. Buelbuel, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Mike Schutkowski, Alfred Sze-Lok Cheng, Wolfgang Sippl
Summary: This study identifies a HDAC8 inhibitor with T cell modulatory properties and demonstrates its potential in reducing hepatocellular carcinoma tumorigenicity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Ping Gu, Kai Ding, Lei Lu, Yu Zhang, Wei Wang, Qingyu Guo, Yannian Liao, Bingjie Yang, Tiantian Wang, Changsheng Zhou, Bin Lu, Alice P. S. Kong, Alfred S. Cheng, Hannah Xiaoyan Hui, Jiaqing Shao
Summary: This study investigated the expressions of major brown adipose markers in white adipose tissue (WAT) of different ages and their associations with metabolic parameters and key adipokines. The findings suggest that UCP1 and PRDM16 have differential clinical correlations with metabolic features in human WAT in an age-dependent manner. UCP1 and PRDM16 may participate in the pathogenesis of ageing-related metabolic diseases with distinct mechanisms.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Yalin Tu, Zhewen Xiong, Chengpeng Zhong, Haoran Wu, Jing Wang, Patrick Pak-Chun Wong, Weiqin Yang, Jingying Zhou, Ka-Fai To, Joseph Sung, Stephen Lam Chan, David Kerr, Nick La Thangue, Alfred Sze-Lok Cheng
Article
Medicine, Research & Experimental
Yifei Wang, Huarong Chen, Weixin Liu, Huan Yan, Yihan Zhang, Alvin H. K. Cheung, Jinglin Zhang, Bonan Chen, Li Liang, Zhaocai Zhou, Chi Chun Wong, William K. K. Wu, Michael W. Y. Chan, Alfred S. L. Cheng, Brigette B. Y. Ma, Jun Yu, Kwok Wai Lo, Ka Fai To, Wei Kang
Summary: This study reveals the importance of the YAP-MCM6 axis in gastric cancer, where YAP hyperactivation induces MCM6 transcription. Increased expression of MCM6 is associated with poor prognosis in gastric cancer patients and promotes the proliferation and metastasis of gastric cancer cells through the PI3K/Akt signaling pathway. Inhibition of MCM6 suppresses gastric cancer growth and enhances sensitivity to genotoxic agents by modulating the ATR/Chk1-dependent DNA damage response.
Article
Immunology
Wenshu Tang, Jingying Zhou, Weiqin Yang, Yu Feng, Haoran Wu, Myth T. S. Mok, Lingyun Zhang, Zhixian Liang, Xiaoyu Liu, Zhewen Xiong, Xuezhen Zeng, Jing Wang, Jiahuan Lu, Jingqing Li, Hanyong Sun, Xiaoyu Tian, Philip Chun Yeung, Yong Hou, Heung Man Lee, Candice C. H. Lam, Howard H. W. Leung, Anthony W. H. Chan, Ka Fai To, John Wong, Paul B. S. Lai, Kelvin K. C. Ng, Simon K. H. Wong, Vincent W. S. Wong, Alice P. S. Kong, Joseph J. Y. Sung, Alfred S. L. Cheng
Summary: Obesity and hypercholesterolemia are major risk factors for hepatocellular carcinoma. This study found that obesity leads to hepatic cholesterol accumulation, which suppresses natural killer T (NKT) cell-mediated antitumor immunosurveillance. By lowering cholesterol and inhibiting cholesterol biosynthesis, the function of NKT cells can be restored to prevent HCC development promoted by obesity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)