Article
Medicine, General & Internal
Mahdi M. Fadlallah, Darine M. Kharroubi, Zeinab Zeineddine, Sarah M. Salman
Summary: Chryseobacterium indologenes is a rare non-fermenting gram-negative pathogen that can cause nosocomial infections, with high intrinsic resistance to broad-spectrum antibiotics. This study presents the first reported case of C. indologenes infection in Lebanon, successfully treated with ciprofloxacin antibiotic.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Infectious Diseases
Ting-Kuang Yeh, Zong-Hao Li, Yao-Ting Huang, Po-Yu Liu
Summary: A case report is presented of a COVID-19 patient who developed carbapenem-resistant Chryseobacterium indologenes bacteremia, with the detection of bla(CcrA) which is reported for the first time. Antimicrobial resistance is a challenge to global health during the COVID-19 pandemic, and further study and surveillance of underlying mechanisms are needed.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Iradj Ashrafi Tamai, Babak Pakbin, Zahra Ziafati Kafi, Wolfram Manuel Bruck
Summary: This study reported a case of Chryseobacterium indologenes infection in an oral abscess of a ball python, which completely recovered after antibiotic therapy. This suggests that C. indologenes may be an opportunistic animal pathogen with zoonotic potentiality.
Article
Pediatrics
Peng Jiang, Jing Wei
Summary: This study explored the application value of lung ultrasound (LUS) in neonatal ventilator-associated pneumonia (NVAP). The results showed that LUS has higher accuracy and consistency in diagnosing and predicting the outcomes of pneumonia compared to chest X-ray. Therefore, LUS can be considered as the preferred imaging examination for NVAP.
FRONTIERS IN PEDIATRICS
(2022)
Editorial Material
Medicine, General & Internal
Jing Liu, Ru-Xin Qiu
Summary: This paper introduces the typical lung ultrasound findings of Legionella-associated ventilator-associated pneumonia (VAP) in extremely low-birth-weight (ELBW) infants. It provides important reference values for predicting prognosis and shares treatment and management experiences, deepening our understanding of the disease and preventing missed diagnoses.
Article
Microbiology
Fabio Aguiar-Alves, Hoan N. Le, Vuvi G. Tran, Emmanuelle Gras, Trang T. T. Vu, Oliver X. Dong, Josiane Silva Quetz, Lily Cheng, Li Yu, Bret R. Sellman, Charles K. Stover, Antonio DiGiandomenico, Binh An Diep
Summary: The use of MEDI3902 antibody for prophylactic treatment has been shown to protect rabbits from Pseudomonas aeruginosa infection and reduce lung lesions and bacteremia. Compared to MEDI3902 treatment, rabbits treated with irrelevant control IgG exhibited severe pneumonia and systemic pathophysiological changes. These results suggest that MEDI3902 prophylaxis can decrease the severity of P. aeruginosa ventilator-associated pneumonia.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Nursing
Eman Arafa Hassan, Suad Elsayed Abdelmotalb Elsaman
Summary: Compliance with the ventilator bundle was found to be associated with a decreased risk of ventilator-associated events (VAEs) occurrence. Mechanically ventilated patients had a lower likelihood of experiencing VAEs when receiving the ventilator bundle.
Article
Infectious Diseases
Amira Mohamed, Enas Daef, Amany Nafie, Lamia Shaban, Maggie Ibrahim
Summary: This study aimed to investigate the frequency of carbapenem-resistance and the rates of MDR, XDR, and PDR in CR-GNB infections in VAP. The study found a high presence of carbapenem-resistance genes in the isolates, with bla(NDM) being the most predominant gene. All isolates exhibited high resistance to most antibiotics.
