Pharmacologic Inhibition of Host Phosphodiesterase-4 Improves Isoniazid-Mediated Clearance of Mycobacterium tuberculosis

Immune activation of the host cell induces drug tolerance inMycobacterium tuberculosisboth in vitro and in vivo

(2016) Yancheng Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Moxifloxacin and gatifloxacin for initial therapy of tuberculosis: a meta-analysis of randomized clinical trials

(2016) Qiaoling Ruan et al.   Emerging Microbes & Infections

Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

(2016) Selvakumar Subbian et al.   EBioMedicine

Roflumilast, a Type 4 Phosphodiesterase Inhibitor, Shows Promising Adjunctive, Host-Directed Therapeutic Activity in a Mouse Model of Tuberculosis

(2015) Mariama C. Maiga et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Host-directed therapies for improving poor treatment outcomes associated with the middle east respiratory syndrome coronavirus infections

(2015) Alimuddin Zumla et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

WHO's new End TB Strategy

(2015) Mukund Uplekar et al.   LANCET

Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers

(2015) I. V. Lyadova et al.   MEDIATORS OF INFLAMMATION

The Unrecognized Effects of Phosphodiesterase 4 on Epithelial Cells in Pulmonary Inflammation

(2015) Franziska M. Konrad et al.   PLoS One

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

(2015) Meenal Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Etanercept Exacerbates Inflammation and Pathology in a Rabbit Model of Active Pulmonary Tuberculosis

(2014) Liana Tsenova et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Adjuvant Host-Directed Therapy with Types 3 and 5 but Not Type 4 Phosphodiesterase Inhibitors Shortens the Duration of Tuberculosis Treatment

(2013) Mamoudou Maiga et al.   JOURNAL OF INFECTIOUS DISEASES

Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages

(2012) Mi-Sun Koo et al.   Cell Communication and Signaling

Phosphodiesterase-4 Inhibition Combined with Isoniazid Treatment of Rabbits with Pulmonary Tuberculosis Reduces Macrophage Activation and Lung Pathology

(2011) Selvakumar Subbian et al.   AMERICAN JOURNAL OF PATHOLOGY

Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

(2011) Mi-Sun Koo et al.   PLoS One

Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

(2011) Selvakumar Subbian et al.   PLoS Pathogens

Letting Sleeping dos Lie: Does Dormancy Play a Role in Tuberculosis?

(2010) Michael C. Chao et al.   Annual Review of Microbiology

Excess lung function decline in gold miners following pulmonary tuberculosis

(2010) J. Ross et al.   THORAX

Advances in Immunotherapy for Tuberculosis Treatment

(2009) Gavin J. Churchyard et al.   CLINICS IN CHEST MEDICINE