Article
Medicine, Research & Experimental
Donghyun D. Lee, Martin Komosa, Sumedha Sudhaman, Ricardo Leao, Cindy H. Zhang, Joana D. Apolonio, Thomas Hermanns, Peter J. Wild, Helmut Klocker, Farshad Nassiri, Gelareh Zadeh, Bill H. Diplas, Hai Yan, Steven Gallinger, Trevor J. Pugh, Vijay Ramaswamy, Michael D. Taylor, Pedro Castelo-Branco, Nuno Miguel Nunes, Uri Tabori
Summary: The research found that allele-specific DNA methylation within the TERT promoter plays a significant regulatory role in cancer, especially more common in adult cancers and enriched in tumors with TERT promoter mutations. This allele-specific DNA methylation is essential for the regulation of TERT expression in cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Buze Chen, Xiaojuan Ding, Ailing Wan, Xin Qi, Xiaoman Lin, Haihong Wang, Wenyu Mu, Gang Wang, Junnian Zheng
Summary: TLX2 plays an important role in multiple tumors and its abnormal expression is associated with a poor overall survival rate in several cancer types. The most common type of alteration in TLX2 is amplification, and it co-occurs with alterations in other genes. TLX2 has high methylation levels in various tumors. Its expression is related to immune infiltration, immune checkpoint genes, and chemoresistance.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Fernanda Wisnieski, Jaqueline Cruz Geraldis, Leonardo Caires Santos, Mariana Ferreira Leal, Danielle Queiroz Calcagno, Carolina Oliveira Gigek, Elizabeth Suchi Chen, Ana Carolina Anauate, Ricardo Artigiani, Samia Demachki, Paulo Pimentel Assumpcao, Laercio Gomes Lourenco, Carlos Haruo Arasaki, Julie Krainer, Stephan Pabinger, Rommel Rodriguez Burbano, Marilia Arruda Cardoso Smith
Summary: In this study, the research group identified a list of 83 genes potentially modulated by DNA methylation in GC cell lines, with LRRC37A2 playing a role in undifferentiated and poorly differentiated tumors. The study showed that reduced LRRC37A2 mRNA levels and increased LRRC37A2 exon methylation are associated with GC progression, emphasizing the potential utility of gene-related stratification for epigenetic therapy in GC patients.
Article
Cell Biology
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin
Summary: The abnormal expression of NR2F1-AS1 in gastric cancer is related to its correlation with NR2F1 expression, as well as their response to epithelial-to-mesenchymal transition signaling. NR2F1-AS1 modulates the miR-29a-3p/VAMP7 axis and plays a crucial role in the progression of gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Cristina Montero-Conde, Luis Javier Leandro-Garcia, Angel M. Martinez-Montes, Paula Martinez, Francisco J. Moya, Rocio Leton, Eduardo Gil, Natalia Martinez-Puente, Sonsoles Guadalix, Maria Curras-Freixes, Laura Garcia-Tobar, Carles Zafon, Mireia Jorda, Garcilaso Riesco-Eizaguirre, Patricia Gonzalez-Garcia, Maria Monteagudo, Rafael Torres-Perez, Veronika Mancikova, Sergio Ruiz-Llorente, Manuel Perez-Martinez, Guillermo Pita, Juan Carlos Galofre, Anna Gonzalez-Neira, Alberto Cascon, Cristina Rodriguez-Antona, Diego Megias, Maria A. Blasco, Eduardo Caleiras, Sandra Rodriguez-Perales, Mercedes Robledo
Summary: Comprehensive molecular studies were conducted on thyroid tumors to identify prognostic biomarkers. Telomere-related alterations, especially TERT and TERC, were found in aggressive tumors. Short telomeres led to reorganization in the 5p subtelomeric region, resulting in increased gene upregulation and a more relaxed chromatin configuration in the tumors.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Yuanyuan Wu, Juan Du
Summary: This study aimed to investigate the role of LINC00467 in the growth and metastasis of gastric cancer (GC). The results showed that LINC00467 promoted the methylation of the Reprimo promoter by recruiting DNMT1, leading to decreased expression of Reprimo. Knockdown of LINC00467 weakened the malignant properties of GC cells and reduced tumorigenesis and metastasis in vivo.
Article
Biotechnology & Applied Microbiology
Chunhe Zhang, Shaowei Fu, Luyue Wang, Fang Wang, Dan Wu, Xiangyi Zhe, Huizhen Xin, Hongtao Li, Dongmei Li, Fuyuan Jin, Renfu Shao, Zemin Pan
Summary: The study aimed to investigate the association between ZNF582 gene methylation and cervical cancer, as well as its correlation with high risk HPV16/18 infection. The findings showed that ZNF582 gene methylation had high specificity and sensitivity in detecting highly diseased cervical lesions, and ZNF582 protein was highly expressed in cervical cancer tissues but with low mRNA expression.
