Review
Endocrinology & Metabolism
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Assefa Agegnehu Teshome, Edgeit Abebe Zewde, Zelalem Tilahun Muche, Muluken Teshome Azezew
Summary: Diabetes Mellitus is a global health issue that can lead to various complications, including cardiovascular diseases such as heart failure. While hypertension and coronary artery disease are commonly associated with heart failure in diabetes patients, it is also prevalent even in the absence of these risk factors. Understanding the cellular and molecular mechanisms by which diabetes increases the risk of heart failure is crucial for developing effective therapeutics to prevent these changes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zheng Lian, Jun-Xian Song, Shi-Ran Yu, Li-Na Su, Yu-Xia Cui, Su-Fang Li, Chong-Yoo Lee, Hui-Zhu Liang, Hong Chen
Summary: The study utilized network pharmacology approach and experiments to explore the potential targets underlying the effect of rosuvastatin on heart failure, identifying 35 therapeutic targets and 13 significant treatment pathways related to HF. The therapeutic mechanism of rosuvastatin against HF may be closely related to the inhibition of the expression of apoptosis-related proteins, inflammatory factors, and fibrosis-related genes, with IL-1B being one of the most important target genes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
David Aluja, Sara Delgado-Tomas, Marisol Ruiz-Meana, Jose A. Barrabes, Javier Inserte
Summary: Despite advances in treatment, heart failure remains a major cause of illness and death. Preventing myocardial hypertrophy, which is an independent risk factor for heart failure, is a clinical objective. Recent studies suggest that calpains, a type of protein, play a role in the development of cardiac hypertrophy, and inhibiting calpains may be a potential pharmacological strategy. New compounds are being developed and tested in animal models to evaluate the effectiveness of calpain inhibition in treating pathological cardiac hypertrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Christelle Lteif, Ali Ataya, Julio D. Duarte
Summary: PH caused by LHD is believed to be the most common form, with challenges in treatment. Specific therapies for PH-LHD have not been identified yet, and pulmonary artery hypertension-targeted therapies are not recommended.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Pharmacology & Pharmacy
Anna Goracy, Jakub Rosik, Joanna Szostak, Bartosz Szostak, Szymon Retfinski, Filip Machaj, Andrzej Pawlik
Summary: Heart failure is a complex clinical syndrome caused by the unsuccessful compensation of symptoms of myocardial damage. Mitochondrial dysfunction is a process that occurs due to the disruption of metabolic and energetic pathways in the myocardium. This review focuses on new therapeutic strategies targeting mitochondrial function in the treatment of heart failure.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Review
Medicine, Research & Experimental
Zahra Vaziri, Kiarash Saleki, Cena Aram, Parsa Alijanizadeh, Ramtin Pourahmad, Abbas Azadmehr, Naghmeh Ziaei
Summary: Cancer and cardiovascular disorders are leading causes of mortality worldwide. Chemotherapy-induced cardiotoxicity is a common adverse effect of cancer treatment. SGLT2 inhibitors, a class of antidiabetic drugs, have shown protective effects on the heart and body, reducing inflammation and improving cardiovascular risk factors. They can also regulate excessive inflammation, affecting neurological and cardiovascular disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Albert Henry, Maria Gordillo-Maranon, Chris Finan, Amand F. Schmidt, Joao Pedro Ferreira, Ravi Karra, Johan Sundstrom, Lars Lind, Johan Arnlov, Faiez Zannad, Anders Malarstig, Aroon D. Hingorani, R. Thomas Lumbers
Summary: This study investigated the associations and causal relationships of 90 cardiovascular proteins with heart failure (HF). It identified 44 proteins that were associated with incident HF, of which 8 showed evidence of a causal relationship and 7 were druggable. Adrenomedullin (ADM) was highlighted as a particularly promising drug target.
Article
Pharmacology & Pharmacy
Charifa Awada, Olivier Boucherat, Steeve Provencher, Sebastien Bonnet, Francois Potus
Summary: Pulmonary hypertension due to left heart disease (PH-LHD) is a common and deadly form of PH, occurring secondary to left ventricular heart failure, valvular diseases, and congenital abnormalities. It is divided into isolated postcapillary PH (IpcPH) and combined pre- and postcapillary PH (CpcPH). CpcPH has worse outcomes and no specific treatment, while IpcPH can be improved by treating the underlying LHD. Understanding the mechanisms and finding effective treatment strategies for PH-LHD is urgently needed.