Editorial Material
Microbiology
Brianna M. Eales, Vincent H. Tam
Summary: This article presents a challenging case of ventilator-associated pneumonia in which bacteriophage therapy was used as a last resort treatment in combination with systemic antibiotics. The data are promising, and several key areas for future research are highlighted.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Marcelo Silva Folhas Damas, Roumayne Lopes Ferreira, Emeline Boni Campanini, Gabriela Guerrera Soares, Leslie Camelo Campos, Pedro Mendes Laprega, Andrea Soares da Costa, Caio Cesar de Melo Freire, Andre Pitondo-Silva, Louise Teixeira Cerdeira, Anderson Ferreira da Cunha, Maria-Cristina da Silva Pranchevicius
Summary: This study provides a detailed draft genome sequence of a multidrug-resistant Chryseobacterium indologenes strain isolated from a Brazilian Tertiary Hospital, showing its outstanding resistance to a variety of antibiotics and the presence of related resistance and virulence genes.
FRONTIERS IN MEDICINE
(2022)
Article
Fisheries
Yangyang Xing, Mingyang Xue, Zidong Xiao, Xiaowei Hu, Jiale Zhai, Chunjie Zhang, Nan Jiang, Yuding Fan, Yan Meng, Yong Zhou
Summary: In this study, the pathogen causing the death of farmed Pelodiscus sinensis was isolated and identified as Chryseobacterium indologenes. Histopathological analysis revealed the pathological changes in tissues, and antibiotic susceptibility tests showed that the bacteria could be treated with certain antibiotics. These findings contribute to the future diagnosis and treatment of the disease.
JOURNAL OF FISH DISEASES
(2023)
Article
Immunology
Vu Quoc Dat, Lam Minh Yen, Huynh Thi Loan, Vu Dinh Phu, Nguyen Thien Binh, Ronald B. Geskus, Dong Huu Khanh Trinh, Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Nguyen Phu Huong Lan, Tran Phuong Thuy, Nguyen Vu Trung, Nguyen Trung Cap, Dao Tuyet Trinh, Nguyen Thi Hoa, Nguyen Thi Thu Van, Vy Thi Thu Luan, Tran Thi Quynh Nhu, Hoang Bao Long, Nguyen Thi Thanh Ha, Ninh Thi Thanh Van, James Campbell, Ehsan Ahmadnia, Evelyne Kestelyn, Duncan Wyncoll, Guy E. Thwaites, Nguyen Van Hao, Le Thanh Chien, Nguyen Van Kinh, Nguyen Van Vinh Chau, H. Rogier van Doorn, C. Louise Thwaites, Behzad Nadjm
Summary: The study found that continuous cuff pressure control (CPC) using an automated electronic device did not reduce the incidence of ventilator-associated respiratory infection (VARI) in intubated patients compared to intermittent CPC.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Cristina Oana Marginean, Anca Meda Georgescu, Lorena Elena Melit
Summary: Mycoplasma pneumoniae infection in infants is often overlooked and can lead to complications such as arthritis. Early recognition and treatment are crucial in preventing delays in diagnosis and proper management.
Article
Pediatrics
Amrit Tuteja, Femitha Pournami, Anand Nandakumar, Jyothi Prabhakar, Naveen Jain
Summary: The utility of endotracheal aspirates (ETA) for analyzing microbiological yield, incidence, risk factors for ventilator-associated pneumonia (VAP), and clinically relevant outcomes were explored in this study. It was found that gram-negative bacilli were the most common culture yield from ETA in neonates suspected to have VAP. Duration of ventilation and reintubations were identified as significant risk factors for VAP, which could be potentially modified to reduce VAP incidence. Positive ETA culture was associated with longer needs for respiratory supports, while negative ETA culture might encourage clinicians to stop antibiotics.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Critical Care Medicine
Saad Nseir, Ignacio Martin-Loeches, Pedro Povoa, Matthieu Metzelard, Damien Du Cheyron, Fabien Lambiotte, Fabienne Tamion, Marie Labruyere, Demosthenes Makris, Claire Boulle Geronimi, Marc Pinetonde Chambrun, Martine Nyunga, Olivier Pouly, Bruno Megarbane, Anastasia Saade, Gemma Goma, Eleni Magira, Jean-Francois Llitjos, Antoni Torres, Iliana Ioannidou, Alexandre Pierre, Luis Coelho, Jean Reignier, Denis Garot, Louis Kreitmann, Jean-Luc Baudel, Guillaume Voiriot, Damien Contou, Alexandra Beurton, Pierre Asfar, Alexandre Boyer, Arnaud W. Thille, Armand Mekontso-Dessap, Vassiliki Tsolaki, Christophe Vinsonneau, Pierre-Edouard Floch, Loic Le Guennec, Adrian Ceccato, Antonio Artigas, Mathilde Bouchereau, Julien Labreuche, Alain Duhamel, Anahita Rouze
Summary: This study found that VAP was significantly associated with increased 28-day mortality in SARS-CoV-2 patients, but SARS-CoV-2 pneumonia did not significantly modify the relationship between VAP and 28-day mortality compared to influenza pneumonia or no viral infection.
