Review
Biochemistry & Molecular Biology
Nadia Bolandi, Afshin Derakhshani, Nima Hemmat, Amir Baghbanzadeh, Zahra Asadzadeh, Mina Afrashteh Nour, Oronzo Brunetti, Renato Bernardini, Nicola Silvestris, Behzad Baradaran
Summary: Gastric cancer is the third leading cause of death globally, despite a stable reduction in its incidence. Poor response to common treatments and late diagnosis make it a lethal cancer. The emerging use of immunotherapy and immune checkpoint inhibitors has changed the landscape of treatment for gastric cancer patients, with the manipulation of signals from the B7 family showing significant potential in management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Muhammad Khan, Sumbal Arooj, Hua Wang
Summary: Soluble checkpoint molecules play important roles in immune regulation and anti-cancer immunotherapy, with correlations to tumor progression, metastasis, and prognosis. Understanding their production mechanisms and biological activities may pave the way for their use as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiangyang Deng, Kezhu Chen, Junwei Ren, Jun Zeng, Quan Zhang, Tianwen Li, Qisheng Tang, Jianhong Zhu
Summary: This study systematically analyzed the expression profiles of B7-CD28 gene family and developed a prognostic signature based on this gene family to predict survival and immune host status in diffuse gliomas. The signature showed significant prognostic value and could be used as a biomarker to distinguish pathological grade and gene mutation status. Additionally, the signature was closely related to immune response and immune cell population, indicating its potential as a predictive marker for immunotherapy and tumor microenvironment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bita Amir Taghavi, Nazila Alizadeh, Hossein Saeedi, Noora Karim Ahangar, Afshin Derakhshani, Khalil Hajiasgharzadeh, Nicola Silvestris, Behzad Baradaran, Oronzo Brunetti
Summary: It is estimated that there were 18.1 million cancer cases worldwide in 2018, with about 9 million deaths. Proper diagnosis and treatment are crucial for effective cancer therapy. Immunotherapy, particularly targeting immune checkpoint molecules, has garnered significant attention for its potential in treating various cancers. However, resistance to chemotherapy and immunotherapy is a major challenge in cancer treatment. The B7 family checkpoints have been identified as key players in this resistance, and targeting these molecules may offer a promising approach to overcoming it.
Review
Biochemistry & Molecular Biology
Xin Chen, Jie Li, Yue Chen, Ziting Que, Jiawei Du, Jianqiong Zhang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a low survival rate, and immune checkpoint blockade has shown limited effectiveness in treating it. B7 family immune checkpoints, including PD-L1, PD-L2, B7-H3, B7-H4, VISTA and HHLA2, play a significant role in controlling tumor immune responses. Targeting these checkpoints could lead to novel immunotherapeutic treatments for pancreatic cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Mao Yang, Simeng Tian, Zhoujun Lin, Zhenkun Fu, Chenggang Li
Summary: Accumulating evidence demonstrates the active involvement of vascular inflammation in the pathogenesis of atherosclerosis. Innate antigen-presenting cells (APCs), including dendritic cells, macrophages, and T lymphocytes, play a predominant role in the vascular inflammatory events within atherosclerotic plaques. The interaction between APCs and T cells, mediated by B7-CD28 family members, is crucial for the initiation and progression of vascular inflammation during atherosclerosis formation. Recent studies suggest that targeting costimulatory molecules on APCs and T cells may have therapeutic potential in treating vascular inflammatory diseases, especially atherosclerosis.
Article
Chemistry, Multidisciplinary
Zeyu Jiang, Xiangwu Chen, Yang Lin, Qian Li, Xinxin Nie, Guixiang Xu, Cancan Yu, Xinke Zhang, Yuxia Luan
Summary: A B7-H4 checkpoint-based photodynamic nanodrug combined with NETs-degrading enzyme DNase I is designed for treating immune-cold triple-negative breast cancer (TNBC). This synergistic approach enables cascade amplification of B7-H4 target-based outcomes and disrupts NETs-mediated metastasis, providing a potent strategy to reinvigorate the antitumor immune response and enhance the efficacy of TNBC immunotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Health Care Sciences & Services
Francesca De Felice, Daniela Musio, Vincenzo Tombolini
Summary: Tailored approaches are needed in head and neck cancer management to optimize clinical outcomes. Recent studies focus on the combination of immune check-point inhibitors and (chemo)radiotherapy, aiming to improve survival rates and reduce toxicity for patients. These strategies provide a useful clinical tool for further research in the field.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ranjana K. Kanchan, David Doss, Parvez Khan, Mohd. Wasim Nasser, Sidharth Mahapatra
