Article
Geriatrics & Gerontology
Dan Xie, Xuefan Wang, Yao Li, Ruiling Chen, Yingying Zhao, Chunling Xu, Qian Zhang, Yongbo Zhang
Summary: This case report demonstrates the safety and effectiveness of using idarucizumab to reverse dabigatran anticoagulation in patients with atrial fibrillation who develop acute ischemic stroke requiring rt-PA intravenous thrombolysis. The patient showed significant improvement after the treatment and was discharged after two weeks.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Senta Frol, Dimitrios Sagris, Janja Pretnar Oblak, Miso Sabovic, George Ntaios
Summary: This systematic review evaluated the safety and efficacy of IVT in dabigatran-treated AIS patients after idarucizumab reversal. The rates of HT, SICH, and mortality, as well as NIHSS reduction, were comparable with previous studies in non-anticoagulated patients, providing reassuring evidence about the safety and efficacy of this therapeutic strategy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Senta Frol, Lana Podnar Sernec, Liam Korosec Hudnik, Miso Sabovic, Janja Pretnar Oblak
Summary: Idarucizumab use in dabigatran-treated patients with AIS resulted in significantly more efficacious intravenous thrombolysis treatment and a non-significantly better outcome in dabigatran-treated patients with ICH compared with controls. There was no difference regarding complications.
Article
Cardiac & Cardiovascular Systems
Senta Frol, Janja Pretnar Oblak, Miso Sabovic, Pawel Kermer
Summary: This article reviews the progress of using idarucizumab to reverse dabigatran anticoagulant effects and discusses its application in patients with acute ischemic stroke and intracranial hemorrhage. Based on two clinical cases, standard operating procedures are provided, and evidence is summarized that idarucizumab application can reduce mortality rate and improve functional recovery in stroke patients.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Immunology
Dehao Yang, Honghao Huang, Yiyun Weng, Junli Ren, Chenguang Yang, Jianing Wang, Beibei Gao, Tian Zeng, Jingyu Hu, Wenjing Pan, Fangyue Sun, Xinbo Zhou, Guangyong Chen
Summary: The study found that dynamic decrease in eosinophil after intravenous thrombolysis in AIS patients with r-tPA treatment can predict a 3-month poor outcome and death, and it also improves the predictive ability of conventional model. However, this result should be interpreted cautiously in non-cardioembolic AIS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Charith Cooray, Michal Karlinski, Adam Kobayashi, Peter Ringleb, Janika Korv, Mary J. Macleod, Anand Dixit, Elsa Azevedo, Christopher Bladin, Niaz Ahmed
Summary: In acute ischemic stroke patients treated with intravenous thrombolysis, those with prestroke disability did not have a significantly increased risk of symptomatic intracerebral hemorrhage or parenchymal hemorrhage. However, they were associated with a higher risk of early mortality compared to patients without prestroke disability.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Medicine, General & Internal
Nat Satumanatpan, Warinyupa Tonpho, Nutchanon Thiraratananukulchai, Pheerawat Chaichanamongkol, Pittawat Lekcharoen, Kitti Thiankhaw
Summary: This study found that older age, diabetes, atrial fibrillation, higher admission NIHSS, and lower ASPECTS on the initial NCCT brain were related to unfavorable functional outcomes following IVT.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Clinical Neurology
Yuan Shen, Zhifeng Dong, Gang Xu, Jianguo Zhong, Pinglei Pan, Zhipeng Chen, Haicun Shi
Summary: This study found that intracranial carotid artery calcification (ICAC) is closely related to the prognosis of acute ischemic stroke (AIS) after intravenous thrombolysis (IVT). The high calcification burden (HCB) group had higher incidence of atrial fibrillation and coronary heart disease compared to the low calcification burden (LCB) group, as well as higher serum homocysteine and hemoglobin A1c levels. Atrial fibrillation and HbA1c were independent risk factors for ICAC. After adjusting for other risk factors, symptomatic-side and bilateral ICACs were independent risk factors for poor prognosis and mortality in AIS patients who received IVT.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Igor Sibon, Mikael Mazighi, Didier Smadja
Summary: This paper proposes algorithms for stroke management in patients on anticoagulation based on current guidelines and published data. Reversion can be achieved with specific antidotes for patients on non-vitamin K oral anticoagulants. The time since symptom onset may be taken into account to optimize intracerebral hemorrhage management.
