Review
Cell Biology
Tang Qi, Liao Li, Tian Weidong
Summary: Research on bioactive lipids, specifically sphingolipids and their metabolites, has revealed their important role in skeletal remodeling and cellular functions like the interaction between osteoblasts and osteoclasts. Understanding the crosstalk between sphingomyelin, ceramide, and S1P in the sphingolipid family provides potential therapeutic options for bone diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Sonali J. Karnik, Murad K. Nazzal, Melissa A. Kacena, Angela Bruzzaniti
Summary: The bone marrow microenvironment contains diverse cell types and provides a novel and complex mechanism for bone regulation. Megakaryocytes potentially act as a master regulator of the microenvironment by affecting hematopoiesis, osteoblastogenesis, and osteoclastogenesis. The regulatory effects of megakaryocytes on different cell populations change with aging and disease states. Understanding the role of megakaryocytes can provide insight into therapies for hematopoietic and skeletal disorders.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Danka Grcevic, Archana Sanjay, Joseph Lorenzo
Summary: Bone remodeling involves interactions among osteoblasts, osteocytes, and osteoclasts, as well as other cell types in the bone marrow. The bone marrow microenvironment, supported by bone cells, plays a role in B lymphopoiesis. In turn, B lymphocytes influence bone cells. Imbalanced interactions between bone cells and other lineages can have detrimental effects on bone health. This review summarizes the development of B lymphocytes and their interactions with bone cells in both health and disease.
Article
Endocrinology & Metabolism
Thomas Levin Andersen, Pia Rosgaard Jensen, Tanja Tvistholm Sikjaer, Lars Rejnmark, Charlotte Ejersted, Jean-Marie Delaisse
Summary: Proper bone remodeling relies not only on the actions of osteoclasts and osteoblasts, but also on the delivery of osteoblast lineage cells to the remodeling site. A CD271-positive/PDGF beta-R-positive cell layer surrounding the bone marrow provides osteoblastogenic potential on all bone surfaces, including both quiescent and remodeling sites. This cell layer, known as the canopy, plays a critical role in initiating bone remodeling by activating early markers of osteoblastogenesis and supporting cell delivery to the bone surface.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ricardo Usategui-Martin, Ricardo Rigual, Marta Ruiz-Mambrilla, Jose-Maria Fernandez-Gomez, Antonio Duenas, Jose Luis Perez-Castrillon
Summary: Bone is crucial for support, protection, and mineral storage. It is continuously renewed to maintain healthy functioning. Hypoxia can negatively affect bone health by inhibiting bone formation and increasing bone resorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jung Ha Kim, Kabsun Kim, Inyoung Kim, Semun Seong, Hyun Kook, Kyung Keun Kim, Jeong-Tae Koh, Nacksung Kim
Summary: CrkL regulates the coupling signals between osteoblasts and osteoclasts by decreasing RANKL expression, which plays a crucial role in bone homeostasis by inhibiting both osteoblast-dependent osteoclast differentiation and osteoclast-dependent osteoblast differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Haifang Li, Dalin He, Xue Xiao, Guanliu Yu, Geng Hu, Wenqian Zhang, Xin Wen, Yun Lin, Xianyao Li, Hai Lin, Youxiang Diao, Yi Tang
Summary: N-MWCNTs enhance bone remodeling and bone cell activity, showing potential applications in bone tissue engineering.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Gabriel Bassan Marinho Maciel, Roberto Marinho Maciel, Cristiane Cademartori Danesi
Summary: This work summarizes the characteristics of bone cells involved in physiological bone remodeling. Remodeling is a distinct process from modeling, and it allows the renewal of old or damaged bone tissue to maintain bone fracture resistance and calcium and phosphorus homeostasis. The role of osteoclasts, osteoblasts, osteocytes, and bone lining cells in bone remodeling is addressed, and the regulation of bone remodeling through hormones and growth factors is discussed. Understanding physiological bone remodeling is essential for studying bone-related pathologies and developing new therapies.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Immunology
Tatjana Bordukalo-Niksic, Vera Kufner, Slobodan Vukicevic
Summary: Bone remodeling in the adult skeleton involves a continuous process of old and damaged bone removal by osteoclasts and subsequent new bone formation by osteoblasts. BMPs play a crucial role in maintaining healthy bone, affecting both bone formation and resorption, and may be involved in pathological processes related to inflammatory disorders affecting bones and joints.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Claire Dumortier, Soula Danopoulos, Frederic Velard, Denise Al Alam
