Article
Clinical Neurology
Miaomiao Yang, Wei Zhong, Wenhui Zou, Jingzi Peng, Xiangqi Tang
Summary: This study aimed to establish a nomogram to predict the probability of hemorrhagic transformation (HT) after intravenous thrombolysis in patients with ischemic stroke. Early infarct signs, NIHSS scores, uric acid, and albumin-to-globulin ratio were identified as independent predictors for HT, and a nomogram was constructed. The nomogram showed good discriminative performance, calibration performance, and clinical validity in both the training and validation cohorts.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Sarah Gelhard, Roxane-Isabelle Kestner, Moritz Armbrust, Helmuth Steinmetz, Christian Foerch, Ferdinand O. Bohmann
Summary: This study evaluated the risk of hemorrhagic transformation (HT) and worsening functional outcome after rt-PA treatment in experimental ischemic stroke, with or without additional hyperglycemia. Hyperglycemia was found to be a risk factor for neurological deterioration after rt-PA treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Chunmiao Duan, Yunyun Xiong, Hong-Qiu Gu, Shang Wang, Kai-Xuan Yang, Manjun Hao, Xingquan Zhao, Xia Meng, Yongjun Wang
Summary: This study aimed to investigate the short-, medium-, and long-term outcomes of intravenous thrombolysis in minor stroke patients. The results suggest that intravenous thrombolysis may be safe and effective in improving functional outcomes in minor stroke patients within a 4.5-h window. However, further randomized controlled trials are needed for validation. The functional recovery rate in the overall study population ranged from 12.8% to 18.85%.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Tianyu Jin, Danyu Chen, Zhicai Chen, Dujin Feng, Manqi Zheng, Peng Wang, Chao Xu
Summary: This study investigated the association of post-thrombolytic D-dimer elevation with symptomatic intracranial hemorrhage (sICH) and functional outcome in patients with acute ischemic stroke receiving intravenous thrombolysis. The study found that elevated post-thrombolytic D-dimer levels were associated with sICH and poor functional outcome, and Delta D-dimer was a better predictive biomarker for long-term outcome at 3 months.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Geriatrics & Gerontology
Junfeng Liu, Yanan Wang, Jing Li, Shanshan Zhang, Qian Wu, Chenchen Wei, Ting Cui, Bo Wu, Joshua Z. Willey, Ming Liu
Summary: This study investigated the current management of thrombolysis related hemorrhagic transformation (HT) in real-world practice and found that refusing treatment increased the risk of 3-month death and hematoma expansion. The study also revealed the occurrence of hematoma expansion among asymptomatic HT patients in non-western populations.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Peripheral Vascular Disease
Yao Yu, Fu-Liang Zhang, Yin-Meng Qu, Peng Zhang, Hong-Wei Zhou, Yun Luo, Yan Wang, Jia Liu, Hai-Qiang Qin, Zhen-Ni Guo, Yi Yang
Summary: This study investigated the relationship between calcification in the main cerebral vessels and hemorrhagic transformation following thrombolysis treatment. The results showed that calcification volume on the lesion side was associated with hemorrhagic transformation, and an increased number of calcified vessels correlated with a higher risk of poor prognosis.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Clinical Neurology
Yuxuan Tian, Qianqian Xie, Jiulin You, Shaonan Yang, Hongqin Zhao, Yuqiang Song
Summary: The study found that in patients with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT), lower levels of serum uric acid (UA) were associated with hemorrhagic transformation (HT), indicating that patients with low UA levels are more likely to experience HT.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Bartosz Jablonski, Anna Gojska-Grymajlo, Daria Ossowska, Edyta Szurowska, Adam Wyszomirski, Bartlomiej Rojek, Bartosz Karaszewski
Summary: This study investigated the relationship between rtPA administration in AIS patients and the appearance of new CMBs, as well as the association between the initial load of CMBs and hemorrhagic transformation.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Miaomiao Yang, Lisha Tang, Zhiping Hu, Xiangqi Tang
Summary: Neuroimaging techniques and related parameters have potential value in predicting hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke. Understanding the predictive performance of these parameters can help assess the risk of hemorrhagic transformation and guide treatment decisions.