FRONTIERS IN NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Jiali Xie, Chunyang Pang, Huan Yu, Wanli Zhang, Chuancheng Ren, Binbin Deng
Summary: This study shows that leukocytes, especially leukocyte count, neutrophil count, and the NLR, are independently associated with hemorrhagic transformation (HT) and functional outcomes in stroke patients.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Medicine, General & Internal
Xue Jia, Wen Wang, Bo Wu, Xin Sun
Summary: The study shows that IVT in patients with stroke onset for >4.5 h can improve functional outcomes at 90 days, but may increase the risk of symptomatic intracerebral hemorrhage. Care for these patients should carefully balance the potential benefits and harms of IVT.
CHINESE MEDICAL JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Houwei Du, Hanhan Lei, Gareth Ambler, Shuangfang Fang, Raoli He, Qilin Yuan, David J. Werring, Nan Liu
Summary: This meta-analysis comparing direct mechanical thrombectomy (dMT) to bridging therapy (BT) in acute ischemic stroke patients found no significant differences in 90-day functional outcome or mortality, but a lower rate of symptomatic intracranial hemorrhage in the dMT group.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Marcin Wnuk, Justyna Derbisz, Leszek Drabik, Maciej Malecki, Agnieszka Slowik
Summary: The study demonstrated that fasting normoglycemia after intravenous thrombolysis for acute ischemic stroke is associated with a favorable long-term outcome, and it acts as an independent protective factor specifically for non-diabetic patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Rajeel Imran, Ghada A. Mohamed, Fadi Nahab
Summary: The field of acute stroke treatment has seen significant progress, particularly in understanding the pathophysiology of acute ischemic injury and neuroimaging thrombolysis therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Yiyun Weng, Yufan Gao, Mingyue Zhao, Tian Zeng, Jiaqi Huang, Haobo Xie, Jiexi Huang, Yiqun Chen, Xiaoya Hu, Jiahan Xu, Jinrong Zhu, Suichai Lin, Tingting Ke, Xiang Li, Xu Zhang
Summary: This study aimed to investigate the prognostic value of white blood cell count to mean platelet volume ratio (WMR) in patients with acute ischemic stroke (AIS). The results showed that WMR was significantly correlated with stroke severity and was an independent risk factor for poor prognosis at 3 months. The study also found a significant association between WMR and poor outcome in patients with high baseline stroke severity. A nomogram that included age, sex, NIHSS on admission, and high WMR was developed to predict 1-year survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
A. Karamyan, H. Brandtner, S. Grinzinger, V. Chroust, C. Bacher, F. Otto, M. Reisp, L. Hauer, J. Sellner
ACTA NEUROLOGICA SCANDINAVICA
(2017)
Article
Neurosciences
Thomas Seifert-Held, Beate J. Langner-Wegscheider, Martina Komposch, Philipp Simschitz, Claudia Franta, Barbara Teuchner, Hans Offenbacher, Ferdinand Otto, Johann Sellner, Helmut Rauschka, Franz Fazekas
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2017)
Review
Clinical Neurology
Muhammad Faraz Raghib, Johannes Sebastian Mutzenbach, Cornelia Roesler, Ferdinand Otto, Mark Mc Coy, Erasmia Mueller-Thies-Broussalis, Slaven Pikija
JOURNAL OF CLINICAL NEUROSCIENCE
(2018)
Article
Immunology
Georg Pilz, Peter Wipfler, Ferdinand Otto, Wolfgang Hitzl, Shahrzad Afazel, Elisabeth Haschke-Becher, Eugen Trinka, Andrea Harrer
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Neurosciences
Tobias Moser, Gayane Harutyunyan, Anush Karamyan, Ferdinand Otto, Carola Bacher, Vaclav Chroust, Markus Leitinger, Helmut E. Novak, Eugen Trinka, Johann Sellner
Article
Immunology
Georg Pilz, Regina Steger, Peter Wipfler, Ferdinand Otto, Shahrzad Afazel, Elisabeth Haschke-Becher, Eugen Trinka, Andrea Harrer
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Editorial Material
Clinical Neurology
Ferdinand Otto, Tobias Moser, Julia Feige, Michael Seiberl, Lara Bieler, Johann Sellner
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Medicine, General & Internal
Ferdinand Otto, Christine Harrer, Georg Pilz, Peter Wipfler, Andrea Harrer
Summary: Cerebrospinal fluid (CSF) has seen a resurgence in diagnostics and research, but advancements in CSF cell analysis have been limited. While CSF cell count and cytology have been central in diagnosing CNS diseases, the lack of incorporation of modern immune phenotyping technologies has left valuable information unexplored. This gap is particularly concerning given the important role of CSF cells in CNS immune defense and autoimmune processes, as well as the diagnostic challenges posed by overlapping infectious and immune-mediated CNS diseases.