ONCOTARGETS AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Rose Ghemrawi, Aya Al Qassem, Azza Ramadan, Raghad Aldulaymi, Nour Sammani, Walaa K. Mousa, Mostafa Khair
Summary: Protein and DNA methylation play important roles in various biological functions. Abnormal regulation of methyltransferases has been implicated in cancer, but its association with autophagy and carcinogenesis in breast and lung cancer is not well understood. In this study, we used UALCAN to analyze breast and lung cancer databases and found that 17 methyltransferases are upregulated in these cancers. We investigated the effects of methylation inhibition on breast and lung cancer cell lines and found that inhibiting methylation reduced cell migration, growth, and autophagy activity. This suggests that targeting methylation ability could be a potential treatment for breast and lung cancer.
Article
Oncology
Xiaoqing Yu, Ling Cen, Y. Ann Chen, Joseph Markowitz, Timothy Shaw, Kenneth Y. Tsai, Jose R. Conejo-Garcia, Xuefeng Wang
Summary: DNA methylation signatures can be used as reliable biomarkers to predict patient prognosis and immune status in tumors. This study introduces the concept of tumor-based expression quantitative trait methylation (eQTM) for the identification of predictive biomarkers. eQTM CpGs and genes represent new and efficient candidate targets for prognosis and immune status monitoring.
Article
Cell Biology
Wei Zhuo, Meng Sun, Kun Wang, Lu Zhang, Kai Li, Danyang Yi, Mengjie Li, Qiang Sun, Xixi Ma, Wei Liu, Lisong Teng, Chengqi Yi, Tianhua Zhou
Summary: This study reveals the significance of PCIF1 and m(6)Am modification in gastric cancer. Increased expression of PCIF1 and m(6)Am modification are associated with gastric cancer progression and poor prognosis. Silencing PCIF1 inhibits the proliferation and invasion of gastric cancer cells, and suppresses tumor growth and metastasis in a mouse model. PCIF1 modifies TM9SF1 mRNA with m(6)Am, leading to decreased TM9SF1 translation. TM9SF1 reverses the effects of PCIF1 on gastric cancer cell aggressiveness.
Article
Biotechnology & Applied Microbiology
Haifeng Jin, Zheng Wu, Bibo Tan, Zhen Liu, Zhanfei Zu, Xiaoyun Wu, Yuwang Bi, Xingmao Hu
Summary: The study found that ibuprofen epigenetically increased the expression of p75NTR in gastric cancer cells by regulating promoter methylation and m6A-RNA methylation. These findings reveal a novel mechanism for p75NTR regulation by nonsteroidal anti-inflammatory drugs.
Article
Oncology
Jing-jing Teng, Wen-jing Zhao, Xun-lei Zhang, Da-Kun Zhao, Xin-Yue Qiu, Xu-dong Chen, Lei Yang
Summary: PRDM5 is downregulated in gastric cancer and associated with poor survival and tumor progression. Methylation of PRDM5 promoter is closely related to histological types and tumor progression in gastric cancer.
Article
Biochemistry & Molecular Biology
Xu Pan, Xin Li, Jie Sun, Zhiying Xiong, Haoyu Hu, Shangwei Ning, Hui Zhi
Summary: This study reveals that DNA methylation can drive tissue-specific enhancer basal transcription and target gene expression in human cancers. By integrating methylome, transcriptome, and 3D genomic data, enhancer methylation triplets were identified and regulatory patterns within them were dissected. Cancer-specific core TFs regulated by enhancers were observed to shape enhancer methylation forming enhancer methylation-driven CRCs (emCRCs).
Article
Oncology
Meng-jie Shan, Ling-bing Meng, Peng Guo, Yuan-meng Zhang, Dexian Kong, Ya-bin Liu
Summary: This study identified CDH3, LEF1, and MMP7 as potential biomarkers for gastric cancer through gene expression analysis, and established a neural network model for early diagnosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qing Wang, Jiahong Liang, Xianyu Hu, Songgang Gu, Qiaodong Xu, Jiang Yan
Summary: This study evaluated the prognostic value of Early B-cell factors (EBFs) in gastric cancer (GC), identifying that increased EBFs were associated with poor prognosis. A prognostic model was established and validated in different cohorts, with impacts on DNA methylation, signaling pathways, and potential treatments such as immunotherapy and chemotherapy targeting EBFs.