VASCULAR PHARMACOLOGY
(2023)
Review
Physiology
Marta Reina-Couto, Patricia Pereira-Terra, Janete Quelhas-Santos, Carolina Silva-Pereira, Antonio Albino-Teixeira, Teresa Sousa
Summary: Inflammation is a major contributor to different types of heart failure, but trials of anti-inflammatory strategies in HF patients have shown inconsistent results. Future therapeutic advances may involve tailored anti-inflammatory treatments based on individual inflammatory profiles and the development of resolution pharmacology targeting inflammation pathways in HF.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Alexander J. Winkle, Drew M. Nassal, Rebecca Shaheen, Evelyn Thomas, Shivangi Mohta, Daniel Gratz, Seth H. Weinberg, Thomas J. Hund
Summary: Cardiac hypertrophy is associated with adverse outcomes in cardiovascular diseases. The link between pathophysiological stress stimuli and specific myocyte/heart growth profiles remains unclear. This review discusses the molecular mechanisms underlying cardiac hypertrophy and highlights the role of spectrin-based cytoskeleton in regulating myocyte dimensions. Opportunities for directing myocyte growth in response to hypertrophic stimuli as a therapeutic approach are also discussed.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Review
Cell Biology
Changhai Tian, Jessica N. Ziegler, Irving H. Zucker
Summary: Extracellular vesicles (EVs) are important in cardiovascular diseases (CVDs), particularly in heart failure, where they transfer bioactive substances. miRNAs in EVs play a role in the progression of heart failure and their sorting is tightly controlled. Extracellular miRNAs, especially circulating EV-miRNAs, show promise as biomarkers and therapeutic targets for heart failure. This review summarizes the latest progress in understanding the role of EV-miRNAs in heart failure and their potential in therapeutic strategies.
Review
Biochemistry & Molecular Biology
Yu-Wen Zhou, Yao Xie, Lian-Sha Tang, Dan Pu, Ya-Juan Zhu, Ji-Yan Liu, Xue-Lei Ma
Summary: Due to limitations in current drug discovery efforts against SARS-CoV-2 and a lack of understanding of the biological mechanisms underlying COVID-19, alternative therapeutic targets are urgently needed. This study classified current COVID-19 therapeutic strategies into targeting the virus and targeting the host, focusing on repurposing drugs, emerging approaches, and promising potential targets.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Gaku Tsuji, Kazuhiko Yamamura, Koji Kawamura, Makiko Kido-Nakahara, Takamichi Ito, Takeshi Nakahara
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex pathogenesis involving skin barrier dysfunction, type II immune response, and pruritus. Advances in understanding the immunological mechanisms of AD have identified multiple novel therapeutic targets. New biologic agents targeting various cytokines and pathways are being developed for systemic and topical therapy, including JAK inhibitors, histamine H4 receptor antagonists, and microbiome modulation. This review provides insights into the current and future directions of novel therapies for AD and highlights their mechanisms of action and efficacy, supporting the advancement of precision medicine in the treatment of AD.
Article
Medicine, Research & Experimental
Bernhard Laggerbauer, Stefan Engelhardt
Summary: The discovery of microRNAs and their role in cardiovascular diseases has sparked interest in using microRNAs as drug targets. MicroRNA-based drugs have made significant progress in preclinical and clinical testing for cardiovascular diseases, showing great potential in treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Cardiac & Cardiovascular Systems
Qutuba G. Karwi, Kim L. Ho, Simran Pherwani, Ezra B. Ketema, Qiuyu Sun, Gary D. Lopaschuk
Summary: Diabetes increases the risk of heart failure, with both diseases exacerbating cardiovascular outcomes and progression. Factors contributing to diabetic cardiomyopathies are not fully understood.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Clee Yoong Foo, Kwadwo Osei Bonsu, Brahmajee K. Nallamothu, Christopler M. Reid, Teerapon Dhippayom, Daniel D. Reidpath, Nathorn Chaiyakunapruk
Meeting Abstract
Peripheral Vascular Disease
I. Owusu, F. Adomako-Boateng, F. Kueffer, M. Guy, C. Lang'at, T. Whitman, K. Holloman, D. Hettrick, K. Opare-Sem, G. Lazarus
JOURNAL OF HYPERTENSION
(2018)
Article
Peripheral Vascular Disease
Ntani Suh Nsutebu, Isaac Kofi Owusu, Kwame Ohene Buabeng, Kwadwo Osei Bonsu
JOURNAL OF CLINICAL HYPERTENSION
(2020)
Article
Cardiac & Cardiovascular Systems
Jie Li, Isaac Kofi Owusu, Qingshan Geng, Aba Ankomaba Folson, Zhichao Zheng, Yaw Adu-Boakye, Xinran Dong, Wen-Chih Wu, Francis Agyekum, Hongwen Fei, Harold Ayetey, Mulan Deng, Fred Adomako-Boateng, Zuxun Jiang, Braimah Baba Abubakari, Zhao Xian, Forster Nketiah Fokuoh, Lambert Tetteh Appiah, Simin Liu, Chunying Lin
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Respiratory System
Michael Asamoah-Boaheng, Jamie Farrell, Kwadwo Osei Bonsu, William K. Midodzi
Summary: This study found that male sex, older age (>40 years), smoking history, frequent asthma exacerbations, frequent emergency admissions, longer hospital stays, increased burden of comorbidities, obese male sex, SABA overuse, moderate and severe asthma all accelerated the time-to-COPD diagnosis among asthma patients. On the other hand, high medication adherence (MA >=0.80) was significantly associated with a delayed COPD diagnosis by 83%. This emphasizes the importance of medication adherence in delaying the onset of COPD among asthma patients.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Allergy
Michael Asamoah-Boaheng, Jamie Farrell, Kwadwo Osei Bonsu, William K. Midodzi
Summary: This study examined the relationship between medication adherence levels and asthma exacerbations in physician-diagnosed asthma patients. The results showed that maintaining a medication adherence threshold level greater than 0.80 can significantly reduce the likelihood of experiencing asthma exacerbations.