Article
Infectious Diseases
Serdar Pekuz, Ahmet Soysal, Gulsen Akkoc, Serkan Atici, Nurhayat Yakut, Gulsen Altinkanat Gelmez, Eda Kepenekli Kadayifci, Deniz Guneser, Sevliya Ocal Demir, Guner Soyletir, Mustafa Bakir
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Infectious Diseases
Sevliya Ocal Demir, Serkan Atici, Eda Kepenekli Kadayifci, Gulsen Akkoc, Nurhayat Yakut, Feyza Incekoy Girgin, Nilufer Yalindag Ozturk, Ahmet Soysal
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2019)
Article
Pediatrics
Zeynep Alp Unkar, Nur Canpolat, Mine Kucur, Salim Caliskan, Lale Sever
IRANIAN JOURNAL OF PEDIATRICS
(2019)
Article
Infectious Diseases
Jon Salmanton-Garcia, Philipp Koehler, Anupma Kindo, Iker Falces-Romero, Julio Garcia-Rodriguez, Zdenek Racil, Sharon C-A Chen, Nikolai Klimko, Guillaume Desoubeaux, George R. Thompson, Miguel-Angel Benitez-Penuela, Jose-Yesid Rodriguez, Donald C. Sheppard, Martin Hoenigl, Yohann Le Govic, Hamid Badali, John W. Baddley, Jagdish Chander, Paul R. Ingram, Diana L. Pakstis, Sibylle C. Mellinghoff, Serkan Atici, Simone Cesaro, Arunaloke Chakrabarti, Damien Dupont, Gloria M. Gonzalez, Lorant Hatvani, Raoul Herbrecht, Galina Klyasova, Cornelia Lass-Florl, Mihai Mares, Kathleen Mullane, Donald C. Vinh, Hilmar Wisplinghoff, Michaela Lackner, Oliver A. Cornely, Danila Seidel
JOURNAL OF INFECTION
(2020)
Article
Immunology
Yesim Coskun, Serkan Atici
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2020)
Article
Infectious Diseases
Serkan Atici, Omer Faruk Ek, Mehmet Siddik Yildiz, Mehmet Mahfuz Sikgenc, Efraim Guzel, Ahmet Soysal
Summary: Concerns are rising about the risk of COVID-19 recurrence in patients who have recovered. Increased infection and recurrence rates in healthcare workers could lead to healthcare system collapse. Key questions in the COVID-19 pandemic, such as the duration of acquired immunity and severity of recurrence, are still awaiting answers.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2021)
Article
Biotechnology & Applied Microbiology
Erdem Gonullu, Ahmet Soysal, Serkan Atici, Mesut Engin, Osman Yesilbas, Tuba Kasap, Atiye Fedakar, Emre Bilgic, Emine Betul Tavil, Ercan Tutak, Ismail Yildiz, Teoman Akcay, Sebahat Yilmaz Agladioglu, Turan Tunc, Ilkay Can, Metin Karabocuoglu, Nalan Karabayir
Summary: The study found that pediatricians have a high willingness to accept the COVID-19 vaccine for themselves, their families, and pediatric patients. It is crucial to share information about vaccine effectiveness and safety transparently to prevent vaccine hesitancy and anti-vaccine movements.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Genetics & Heredity
Beyhan Tuysuz, Zeynep Alp Unkar, Hande Turan, Alper Gezdirici, Dilek Uludag Alkaya, Busra Kasap, Gozde Yesil, Mehmet Vural, Oya Ercan
Summary: 3M syndrome is a rare genetic disorder characterized by distinctive facial and skeletal features. This study identified new early-diagnostic signs for infants and provided important insights into the long-term follow-up findings of patients with this syndrome.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2021)
Article
Genetics & Heredity
Emre Ozer, Filiz Geyik, Zeynep Alp Unkar, Oya Ercan, Beyhan Tuysuz
Summary: The loss of methylation in the ICR1 of chromosome 11p15.5 is common in Silver-Russell syndrome patients, leading to typical craniofacial features. Maternal uniparental disomy was found in some SRS patients, and detection of typical facial findings is effective in the diagnosis of SRS. In contrast, methylation patterns were not impaired in nonsyndromic IUGR patients. Metabolic problems such as hypercalciuria, insulin resistance, and dyslipidemia were observed in both syndromic and nonsyndromic IUGR patients, emphasizing the importance of monitoring metabolic complications in patients with IUGR.