CEREBROVASCULAR DISEASES
(2023)
Article
Geriatrics & Gerontology
Xiaoqing Chen, Xiangchou Yang, Xia Xu, FangWang Fu, Xiangwei Huang
Summary: This study aimed to explore the relationship between serum bilirubin and hemorrhagic transformation (HT) after intravenous thrombolysis in patients with acute ischemic stroke. The results showed that patients with higher serum bilirubin levels had an increased risk of HT and symptomatic intracranial hemorrhage (sICH). This suggests a linear relationship between serum bilirubin levels and the risk of HT and sICH in patients with acute ischemic stroke undergoing intravenous thrombolysis.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Y-S Lei, H. Li, J-Y Lei, S-X Li, D-F Li
Summary: The safety and efficacy of intravenous thrombolysis with rt-PA in patients with acute ischemic stroke and cerebral microbleeds were investigated, and the risk factors for hemorrhagic transformation were analyzed. The results showed that intravenous thrombolysis with rt-PA significantly improved short-term neurological function recovery and long-term prognosis, with no statistically significant differences in the incidence and mortality rates of ICH. Furthermore, the time from stroke onset to thrombolysis, baseline NIHSS score, and history of atrial fibrillation were identified as independent risk factors for hemorrhagic transformation in patients treated with intravenous thrombolysis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Geriatrics & Gerontology
Yiqiao Wang, Xiaoting Yan, Jie Zhan, Peiming Zhang, Guangming Zhang, Shuqi Ge, Hao Wen, Lin Wang, Nenggui Xu, Liming Lu
Summary: This study revealed that AIS patients with neuroimaging markers of CSVD are at increased risk of hemorrhagic transformation and poor functional outcome at 3 months, especially for patients with a CSVD score of 2-4.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Nat Satumanatpan, Warinyupa Tonpho, Nutchanon Thiraratananukulchai, Pheerawat Chaichanamongkol, Pittawat Lekcharoen, Kitti Thiankhaw
Summary: This study found that older age, diabetes, atrial fibrillation, higher admission NIHSS, and lower ASPECTS on the initial NCCT brain were related to unfavorable functional outcomes following IVT.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Cell Biology
Hongyang Fan, Xiaojie Liu, Sai Li, Peipei Liu, Yuxia Song, Haili Wang, Xiaojia Tang, Yuhan Luo, Jun Li, Yan Zhu, Yingzhu Chen
Summary: This study found that high RDW levels may be an independent predictor of hemorrhagic transformation (HT) in stroke patients after thrombolysis. High RDW levels were positively associated with the occurrence of HT and symptomatic HT.
Article
Clinical Neurology
Miaomiao Yang, Lisha Tang, Shijia Bing, Xiangqi Tang
Summary: This study explores the relationship between the fibrinogen-to-albumin ratio (FAR), a novel systemic inflammation biomarker, and hemorrhagic transformation (HT) after intravenous thrombolysis in patients with ischemic stroke. The results showed that a higher FAR level is significantly associated with an increased risk of HT.
NEUROLOGICAL SCIENCES
(2023)
Article
Cell Biology
Huan Yu, Hui Li, Xiaoqian Liu, Xiaoli Du, Binbin Deng
Article
Clinical Neurology
Zhifang Pan, Xueming Zhang, Xun Wang, Binbin Deng, Wanli Zhang, Huanjie Huang
PARKINSONS DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Ya-Ying Zeng, Wen-Bo Zhang, Lin Cheng, Li Wang, Dan-Dan Geng, Wen-Jie Tang, Jin-Cai He, Bin-Bin Deng
Summary: This study aimed to investigate the prognosis of non-LAA patients and establish a diagnostic model. Logistic regression analysis identified several risk factors associated with prognosis, leading to the development of three predictive models, with model 2 ultimately being considered accurate.
MOLECULAR MEDICINE
(2021)
Article
Clinical Neurology
Xiaohang Li, Chengju Wang, Xueming Zhang, Wanli Zhang, Binbin Deng, Xun Wang, Huanjie Huang
Summary: The incidence of related autonomic damage in PD group is lower than MSA-P group. PD patients have shorter latency period and lower amplitude and elicitation rates in BCR compared to MSA-P patients. Both MSA-P and PD patients have damage to the BCR arc, but the severity is higher in MSA-P patients.