Summary: The prominent deregulation of B7-H3 in various cancers may lead to tumor growth and metastasis, highlighting the importance of understanding its signaling properties for developing efficacious therapies. The article delves into the ways B7-H3 acts as an immunomodulator to promote tumor development and spread, proposing therapeutic strategies to exploit these interactions and associated limitations.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Oncology
Gaia Zuccolotto, Alessandro Penna, Giulio Fracasso, Debora Carpanese, Isabella Monia Montagner, Silvia Dalla Santa, Antonio Rosato
Summary: Prostate cancer is the second leading cause of malignancy-related mortality in males in the Western world. Although treatments like prostatectomy and radiotherapy are effective for localized cancer, new methods are urgently needed for aggressive and metastatic forms of the disease. A study on third generation CAR-T cells showed that the addition of extra costimulatory elements may lead to increased activation-induced cell death and decreased efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Quanping Su, Jingyi Du, Xingfang Xiong, Xiaoli Xie, Lijuan Wang
Summary: Cancer immunotherapy enhances the body's immunity against tumors by mitigating immune escape and has advantages over traditional chemotherapy. B7-H7 is a member of the B7 family of costimulatory molecules and is widely present in human tumor tissues. B7-H7 promotes tumor progression, inhibits antitumor immunity, and is associated with clinical stage and prognosis. It is a promising immunotherapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
Chuan Liu, Guangwei Zhang, Kanghui Xiang, Yohan Kim, Roxane R. Lavoie, Fabrice Lucien, Ti Wen
Summary: This review discusses the recent results of clinical trials evaluating the antitumor activity and safety of B7-H3 targeting drugs, as well as the challenges and opportunities arising from their application in cancer treatment. Current gaps in understanding the function and regulation of B7-H3 are pointed out as crucial for unleashing the full clinical utility of B7-H3-based therapies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Ganggang Zhang, Bin Lan, Xin Zhang, Mengyao Lin, Yi Liu, Junsong Chen, Fang Guo
Summary: PD-1 and its ligand PD-L1 protect tumor cells from T cell-mediated killing. Understanding the regulatory mechanisms of PD-L1 expression can help develop more effective therapeutic strategies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Noora Karim Ahangar, Nima Hemmat, Mohammad Khalaj-Kondori, Mahdi Abdoli Shadbad, Hani Sabaie, Ahad Mokhtarzadeh, Nazila Alizadeh, Afshin Derakhshani, Amir Baghbanzadeh, Katayoun Dolatkhah, Nicola Silvestris, Behzad Baradaran
Summary: This study reviewed and discussed the regulatory cross-talk between microRNAs and new B7 family immune checkpoint molecules, identifying 27 articles that fulfilled the inclusion criteria. The findings provide valuable insights into the pathogenesis of various human diseases through the interaction between miRs and B7 family molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xiaozhen Zhang, Mengyi Lao, Jian Xu, Yi Duan, Hanshen Yang, Muchun Li, Honggang Ying, Lihong He, Kang Sun, Chengxiang Guo, Wen Chen, Haitao Jiang, Xiaoyu Zhang, Xueli Bai, Tingbo Liang
Summary: Combination therapy with anti-TNFR2 and anti-PD-L1 can eradicate tumors, prolong overall survival, and activate robust antitumor immune response in advanced pancreatic ductal adenocarcinoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Jiajie Luan, Kui Yang, Yanyun Ding, Xiaotong Zhang, Yaqin Wang, Haiju Cui, Deixi Zhou, Lu Chen, Zhangqing Ma, Wusan Wang, Wen Zhang, Xiaoyun Liu
Summary: The study reveals that valsartan chronotherapy can regulate the circadian rhythm of blood pressure by restoring the expression of clock genes in blood vessels.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Cell Biology
Yi-jin Wu, Li Wang, Chao-fan Ji, Shao-fei Gu, Qin Yin, Jian Zuo
Summary: Research suggests that Alpha 7 nicotinic acetylcholine receptor (α7nAChR) plays a crucial role in regulating inflammatory responses, with activation of this receptor significantly reducing inflammation. However, the mechanism through which the cholinergic anti-inflammatory pathway (CAP) curbs excessive pro-inflammatory responses and maintains immune homeostasis is not fully understood, requiring further studies to elucidate.
Article
Immunology
Jian Zuo, Meng-Qing Tao, Xin-Yue Wu, Tian-Tian Jiang, Opeyemi Joshua Olatunji, Jiyang Dong, Jun Han, Cong-Lan Ji
Summary: The bioactive fraction from S. inappendiculata showed joint protective advantages in CIA rats over MTX, with xanthones derived from S. inappendiculata suppressing the erosive nature of synovioblast by regulating PPAR-gamma signaling-controlled metabolism-immunity feedback.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Shu Pan, Yi-Jin Wu, Sa-Sa Zhang, Xiu-Ping Cheng, Opeyemi Joshua Olatunji, Qin Yin, Jian Zuo
Summary: This review summarizes the roles of different T cells and macrophages subsets in the occurrence and progression of RA, and highlights the immune consequences of CAP activation in these cells under RA circumstances. The discussion is intended to inspire the development of novel cell-specific CAP-targeting anti-rheumatic regimens.