BIOSCIENCE REPORTS
(2021)
Article
Multidisciplinary Sciences
Sadegh Fattahi, Galia Amirbozorgi, Maryam Lotfi, Batoul Amini Navaei, Saeid Kavoosian, Mohsen Asouri, Haleh Akhavan-Niaki
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2018)
Article
Infectious Diseases
Sadegh Fattahi, Novin Nikbakhsh, Hassan Taheri, Elham Ghadami, Mohadeseh Kosari-Monfared, Galia Amirbozorgi, Mohsen Asouri, Maryam Pilehchian-Langroudi, Mohammad Ranaee, Ali Akbar Samadani, Mandi Paryan, Haleh Akhavan-Niaki
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2018)
Review
Cell Biology
Sadegh Fattahi, Maryam Pilehchian Langroudi, Haleh Akhavan-Niaki
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Genetics & Heredity
Sholeh Kiani, Haleh Akhavan-Niaki, Sadegh Fattahi, Saeid Kavoosian, Nadali Babaian Jelodar, Nadali Bagheri, Hamid Najafi Zarrini
Article
Cell Biology
Elham Ghadami, Novin Nikbakhsh, Sadegh Fattahi, Mohadeseh Kosari-Monfared, Mohammad Ranaee, Hassan Taheri, Fatemeh Amjadi-Moheb, Gholamali Godazandeh, Shahryar Shafaei, Anahita Nosrati, Maryam Pilehchian Langroudi, Ali Akbar Samadani, Galia Amirbozorgi, Vahideh Mirnia, Haleh Akhavan-Niaki
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Mohadeseh Kosari-Monfared, Novin Nikbakhsh, Sadegh Fattahi, Elham Ghadami, Mohammad Ranaei, Hassan Taheri, Fatemeh Amjadi-Moheb, Gholam A. Godazandeh, Shahryar Shafaei, Maryam Pilehchian-Langroudi, Ali Akbar Samadani, Haleh Akhavan-Niaki
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Oncology
Ali Akbar Samadani, Novin Nikbakhsh, Hassan Taheri, Shahriyar Shafaee, Sadegh Fattahi, Maryam Pilehchian Langroudi, Karimollah Hajian, Haleh Akhavan-Niaki
PATHOLOGY & ONCOLOGY RESEARCH
(2019)
Review
Cell Biology
Sadegh Fattahi, Mohadeseh Kosari-Monfared, Monireh Golpour, Zakieh Emami, Mohammad Ghasemiyan, Maryam Nour, Haleh Akhavan-Niaki
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Environmental Sciences
Elahe Bakhtiari, Ali Shabestani Monfared, Hale Akhavan Niaki, Sajad Borzoueisileh, Fatemeh Niksirat, Sadegh Fattahi, Mohadese Kosari Monfared, Kourosh Ebrahimnejad Gorji
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2019)
Article
Neurosciences
Mohammad Saied Salehi, Sareh Pandamooz, Anahid Safari, Benjamin Jurek, Amin Tamadon, Mohammad Reza Namavar, Mehdi Dianatpour, Leila Dargahi, Negar Azarpira, Sadegh Fattahi, Seyed Mostafa Shid Moosavi, Somaye Keshavarz, Zahra Khodabandeh, Shahrokh Zare, Somayeh Nazari, Mojdeh Heidari, Sadegh Izadi, Maryam Poursadeghfard, Afshin Borhani-Haghighi
CNS NEUROSCIENCE & THERAPEUTICS
(2020)
Article
Genetics & Heredity
Roghayeh Pourbagher, Haleh Akhavan-Niaki, Seyed Gholam Ali Jorsaraei, Sadegh Fattahi, Davood Sabour, Ebrahim Zabihi, Zeinab Abedian, Masoumeh Ghasemi, Monireh Golpour, Amrollah Mostafazadeh
Article
Environmental Sciences
Hoda Talebian, Ali Shabestani Monfared, Haleh Akhavan Niaki, Sadegh Fattahi, Elaheh Bakhtiari, Vahid Changizi
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2020)
Review
Integrative & Complementary Medicine
Sogand Vahidi, Ebrahim Mirzajani, Seyedeh Elham Norollahi, Mohsen Aziminezhad, Ali Akbar Samadani
Summary: Gastric cancer is a major cause of cancer mortality, and abnormal DNA methylation in gene promoter regions plays a key role in the development of gastric cancer. Helicobacter pylori infection is identified to be associated with gastric cancer. Abnormal DNA methylation triggers inactivation of multiple genes, and is more common in cancer-related processes than mutations. The extent of abnormal DNA methylation is closely linked to the risk of developing gastric cancer.
JOURNAL OF PHARMACOPUNCTURE
(2022)
Article
Medicine, Research & Experimental
Sahar Ghazanfari, Shahla Roudbar Mohammadi, Sassan Rezaie, Sadegh Khodavaisy, Ali Akbar Samadani
Summary: This study investigated the effects of air pollutants on the growth and drug resistance of fungi, and found that exposure to CO2 and MTBE led to drug resistance in Candida. This has important implications for understanding and addressing treatment methods for candidiasis infections.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2022)
Article
Genetics & Heredity
Seyedeh Elham Norollahi, Seyed Mohammad Taghi Hamidian, Sogand Vahidi, Kosar Babaei, Ali Akbar Samadani