PARKINSONS DISEASE
(2021)
Article
Endocrinology & Metabolism
Yuqin Qian, Yaying Zeng, Qingxia Lin, Huanjie Huang, Wanli Zhang, Huan Yu, Binbin Deng
Summary: The study found that patients with type 2 diabetes mellitus who developed neuropathy had lower levels of platelet count and plateletcrit than healthy controls. Lower PLT and PCT levels were significantly associated with poorer peripheral nerve conduction functions and the presence of neuropathy in type 2 diabetes mellitus patients.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Biotechnology & Applied Microbiology
Qingjia Zeng, Yaying Zeng, Mark Slevin, Baoqiang Guo, Zhipeng Shen, Binbin Deng, Wenbo Zhang
Summary: This study found that in patients with large artery atherosclerosis (LAA)-type acute ischemic stroke (AIS), high CRP levels were positively associated with poor outcomes. This provides clinicians with a basis for making treatment decisions for these patients.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Clinical Neurology
Weilei He, Chunyang Pang, Luowei Chen, Yaying Zeng, Lingfei Gao, Huanjie Huang, Wanli Zhang, Xun Wang, Binbin Deng
Summary: This study investigated the association between low T3 syndrome and DPN in patients with T2DM, and found that low T3 syndrome was independently associated with the occurrence and severity of DPN.
Article
Nutrition & Dietetics
Jiali Xie, Yinmeng Zhu, Chunyang Pang, Lingfei Gao, Huan Yu, Wenjing Lv, Wanli Zhang, Binbin Deng
Summary: Stroke, especially non-cardioembolism, has a high morbidity and mortality rate. Liver function parameters, such as AST and TP, have been found to be independently correlated with the incidence of unfavorable outcomes after stroke. This study provides further understanding of the prognostic factors in stroke and highlights the importance of liver function parameters in predicting functional outcomes.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Cheng-ju Wang, Chun-yang Pang, Huan-Yu, Yi-fan Cheng, Hong Wang, Bin-bin Deng, Huan-jie Huang
Summary: This study conducted in-depth research on the relationship between MLR and prognosis in LAA-type AIS patients for the first time, and found that patients with high MLR had a poor prognosis.
Article
Neurosciences
Qingxia Lin, Kezheng Li, Yinuo Chen, Jiali Xie, Chunxue Wu, Can Cui, Binbin Deng
Summary: Diabetic peripheral neuropathy (DPN) is a common and serious complication of diabetes mellitus. Oxidative stress plays a crucial role in the development of DPN, leading to oxidative damage. This review focuses on the interaction between oxidative stress and other physiological pathways, such as glycolytic pathway, polyol pathway, advanced glycosylation end products, protein kinase C pathway, inflammation, and non-coding RNAs, and discusses potential therapeutic strategies targeting oxidative stress for DPN. Antioxidant supplements, exercise, and novel drug delivery systems are proposed as effective treatment options for DPN through ROS-mediated mechanisms.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Kezheng Li, Yinuo Chen, Jiali Xie, Weiwei Cai, Chunyang Pang, Can Cui, Yu Huan, Binbin Deng
Summary: This review summarizes the knowledge on the interaction between vitamins and diabetic peripheral neuropathy (DPN) and evaluates the clinical evidence supporting the use of vitamins to ameliorate DPN. Vitamins may have potential as therapeutic agents.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Yinuo Chen, Kezheng Li, Wenjing Lv, Jiali Xie, Yuqin Qian, Can Cui, Binbin Deng
Summary: This article discusses the impact of COVID-19 on rare diseases like Guillain-Barre syndrome (GBS) and the occurrence of GBS after COVID-19 vaccination. It highlights the differences between COVID-19-related GBS and GBS without COVID-19 in terms of diagnosis and clinical manifestations. The article also provides insights into the vaccines associated with increased GBS risks, offering guidance for vaccination policies and clinical practice.
MOLECULAR NEUROBIOLOGY
(2023)