NEUROCHEMICAL RESEARCH
(2022)
Article
Immunology
Ming Lei, Meng-Qing Tao, Yi-Jin Wu, Liang Xu, Zhe Yang, Yan Li, Opeyemi Joshua Olatunji, Xiao-Wan Wang, Jian Zuo
Summary: The study found that NAMPT and TPI1 dominate different stages of collagen-induced arthritis (CIA), and both of them similarly provoke monocyte-mediated inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Yuhan Xing, Maggie H. Wang, Ting-Fan Leung, Chun-Kwok Wong, Marjut Roponen, Bianca Schaub, Jing Li, Gary W. K. Wong
Summary: It has been confirmed that living in a rural environment has a protective effect against asthma in children, and exposure to poultry and agricultural farming are the most important factors associated with this protection.
Article
Medicine, Research & Experimental
Qi-Hai Wang, Shu Pan, Xiu-Ping Cheng, Opeyemi Joshua Olatunji, Qingcheng Mao, Jian Zuo
Summary: This study found that rheumatoid arthritis conditions can increase the oral absorption of MTX, and this is related to changes in MTX absorption-related transporters in the intestines. Additionally, glycolysis-driven high energy metabolism can increase the absorption of MTX in rheumatic subjects, leading to exacerbated toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Jing Song, Jing Peng, Xiaoyun Liu, Dexi Zhou, Chunyan Yang, Jiajie Luan
Summary: This study explores the guiding significance of ATP-TCA in the treatment of NSCLC patients with pleural effusion. The results showed that the survival rate of patients in the experimental group was significantly higher than that of patients in the control group, but there was no significant difference in the quality of life between the two groups after treatment.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing Song, Huifang Xu, Wen Zhang, Chunyan Yang, Long Li, Jiajie Luan
Summary: This study conducts a statistical analysis of SLC47A1 gene polymorphism and diabetes patient data, revealing the significant impact of SLC47A1 gene polymorphism on diabetes treatment and highlighting that patients with the AA genotype have the best treatment effect.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Shi Zhao, Zihao Guo, Marc Ka Chun Chong, Daihai He, Maggie H. Wang
Summary: The study found that the SARS-CoV-2 Delta variant has a super-spreading potential, with 15% of cases causing 80% of offspring cases.
JOURNAL OF TRAVEL MEDICINE
(2022)
Editorial Material
Public, Environmental & Occupational Health
Zihao Guo, Shi Zhao, Shui Shan Lee, Chris Ka Pun Mok, Ngai Sze Wong, Jingxuan Wang, Katherine Min Jia, Maggie Haitian Wang, Carrie Ho Kwan Yam, Tsz Yu Chow, Ka Chun Chong, Eng Kiong Yeoh
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Genetics & Heredity
Xiaoxuan Xia, Yexian Zhang, Rui Sun, Yingying Wei, Qi Li, Marc Ka Chun Chong, William Ka Kei Wu, Benny Chung-Ying Zee, Hua Tang, Maggie Haitian Wang
Summary: In this study, a novel statistical approach was developed to analyze and predict complex human traits using genotype data. Different from existing methods that focus on refining the effect size of genetic factors, the proposed method, Prism Vote (PV), improves risk prediction from an individual-centered perspective, treating disease probability as a composite risk shaded by multiple subpopulations. Through simulation studies and real genome-wide association data, it was demonstrated that the PV significantly enhances prediction accuracy in mixed populations and high genetic heterogeneity scenarios. The PV framework offers an effective and scalable approach to incorporate subpopulation information for risk prediction.
Review
Materials Science, Biomaterials
Jingjing Chai, Junfei Zhu, Yu Tian, Kui Yang, Jiajie Luan, Yan Wang
Summary: Cancer is a life-threatening disease that poses a serious threat to humanity. The current treatment methods for cancer often have multiple side effects, limited targeting, and poor efficacy. Recent studies have shown the physiological regulatory role of carbon monoxide (CO) in cancer and explored CO-related nano-drugs, which offer better prospects for cancer treatment and provide new ideas for therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Multidisciplinary Sciences
Sheng Wang, Songsen Gao, Liang Shan, Xueyi Qian, Jiajie Luan, Xiongwen Lv
Summary: By analyzing the pathology and gene expression of liver cancer patients, a model for predicting the survival status of liver cancer patients was established. The model was found to be closely related to the immune microenvironment, providing a basis for the treatment and research of liver cancer.
Review
Medicine, Research & Experimental
Sheng Wang, Songsen Gao, Wufei Ye, Yueran Li, Jiajie Luan, Xiongwen Lv
Summary: N6-methyladenosine (m6A) modification is a common type of inner RNA modification in eukaryotes, playing various roles in normal and abnormal biological processes. It is modulated by m6A writer, eraser, and reader, and impacts RNA metabolism processes such as processing, translation, export, localization, and decay. The potential molecular mechanism and specific role of m6A modification in liver disease are not fully understood. In this review, we summarize the latest research progress on m6A modification in liver disease and explore its impact on RNA metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