Article
Medicine, General & Internal
Isaac Kofi Owusu, Yaw Amo Wiafe, Stephen Opoku, Enoch Odame Anto, Emmanuel Acheamfour-Akowuah
Summary: Cardiac abnormalities are common in people living with HIV regardless of treatment with HAART. Echocardiographic and electrographic assessments are highly recommended for all PLWHIV.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Isaac Kofi Owusu, Emmanuel Acheamfour-Akowuah, Yaw Amo Wiafe
Summary: The study found that RHD is more common in the third decade of life, with rural women being the most affected. Efforts to reduce prevalence rates should be strengthened.
RESEARCH REPORTS IN CLINICAL CARDIOLOGY
(2022)
Review
Medicine, Research & Experimental
Gordon Manu Amponsah, Yaw Adu-Boakye, Maureen Nyarko, Henry Kofi Andoh, Kwaku Gyasi Danso, Manolo Agbenoku, Isaac Kofi Owusu
Summary: Thyrotoxic periodic paralysis (TPP) is a rare symmetrical paralysis that primarily affects proximal muscles and occurs in hyperthyroidism with hypokalemia. It is more common in East Asian males and extremely rare in blacks. There is limited data on TPP in Africa, and no cases have been reported in Ghana. We present a case of a middle-aged Ghanaian man who experienced three episodes of paralysis in all four limbs, with the second and third episodes requiring hospitalization. He did not show signs of hyperthyroidism during the first hospital visit but developed clinical and biochemical evidence of hyperthyroidism during the second visit, with serum potassium levels of 1.9 mmol/L, leading to a diagnosis of TPP. His paralysis resolved after correcting the hypokalemia. It is important to consider less common differentials, such as TPP, in patients presenting with paralysis to ensure early diagnosis and treatment and prevent complications.
AIMS MEDICAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Isaac Kofi Owusu, Emmanuel Acheamfour-Akowuah, Lois Amoah-Kumi, Yaw Amo Wiafe, Stephen Opoku, Enoch Odame Anto
Summary: In patients seen at a specialist clinic in Ghana, obesity was found to be significantly associated with female gender, increasing age, and increasing blood pressure.
AIMS MEDICAL SCIENCE
(2023)
Article
Respiratory System
Paul Poku Sampene Ossei, Isaac Kofi Owusu, Gerald Owusu-Asubonteng, Frank Ankobea-Kokroe, William Gilbert Ayibor, Nicholas Niako
CLINICAL MEDICINE INSIGHTS-CIRCULATORY RESPIRATORY AND PULMONARY MEDICINE
(2020)
Article
Education, Special
Isaac Owusu, Acheampong Enoch, Wisdom Kwadwo Mprah, Hashani Vampere
INTERNATIONAL JOURNAL OF SPECIAL EDUCATION
(2018)
Article
Peripheral Vascular Disease
George Asafu Adjaye Frimpong, Isaac Kofi Owusu, Ijeoma Chinedum Anyitey-Kokor, Caitlin Selassie Naa Sarku Wiafe-Kwakye, Evans Aboagye, Nana Esi Coleman, Pierre Amankwah, Nakao Kuukua Abaidoo
VASCULAR HEALTH AND RISK MANAGEMENT
(2018)
Article
Social Sciences, Interdisciplinary
Reindolf Anokye, Enoch Acheampong, Isaac Owusu, Edmund Isaac Obeng
COGENT SOCIAL SCIENCES
(2018)