MOLECULAR SYNDROMOLOGY
(2021)
Article
Genetics & Heredity
Beyhan Tuysuz, Busra Kasap, Dilek Uludag Alkaya, Zeynep Alp Unkar, Pinar Koseoglu, Filiz Geyik, Emre Ozer, Hasan Onal, Alper Gezdirici, Oya Ercan
Summary: Intrauterine onset syndromic short stature is a rare and clinically and molecularly heterogeneous group of diseases. This study aimed to investigate the (epi)genetic causes in children born small for gestational age (SGA) with undiagnosed syndromic short stature. The study identified various genetic variants and copy number variants (CNVs) that contribute to syndromic SGA, including novel genes and CNVs. The study achieved a high diagnosis rate through the use of chromosomal microarray (CMA), epigenetic analysis, and whole exome sequencing (WES).
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2023)
Review
Pediatrics
Serkan Atici, Buket Dalgic
Summary: Analysis on medical costs of patients with acute gastroenteritis in a tertiary center in Turkey showed that a significant percentage of testing and treatment costs were inappropriate according to current guidelines. Health professionals, especially pediatricians, should aim to apply appropriate diagnostic and therapeutic approaches to reduce medical costs and avoid waste in acute gastroenteritis cases.
GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS
(2023)
Article
Pediatrics
Aslan Yilmaz, Nesrin Kaya, Zeynep Alp Unkar, Ersin Ulu, Sumeyye Nur Aydin, Yildiz Perk, Mehmet Vural
Summary: This study aimed to compare the short-term outcomes of infants from a level IIIC neonatal intensive care unit in two different time periods. Cohort data of preterm infants were divided into two periods, and the results showed differences in the prognosis and treatment choices between the two periods. The analysis of neonatal intensive care unit data may provide opportunities for quality improvement projects.
TURKISH ARCHIVES OF PEDIATRICS
(2023)
Article
Pediatrics
Ahmet Soysal, Burcu Topcu, Serkan Atici, Erdem Gonullu, Cevat N. Oner
Summary: Two girls who recovered from MIS-C and were reinfected with SARS-CoV-2 did not experience a recurrence of MIS-C.
ARCHIVOS ARGENTINOS DE PEDIATRIA
(2023)
Article
Parasitology
Serkan Atici, Ahmet Soysal, Erdem Gonullu, Gokhan Aydemir, Naci Oner, Servet Alan, Havva Engin, Melek Yildiz, Metin Karabocuoglu
Summary: Heterologous COVID-19 booster vaccination with BNT162b2 effectively boosts neutralizing antibody levels in individuals primed with the CoronaVac vaccine.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2023)
Article
Pediatrics
Hulya Ozdemir, Hulya Selva Bilgen, Asli Memisoglu, Zeynep Alp Unkar, Ali Mutlu, Eren Ozek
JOURNAL OF PEDIATRIC RESEARCH
(2019)
