Modulation of Inflammatory Responses by Wnt/β-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer

Increased Expression of the Wnt Signalling Inhibitor Dkk-1 in Non-lesional Skin and Peripheral Blood Mononuclear Cells of Patients with Plaque Psoriasis

(2015) O Seifert et al.   ACTA DERMATO-VENEREOLOGICA

 -Catenin Promotes Regulatory T-cell Responses in Tumors by Inducing Vitamin A Metabolism in Dendritic Cells

(2015) Y. Hong et al.   CANCER RESEARCH

miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts

(2015) Cheng-gui Miao et al.   IMMUNOLOGY LETTERS

Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation

(2015) Amol Suryawanshi et al.   JOURNAL OF IMMUNOLOGY

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+T cells through regulation of IL-10

(2015) Chunmei Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy

(2015) A. Holtzhausen et al.   Cancer Immunology Research

Tumors induce immune tolerance through activation of β-catenin/TCF4 signaling in dendritic cells: A novel therapeutic target for cancer immunotherapy

(2015) Amol Suryawanshi et al.   OncoImmunology

Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity

(2015) Yuan Hong et al.   OncoImmunology

Macrophages derived from infiltrating monocytes mediate autoimmune myelin destruction

(2014) Michael T. Heneka   JOURNAL OF EXPERIMENTAL MEDICINE

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR2-Dependent Activation of β-Catenin Pathway in Dendritic Cells Induces Regulatory Responses and Attenuates Autoimmune Inflammation

(2014) Indumathi Manoharan et al.   JOURNAL OF IMMUNOLOGY

The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria

(2014) Octavio Silva-García et al.   MEDIATORS OF INFLAMMATION

Aberrant Activation of the WNT/β-Catenin Signaling Pathway in Lupus Nephritis

(2014) Xiao-dong Wang et al.   PLoS One

Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling

(2013) Cheng-gui Miao et al.   CELLULAR SIGNALLING

Fas Signal Promotes the Immunosuppressive Function of Regulatory Dendritic Cells via the ERK/β-Catenin Pathway

(2013) Cheng Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of PLCγ2–β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer

(2013) Aude-Hélène Capietto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Canonical and Noncanonical Wnt Proteins Program Dendritic Cell Responses for Tolerance

(2013) C. Oderup et al.   JOURNAL OF IMMUNOLOGY

 -Catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8+ T cells

(2013) X. Liang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Wnt your brain be inflamed? Yes, it Wnt!

(2013) Bianca Marchetti et al.   TRENDS IN MOLECULAR MEDICINE

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The Akt1 Isoform Is Required for Optimal IFN-  Transcription through Direct Phosphorylation of  -Catenin

(2012) B. N. Gantner et al.   JOURNAL OF IMMUNOLOGY

Interplay between FOXO, TOR, and Akt

(2011) Nissim Hay   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dendritic cell control of tolerogenic responses

(2011) Santhakumar Manicassamy et al.   IMMUNOLOGICAL REVIEWS

Wnt5a Skews Dendritic Cell Differentiation to an Unconventional Phenotype with Tolerogenic Features

(2011) Jaris Valencia et al.   JOURNAL OF IMMUNOLOGY

TGF-β Suppresses β-Catenin-Dependent Tolerogenic Activation Program in Dendritic Cells

(2011) Bryan Vander Lugt et al.   PLoS One

Alterations in Wnt pathway activity in mouse serum and kidneys during lupus development

(2010) Anders Aune Tveita et al.   ARTHRITIS AND RHEUMATISM

A p120-catenin-CK1  complex regulates Wnt signaling

(2010) D. Casagolda et al.   JOURNAL OF CELL SCIENCE

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

(2010) Pengyuan Yang et al.   NATURE IMMUNOLOGY

Programming dendritic cells to induce TH2 and tolerogenic responses

(2010) Bali Pulendran et al.   NATURE IMMUNOLOGY

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion

(2009) Meghan T. Maher et al.   JOURNAL OF CELL BIOLOGY

Dendritic cells in intestinal homeostasis and disease

(2009) Maria Rescigno et al.   JOURNAL OF CLINICAL INVESTIGATION

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity

(2009) Santhakumar Manicassamy et al.   NATURE MEDICINE

Importance of Wnt Signaling in the Tumor Stroma Microenvironment

(2008) Maria Macheda et al.   CURRENT CANCER DRUG TARGETS

The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis

(2008) Frank J. T. Staal et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages

(2008) Santhakumar Manicassamy et al.   SEMINARS IN IMMUNOLOGY