Summary: Cystic fibrosis-related bone disease is characterized by decreased bone formation and increased bone resorption, impacted by CFTR mutations that affect osteoblast and osteoclast differentiation and disrupt signaling pathways involved in stem cell commitment to bone lineages. The role of CFTR in inflammation and Wnt signaling in osteoblasts, as well as its potential direct impact on osteoclast function, is also highlighted.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Sajad Chamani, Luca Liberale, Leila Mobasheri, Fabrizio Montecucco, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Statins not only reduce LDL-C levels, but also have regulatory effects on bone metabolism, increasing bone formation and improving bone density. Therefore, statins may play a role in the treatment of bone disorders.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Hyunji Cho, Jisoo Lee, Seoyoung Jang, Jungsun Lee, Tong In Oh, Youngsook Son, EunAh Lee
Summary: The calcium concentration gradient near the BRC may play a role in bone remodeling by acting on BMSCs through CaSR, affecting proliferation and differentiation, and influencing the coupling mechanism between osteoblasts and osteoclasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Vishwa Deepak, Shu-Ting Yang, Ziqing Li, Xinhua Li, Andrew Ng, Ding Xu, Yi-Ping Li, Merry Jo Oursler, Shuying Yang
Summary: This study identifies a negative function of IFT80 in osteoclasts by regulating the stabilization and degradation of Cbl-b and TRAF6, thereby affecting osteoclast formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Ji-Un Hong, Jin-Ju Kwon, Soon Chul Heo, Sang-Hun Shin, Hyung Joon Kim, Jae-Yeol Lee
Summary: The study found that photobiomodulation (PBM) can significantly reduce osteoclast differentiation and enhance osteoblast differentiation in an in vitro osteoblast/osteoclast co-culture system. These effects may be achieved through decreasing RANKL expression and increasing OPG expression.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Orthopedics
Masayoshi Ishida, Naoyuki Kawao, Yuya Mizukami, Yoshimasa Takafuji, Hiroshi Kaji
Summary: This study demonstrates that Angptl1 suppresses osteoclast formation and enhances osteoblastic differentiation in mouse cells, while inhibiting adipogenic differentiation of 3T3-L1 cells.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cell & Tissue Engineering
Ronaldo J. F. C. do Amaral, Amos Matsiko, Marcel R. P. Tomazette, Wanessa K. R. Rocha, Eric Cordeiro-Spinetti, Tanya J. Levingstone, Marcos Farina, Fergal J. O'Brien, Marcia C. El-Cheikh, Alex Balduino
JOURNAL OF TISSUE ENGINEERING
(2015)
Article
Cell & Tissue Engineering
Ronaldo Jose Farias Correa do Amaral, Nemias Pereira da Silva, Natalia Ferreira Haddad, Luana Siqueira Lopes, Fabio Dias Ferreira, Ricardo Bastos Filho, Paola Alejandra Cappelletti, Wallace de Mello, Eric Cordeiro-Spinetti, Alex Balduino
STEM CELLS INTERNATIONAL
(2016)
Article
Orthopedics
Ricardo Bastos, Marcelo Mathias, Renato Andrade, Raquel Bastos, Alex Balduino, Vinicius Schott, Scott Rodeo, Joao Espregueira-Mendes
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2018)
Article
Biochemistry & Molecular Biology
Eric Cordeiro-Spinetti, Russell S. Taichman, Alex Balduino
JOURNAL OF CELLULAR BIOCHEMISTRY
(2015)
Article
Orthopedics
Ricardo Bastos, Marcelo Mathias, Renato Andrade, Ronaldo J. F. C. Amaral, Vinicius Schott, Alex Balduino, Raquel Bastos, J. Miguel Oliveira, Rui L. Reis, Scott Rodeo, Joao Espregueira-Mendes
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2020)
Article
Endocrinology & Metabolism
Ana Carolina Monteiro, Adriana Bonomo
Summary: Bone metastases in patients with advanced breast cancer are common, leading to severe morbidity and increased mortality due to osteolytic lesions driven by osteoclasts in the bone marrow microenvironment. The primary tumor can actively modify the bone marrow microenvironment before metastatic spread, with specific T cells playing a crucial role in this process.
Article
Endocrinology & Metabolism
Ana Carolina Monteiro, Adriana Bonomo
Summary: Our study shows the impact of immune cells primed by breast primary tumor cells on the bone microenvironment before bone colonization. Specifically, RANKL(+) CD4(+) T cells and dendritic cells play crucial roles in pre-metastatic niche formation and osteolytic profile induced by metastatic tumors. Additionally, non-metastatic tumor cells can modify distant sites like the bone, affecting osteoclasts and osteoblasts activities, highlighting the opposing roles of CD4(+) and CD8(+) T cell subtypes in breast cancer progression and bone metastases establishment.
Editorial Material
Immunology
Ana Carolina Monteiro, Ana Paula Lepique, Martin Bonamino, Mercedes Beatriz Fuertes
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Education, Scientific Disciplines
Laura Maria Andrade de Oliveira, Eric Cordeiro-Spinetti, Felipe Piedade Goncalves Neves, Patricia Sanae Sujii, Rachel Leite Ribeiro, Sidcley Silva de Lyra, Tatiana Castro Abreu Pinto, Maria Leticia Bonatelli
Summary: DivulgaMicro is a Brazilian Science Communication and Outreach project run by three young female scientists. In 2020, they promoted the first virtual edition of the DivulgaMicro Workshop, successfully delivering the workshop content through a combination of short lectures and interactive activities, which was highly praised by the participants.
JOURNAL OF MICROBIOLOGY & BIOLOGY EDUCATION
(2021)
Article
Multidisciplinary Sciences
Yolanda Colino-Sanguino, Evan M. Cornett, David Moulder, Grady C. Smith, Joel Hrit, Eric Cordeiro-Spinetti, Robert M. Vaughan, Krzysztof Krajewski, Scott B. Rothbart, Susan J. Clark, Fatima Valdes-Mora