Article
Clinical Neurology
Tobias Moser, Ferdinand Otto, Ciara O'Sullivan, Wolfgang Hitzl, Georg Pilz, Andrea Harrer, Eugen Trinka, Peter Wipfler
Summary: Despite concomitant anti-CD20 therapy, people with multiple sclerosis (pwMS) still exhibit humoral response to recall antigens from COVID-19 booster vaccines. This finding could have implications in the management of individuals about to start B cell medications.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Review
Cell Biology
Christine Harrer, Ferdinand Otto, Richard Friedrich Radlberger, Tobias Moser, Georg Pilz, Peter Wipfler, Andrea Harrer
Summary: This review summarizes the recent advances in our understanding of the CXCL13/CXCR5 immune axis and its role in vaccination, autoimmunity, and infection, with a special focus on its relevance for intrathecal B cell activities in inflammatory CNS diseases.
Article
Clinical Neurology
Tobias Moser, Ciara O'Sullivan, Ferdinand Otto, Wolfgang Hitzl, Georg Pilz, Kerstin Schwenker, Cornelia Mrazek, Elisabeth Haschke-Becher, Eugen Trinka, Peter Wipfler, Andrea Harrer
Summary: The inhibition of humoral responses to COVID-19 vaccines induced by anti-CD20 therapy is transient, and antibody production is more pronounced after discontinuation of anti-CD20 treatment for 18 months. The immunological effect on B-cell counts appears to wane by the same time.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Eirini Mylonaki, Michael Seiberl, Neil Jones, Heike Bernhard, Ferdinand Otto, Georg Pilz, Eugen Trinka, Peter Wipfler
Summary: Tick-borne encephalitis is a common viral disease transmitted by ticks in Middle-East Europe and North Asia. This case report from Austria highlights the importance of considering tick-borne encephalitis in the differential diagnosis of febrile diseases and the potential transmission through unpasteurized dairy products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Christine Harrer, Ferdinand Otto, Georg Pilz, Elisabeth Haschke-Becher, Eugen Trinka, Wolfgang Hitzl, Peter Wipfler, Andrea Harrer
Summary: The study found a strong correlation between intrathecal CXCL13 elevations and CXCR5+CD4 T cell frequencies in CSF, suggesting recruitment of possible professional B cell helpers to the inflamed CNS, which is important for infection control, chronic inflammation, and CNS autoimmunity.
FLUIDS AND BARRIERS OF THE CNS
(2021)
Article
Clinical Neurology
Barbara Ladisich, Ferdinand Otto, Lukas Machegger, Waltraud Kleindienst, Eugen Trinka, Giorgi Kuchukhidze
EPILEPSY & BEHAVIOR REPORTS
(2020)
Article
Virology
Eirini Mylonaki, Andrea Harrer, Georg Pilz, Patrick Stalzer, Ferdinand Otto, Eugen Trinka, Peter Wipfler
JOURNAL OF CLINICAL VIROLOGY
(2020)
