Advances in the treatment of virus-induced asthma

Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells

(2015) M. Contoli et al.   ALLERGY

Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia

(2015) Paola Mastromarino et al.   ANTIVIRAL RESEARCH

Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement

(2015) D Tsitoura et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Resveratrol potentiates the effect of dexamethasone in rat model of acute lung inflammation

(2015) Bhakti N. Sadarani et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons

(2015) Vera Gielen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations

(2015) Stephen J. Teach et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia

(2015) Luke Hatchwell et al.   THORAX

Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells

(2015) L. E. M. Kistemaker et al.   THORAX

Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies

(2015) Nicola A Hanania et al.   THORAX

The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial

(2014) Ratko Djukanović et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma ExacerbationsIn Vivo

(2014) David J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting 5-lipoxygenase-activating protein in asthma and chronic obstructive pulmonary disease

(2014) Sabina Antonela Antoniu   EXPERT OPINION ON THERAPEUTIC TARGETS

Enhanced innate type 2 immune response in peripheral blood from patients with asthma

(2014) Kathleen R. Bartemes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

(2014) Gail M. Gauvreau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll-Like Receptor Ligands LPS and Poly (I:C) Exacerbate Airway Hyperresponsiveness in a Model of Airway Allergy in Mice, Independently of Inflammation

(2014) Magnus Starkhammar et al.   PLoS One

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

(2014) J. Beale et al.   Science Translational Medicine

Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon

(2014) Belinda J. Thomas et al.   Scientific Reports

Interferon-stimulated genes: roles in viral pathogenesis

(2014) John W Schoggins   Current Opinion in Virology

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

(2014) Mario Castro et al.   Lancet Respiratory Medicine

EAACI position statement on asthma exacerbations and severe asthma

(2013) A. Custovic et al.   ALLERGY

Toll-like Receptor 7 Rapidly Relaxes Human Airways

(2013) Matthew G. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells

(2013) I. Ioannidis et al.   JOURNAL OF VIROLOGY

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

TLR3, TLR4 and TLRs7–9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma

(2013) Annemarie Sykes et al.   PLoS One

Species-Specific and Cross-Reactive IgG1 Antibody Binding to Viral Capsid Protein 1 (VP1) Antigens of Human Rhinovirus Species A, B and C

(2013) Jua Iwasaki et al.   PLoS One

An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation

(2013) Stephanie Traub et al.   PLoS Pathogens

Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein

(2013) Nicholas Glanville et al.   PLoS Pathogens

Cysteinyl leukotriene receptors, old and new; implications for asthma

(2012) T. M. Laidlaw et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus

(2012) Nathan W. Bartlett et al.   EMBO Molecular Medicine

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma

(2012) Edward Piper et al.   EUROPEAN RESPIRATORY JOURNAL

Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children

(2012) Sandy R. Durrani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Dissociated Glucocorticoid Receptor Modulator Reduces Airway Hyperresponsiveness and Inflammation in a Mouse Model of Asthma

(2012) L. L. Reber et al.   JOURNAL OF IMMUNOLOGY

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Impaired innate interferon induction in severe therapy resistant atopic asthmatic children

(2012) M R Edwards et al.   Mucosal Immunology

Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

(2012) Huib A.M. Kerstjens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Inhaled Glucocorticoids in Childhood on Adult Height

(2012) H. William Kelly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhaled corticosteroid and long-acting β2-agonist pharmacological profiles: effective asthma therapy in practice

(2012) Michael Tamm et al.   RESPIRATORY MEDICINE

Efficacy of anticholinergic drugs in asthma

(2012) Federica Novelli et al.   Expert Review of Respiratory Medicine

A Mechanistic Role for Type III IFN-λ1in Asthma Exacerbations Mediated by Human Rhinoviruses

(2011) E. Kathryn Miller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease

(2011) Ourania Koltsida et al.   EMBO Molecular Medicine

Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections

(2011) Katarzyna Niespodziana et al.   FASEB JOURNAL

Tiotropium improves lung function in patients with severe uncontrolled asthma: A randomized controlled trial

(2011) Huib A.M. Kerstjens et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Symptomatic Viral Infection is Associated with Impaired Response to Treatment in Children with Acute Asthma

(2011) Kristina Rueter et al.   JOURNAL OF PEDIATRICS

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

(2011) G. Lu et al.   JOURNAL OF VIROLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Tiotropium versus Salmeterol for the Prevention of Exacerbations of COPD

(2011) Claus Vogelmeier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

(2011) William W. Busse et al.   NEW ENGLAND JOURNAL OF MEDICINE

Budesonide and Formoterol Reduce Early Innate Anti-Viral Immune Responses In Vitro

(2011) Janet M. Davies et al.   PLoS One

Antibodies induced with recombinant VP1 from human rhinovirus exhibit cross-neutralisation

(2010) J. Edlmayr et al.   EUROPEAN RESPIRATORY JOURNAL

A randomized placebo-controlled study of intravenous montelukast for the treatment of acute asthma

(2010) Carlos A. Camargo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Counterregulation between the Fc RI Pathway and Antiviral Responses in Human Plasmacytoid Dendritic Cells

(2010) M. A. Gill et al.   JOURNAL OF IMMUNOLOGY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal

(2010) K. R. Chapman et al.   THORAX

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Budesonide and formoterol inhibit inflammatory mediator production by bronchial epithelial cells infected with rhinovirus

(2009) C. L. Skevaki et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Innate immune receptors on neutrophils and their role in chronic lung disease

(2009) B. Koller et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptor 7 function is reduced in adolescents with asthma

(2009) M. Roponen et al.   EUROPEAN RESPIRATORY JOURNAL

In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects

(2009) Nilceia Lopez-Souza et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Esophageal Candidiasis—An Adverse Effect of Inhaled Corticosteroids Therapy

(2009) Marcelo Vivolo Aun et al.   JOURNAL OF ASTHMA

Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma

(2009) Y A Bochkov et al.   Mucosal Immunology

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

(2008) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early identification of atopy in the prediction of persistent asthma in children

(2008) Peter D Sly et al.   LANCET

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

(2008) S. D. Message et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

(2008) S Moller-Larsen et al.   THORAX

How corticosteroids control inflammation: Quintiles Prize Lecture 2005

(2006) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY